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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC GRK7 203
AGC AKT1 150
AGC AKT3 148
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK CAMK2A 13
CAMK CAMK2B 14
CMGC CDC2L5 705
CMGC CDK2 4
CMGC CDK3 4
CMGC CDKL2 4
CAMK CHEK2 220
AGC CIT 97
CAMK DAPK1 13
Other EIF2AK2 267
AGC GRK4 187
CMGC GSK3A 119
CMGC GSK3B 56
CMGC ICK 4
TKL MAP3K7 36
CMGC MAPK10 64
CMGC MAPK14 24
CAMK NUAK2 97
STE PAK7 449
Other PLK4 12
AGC PRKACA 44
AGC PRKACB 44
CAMK PRKD3 576
AGC PRKG1 375
AGC PRKG2 453
AGC PRKX 49
AGC ROCK1 76
AGC ROCK2 92
Other ULK1 16
Other ULK2 9
---F-TEFRVLGKGGFGEVCAVQVK-NTGK-MYACKKLDKKR-LKKKG--GEKMAL-----LEKEILEKVSSPFIVSLAYAFES-----------------------------KTHLC--LVMSLMNGG--DLKFHIYN--VGTR----GLDMSRVIFYSAQIACGMLHLHE-LG---IVYRDMKPENVLLD-DLG-NC---------RLSDLGLAVE--MKGGKPITQ---RAGTNGYMAPEILM-----EKVSYSYPVDWFAMGCSIYEMVA-GR-TPFKDY--KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------EEAKDICRLFLAKKPEQ--RLG-----SRE-------KSDDPR
---F-EYLKLLGKGTFGKVILVKEK-ATGR-YYAMKILKKEV-IVAKD--EVAHTL-----TENRVLQNSRHPFLTALKYSFQT-----------------------------HDRLC--FVMEYANGG--ELFFHLS----RER----VFSEDRARFYGAEIVSALDYLHSEKN---VVYRDLKLENLMLD-KDG-HI---------KITDFGLCKEG-IKDGATMKT---FCGTPEYLAPEVLE------DNDYGRAVDWWGLGVVMYEMMC-GR-LPFYNQ------DHEKLFELILMEEIRFPRTLG---------------------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF------
--FD--YLKLLGKGTFGKVILVREK-ASGK-YYAMKILKKEV-IIAKD--EVAHTL-----TESRVLKNTRHPFLTSLKYSFQT-----------------------------KDRLC--FVMEYVNGG--ELFFHLS----RER----VFSEDRTRFYGAEIVSALDYLHS-GK---IVYRDLKLENLMLD-KDG-HI---------KITDFGLCKEG-ITDAATMKT---FCGTPEYLAPEVLE------DNDYGRAVDWWGLGVVMYEMMC-GR-LPFYNQ------DHEKLFELILMEDIKFPRTLS---------------------------------------SDAKSLLSGLLIKDPNK--RLGGGPDDAKEIMRHSFF------
----FEIGRPLGKGKFGNVYLAREK-QSKF-ILALKVLFKAQLEKAGV--EHQLRR------EVEIQSHLRHPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLS----KFDEQRTATYITELANALSYCHS-KR---VIHRDIKPENLLLG-SAG-EL---------KIADFGWSV---HAPSSRRTT---LCGTLDYLPPEMIE------GRMHDEKVDLWSLGVLCYEFLV-GK-PPFEAN------TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI------
----FEIGRPLGKGKFGNVYLAREK-KSHF-IVALKVLFKSQ-IEKEG--VEHQLR-----REIEIQAHLHHPNILRLYNYFYD-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSC----TFDEQRTATIMEELADALMYCHG-KK---VIHRDIKPENLLLG-LKG-EL---------KIADFGWSV---HAPSLRRKT---MCGTLDYLPPEMIE------GRMHNEKVDLWCIGVLCYELLV-GN-PPFESA------SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV------
----FEIGRPLGKGKFGNVYLARLK-ESHF-IVALKVLFKSQ-IEKEG--LEHQLR-----REIEIQAHLQHPNILRLYNYFHD-----------------------------ARRVY--LILEYAPRG--ELYKELQ----KSE----KLDEQRTATIIEELADALTYCHD-KK---VIHRDIKPENLLLG-FRG-EV---------KIADFGWSV---HTPSLRRKT---MCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GY-PPFESA------SHSETYRRILKVDVRFPLSMP---------------------------------------LGARDLISRLLRYQPLE--RLP-----LAQILKHPWV------
