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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BMX 422
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
CAMK CAMK4 46
Other CAMKK1 128
Other CAMKK2 165
CMGC CDC2 4
AGC CDC42BPB 76
CMGC CDK11A 438
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CAMK DAPK3 13
CAMK DCLK3 356
AGC DMPK 81
CMGC DYRK1B 111
TK EGFR 712
Other EIF2AK2 267
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK IGF1R 999
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
CAMK MARK2 53
CAMK MARK4 59
CAMK MKNK2 84
TK MUSK 575
Other NEK1 4
Other NEK3 4
Other NEK8 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK4 321
STE PAK6 407
AGC PDPK1 82
CAMK PHKG1 20
AGC PKN1 615
AGC PKN2 657
Other PLK1 53
Other PLK3 62
Other PLK4 12
AGC PRKACA 44
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK2 422
TK RET 724
TK ROS1 1945
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA4 33
AGC RPS6KA6 73
AGC RPS6KB1 91
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
STE STK10 36
CAMK STK17A 61
STE STK24 24
STE STK25 20
Other TLK1 477
Other TLK2 440
CAMK TSSK1B 12
Other ULK1 16
Other ULK2 9
-----YTDIKVIGNGSFGVV---YQARL---A-------ETRE---LVAIKKVLQDK-RFKNR-----------------------------------ELQIMRKL--D---HCN-----IVRLRYFFY--SSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT--KAKL-------------------------TI---PILYVKVYMYQLFRSLAYIHS--Q--GVCHRDIKPQNLLVD-PD-----TAVL---------KLCDFGSAKQ----------LVRGE-PN--------------VS---YICSRYYRAPELIF------GATD--YTSSIDVWSAGCVLAELLL-GQ-PI---------------FPGD------------SGVDQLVEIIKVLGTPTREQIREM-NP-NYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-------PL-EACAHSFF--------------
-----ITMKHKLGGGQYGEV---YEGVW---K-------KYSL---TVAVKTLK-ED-TM-EV--E-E-FL-K-------------------------EAAVMKEI--K---HPN-----LVQLLGVCT--R-----------------------------EPPFY--IITEFMTYG--NLLDYLR----EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--K--NFIHRDLAARNCLVG--E-----NHLV---------KVADFGLSRLM---------T--GD-TY--------------TAHAGAKFPIKWTAPESLA-------YNK--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI------------DLSQVYELLEKDYRMERPEGCP-----------------------------------------------------------------EKVYELMRACWQWNPSDRPS-------FA-EIHQA--F--------------
----I-TLIRGLGHGAFGEV---YEGQV---SG--MPNDPSPL---QVAVKTLP-EV-CS-EQDEL-D-FL-M-------------------------EALIISKF--N---HQN-----IVRCIGVSL--Q-----------------------------SLPRF--ILLELMAGG--DLKSFLR----ETRP-----------------RPSQPSSL---AMLDLLHVARDIACGCQYLEE--N--HFIHRDIAARNCLLT--CP--GPGRVA---------KIGDFGMARDI----Y----R--AS-YY--------------RKGGCAMLPVKWMPPEAFM-------EGI--FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK------------SNQEVLEFVTSGGRMDPPKNCP-----------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN-------FA-IILER--I--------------
-----FEIGRPLGKGKFGNV---YLARE---K-------QSKF---ILALKVLFKAQLEKAGV--E-H-QLRR-------------------------EVEIQSHL--R---HPN-----ILRLYGYFH--D-----------------------------ATRVY--LILEYAPLG--TVYRELQ---KLS-------------------------KF---DEQRTATYITELANALSYCHS--K--RVIHRDIKPENLLLG--S-----AGEL---------KIADFGWSV-----------HAPSS-RR--------------TT---LCGTLDYLPPEMIE-------GRM--HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN---------------TYQETYKRISRVEFTFPDFVT---------------------------------------------------------------EGARDLISRLLKHNPSQRPM-------LR-EVLEHPWI--------------
-----FEIGRPLGKGKFGNV---YLARE---K-------KSHF---IVALKVLFKSQ-IEKEG--V-E-HQLR------------------------REIEIQAHL--H---HPN-----ILRLYNYFY--D-----------------------------RRRIY--LILEYAPRG--ELYKELQ---KSC-------------------------TF---DEQRTATIMEELADALMYCHG--K--KVIHRDIKPENLLLG--L-----KGEL---------KIADFGWSV-----------HAPSL-RR--------------KT---MCGTLDYLPPEMIE-------GRM--HNEKVDLWCIGVLCYELLV-GN-PP---------------FESA---------------SHNETYRRIVKVDLKFPASVP---------------------------------------------------------------MGAQDLISKLLRHNPSERLP-------LA-QVSAHPWV--------------
-----FEIGRPLGKGKFGNV---YLARL---K-------ESHF---IVALKVLFKSQ-IEKEG--L-E-HQLR------------------------REIEIQAHL--Q---HPN-----ILRLYNYFH--D-----------------------------ARRVY--LILEYAPRG--ELYKELQ---KSE-------------------------KL---DEQRTATIIEELADALTYCHD--K--KVIHRDIKPENLLLG--F-----RGEV---------KIADFGWSV-----------HTPSL-RR--------------KT---MCGTLDYLPPEMIE-------GRT--YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA---------------SHSETYRRILKVDVRFPLSMP---------------------------------------------------------------LGARDLISRLLRYQPLERLP-------LA-QILKHPWV--------------
-----ITLLKELGSGQFGVV---QLGKW---K--------GQY---DVAVKMIK-EG-SM-SE--D-E-FF-Q-------------------------EAQTMMKL--S---HPK-----LVKFYGVCS--K-----------------------------EYPIY--IVTEYISNG--CLLNYLR----SH-----------------------GKGL---EPSQLLEMCYDVCEGMAFLES--H--QFIHRDLAARNCLVD--R-----DLCV---------KVSDFGMTRYV---------L--DD-QY--------------VSSVGTKFPVKWSAPEVFH-------YFK--YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY------------DNSQVVLKVSQGHRLYRPHLAS-----------------------------------------------------------------DTIYQIMYSCWHELPEKRPT-------FQ-QLLSS--I--------------
-----YRLEKTLGKGQTGLV---KLGVH---C-------ITGQ---KVAIKIVNREK-LSESV--L-M-KVER-------------------------EIAILKLI--E---HPH-----VLKLHDVYE--N-----------------------------KKYLY--LVLEHVSGG--ELFDYLV---KKG-------------------------RL---TPKEARKFFRQIVSALDFCHS--Y--SICHRDLKPENLLLD--E-----KNNI---------RIADFGMASL----------QVGDS-LL--------------ET---SCGSPHYACPEVIK------GEKY--DGRRADMWSCGVILFALLV-GA-LP---------------FDDD---------------NLRQLLEKVKRGVFHMPHFIP---------------------------------------------------------------PDCQSLLRGMIEVEPEKRLS-------LE-QIQKHPW-Y-------------
