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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CMGC CLK2 163
TK FGFR1 478
TK FGFR2 481
TK FGR 263
TK FYN 271
CMGC GSK3B 56
TK LCK 245
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
CMGC NLK 126
Other PLK1 53
CAMK PRKD3 576
AGC RPS6KA2 59
TK SRC 270
TK YES1 277
---YTDIKVIGNGSFGVVYQARLA-------ETRE---LVAIKKVLQDKRFKNR---------ELQIMRKL-D-----HCN-IVRLRYFFYSSG----EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------------TI--PILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL-------------------KLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF
---YTKIEKIGEGTYGVVYKGRHK-------TTGQ---VVAMKKIRLESEEEGV--PSTAIR-EISLLKEL-R-----HPN-IVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF-----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF
---FQKVEKIGEGTYGVVYKARNK-------LTGE---VVALKKIRLDTETEGV--PSTAIR-EISLLKEL-N-----HPN-IVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
---FQKVEKIGEGTYGVVYKAKNR-------ETGQ---LVALKKIRLDLEMEGV--PSTAIR-EISLLKEL-K-----HPN-IVRLLDVVHN--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS-----------------EL--PLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAI-------------------KLADFGLARAF-----GVPLRTYTH---EVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF
---YEKLEKIGEGTYGTVFKAKNR-------ETHE---IVALKRVRLDDDDEGV--PSSALR-EICLLKEL-K-----HKN-IVRLHDVLHS--------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL-------------------KLADFGLARAF-----GIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF
---YEKLAKIGQGTFGEVFKARHR-------KTGQ---KVALKKVLMENEKEGF--PITALR-EIKILQLL-K-----HEN-VVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV-----------------KF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL-------------------KLADFGLARAFSL-AKNSQPNRYTN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF
---YEIVSTLGEGTFGRVVQCVDH-------RRGG--ARVALKIIKNVEKYKEA--AR---L-EINVLEKI-NEKDPDNKNLCVQMFDWFDY--------HGHMC--ISFELLGL---STFDFLK----DNN-----------------YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV-NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT--------FDHEHHST---IVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYV-GFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-----LGEALQHPFF
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT---KVAVKMLK-SDAT-EKDLSDLI-S-EMEMMKMIGK-----HKN-IINLLGACTQ--------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQL--SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM-------------------KIADFGLARDI--H--H--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL--
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAV---TVAVKMLK-DDAT-EKDLSDLV-S-EMEMMKMIGK-----HKN-IINLLGACTQ--------DGPLY--VIVEYASKG--NLREYLR-----ARRPPGMEYSYDINRVPEEQM--TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVM-------------------KIADFGLARDI--N--N--IDYYKKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT-------------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL--
---ITLERRLGTGCFGDVWLGTWN--------GST---KVAVKTLK-PGTM-SP--KAFL-E-EAQVMKLL-R-----HDK-LVQLYAVVS---------EEPIY--IVTEFMCHG--SLLDFLK-----NP--------------EGQDL--RLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVG-ERLAC-------------------KIADFGLARLI-----K--DDEYNPCQGSKFPIKWTAPEAAL-FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCP-------------------------------------------ASLYEAMEQTWRLDPEERPT-----FEYLQSFL--
---LQLIKRLGNGQFGEVWMGTWN--------GNT---KVAIKTLK-PGTM-SP--ESFL-E-EAQIMKKL-K-----HDK-LVQLYAVVS---------EEPIY--IVTEYMNKG--SLLDFLK-----DG--------------EGRAL--KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLIC-------------------KIADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP-------------------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL--
---YTDTKVIGNGSFGVVYQAKLC-------DSGE---LVAIKKVLQDKRFKNR---------ELQIMRKL-D-----HCN-IVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-------------------KLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF
---LKLVERLGAGQFGEVWMGYYN--------GHT---KVAVKSLK-QGSM-SP--DAFL-A-EANLMKQL-Q-----HQR-LVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC-------------------KIADFGLARLI-----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L
---YQNLKPIGSGAQGIVCAAYDA-------VLDR---NVAIKKLSRPFQNQTH--AKRAYR-ELVLMKCV-N-----HKN-IISLLNVFTPQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI
LQG---LRPVGSGAYGSVCSAYDA-------RLRQ---KVAVKKLSRPFQSLIH--ARRTYR-ELRLLKHL-K-----HEN-VIGLLDVFTPATS--IEDFSEVY--LVTTLMGA---DLNNIVK-----CQ-----------------AL--SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCEL-------------------RILDFGLAR--------QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-------------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF
---YQNLSPVGSGAYGSVCAAFDT-------KTGL---RVAVKKLSRPFQSIIH--AKRTYR-ELRLLKHM-K-----HEN-VIGLLDVFTPARS--LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL-------------------KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF
---YQNLKPIGSGAQGIVCAAYDA-------ILER---NVAIKKLSRPFQNQTH--AKRAYR-ELVLMKCV-N-----HKN-IIGLLNVFTPQKS--LEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK--LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI
---YQQLKPIGSGAQGIVCAAFDT-------VLGI---NVAVKKLSRPFQNQTH--AKRAYR-ELVLLKCV-N-----HKN-IISLLNVFTPQKT--LEEFQDVY--LVMELMDA---NLCQVIH------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART------ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE--LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI
IEP---DRPIGYGAFGVVWSVTDP-------RDGK---RVALKKMPNVFQNLVS--CKRVFR-ELKMLCFF-K-----HDN-VLSALDILQPPH---IDYFEEIY--VVTELMQS---DLHKIIV----SPQ-----------------PL--SSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN-SNCVL-------------------KICDFGLARVE----ELDESRHMTQ---EVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP------------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL
-YV--RGRFLGKGGFAKCFEISDA-------DTKE---VFAGKIVPKSLLLKPH--QREKMSMEISIHRSL-A-----HQH-VVGFHGFFED--------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------AL--TEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV-------------------KIGDFGLATKV-----EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF
FAD----EVLGSGQFGIVYGGKHR-------KTGR---DVAIKVIDKMRFPTKQ--ESQLRN-EVAILQNL-H-----HPG-IVNLECMFET--------PERVF--VVMEKLHGD--MLEMILS---SEKS-----------------RL--PERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA-SAEPFP----------------QVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR-SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS-------------------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL
---FELLKVLGQGSYGKVFLVRKV-------KGSDAGQLYAMKVLKKATLKVRD--RVRSKM-ERDILAEV-N-----HPF-IVKLHYAFQT--------EGKLY--LILDFLRGG--DLFTRLS----KEV-----------------MF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI-------------------KITDFGLSKEA-----IDHDKRAYS---FCGTIEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLT-GSLPFQGK---DRKETMALILKAKLGMPQFLS-----------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF
--L-RLEVKLGQGCFGEVWMGTWN--------GTT---RVAIKTLK-PGTM-SP--EAFL-Q-EAQVMKKL-R-----HEK-LVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC-------------------KVADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L
--L-RLEVKLGQGCFGEVWMGTWN--------GTT---KVAIKTLK-PGTM-MP--EAFL-Q-EAQIMKKL-R-----HDK-LVPLYAVVS---------EEPIY--IVTEFMSKG--SLLDFLK-----EG--------------DGKYL--KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG-ENLVC-------------------KIADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCP-------------------------------------------ESLHELMNLCWKKDPDERPT-----FEYIQSFL--
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