----YQLFEELGKGAFSVVRRCVKV-LAGQ-EYAAKIINTKK-LSARD--HQKLER------EARICRLLKHPNIVRLHDSISE-----------------------------EGHHY--LIFDLVTGG--ELFEDIV----ARE----YYSEADASHCIQQILEAVLHCHQ-MG---VVHRDLKPENLLLA-SKL-KGA------AVKLADFGLAIEV-EGEQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDLWACGVILYILLV-GY-PPFWDE------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------PEAKDLINKMLTINPSK--RIT-----AAEALKHPWI------
----YQLYEDIGKGAFSVVRRCVKL-CTGH-EYAAKIINTKK-LSARD--HQKLER------EARICRLLKHSNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE----YYSEADASHCIQQILEAVLHCHQ-MG---VVHRDLKPENLLLA-SKC-KGA------AVKLADFGLAIEV-QGDQQAWFG---FAGTPGYLSPEVLR------KEAYGKPVDIWACGVILYILLV-GY-PPFWDE------DQHKLYQQIKAGAYDFPSPEWDTVT-----------------------------------PEAKNLINQMLTINPAK--RIT-----AHEALKHPWV------
---F-DIIGIIGEGTYGQVYKARDK-DTGE-MVALKKVRLDN-EKEGF--PITAIR------EIKILRQLTHQSIINMKEIVTDKEDAL-------------------DFKKDKGAFY--LVFEYMDH---DLMGLLE---SGLV----HFNENHIKSFMRQLMEGLDYCHK-KN---FLHRDIKCSNILLN-NRG-QI---------KLADFGLARLYSSEESRPYTN---KVITLWYRPPELLL-----GEERYTPAIDVWSCGCILGELFT-KK-PIFQAN---QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQY------------RRKLREEFVFIPAAALDLFDYMLALDPSK--RCT-----AEQALQCEF-L-----
----FQKVEKIGEGTYGVVYKARNK-LTGE-VVALKKIRLDT-ETEGV--PSTAIR------EISLLKELNHPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT----GIPLPLIKSYLFQLLQGLAFCHS-HR---VLHRDLKPQNLLIN-TEG-AI---------KLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGD---SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF------
----FQKVEKIGEGTYGVVYKAKNR-ETGQ-LVALKKIRLDL-EMEGV--PSTAIR------EISLLKELKHPNIVRLLDVVHN-----------------------------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS----ELPLHLIKSYLFQLLQGVSFCHS-HR---VIHRDLKPQNLLIN-ELG-AI---------KLADFGLARAF-GVPLRTYTH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RK-ALFPGD---SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQ--RIT-----AKTALAHPYF------
----YENLGLVGEGSYGMVMKCRNK-DTGR-IVAIKKFLESD-DDKMV--KKIAMR------EIKLLKQLRHENLVNLLEVCKK-----------------------------KKRWY--LVFEFVDHT--ILDDLEL----FPN----GLDYQVVQKYLFQIINGIGFCHS-HN---IIHRDIKPENILVS-QSG-VV---------KLCDFGFARTL-AAPGEVYTD---YVATRWYRAPELLV-----GDVKYGKAVDVWAIGCLVTEMFM-GE-PLFPGD---SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------REPLERRYPKLSEVVIDLAKKCLHIDPDK--RPF-----CAELLHHDFF------
--YI--MSKTLGSGACGEVKLAFER-KTCK-KVAIKIISKRK-FAIGS--AREADPALNVETEIEILKKLNHPCIIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNK----RLKEATCKLYFYQMLLAVQYLHE-NG---IIHRDLKPENVLLS-SQE-EDC------LIKITDFGHSKI--LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GY-PPFSEH-----RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKA--RFT-----TEEALRHPWL------
---F-EVRSLVGCGHFAEVQVVREK-ATGD-IYAMKVMKKKA-LLAQE--QVSFFE-----EERNILSRSTSPWIPQLQYAFQD-----------------------------KNHLY--LVMEYQPGG--DLLSLLN---RYED----QLDENLIQFYLAELILAVHSVHL-MG---YVHRDIKPENILVD-RTG-HI---------KLVDFGSAAKMNSNKMVNAKL---PIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIY-GR-SPFAEG------TSARTFNNIMNFQRFLKFPDDPKVS-----------------------------------SDFLDLIQSLLCG-QKE--RLK-----FEGLCCHPFF------