-----YRLEKTLGKGQTGLV---KLGVH---C-------VTCQ---KVAIKIVNREK-LSESV--L-M-KVER-------------------------EIAILKLI--E---HPH-----VLKLHDVYE--N-----------------------------KKYLY--LVLEHVSGG--ELFDYLV---KKG-------------------------RL---TPKEARKFFRQIISALDFCHS--H--SICHRDLKPENLLLD--E-----KNNI---------RIADFGMASL----------QVGDS-LL--------------ET---SCGSPHYACPEVIR------GEKY--DGRKADVWSCGVILFALLV-GA-LP---------------FDDD---------------NLRQLLEKVKRGVFHMPHFIP---------------------------------------------------------------PDCQSLLRGMIEVDAARRLT-------LE-HIQKHIW-Y-------------
-----YQLYEDIGKGAFSVV---RRCVK---L-------CTGH---EYAAKIINTKK-LSARD--H-Q-KLER-------------------------EARICRLL--K---HSN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDLVTGG--ELFEDIV---ARE-------------------------YY---SEADASHCIQQILEAVLHCHQ--M--GVVHRDLKPENLLLA--S-----KCKGA------AVKLADFGLAIEV---------QGDQQ-AW--------------FG---FAGTPGYLSPEVLR-------KEA--YGKPVDIWACGVILYILLV-GY-PP---------------FWDE---------------DQHKLYQQIKAGAYDFPSPEW-DT-VT---------------------------------------------------------PEAKNLINQMLTINPAKRIT-------AH-EALKHPWV--------------
-----YQLFEELGKGAFSVV---RRCMK---I-------PTGQ---EYAAKIINTKK-LSARD--H-Q-KLER-------------------------EARICRLL--K---HPN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDLVTGG--ELFEDIV---ARE-------------------------YY---SEADASHCIQQILESVNHCHL--N--GIVHRDLKPENLLLA--S-----KSKGA------AVKLADFGLAIEV---------QGDQQ-AW--------------FG---FAGTPGYLSPEVLR-------KDP--YGKPVDMWACGVILYILLV-GY-PP---------------FWDE---------------DQHRLYQQIKAGAYDFPSPEW-DT-VT---------------------------------------------------------PEAKDLINKMLTINPAKRIT-------AS-EALKHPWI--------------
-----YQLFEELGKGAFSVV---RRCVK---K-------TSTQ---EYAAKIINTKK-LSARD--H-Q-KLER-------------------------EARICRLL--K---HPN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDLVTGG--ELFEDIV---ARE-------------------------YY---SEADASHCIHQILESVNHIHQ--H--DIVHRDLKPENLLLA--S-----KCKGA------AVKLADFGLAIEV---------QGEQQ-AW--------------FG---FAGTPGYLSPEVLR-------KDP--YGKPVDIWACGVILYILLV-GY-PP---------------FWDE---------------DQHKLYQQIKAGAYDFPSPEW-DT-VT---------------------------------------------------------PEAKNLINQMLTINPAKRIT-------AD-QALKHPWV--------------
-----FEVESELGRGATSIV---YRCKQ---K-------GTQK---PYALKVLKKTV-DKKIV--R------T-------------------------EIGVLLRL--S---HPN-----IIKLKEIFE--T-----------------------------PTEIS--LVLELVTGG--ELFDRIV---EKG-------------------------YY---SERDAADAVKQILEAVAYLHE--N--GIVHRDLKPENLLYA--T------PAPDA-----PLKIADFGLSKI----------VEHQV-LM--------------KT---VCGTPGYCAPEILR-------GCA--YGPEVDMWSVGIITYILLC-GF-EP---------------FYDE--------------RGDQFMFRRILNCEYYFISPWW-DE-VS---------------------------------------------------------LNAKDLVRKLIVLDPKKRLT-------TF-QALQHPWV--------------
-----YKLQSEIGKGAYGVV---RLAYN---E-------SEDR---HYAMKVLSKKK-LLKQY--G-F-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D---HVN-----VVKLIEVLD--DP---------------------------AEDNLY--LVFDLLRKG--PVMEVPC----DK-------------------------PF---SEEQARLYLRDVILGLEYLHC--Q--KIVHRDIKPSNLLLG--D-----DGHV---------KIADFGVSNQF---------EGNDA-QL--------------SS---TAGTPAFMAPEAISD----SGQSF--SGKALDVWATGVTLYCFVY-GK-CP---------------FIDD---------------FILALHRKIKNEPVVFPEEPE-IS------------------------------------------------------------EELKDLILKMLDKNPETRIG-------VP-DIKLHPWV--------------
-----YTLKDEIGKGSYGVV---KLAYN---E-------NDNT---YYAMKVLSKKK-LIRQA--G-F-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D---HPN-----VVKLVEVLD--DP---------------------------NEDHLY--MVFELVNQG--PVMEVPT----LK-------------------------PL---SEDQARFYFQDLIKGIEYLHY--Q--KIIHRDIKPSNLLVG--E-----DGHI---------KIADFGVSNEF---------KGSDA-LL--------------SN---TVGTPAFMAPESLS------ETRKIFSGKALDVWAMGVTLYCFVF-GQ-CP---------------FMDE---------------RIMCLHSKIKSQALEFPDQPD-IA------------------------------------------------------------EDLKDLITRMLDKNPESRIV-------VP-EIKLHPWV--------------
-----YTKIEKIGEGTYGVV---YKGRH---K-------TTGQ---VVAMKKIRLES-EEEGV--P-S-TAIR-------------------------EISLLKEL--R---HPN-----IVSLQDVLM--Q-----------------------------DSRLY--LIFEFLSM---DLKKYLDSIPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--R--RVLHRDLKPQNLLID--D-----KGTI---------KLADFGLARAF---------GIPIR-VY--------------TH---EVVTLWYRSPEVLL------GSAR--YSTPVDIWSIGTIFAELAT-KK-PL---------------FHGD------------SEIDQLFRIFRALGTPNNEVWPEV-ES-LQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-------GK-MALNHPYF--------------
-----FEIIKVIGRGAFGEV---AVVKM---K-------NTER---IYAMKILNKWE-MLKRA--E-T-ACFR------------------------EERDVLVNG--D---CQW-----ITALHYAFQ--D-----------------------------ENHLY--LVMDYYVGG--DLLTLLS--KFED-------------------------KL---PEDMARFYIGEMVLAIDSIHQ--L--HYVHRDIKPDNVLLD--V-----NGHI---------RLADFGSCLKM---------NDDGTVQS--------------SV---AVGTPDYISPEILQAM--EDGMGK--YGPECDWWSLGVCMYEMLY-GE-TP---------------FYAE---------------SLVETYGKIMNHEERFQFPSHVTD-VS---------------------------------------------------------EEAKDLIQRLICSRE-RRLGQ----NGIE-DFKKHAF-F-------------
-----FQCLNRIEEGTYGVV---YRAKD---K-------KTDE---IVALKRLKMEK-EKEGF--P-I-TSLR-------------------------EINTILKA--Q---HPN-----IVTVREIVV--GS---------------------------NMDKIY--IVMNYVEH---DLKSLME--TMKQ-------------------------PF---LPGEVKTLMIQLLRGVKHLHD--N--WILHRDLKTSNLLLS--H-----AGIL---------KVGDFGLAREY---------GSPLK-AY--------------TP---VVVTLWYRAPELLL------GAKE--YSTAVDMWSVGCIFGELLT-QK-PL---------------FPGK------------SEIDQINKVFKDLGTPSEKIWPGY-SE-LPAVKKMTFSEHPY---------------------------------NNLRKRFGALLSDQGFDLMNKFLTYFPGRRIS-------AE-DGLKHEYF--------------
