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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC GSK3B 56
TK ITK 363
TK JAK3 822
TK LCK 245
CMGC MAPK1 13
CMGC MAPK14 24
-YTDIKVIGNGSFGVVYQARLA----ETRE-LVAIKKVLQDK-RFK---NR-------ELQIMRKLD---HCNIVRLRYFFY--SSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI-------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-
-FEIGRPLGKGKFGNVYLAREK----QSKF-ILALKVLFKAQLEKA---GV-EHQLRREVEIQSHLR---HPNILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV-------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP-------------FEAN----TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-
-YTKIEKIGEGTYGVVYKGRHK----TTGQ-VVAMKKIRLES-EEE---GV-PSTAIREISLLKELR---HPNIVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF-----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL-------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-
-FQKVEKIGEGTYGVVYKARNK----LTGE-VVALKKIRLDT-ETE---GV-PSTAIREISLLKELN---HPNIVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
Y-EPVAEIGVGAYGTVYKARDP----HSGH-FVALKSVRVPN-GGGGGGGL-PISTVREVALLRRLEAFEHPNVVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI------YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL-------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-
-YECVAEIGEGAYGKVFKARDL----KNGGRFVALKRVRVQT-GEE---GM-PLSTIREVAVLRHLETFEHPNVVRLFDVCT--VSR-TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP---GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARI------YSFQMALTS---VVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPL-------------FRGS-SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ----PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-
-YTDTKVIGNGSFGVVYQAKLC----DSGE-LVAIKKVLQDK-RFK---NR-------ELQIMRKLD---HCNIVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI-------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-
-LTFVQEIGSGQFGLVHLGYWL-----NKD-KVAIKTIR-EG-AM----SE-EDFI-EEAEVMMKLS---HPKLVQLYGVCL--E------QAPIC--LVFEFMEHG--CLSDYLR-----TQ-RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFV-----L--DDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIP-------------YENR-SNSEVVEDISTGFRLYKPRLAS------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL---
L-KYISQLGKGNFGSVELCRYDPLGDNTGA-LVAVKQLQ-HS-GP----DQQRDFQ-REIQILKALH---SDFIVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHVKIADFGLAKLL-PL--D--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACP------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL
-LKLVERLGAGQFGEVWMGYYN-----GHT-KVAVKSLK-QG-SM----SP-DAFL-AEANLMKQLQ---HQRLVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI-----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP-------------YPGM-TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
-YTNLSYIGEGAYGMVCSAYDN----VNKV-RVAIKKISPFE-HQT---YC-QRT-LREIKILLRFR---HENIIGINDIIR--APT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVAD--PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPI-------------FPGK-HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL-
-YQNLSPVGSGAYGSVCAAFDT----KTGL-RVAVKKLSRPF-QSI---IH-AKRTYRELRLLKHMK---HENVIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL-------------FPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
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