----YDTGEELGSGQFAVVKKCREK-STGL-QYAAKFIKKRR-TKSSR--RGVSREDI--EREVSILKEIQHPNVITLHEVYEN-----------------------------KTDVI--LILELVAGG--ELFDFLA----EKE----SLTEEEATEFLKQILNGVYYLHS-LQ---IAHFDLKPENIMLL-DRN-VPKP-----RIKIIDFGLAHK--IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GA-SPFLGD------TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKK--RMT-----IQDSLQHPWI------
---F-KEIELIGSGGFGQVFKAKHR-IDGK-TYVIKRVKYNN-EKAER--------------EVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE----KLDKVLALELFEQITKGVDYIHS-KK---LIHRDLKPSNIFLV-DTK-QV---------KIGDFGLVTS--LKNDGKRTR---SKGTLRYMSPEQIS------SQDYGKEVDLYALGLILAELLH-VCDTAFET----------SKFFTDLRDGIISDIFDK----------------------------------------KEKTLLQKLLSKKPED--RPN-----TSEILR----TLT---
--FR--HYRVLGKGGFGEVCACQVR-ATGK-MYACKKLQKKR-IKKRK--GEAMAL-----NEKRILEKVQSRFVVSLAYAYET-----------------------------KDALC--LVLTIMNGG--DLKFHIYN--LGNP----GFDEQRAVFYAAELCCGLEDLQR-ER---IVYRDLKPENILLD-DRG-HI---------RISDLGLATE--IPEGQRVRG---RVGTVGYMAPEVVN------NEKYTFSPDWWGLGCLIYEMIQ-GH-SPFKKY---KEKVKWEEVDQRIKNDTEEYSE---KFS-----------------------------------EDAKSICRMLLTKNPSK--RLGCRGEGAAGVKQHPV-F-----
----YTDIKVIGNGSFGVVYQARLA-ETRE-LVAIKKVLQDK-RFKNR--------------ELQIMRKLDHCNIVRLRYFFYSSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT---KAKL----TIPILYVKVYMYQLFRSLAYIHS-QG---VCHRDIKPQNLLVDPDTA-VL---------KLCDFGSAKQ--LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGD---SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-----PLEACAHSFF------
----YTDTKVIGNGSFGVVYQAKLC-DSGE-LVAIKKVLQDK-RFKNR--------------ELQIMRKLDHCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ----TLPVIYVKLYMYQLFRSLAYIHS-FG---ICHRDIKPQNLLLDPDTA-VL---------KLCDFGSAKQ--LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGD---SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF------
----YTTIRQLGDGTYGSVLLGRSI-ESGE-LIAIKKMKRKF-YSWEE--C-MNLR------EVKSLKKLNHANVVKLKEVIRE-----------------------------NDHLY--FIFEYMKE---NLYQLIK---ERNK----LFPESAIRNIMYQILQGLAFIHK-HG---FFHRDLKPENLLCM-GPE-LV---------KIADFGLARE--IRSKPPYTD---YVSTRWYRAPEVLL-----RSTNYSSPIDVWAVGCIMAEVYT-LR-PLFPGA---SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------PNNLKTLIPNASSEAVQLLRDMLQWDPKK--RPT-----ASQALRYPYF------
----IEVEEVVGRGAFGVVCKAKWR---AK-DVAIKQIE-----S-ESERKAFI-V------ELRQLSRVNHPNIVKLYGACL-------------------------------NPVC--LVMEYAEGG--SLYNVLH-----GAEPLPYYTAAHAMSWCLQCSQGVAYLHS-MQPKALIHRDLKPPNLLLV-AGGTVL---------KICDFGTACDI-------QTHMTNNKGSAAWMAPEVFE------GSNYSEKCDVFSWGIILWEVITR-R-KPFDEIGG-PAFRIMWAVHNGTRPPLIKNLP-----------------------------------------KPIESLMTRCWSKDPSQ--RPS-----MEEIVKI--M------