-----FQKVEKIGEGTYGVV---YKARN---K-------LTGE---VVALKKIRLDT-ETEGV--P-S-TAIR-------------------------EISLLKEL--N---HPN-----IVKLLDVIH--T-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA-SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H--RVLHRDLKPQNLLIN--T-----EGAI---------KLADFGLARAF---------GVPVR-TY--------------TH---EVVTLWYRAPEILL------GCKY--YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD------------SEIDQLFRIFRTLGTPDEVVWPGV-TS-MPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AK-AALAHPFF--------------
-----FQKVEKIGEGTYGVV---YKAKN---R-------ETGQ---LVALKKIRLDL-EMEGV--P-S-TAIR-------------------------EISLLKEL--K---HPN-----IVRLLDVVH--N-----------------------------ERKLY--LVFEFLSQ---DLKKYMDS-TPGS-------------------------EL---PLHLIKSYLFQLLQGVSFCHS--H--RVIHRDLKPQNLLIN--E-----LGAI---------KLADFGLARAF---------GVPLR-TY--------------TH---EVVTLWYRAPEILL------GSKF--YTTAVDIWSIGCIFAEMVT-RK-AL---------------FPGD------------SEIDQLFRIFRMLGTPSEDTWPGV-TQ-LPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-------AK-TALAHPYF--------------
-----YEKLEKIGEGTYGTV---FKAKN---R-------ETHE---IVALKRVRLDD-DDEGV--P-S-SALR-------------------------EICLLKEL--K---HKN-----IVRLHDVLH--S-----------------------------DKKLT--LVFEFCDQ---DLKKYFD--SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS--R--NVLHRDLKPQNLLIN--R-----NGEL---------KLADFGLARAF---------GIPVR-CY--------------SA---EVVTLWYRPPDVLF------GAKL--YSTSIDMWSAGCIFAELANAGR-PL---------------FPGN------------DVDDQLKRIFRLLGTPTEEQWPSM-TK-LPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-------AE-EALQHPYF--------------
-----YECVAEIGEGAYGKV---FKARD---L-------KNGG--RFVALKRVRVQT-GEEGM--P-L-STIR-------------------------EVAVLRHL--ETFEHPN-----VVRLFDVCT--VSR------------------------TDRETKLT--LVFEHVDQ---DLTTYLDK-VPEP-------------------------GV---PTETIKDMMFQLLRGLDFLHS--H--RVVHRDLKPQNILVT--S-----SGQI---------KLADFGLARI----------YSFQM-AL--------------TS---VVVTLWYRAPEVLL-------QSS--YATPVDLWSVGCIFAEMFR-RK-PL---------------FRGS------------SDVDQLGKILDVIGLPGEEDWPRD-VA-LPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-------AY-SALSHPYF--------------
-----YEKLAKIGQGTFGEV---FKARH---R-------KTGQ---KVALKKVLMEN-EKEGF--P-I-TALR-------------------------EIKILQLL--K---HEN-----VVNLIEICR--TKASP---------------------YNRCKGSIY--LVFDFCEH---DLAGLLS--NVLV-------------------------KF---TLSEIKRVMQMLLNGLYYIHR--N--KILHRDMKAANVLIT--R-----DGVL---------KLADFGLARAFSL-----AKNSQPN-RY--------------TN---RVVTLWYRPPELLL------GERD--YGPPIDLWGAGCIMAEMWT-RS-PI---------------MQGN------------TEQHQLALISQLCGSITPEVWPNV-DN-YELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-------SD-DALNHDFF--------------
---YI--MSKTLGSGACGEV---KLAFE---R-------KTCK---KVAIKIISKRK-FAIGS--A-R-EADPALN-------------------VETEIEILKKL--N---HPC-----IIKIKNFF---D-----------------------------AEDYY--IVLELMEGG--ELFDKVV---GNK-------------------------RL---KEATCKLYFYQMLLAVQYLHE--N--GIIHRDLKPENVLLS--S-----QEEDC------LIKITDFGHSKI----------LGETS-LM--------------RT---LCGTPTYLAPEVLVS----VGTAG--YNRAVDCWSLGVILFICLS-GY-PP---------------FSEH--------------RTQVSLKDQITSGKYNFIPEVW-AE-VS---------------------------------------------------------EKALDLVKKLLVVDPKARFT-------TE-EALRHPWL--------------
-----YEMGEELGSGQFAIV---RKCRQ---K-------GTGK---EYAAKFIKKRR-LSSSR--R-G-VSREEI---------------------EREVNILREI--R---HPN-----IITLHDIFE--N-----------------------------KTDVV--LILELVSGG--ELFDFLA---EKE-------------------------SL---TEDEATQFLKQILDGVHYLHS--K--RIAHFDLKPENIMLL--D-----KNVPNP-----RIKLIDFGIAHK----------IEAGN-EF--------------KN---IFGTPEFVAPEIVN-------YEP--LGLEADMWSIGVITYILLS-GA-SP---------------FLGE---------------TKQETLTNISAVNYDFDEEYF-SN-TS---------------------------------------------------------ELAKDFIRRLLVKDPKRRMT-------IA-QSLEHSWI--------------
-----YETGRVIGDGNFAVV---KECRH---R-------ETRQ---AYAMKIIDKSR-LKGKE--D-M-V-DS-------------------------EILIIQSL--S---HPN-----IVKLHEVYE--T-----------------------------DMEIY--LILEYVQGG--DLFDAII---ESV-------------------------KF---PEPDAALMIMDLCKALVHMHD--K--SIVHRDLKPENLLVQ--R-----NEDKST-----TLKLADFGLAK------------HVVR-PI--------------FT---VCGTPTYVAPEILS-------EKG--YGLEVDMWAAGVILYILLC-GF-PP---------------FRSP-------------ERDQDELFNIIQLGHFEFLPPYW-DN-IS---------------------------------------------------------DAAKDLVSRLLVVDPKKRYT-------AH-QVLQHPWI--------------
-----FEILKVIGRGAFSEV---AVVKM---K-------QTGQ---VYAMKIMNKWD-MLKRG--E-V-SCFR------------------------EERDVLVNG--D---RRW-----ITQLHFAFQ--D-----------------------------ENYLY--LVMEYYVGG--DLLTLLS--KFGE-------------------------RI---PAEMARFYLAEIVMAIDSVHR--L--GYVHRDIKPDNILLD--R-----CGHI---------RLADFGSCLKL--------RADGTV-RS--------------LV---AVGTPDYLSPEILQAVGGGPGTGS--YGPECDWWALGVFAYEMFY-GQ-TP---------------FYAD------------STAETYGKIVHYKE---HLSLPLV-DEGVP---------------------------------------------------------EEARDFIQRLLCPP-ETRLGR----GGAG-DFRTHPFF--------------
-----YEIDSLIGKGSFGQV---VKAYD---H-------QTQE---LVAIKIIKNKK-AFLNQ--A-Q-I----------------------------ELRLLELM-NQ---HDTEMKYYIVHLKRHFM--F-----------------------------RNHLC--LVFELLSY---NLYDLLR----NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPEL--SIIHCDLKPENILLCNPK-----RSAI---------KIVDFGSSCQ------------LGQ-RI--------------YQ---YIQSRFYRSPEVLL-------GTP--YDLAIDMWSLGCILVEMHT-GE-PL---------------FSGS------------NEVDQMNRIVEVLGIPPAAMLDQA-PK-ARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-------PL-GALQHGFF--------------
----F-KKIKVLGSGAFGTV---YKGLW---IP---EGEKVKI---PVAIKELR-EA-TS-PKANK-E-IL-D-------------------------EAYVMASV--D---NPH-----VCRLLGICL--------------------------------TSTVQ--LITQLMPFG--CLLDYVR----EH-----------------------KDNI---GSQYLLNWCVQIAKGMNYLED--R--RLVHRDLAARNVLVK--T-----PQHV---------KITDFGLAKLL----G----A--EE-KE--------------YHAEGGKVPIKWMALESIL-------HRI--YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI------------PASEISSILEKGERLPQPPICT-----------------------------------------------------------------IDVYMIMVKCWMIDADSRPK-------FR-ELI----IEF------------
