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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK3 156
CMGC CLK4 159
CMGC DYRK1B 111
CMGC GSK3B 56
CMGC PCTK1 165
CMGC PCTK2 192
CMGC PCTK3 172
AGC PRKCA 339
-YTDIKVIGNGSFGVVYQARLAE-T-RE-LVAIKKVLQDKRFKNR-------ELQIMRKL-D-----HCN-----IVRLRYFFYSSG----EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTI---PILYVKVYMYQLFRSLAYIHS--QGVCHRDIKPQNLLVD-PDTAVL--------------------KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF--------------
-YTKIEKIGEGTYGVVYKGRHKT-T-GQ-VVAMKKIRLESEEEGVPSTAIR-EISLLKEL-R-----HPN-----IVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI--------------------KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
-FQKVEKIGEGTYGVVYKARNKL-T-GE-VVALKKIRLDTETEGVPSTAIR-EISLLKEL-N-----HPN-----IVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI--------------------KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
-FQKVEKIGEGTYGVVYKAKNRE-T-GQ-LVALKKIRLDLEMEGVPSTAIR-EISLLKEL-K-----HPN-----IVRLLDVVHN--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGSEL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLLIN--ELGAI--------------------KLADFGLARAF----GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF--------------
-YEKLEKIGEGTYGTVFKAKNRE-T-HE-IVALKRVRLDDDDEGVPSSALR-EICLLKEL-K-----HKN-----IVRLHDVLHS--------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL--------------------KLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--------------
-YECVAEIGEGAYGKVFKARDLK-N-GGRFVALKRVRVQTGEEGMPLSTIR-EVAVLRHL-ET--FEHPN-----VVRLFDVCTVSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGV---PTETIKDMMFQLLRGLDFLHS--HRVVHRDLKPQNILVT--SSGQI--------------------KLADFGLARI-----YSFQMALTSVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF--------------
-YEKLAKIGQGTFGEVFKARHRK-T-GQ-KVALKKVLMENEKEGFPITALR-EIKILQLL-K-----HEN-----VVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKF---TLSEIKRVMQMLLNGLYYIHR--NKILHRDMKAANVLIT--RDGVL--------------------KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF--------------
-YEIVDTLGEGAFGKVVECIDHK-AGGR-HVAVKIVKNVDRYCEAARS----EIQVLEHL-NT---TDPNST-FRCVQMLEWFEH--------HGHIC--IVFELLGL---STYDFIK----ENGFLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKR-DERTLINPDIKVVDFGSA-------TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF--------------
-YEIVSTLGEGTFGRVVQCVDHR-R-GGARVALKIIKNVEKYKEAAR---L-EINVLEKI-NEKDPDNKN----LCVQMFDWFDY--------HGHMC--ISFELLGL---STFDFLK----DNNYLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT-------FDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYV-GFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF--------------
-YEIVGNLGEGTFGKVVECLDHA-R-GKSQVALKIIRNVGKYREAAR---L-EINVLKKI-KE--KDKENK--FLCVLMSDWFNF--------HGHMC--IAFELLGK---NTFEFLK-----ENNFQPYPLPHVRHMAYQLCHALRFLHE--NQLTHTDLKPENILFV--NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT-------FDHEHHTTIVATRHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYR-GFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY--------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF--------------
-YEIVDTLGEGAFGKVVECIDHGMD-GM-HVAVKIVKNVGRYREAARS----EIQVLEHL-NS---TDPNSV-FRCVQMLEWFDH--------HGHVC--IVFELLGL---STYDFIK----ENSFLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKR-DERTLKNTDIKVVDFGSA-------TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF--------------
-YEIDSLIGKGSFGQVVKAYDHQ-T-QE-LVAIKIIKNKKAFLNQAQI----ELRLLELMNQ-----HDTEMKYYIVHLKRHFMF--------RNHLC--LVFELLSY---NLYDLLR-----NTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ-------LGQRIYQYIQSRFYRSPEVLL-GTPYDLAIDMWSLGCILVEMHT-GEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF--------------
-YTDTKVIGNGSFGVVYQAKLCD-S-GE-LVAIKKVLQDKRFKNR-------ELQIMRKL-D-----HCN-----IVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL--------------------KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--------------
Y-IKLDKLGEGTYATVYKGKSKL-T-DN-LVALKEIRLEHEEGAPC-TAIR-EVSLLKDL-K-----HAN-----IVTLHDIIHT--------EKSLT--LVFEYLDK---DLKQYLD---DCGNII---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLLIN--ERGEL--------------------KLADFGLARAK----SIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMAT-GRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR----------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF--------------
Y-IKLEKLGEGTYATVYKGRSKL-T-EN-LVALKEIRLEHEEGAPC-TAIR-EVSLLKDL-K-----HAN-----IVTLHDIVHT--------DKSLT--LVFEYLDK---DLKQYMD---DCGNIM---SMHNVKLFLYQILRGLAYCHR--RKVLHRDLKPQNLLIN--EKGEL--------------------KLADFGLARAK----SVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMAS-GRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYK----------------------------------PQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF--------------
-YVKLDKLGEGTYATVFKGRSKL-T-EN-LVALKEIRLEHEEGAPC-TAIR-EVSLLKNL-K-----HAN-----IVTLHDLIHT--------DRSLT--LVFEYLDS---DLKQYLD----HCGNL--MSMHNVKIFMFQLLRGLAYCHH--RKILHRDLKPQNLLIN--ERGEL--------------------KLADFGLARAK----SVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMAT-GRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYL----------------------------------PQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF--------------
F-NFLMVLGKGSFGKVMLADRKG-T-EE-LYAIKILKKDVVIQDDDVECTMVEKRVLALLDK-----PPF-----LTQLHSCFQT--------VDRLY--FVMEYVNGG--DLMYHIQ----QVGKF---KEPQAVFYAAEISIGLFFLHK--RGIIYRDLKLDNVMLD--SEGHI--------------------KIADFGMCKEH----MMDGVTTRTFCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLA-GQPPFDGE---DEDELFQSIMEHNVSYPKSLS-------------------------------------------------------------KEAVSVCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
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