----YQNLKPIGSGAQGIVCAAYDA-VLDR-NVAIKKLSRPF-QNQTH--AKRAYR------ELVLMKCVNHKNIISLLNVFTPQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ------M----ELDHERMSYLLYQMLCGIKHLHS-AG---IIHRDLKPSNIVVK-SDC-TL---------KILDFGLART--AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGEMVR-HK-ILFPGR---DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VDDALQHPYI------
----YQNLSPVGSGAYGSVCAAFDT-KTGL-RVAVKKLSRPF-QSIIH--AKRTYR------ELRLLKHMKHENVIGLLDVFTPARS-----------------------LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ----KLTDDHVQFLIYQILRGLKYIHS-AD---IIHRDLKPSNLAVN-EDC-EL---------KILDFGLAR----HTDDEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GR-TLFPGT---DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF------
----YEFLETLGKGTYGKVKKARES-SGR--LVAIKSIRKDK-IKDEQ--DLMHIR-----REIEIMSSLNHPHIIAIHEVFEN-----------------------------SSKIV--IVMEYASRG--DLYDYIS----ERQ----QLSEREARHFFRQIVSAVHYCHQ-NR---VVHRDLKLENILLD-ANG-NI---------KIADFGLSNL--YHQGKFLQT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GT-MPFDGH------DHKILVKQISNGAYREPPK-----P-----------------------------------SDACGLIRWLLMVNPTR--RAT-----LEDVASHWW-V-----
ANFI-----KIGEGSTGIVCIATEK-HTGK-QVAVKKMDLRK-QQRRE--L--LFN------EVVIMRDYHHDNVVDMYSSYLV-----------------------------GDELW--VVMEFLEGG--ALTDIVT-----HT----RMNEEQIATVCLSVLRALSYLHN-QG---VIHRDIKSDSILLT-SDG-RI---------KLSDFGFCAQV-SKEVPKRKS---LVGTPYWMAPEVIS------RLPYGTEVDIWSLGIMVIEMID-GE-PPYFNE---PPLQAMRRIRDSLPPRVKDLHK----VS-----------------------------------SVLRGFLDLMLVREPSQ--RAT-----AQELLGHPFL------
---F-KVGNLLGKGSFAGVYRAESI-HTGL-EVAIKMIDKKA-MYKAG--MVQRVQ-----NEVKIHCQLKHPSILELYNYFED-----------------------------SNYVY--LVLEMCHNG--EMNRYLK---NRVK----PFSENEARHFMHQIITGMLYLHS-HG---ILHRDLTLSNLLLT-RNM-NI---------KIADFGLATQL-KMPHEKHYT---LCGTPNYISPEIAT------RSAHGLESDVWSLGCMFYTLLI-GR-PPFDTD------TVKNTLNKVVLADYEMPSFLS---------------------------------------IEAKDLIHQLLRRNPAD--RLS-----LSSVLDHPFM------
---F-ERIKTLGTGSFGRVMLVKHK-ETGN-HYAMKILDKQK-VVKLK--QIEHTL-----NEKRILQAVNFPFLVKLEFSFKD-----------------------------NSNLY--MVMEYVPGG--EMFSHLR----RIG----RFSEPHARFYAAQIVLTFEYLHS-LD---LIYRDLKPENLLID-QQG-YI---------QVTDFGFAK----RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GY-PPFFAD------QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF------
---F-ERKKTLGTGSFGRVMLVKHK-ATEQ-YYAMKILDKQK-VVKLK--QIEHTL-----NEKRILQAVNFPFLVRLEYAFKD-----------------------------NSNLY--MVMEYVPGG--EMFSHLR----RIG----RFSEPHARFYAAQIVLTFEYLHS-LD---LIYRDLKPENLLID-HQG-YI---------QVTDFGFAK----RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GY-PPFFAD------QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTK--RFGNLKNGVSDIKTHKWF------
-FAD----EVLGSGQFGIVYGGKHR-KTGR-DVAIKVIDKMR-FPTKQ--ESQLRN------EVAILQNLHHPGIVNLECMFET-----------------------------PERVF--VVMEKLHGD--MLEMILS---SEKS----RLPERITKFMVTQILVALRNLHF-KN---IVHCDLKPENVLLA-SAE-PFP------QVKLCDFGFARI--IGEKSFRRS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GT-FPFNED--------EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRK--RYS-----VDKSLSHPWL------