----F-KEIELIGSGGFGQV---FKAKH---R-------IDGK---TYVIKRVKYNN-EKAER-----------------------------------EVKALAKL--D---HVN-----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK-RRGE-------------------------KL---DKVLALELFEQITKGVDYIHS--K--KLIHRDLKPSNIFLV--D-----TKQV---------KIGDFGLVTS----------LKNDG-KR--------------TR---SKGTLRYMSPEQIS-------SQD--YGKEVDLYALGLILAELLH-VCDTA---------------FET-------------------SKFFTDLRDGIISDIFDK----------------------------------------------------------------KEKTLLQKLLSKKPEDRPN-------TS-EILR----TLT-----------
---VI--LGELLGKGNFGEV---YKGTL---K--------DKT---SVAVKTCK-ED-LP-QELKI-K-FL-Q-------------------------EAKILKQY--D---HPN-----IVKLIGVCT--Q-----------------------------RQPVY--IIMELVSGG--DFLTFLR----RK-----------------------KDEL---KLKQLVKFSLDAAAGMLYLES--K--NCIHRDLAARNCLVG--E-----NNVL---------KISDFGMSRQE---------D--GG-VY--------------SSSGLKQIPIKWTAPEALN-------YGR--YSSESDVWSFGILLWETFSLGV-CP---------------YPGM------------TNQQAREQVERGYRMSAPQHCP-----------------------------------------------------------------EDISKIMMKCWDYKPENRPK-------FS-ELQKEL----------------
----L-VLGEQIGRGNFGEV---FSGRL---R-------ADNT---LVAVKSCR-ET-LP-PDLKA-K-FL-Q-------------------------EARILKQY--S---HPN-----IVRLIGVCT--Q-----------------------------KQPIY--IVMELVQGG--DFLTFLR----TE-----------------------GARL---RVKTLLQMVGDAAAGMEYLES--K--CCIHRDLAARNCLVT--E-----KNVL---------KISDFGMSREE----A----D--GV-YA--------------ASGGLRQVPVKWTAPEALN-------YGR--YSSESDVWSFGILLWETFSLGA-SP---------------YPNL------------SNQQTREFVEKGGRLPCPELCP-----------------------------------------------------------------DAVFRLMEQCWAYEPGQRPS-------FS-TIYQEL----------------
----L-VLGKPLGEGCFGQV---VLAEA---IGLDKDKPNRVT---KVAVKMLK-SD-AT-EKDLS-D-LI-S-------------------------EMEMMKMIG-K---HKN-----IINLLGACT--Q-----------------------------DGPLY--VIVEYASKG--NLREYLQ----ARRPPGLEY--------CYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS--K--KCIHRDLAARNVLVT--E-----DNVM---------KIADFGLARDI----H----H--ID-YY--------------KKTTNGRLPVKWMAPEALF-------DRI--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV------------PVEELFKLLKEGHRMDKPSNCT-----------------------------------------------------------------NELYMMMRDCWHAVPSQRPT-------FK-QLVEDL----------------
-----LTLGKPLGEGCFGQV---VMAEA---VGIDKDKPKEAV---TVAVKMLK-DD-AT-EKDLS-D-LV-S-------------------------EMEMMKMIG-K---HKN-----IINLLGACT--Q-----------------------------DGPLY--VIVEYASKG--NLREYLR----ARRPPGMEY--------SYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--Q--KCIHRDLAARNVLVT--E-----NNVM---------KIADFGLARDI----N----N--ID-YY--------------KKTTNGRLPVKWMAPEALF-------DRV--YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI------------PVEELFKLLKEGHRMDKPANCT-----------------------------------------------------------------NELYMMMRDCWHAVPSQRPT-------FK-QLVEDL----------------
-----LTLGKPLGEGCFGQV---VMAEA---IGIDKDRAAKPV---TVAVKMLK-DD-AT-DKDLS-D-LV-S-------------------------EMEMMKMIG-K---HKN-----IINLLGACT--Q-----------------------------GGPLY--VLVEYAAKG--NLREFLR----ARRPPGLDY--------SFDTCKPPEEQL---TFKDLVSCAYQVARGMEYLAS--Q--KCIHRDLAARNVLVT--E-----DNVM---------KIADFGLARDV----H----N--LD-YY--------------KKTTNGRLPVKWMAPEALF-------DRV--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI------------PVEELFKLLKEGHRMDKPANCT-----------------------------------------------------------------HDLYMIMRECWHAAPSQRPT-------FK-QLVEDL----------------
----L-VLGKPLGEGCFGQV---VRAEA---FGMDPARPDQAS---TVAVKMLK-DN-AS-DKDLA-D-LV-S-------------------------EMEVMKLIG-R---HKN-----IINLLGVCT--Q-----------------------------EGPLY--VIVECAAKG--NLREFLR----ARRPPGPDL--------SPDGPRSSEGPL---SFPVLVSCAYQVARGMQYLES--R--KCIHRDLAARNVLVT--E-----DNVM---------KIADFGLARGV----H----H--ID-YY--------------KKTSNGRLPVKWMAPEALF-------DRV--YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI------------PVEELFSLLREGHRMDRPPHCP-----------------------------------------------------------------PELYGLMRECWHAAPSQRPT-------FK-QLVEAL----------------
-----ITMSRELGQGSFGMV---YEGVA---KG--VVKDEPET---RVAIKTVN-EA-AS-MRERI-E-FL-N-------------------------EASVMKEF--N---CHH-----VVRLLGVVS--Q-----------------------------GQPTL--VIMELMTRG--DLKSYLR----SLRPEM--------------ENNPVLAPP---SLSKMIQMAGEIADGMAYLNA--N--KFVHRDLAARNCMVA--E-----DFTV---------KIGDFGMTRDI----Y----E--TD-YY--------------RKGGKGLLPVRWMSPESLK-------DGV--FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL------------SNEQVLRFVMEGGLLDKPDNCP-----------------------------------------------------------------DMLFELMRMCWQYNPKMRPS-------FL-EIISS--I--------------
--VGG----NKMGEGGFGVV---YKGYV---N-------NTT-----VAVKKLAAMV-DITTE--ELK-QQFD------------------------QEIKVMAKC--Q---HEN-----LVELLGFSS--D-----------------------------GDDLC--LVYVYMPNG--SLLDRLSCLDGTP-------------------------PL---SWHMRCKIAQGAANGINFLHE--N--HHIHRDIKSANILLD--E-----AFTA---------KISDFGLARASE-------KFAQTV-MT--------------SR---IVGTTAYMAPEALR--------GE--ITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH------------REPQLLLDIKEEIEDEEKTIEDYI-DK-KMNDAD-------------------------------------------------STSVEAMYSVASQCLHEKKNKRPD-------IK-KVQQ----LLQ-----------
-----LKFLQQLGKGNFGSV---EMCRY---DP---LQDNTGE---VVAVKKLQ-HS-TE--EHLR-D-FE-R-------------------------EIEILKSL--Q---HDN-----IVKYKGVCYSAG-----------------------------RRNLK--LIMEYLPYG--SLRDYLQ----KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT--K--RYIHRDLATRNILVE--N-----ENRV---------KIGDFGLTKVL---PQ----D--KE-YY--------------KVKEPGESPIFWYAPESLT-------ESK--FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM------------IVFHLIELLKNNGRLPRPDGCP-----------------------------------------------------------------DEIYMIMTECWNNNVNQRPS-------FR-DLA----LRV------------
