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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
CMGC GSK3B 56
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
CAMK MAPKAPK2 64
Other PLK1 53
---YTDIKVIGNGSFGVVYQARLA-----ETRELVAIKKVLQDK-RFKNR---------ELQIMRKL-DHCNIVRLRYFFY--SSGEKKDELYLNLVLEYVPETVYRVARHFT---KAKL--------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPD---TAVL---KLCDFGSAKQ---LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD--SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF--
---ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-ED-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--R----EPPFY--IITEFMTYG--NLLDYLR-----EC-----NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-E---NHLV---KVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI--DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
--I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EV-CS-EQDELDFL-M-EALIISKF-NHQNIVRCIGVSL--Q----SLPRF--ILLELMAGG--DLKSFLR-----ETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT-CPGPGRVA---KIGDFGMARDI-YR--ASYYRKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK--SNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I--
---FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH--D----ATRVY--LILEYAPLG--TVYRELQ----KLS--------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-S---AGEL---KIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN-----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHL-HHPNILRLYNYFY--D----RRRIY--LILEYAPRG--ELYKELQ----KSC--------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-L---KGEL---KIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA-----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV--PSTAIR-EISLLKEL-NHPNIVKLLDVIH--T----ENKLY--LVFEFLHQ---DLKKFMDA--SALT--------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-T---EGAI---KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD--SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
---YTDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQDK-RFKNR---------ELQIMRKL-DHCNIVRLRYFFY--SSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD---TAVL---KLCDFGSAKQ---LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD--SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--
---LTFVQEIGSGQFGLVHLGYWL------NKDKVAIKTIR-EG-AM-SE--EDFI-E-EAEVMMKL-SHPKLVQLYGVCL--E----QAPIC--LVFEFMEHG--CLSDYLR-----TQ------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-E---NQVI---KVSDFGMTRFV--L--DDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR--SNSEVVEDISTGFRLYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAG----RRNLK--LIMEYLPYG--SLRDYLQ-----KH------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-N---ENRV---KIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM--IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-HS-GP-DQ-QRDFQ-R-EIQILKAL-HSDFIVKYRGVSYGPG----RQSLR--LVMEYLPSG--CLRDFLQ-----RH------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-S---EAHV---KIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVP-ALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
---LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QG-SM-SP--DAFL-A-EANLMKQL-QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TP-----SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-D---TLSC---KIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM--TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
KVT---SQVLGLGINGKVLQIFNK-----RTQEKFALKMLQDCP-KAR---------R-EVELHWRASQCPHIVRIVDVYE--NLYAGRKCLL--IVMECLDGG--ELFSRIQD--RGDQ--------AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-S---KRPNAILKLTDFGFAKE---TTSHNSLTT---PCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLC-GYPP---------------FYSN-HGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI--
-YV--RGRFLGKGGFAKCFEISDA-----DTKEVFAGKIVPKSL-LLKPH--QREKMSMEISIHRSL-AHQHVVGFHGFFE--D----NDFVF--VVLELCRRR--SLLELHK----RRK--------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-E---DLEV---KIGDFGLATKV--EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS-----CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF--
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