---F-NIIDTLGVGGFGRVELVQLKSEESK-TFAMKILKKRH-IVDTR--QQEHIR-----SEKQIMQGAHSDFIVRLYRTFKD-----------------------------SKYLY--MLMEACLGG--ELWTILR----DRG----SFEDSTTRFYTACVVEAFAYLHS-KG---IIYRDLKPENLILD-HRG-YA---------KLVDFGFAKK--IGFGKKTWT---FCGTPEYVAPEIIL------NKGHDISADYWSLGILMYELLT-GS-PPFSGP------DPMKTYNIILRGIDMIEFPKKIA-------------------------------------KNAANLIKKLCRDNPSE--RLGNLKNGVKDIQKHKWF------
---L-EIIATLGVGGFGRVELVKVK-NENV-AFAMKCIRKKH-IVDTK--QQEHVY-----SEKRILEELCSPFIVKLYRTFKD-----------------------------NKYVY--MLLEACLGG--ELWSILR----DRG----SFDEPTSKFCVACVTEAFDYLHR-LG---IIYRDLKPENLILD-AEG-YL---------KLVDFGFAKK--IGSGQKTWT---FCGTPEYVAPEVIL------NKGHDFSVDFWSLGILVYELLT-GN-PPFSGV------DQMMTYNLILKGIEKMDFPRKIT-------------------------------------RRPEDLIRRLCRQNPTE--RLGNLKNGINDIKKHRWL------
--FD--TLATVGTGTFGRVHLVKEK-TAKH-FFALKVMSIPD-VIRLK--QEQHVH-----NEKSVLKEVSHPFLIRLFWTWHD-----------------------------ERFLY--MLMEYVPGG--ELFSYLR----NRG----RFSSTTGLFYSAEIICAIEYLHS-KE---IVYRDLKPENILLD-RDG-HI---------KLTDFGFAKK----LVDRTWT---LCGTPEYLAPEVIQ------SKGHGRAVDWWALGILIFEMLS-GF-PPFFDD------NPFGIYQKILAGKIDFPRHLD---------------------------------------FHVKDLIKKLLVVDRTR--RLGNMKNGANDVKHHRWF------
----YEVVKVIGRGAFGEVQLVRHK-STRK-VYAMKLLSKFE-MIKRS--DSAFFW-----EERDIMAFANSPWVVQLFYAFQD-----------------------------DRYLY--MVMEYMPGG--DLVNLMS-----NY----DVPEKWARFYTAEVVLALDAIHS-MG---FIHRDVKPDNMLLD-KSG-HL---------KLADFGTCMKMNKEGMVRCDT---AVGTPDYISPEVLKS--QGGDGYYGRECDWWSVGVFLYEMLV-GD-TPFYAD------SLVGTYSKIMNHKNSLTFPDDNDIS-----------------------------------KEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF------
----YDVVKVIGRGAFGEVQLVRHK-ASQK-VYAMKLLSKFE-MIKRS--DSAFFW-----EERDIMAFANSPWVVQLFYAFQD-----------------------------DRYLY--MVMEYMPGG--DLVNLMS-----NY----DVPEKWAKFYTAEVVLALDAIHS-MG---LIHRDVKPDNMLLD-KHG-HL---------KLADFGTCMKMDETGMVHCDT---AVGTPDYISPEVLKS--QGGDGFYGRECDWWSVGVFLYEMLV-GD-TPFYAD------SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF------
--FS--RKDLIGHGAFAVVFKGRHR-EKHDLEVAVKCINKKN-LAKSQ--T-LLGK------EIKILKELKHENIVALYDFQEM-----------------------------ANSVY--LVMEYCNGG--DLADYLH----AMR----TLSEDTIRLFLQQIAGAMRLLHS-KG---IIHRDLKPQNILLS-NPA-GRRANPNSIRVKIADFGFARY--LQSNMMAAT---LCGSPMYMAPEVIM------SQHYDGKADLWSIGTIVYQCLT-GK-APFQAS---SPQDLRLFYEKNKTLVPTIPRETS---------------------------------------APLRQLLLALLQRNHKD--RMD-----FDEFFHHPFL------
---Y-SKRDLVGHGAFAVVFRGRHR-QKTDWEVAIKSINKKN-LSKSQ---ILLGK------EIKILKELQHENIVALYDVQEL-----------------------------PNSVF--LVMEYCNGG--DLADYLQ----AKG----TLSEDTIRVFLHQIAAAMRILHS-KG---IIHRDLKPQNILLS-YAN-RRKSSVSGIRIKIADFGFARY--LHSNMMAAT---LCGSPMYMAPEVIM------SQHYDAKADLWSIGTVIYQCLV-GK-PPFQAN---SPQDLRMFYEKNRS--LMPSIPRETS-------------------------------------PYLANLLLGLLQRNQKD--RMD-----FEAFFSHPFL------
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