----L-KYISQLGKGNFGSV---ELCRY---DP---LGDNTGA---LVAVKQLQ-HS-GP-DQ-QR-D-FQ-R-------------------------EIQILKAL--H---SDF-----IVKYRGVSYGPG-----------------------------RQSLR--LVMEYLPSG--CLRDFLQ----RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS--R--RCVHRDLAARNILVE--S-----EAHV---------KIADFGLAKLL---PL----D--KD-YY--------------VVREPGQSPIFWYAPESLS-------DNI--FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P----------ALCRLLELLEEGQRLPAPPACP-----------------------------------------------------------------AEVHELMKLCWAPSPQDRPS-------FS-ALGP---QL-------------
-----YRLLKTIGKGNFAKV---KLARH---I-------LTGK---EVAVKIIDKTQ-LNSSS--L-Q-KLFR-------------------------EVRIMKVL--N---HPN-----IVKLFEVIE--T-----------------------------EKTLY--LVMEYASGG--EVFDYLV---AHG-------------------------RM---KEKEARAKFRQIVSAVQYCHQ--K--FIVHRDLKAENLLLD--A-----DMNI---------KIADFGFSNE----------FTFGN-KL--------------DT---FCGSPPYAAPELFQ------GKKY--DGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ---------------NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------TDCENLLKKFLILNPSKRGT-------LE-QIMKDRWM--------------
-----YRLLRTIGKGNFAKV---KLARH---I-------LTGR---EVAIKIIDKTQ-LNPSS--L-Q-KLFR-------------------------EVRIMKGL--N---HPN-----IVKLFEVIE--T-----------------------------EKTLY--LVMEYASAG--EVFDYLV---SHG-------------------------RM---KEKEARAKFRQIVSAVHYCHQ--K--NIVHRDLKAENLLLD--A-----EANI---------KIADFGFSNE----------FTLGS-KL--------------DT---FCGSPPYAAPELFQ------GKKY--DGPEVDIWSLGVILYTLVS-GS-LP---------------FDGH---------------NLKELRERVLRGKYRVPFYMS---------------------------------------------------------------TDCESILRRFLVLNPAKRCT-------LE-QIMKDKWI--------------
-QLQE----DVLGEGAHARV---QTCIN---L-------ITSQ---EYAVKIIEKQP-GHIRS--R----VFR-------------------------EVEMLYQC-QG---HRN-----VLELIEFFE--E-----------------------------EDRFY--LVFEKMRGG--SILSHIH---KRR-------------------------HF---NELEASVVVQDVASALDFLHN--K--GIAHRDLKPENILCE--H-----PNQVS------PVKICDFDLGSGIKLN--GDCSPISTP-EL--------------LT---PCGSAEYMAPEVVEAF--SEEASI--YDKRCDLWSLGVILYILLS-GY-PP---------------FVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDW-AH-IS---------------------------------------------------------CAAKDLISKLLVRDAKQRLS-------AA-QVLQHPWV--------------
----I-EYVRDIGEGAFGRV---FQARA---PG--LLPYEPFT---MVAVKMLK-EE-AS-ADMQA-D-FQ-R-------------------------EAALMAEF--D---NPN-----IVKLLGVCA--V-----------------------------GKPMC--LLFEYMAYG--DLNEFLR----SMSPHTVCSLSHSDLSMRAQVSSPGPPPL---SCAEQLCIARQVAAGMAYLSE--R--KFVHRDLATRNCLVG--E-----NMVV---------KIADFGLSRNI----Y----S--AD-YY--------------KANENDAIPIRWMPPESIF-------YNR--YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM------------AHEEVIYYVRDGNILSCPENCP-----------------------------------------------------------------VELYNLMRLCWSKLPADRPS-------FT-SIHRIL----------------
----Y-VRLQKIGEGSFGKA---ILVKS---T-------EDGR---QYVIKEINISR-MSSKE--R-E-ESRR-------------------------EVAVLANM--K---HPN-----IVQYRESFE--E-----------------------------NGSLY--IVMDYCEGG--DLFKRINA-QKGV-------------------------LF---QEDQILDWFVQICLALKHVHD--R--KILHRDIKSQNIFLT--K-----DGTV---------QLGDFGIARVL---------NSTVE-LA--------------RT---CIGTPYYLSPEICE-------NKP--YNNKSDIWALGCVLYELCT-LK-HA---------------FEAG---------------SMKNLVLKIISGSFPPVSLHY-S-------------------------------------------------------------YDLRSLVSQLFKRNPRDRPS-------VN-SILEKGF-I-------------
----Y-MVLRMIGEGSFGRA---LLVQH---E-------SSNQ---MFAMKEIRLPK-SFSNT--Q-N--SRK-------------------------EAVLLAKM--K---HPN-----IVAFKESFE--A-----------------------------EGHLY--IVMEYCDGG--DLMQKIKQ-QKGK-------------------------LF---PEDMILNWFTQMCLGVNHIHK--K--RVLHRDIKSKNIFLT--Q-----NGKV---------KLGDFGSARLL---------SNPMA-FA--------------CT---YVGTPYYVPPEIWE-------NLP--YNNKSDIWSLGCILYELCT-LK-HP---------------FQAN------------SWKNLILKVCQGCISPLPSHYS-----------------------------------------------------------------YELQFLVKQMFKRNPSHRPS-------AT-TLLS----RGIV----------
-----YERIRVVGRGAFGIV---HLCLR---K-------ADQK---LVIIKQIPVEQ-MTKEE--R-Q-AAQN-------------------------ECQVLKLL--N---HPN-----VIEYYENFL--E-----------------------------DKALM--IAMEYAPGG--TLAEFIQK-RCNS-------------------------LL---EEETILHFFVQILLALHHVHT--H--LILHRDLKTQNILLD-KH-----RMVV---------KIGDFGISKI----------LSSKS-KA--------------YT---VVGTPCYISPELCE-------GKP--YNQKSDIWALGCVLYELAS-LK-RA---------------FEAA---------------NLPALVLKIMSGTFAPISDRY-----S---------------------------------------------------------PELRQLVLSLLSLEPAQRPP-------LS-HIMAQP--LC------------
---IV--LKWELGEGAFGKV---FLAEC---HN--LLPEQDKM---LVAVKALK-EA-SE-SA-RQ-D-FQ-R-------------------------EAELLTML--Q---HQH-----IVRFFGVCT--E-----------------------------GRPLL--MVFEYMRHG--DLNRFLR----SHGPDAKL---------LAGGEDVAPGPL---GLGQLLAVASQVAAGMVYLAG--L--HFVHRDLATRNCLVG--Q-----GLVV---------KIGDFGMSRDI----Y----S--TD-YY--------------RVGGRTMLPIRWMPPESIL-------YRK--FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL------------SNTEAIDCITQGRELERPRACP-----------------------------------------------------------------PEVYAIMRGCWQREPQQRHS-------IK-DVHARL----------------
----I-VLKRELGEGAFGKV---FLAEC---YN--LCPEQDKI---LVAVKTLK-DA-SD-NA-RK-D-FH-R-------------------------EAELLTNL--Q---HEH-----IVKFYGVCV--E-----------------------------GDPLI--MVFEYMKHG--DLNKFLR----AHGPDAV-----------LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS--Q--HFVHRDLATRNCLVG--E-----NLLV---------KIGDFGMSRDV----Y----S--TD-YY--------------RVGGHTMLPIRWMPPESIM-------YRK--FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL------------SNNEVIECITQGRVLQRPRTCP-----------------------------------------------------------------QEVYELMLGCWQREPHMRKN-------IK-GIHTL--L--------------
----I-VLKRELGEGAFGKV---FLAEC---YN--LSPTKDKM---LVAVKALK-DP-TL-AA-RK-D-FQ-R-------------------------EAELLTNL--Q---HEH-----IVKFYGVCG--D-----------------------------GDPLI--MVFEYMKHG--DLNKFLR----AHGPDAMIL--------VDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS--Q--HFVHRDLATRNCLVG--A-----NLLV---------KIGDFGMSRDV----Y----S--TD-YYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-------YRK--FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL------------SNTEVIECITQGRVLERPRVCP-----------------------------------------------------------------KEVYDVMLGCWQREPQQRLN-------IK-EIYKIL----------------
-----YELQETLGKGTYGKV---KRATE---R-------FSGR---VVAIKSIRKDK-IKDEQ--D-M-VHIR------------------------REIEIMSSL--N---HPH-----IISIYEVFE--N-----------------------------KDKIV--IIMEYASKG--ELYDYIS---ERR-------------------------RL---SERETRHFFRQIVSAVHYCHK--N--GVVHRDLKLENILLD--D-----NCNI---------KIADFGLSNL----------YQKDK-FL--------------QT---FCGSPLYASPEIVN------GRPY--RGPEVDSWALGVLLYTLVY-GT-MP---------------FDGF---------------DHKNLIRQISSGEYREPTQP----------------------------------------------------------------SDARGLIRWMLMVNPDRRAT-------IE-DIANHWW-V-------------
-----YEFLETLGKGTYGKV---KKARE---S-------SGR----LVAIKSIRKDK-IKDEQ--D-L-MHIR------------------------REIEIMSSL--N---HPH-----IIAIHEVFE--N-----------------------------SSKIV--IVMEYASRG--DLYDYIS---ERQ-------------------------QL---SEREARHFFRQIVSAVHYCHQ--N--RVVHRDLKLENILLD--A-----NGNI---------KIADFGLSNL----------YHQGK-FL--------------QT---FCGSPLYASPEIVN------GKPY--TGPEVDSWSLGVLLYILVH-GT-MP---------------FDGH---------------DHKILVKQISNGAYREPPK-------P---------------------------------------------------------SDACGLIRWLLMVNPTRRAT-------LE-DVASHWW-V-------------
-DNFI-----KIGEGSTGIV---CIATV---R-------SSGK---LVAVKKMDLRK-QQRRE--L----LFN-------------------------EVVIMRDY--Q---HEN-----VVEMYNSYL--V-----------------------------GDELW--VVMEFLEGG--ALTDIVT----HT-------------------------RM---NEEQIAAVCLAVLQALSVLHA--Q--GVIHRDIKSDSILLT--H-----DGRV---------KLSDFGFCAQV---------SKEVP-RR--------------KS---LVGTPYWMAPELIS-------RLP--YGPEVDIWSLGIMVIEMVD-GE-PP---------------YFNE------------PPLKAMKMIRDNLPPRLKNLHKVS---------------------------------------------------------------PSLKGFLDRLLVRDPAQRAT-------AA-ELLKHPFL--------------
-DSYV-----KIGEGSTGIV---CLARE---K-------HSGR---QVAVKMMDLRK-QQRRE--L----LFN-------------------------EVVIMRDY--Q---HFN-----VVEMYKSYL--V-----------------------------GEELW--VLMEFLQGG--ALTDIVS----QV-------------------------RL---NEEQIATVCEAVLQALAYLHA--Q--GVIHRDIKSDSILLT--L-----DGRV---------KLSDFGFCAQI---------SKDVP-KR--------------KS---LVGTPYWMAPEVIS-------RSL--YATEVDIWSLGIMVIEMVD-GE-PP---------------YFSD------------SPVQAMKRLRDSPPPKLKNSHKVS---------------------------------------------------------------PVLRDFLERMLVRDPQERAT-------AQ-ELLDHPFL--------------
----F-KFGKILGEGSFSTV---VLARE---L-------ATSR---EYAIKILEKRH-IIKEN--K-VPYVTR-------------------------ERDVMSRL--D---HPF-----FVKLYFTFQ--D-----------------------------DEKLY--FGLSYAKNG--ELLKYIR---KIG-------------------------SF---DETCTRFYTAEIVSALEYLHG--K--GIIHRDLKPENILLN--E-----DMHI---------QITDFGTAKVLS-------PESKQA-RA--------------NS---FVGTAQYVSPELLT-------EKS--ACKSSDLWALGCIIYQLVA-GL-PP---------------FRAG---------------NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------PKARDLVEKLLVLDATKRLG-------CE-EM------EGYGPLKAHPF---
-----YEPKEILGRGVSSVV---RRCIH---K-------PTSQ---EYAVKVIDVTG-GGSFS--P-E-EVRELRE------------------ATLKEVDILRKV-SG---HPN-----IIQLKDTYE--T-----------------------------NTFFF--LVFDLMKRG--ELFDYLT---EKV-------------------------TL---SEKETRKIMRALLEVICTLHK--L--NIVHRDLKPENILLD--D-----NMNI---------KLTDFGFSCQ----------LEPGE-RL--------------RE---VCGTPSYLAPEIIECS-MNEDHPG--YGKEVDMWSTGVIMYTLLA-GS-PP---------------FWHR---------------KQMLMLRMIMSGNYQFGSPEW-DD-YS---------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-------AE-EALAHPFF--------------
----F-KFLAVLGRGHFGKV---LLSEF---R-------PSGE---LFAIKALKKGD-IVARD--E-V-ESLM------------------------CEKRILAAV--TSAGHPF-----LVNLFGCFQ--T-----------------------------PEHVC--FVMEYSAGG--DLMLHIH----SD-------------------------VF---SEPRAIFYSACVVLGLQFLHE--H--KIVYRDLKLDNLLLD--T-----EGYV---------KIADFGLCKEG---------MGYGD-RT--------------ST---FCGTPEFLAPEVLT-------DTS--YTRAVDWWGLGVLLYEMLV-GE-SP---------------FPGD---------------DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------AEAIGIMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF--------------
---FR--CCAVLGRGHFGKV---LLAEY---K-------NTNE---MFAIKALKKGD-IVARD--E-V-DSLM------------------------CEKRIFETV--NSVRHPF-----LVNLFACFQ--T-----------------------------KEHVC--FVMEYAAGG--DLMMHIH----TD-------------------------VF---SEPRAVFYAACVVLGLQYLHE--H--KIVYRDLKLDNLLLD--T-----EGFV---------KIADFGLCKEG---------MGYGD-RT--------------ST---FCGTPEFLAPEVLT-------ETS--YTRAVDWWGLGVLIYEMLV-GE-SP---------------FPGD---------------DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------TEAISIMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF--------------
---YV--RGRFLGKGGFAKC---FEISD---A-------DTKE---VFAGKIVPKSL-LLKPH--Q-R-EKMS------------------------MEISIHRSL--A---HQH-----VVGFHGFFE--D-----------------------------NDFVF--VVLELCRRR--SLLELHK---RRK-------------------------AL---TEPEARYYLRQIVLGCQYLHR--N--RVIHRDLKLGNLFLN--E-----DLEV---------KIGDFGLATKV---------EYDGE-RK--------------KT---LCGTPNYIAPEVLS-------KKG--HSFEVDVWSIGCIMYTLLV-GK-PP---------------FETS---------------CLKETYLRIKKNEYSIPKHIN---------------------------------------------------------------PVAASLIQKMLQTDPTARPT-------IN-ELLNDEFF--------------
---YL--KGRLLGKGGFARC---YEATD---T-------ETGS---AYAVKVIPQSR-VAKPH--Q-R-EKIL------------------------NEIELHRDL--Q---HRH-----IVRFSHHFE--D-----------------------------ADNIY--IFLELCSRK--SLAHIWK---ARH-------------------------TL---LEPEVRYYLRQILSGLKYLHQ--R--GILHRDLKLGNFFIT--E-----NMEL---------KVGDFGLAARL---------EPPEQ-RK--------------KT---ICGTPNYVAPEVLL-------RQG--HGPEADVWSLGCVMYTLLC-GS-PP---------------FETA---------------DLKETYRCIKQVHYTLPASLS---------------------------------------------------------------LPARQLLAAILRASPRDRPS-------ID-QILRHDFF--------------
----F-KVGNLLGKGSFAGV---YRAES---I-------HTGL---EVAIKMIDKKA-MYKAG--M-V-QRVQ------------------------NEVKIHCQL--K---HPS-----ILELYNYFE--D-----------------------------SNYVY--LVLEMCHNG--EMNRYLK--NRVK-------------------------PF---SENEARHFMHQIITGMLYLHS--H--GILHRDLTLSNLLLT--R-----NMNI---------KIADFGLATQL---------KMPHE-KH--------------YT---LCGTPNYISPEIAT-------RSA--HGLESDVWSLGCMFYTLLI-GR-PP---------------FDTD---------------TVKNTLNKVVLADYEMPSFLS---------------------------------------------------------------IEAKDLIHQLLRRNPADRLS-------LS-SVLDHPFM--------------
----F-ERIKTLGTGSFGRV---MLVKH---K-------ETGN---HYAMKILDKQK-VVKLK--Q-I-EHTL------------------------NEKRILQAV--N---FPF-----LVKLEFSFK--D-----------------------------NSNLY--MVMEYVPGG--EMFSHLR---RIG-------------------------RF---SEPHARFYAAQIVLTFEYLHS--L--DLIYRDLKPENLLID--Q-----QGYI---------QVTDFGFAK------------RVKG-RT--------------WT---LCGTPEYLAPEIIL-------SKG--YNKAVDWWALGVLIYEMAA-GY-PP---------------FFAD---------------QPIQIYEKIVSGKVRFPSHFS---------------------------------------------------------------SDLKDLLRNLLQVDLTKRFGNL--KNGVN-DIKNHKWF--------------
----F-NFLMVLGKGSFGKV---MLADR---K-------GTEE---LYAIKILKKDV-VIQDD--D-V-ECTM------------------------VEKRVLALL-DK---PPF-----LTQLHSCFQ--T-----------------------------VDRLY--FVMEYVNGG--DLMYHIQ---QVG-------------------------KF---KEPQAVFYAAEISIGLFFLHK--R--GIIYRDLKLDNVMLD--S-----EGHI---------KIADFGMCKEH---------MMDGV-TT--------------RT---FCGTPDYIAPEIIA-------YQP--YGKSVDWWAYGVLLYEMLA-GQ-PP---------------FDGE---------------DEDELFQSIMEHNVSYPKSLS---------------------------------------------------------------KEAVSVCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF
---FI--FHKVLGKGSFGKV---LLGEL---K-------GRGE---YFAIKALKKDV-VLIDD--D-V-ECTM------------------------VEKRVLTLA-AE---NPF-----LTHLICTFQ--T-----------------------------KDHLF--FVMEFLNGG--DLMYHIQ---DKG-------------------------RF---ELYRATFYAAEIMCGLQFLHS--K--GIIYRDLKLDNVLLD--R-----DGHI---------KIADFGMCKEN---------IFGES-RA--------------ST---FCGTPDYIAPEILQ-------GLK--YTFSVDWWSFGVLLYEMLI-GQ-SP---------------FHGD---------------DEDELFESIRVDTPHYPRWIT---------------------------------------------------------------KESKDILEKLFEREPTKRLG------VTG-NIKIHPFF--------------
----F-NFIKVLGKGSFGKV---MLAEL---K-------GKDE---VYAVKVLKKDV-ILQDD--D-V-DCTM------------------------TEKRILALA-RK---HPY-----LTQLYCCFQ--T-----------------------------KDRLF--FVMEYVNGG--DLMFQIQ---RSR-------------------------KF---DEPRSRFYAAEVTSALMFLHQ--H--GVIYRDLKLDNILLD--A-----EGHC---------KLADFGMCKEG---------ILNGV-TT--------------TT---FCGTPDYIAPEILQ-------ELE--YGPSVDWWALGVLMYEMMA-GQ-PP---------------FEAD---------------NEDDLFESILHDDVLYPVWLS---------------------------------------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------
---FI--LHKMLGKGSFGKV---FLAEF---K-------KTNQ---FFAIKALKKDV-VLMDD--D-V-ECTM------------------------VEKRVLSLA-WE---HPF-----LTHMFCTFQ--T-----------------------------KENLF--FVMEYLNGG--DLMYHIQ---SCH-------------------------KF---DLSRATFYAAEIILGLQFLHS--K--GIVYRDLKLDNILLD--K-----DGHI---------KIADFGMCKEN---------MLGDA-KT--------------NT---FCGTPDYIAPEILL-------GQK--YNHSVDWWSFGVLLYEMLI-GQ-SP---------------FHGQ---------------DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-------VRGDIRQHPLF--------------
---PD----EVLGSGQFGIV---YGGKH---R-------KTGR---DVAIKIIDKLR-FPTKQ--E-S-QLRN-------------------------EVAILQNL--H---HPG-----VVNLECMFE--T-----------------------------PERVF--VVMEKLHGD--MLEMILS--SEKG-------------------------RL---PEHITKFLITQILVALRHLHF--K--NIVHCDLKPENVLLA--S-----ADPFP------QVKLCDFGFARI----------IGEKS-FR--------------RS---VVGTPAYLAPEVLR-------NKG--YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED-----------------EDIHDQIQNAAFMYPPNPW-KE-IS---------------------------------------------------------HEAIDLINNLLQVKMRKRYS-------VD-KTLSHPWL--------------
---PD----EVLGSGQFGVV---YGGKH---R-------KTGR---DVAVKVIDKLR-FPTKQ--E-S-QLRN-------------------------EVAILQSL--R---HPG-----IVNLECMFE--T-----------------------------PEKVF--VVMEKLHGD--MLEMILS--SEKG-------------------------RL---PERLTKFLITQILVALRHLHF--K--NIVHCDLKPENVLLA--S-----ADPFP------QVKLCDFGFARI----------IGEKS-FR--------------RS---VVGTPAYLAPEVLL-------NQG--YNRSLDMWSVGVIMYVSLS-GT-FP---------------FNED-----------------EDINDQIQNAAFMYPASPW-SH-IS---------------------------------------------------------AGAIDLINNLLQVKMRKRYS-------VD-KSLSHPWL--------------
--FAD----EVLGSGQFGIV---YGGKH---R-------KTGR---DVAIKVIDKMR-FPTKQ--E-S-QLRN-------------------------EVAILQNL--H---HPG-----IVNLECMFE--T-----------------------------PERVF--VVMEKLHGD--MLEMILS--SEKS-------------------------RL---PERITKFMVTQILVALRNLHF--K--NIVHCDLKPENVLLA--S-----AEPFP------QVKLCDFGFARI----------IGEKS-FR--------------RS---VVGTPAYLAPEVLR-------SKG--YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED-----------------EDINDQIQNAAFMYPPNPW-RE-IS---------------------------------------------------------GEAIDLINNLLQVKMRKRYS-------VD-KSLSHPWL--------------
-----IELGRCIGEGQFGDV---HQGIY---M----SPENPAL---AVAIKTCK-NC-TS-DSVRE-K-FL-Q-------------------------EALTMRQF--D---HPH-----IVKLIGVIT--------------------------------ENPVW--IIMELCTLG--ELRSFLQ----VR-----------------------KYSL---DLASLILYAYQLSTALAYLES--K--RFVHRDIAARNVLVS--S-----NDCV---------KLGDFGLSRYM---------E--DS-TY--------------YKASKGKLPIKWMAPESIN-------FRR--FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV------------KNNDVIGRIENGERLPMPPNCP-----------------------------------------------------------------PTLYSLMTKCWAYDPSRRPR-------FT-ELKAQL----------------
----L-VLGKTLGEGEFGKV---VKATA---FH--LKGRAGYT---TVAVKMLK-EN-AS-PSELR-D-LL-S-------------------------EFNVLKQV--N---HPH-----VIKLYGACS--Q-----------------------------DGPLL--LIVEYAKYG--SLRGFLR----ESRKVGPGYLGSGGSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAE--M--KLVHRDLAARNILVA--E-----GRKM---------KISDFGLSRDV----Y----E--ED-SY--------------VKRSQGRIPVKWMAIESLF-------DHI--YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI------------PPERLFNLLKTGHRMERPDNCS-----------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV-------FA-DISKDL----------------
---LT--LRLLLGSGAFGEV---YEGTA---VDI-LGVGSGEI---KVAVKTLK-KG-ST-DQEKI-E-FL-K-------------------------EAHLMSKF--N---HPN-----ILKQLGVCL--L-----------------------------NEPQY--IILELMEGG--DLLTYLR----KARM-----------------ATFYGPLL---TLVDLVDLCVDISKGCVYLER--M--HFIHRDLAARNCLVS--VKDYTSPRIV---------KIGDFGLARDI----Y----K--ND-YY--------------RKRGEGLLPVRWMAPESLM-------DGI--FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH------------SNLDVLNYVQTGGRLEPPRNCP-----------------------------------------------------------------DDLWNLMTQCWAQEPDQRPT-------FH-RIQDQL----------------
-----FELLKVLGQGSFGKVFLVRKVTR---P-------DSGH---LYAMKVLKKAT-LKVRD--R-V-RTKM-------------------------ERDILADV--N---HPF-----VVKLHYAFQ--T-----------------------------EGKLY--LILDFLRGG--DLFTRLS---KEV-------------------------MF---TEEDVKFYLAELALGLDHLHS--L--GIIYRDLKPENILLD--E-----EGHI---------KLTDFGLSKEA---------IDHEK-KA--------------YS---FCGTVEYMAPEVVN-------RQG--HSHSADWWSYGVLMFEMLT-GS-LP---------------FQGK---------------DRKETMTLILKAKLGMPQFLS---------------------------------------------------------------TEAQSLLRALFKRNPANRLGSG--PDGAE-EIKRHV--FY------------
-----FELLKVLGQGSYGKV---FLVRK---V-------KGSDAGQLYAMKVLKKAT-LKVRD--R-V-RSKM-------------------------ERDILAEV--N---HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDFLRGG--DLFTRLS---KEV-------------------------MF---TEEDVKFYLAELALALDHLHS--L--GIIYRDLKPENILLD--E-----EGHI---------KITDFGLSKEA---------IDHDK-RA--------------YS---FCGTIEYMAPEVVN-------RRG--HTQSADWWSFGVLMFEMLT-GS-LP---------------FQGK---------------DRKETMALILKAKLGMPQFLS---------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAG--IDGVE-EIKRHPFF--------------
-----FELLKVLGQGSFGKV---FLVKK---I-------SGSDARQLYAMKVLKKAT-LKVRD--R-V-RTKM-------------------------ERDILVEV--N---HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDFLRGG--DLFTRLS---KEV-------------------------MF---TEEDVKFYLAELALALDHLHS--L--GIIYRDLKPENILLD--E-----EGHI---------KLTDFGLSKES---------IDHEK-KA--------------YS---FCGTVEYMAPEVVN-------RRG--HTQSADWWSFGVLMFEMLT-GT-LP---------------FQGK---------------DRKETMTMILKAKLGMPQFLS---------------------------------------------------------------PEAQSLLRMLFKRNPANRLGAG--PDGVE-EIKRHSFF--------------
--REP-----ALGQGSFSVC---RRCRQ---R-------QSGQ---EFAVKILSRRL-EANTQ--R--------------------------------EVAALRLC-QS---HPN-----VVNLHEVHH--D-----------------------------QLHTY--LVLELLRGG--ELLEHIR---KKR-------------------------HF---SESEASQILRSLVSAVSFMHE-EA--GVVHRDLKPENILYA--D-----DT-PGA-----PVKIIDFGFARLR--------PQSPGV-PM--------------QT---PCFTLQYAAPELLA-------QQG--YDESCDLWSLGVILYMMLS-GQ-VP---------------FQGASG--------QGGQSQAAEIMCKIREGRFSLDGEAW-QG-VS---------------------------------------------------------EEAKELVRGLLTVDPAKRLK-------LE-GLRGSSW-L-------------
-----FELLKVLGQGSFGKV---FLVRK---K-------TGPDAGQLYAMKVLKKAS-LKVRD--R-V-RTKM-------------------------ERDILVEV--N---HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDFLRGG--DVFTRLS---KEV-------------------------LF---TEEDVKFYLAELALALDHLHQ--L--GIVYRDLKPENILLD--E-----IGHI---------KLTDFGLSKES---------VDQEK-KA--------------YS---FCGTVEYMAPEVVN-------RRG--HSQSADWWSYGVLMFEMLT-GT-LP---------------FQGK---------------DRNETMNMILKAKLGMPQFLS---------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS----EGVE-EIKRHLFF--------------
-----FELLRVLGKGGYGKV---FQVRKVTGA-------NTGK---IFAMKVLKKAM-IVRNA--K-D-TAHTK-----------------------AERNILEEV--K---HPF-----IVDLIYAFQ--T-----------------------------GGKLY--LILEYLSGG--ELFMQLE---REG-------------------------IF---MEDTACFYLAEISMALGHLHQ--K--GIIYRDLKPENIMLN--H-----QGHV---------KLTDFGLCKES---------IHDGT-VT--------------HT---FCGTIEYMAPEILM-------RSG--HNRAVDWWSLGALMYDMLT-GA-PP---------------FTGE---------------NRKKTIDKILKCKLNLPPYLT---------------------------------------------------------------QEARDLLKKLLKRNAASRLGAG--PGDAG-EVQAHPFF--------------
-----YDIERTLGKGNFAVV---KLARH---R-------VTKT---QVAIKIIDKTR-LDSSN--L-E-KIYR-------------------------EVQLMKLL--N---HPH-----IIKLYQVME--T-----------------------------KDMLY--IVTEFAKNG--EMFDYLT---SNG-------------------------HL---SENEARKKFWQILSAVEYCHD--H--HIVHRDLKTENLLLD--G-----NMDI---------KLADFGFGNF----------YKSGE-PL--------------ST---WCGSPPYAAPEVFE------GKEY--EGPQLDIWSLGVVLYVLVC-GS-LP---------------FDGP---------------NLPTLRQRVLEGRFRIPFFMS---------------------------------------------------------------QDCESLIRRMLVVDPARRIT-------IA-QIRQHRWM--------------
-----YDIEGTLGKGNFAVV---KLGRH---R-------ITKT---EVAIKIIDKSQ-LDAVN--L-E-KIYR-------------------------EVQIMKML--D---HPH-----IIKLYQVME--T-----------------------------KSMLY--LVTEYAKNG--EIFDYLA---NHG-------------------------RL---NESEARRKFWQILSAVDYCHG--R--KIVHRDLKAENLLLD--N-----NMNI---------KIADFGFGNF----------FKSGE-LL--------------AT---WCGSPPYAAPEVFE------GQQY--EGPQLDIWSMGVVLYVLVC-GA-LP---------------FDGP---------------TLPILRQRVLEGRFRIPYFMS---------------------------------------------------------------EDCEHLIRRMLVLDPSKRLT-------IA-QIKEHKWM--------------
-----WEIIGELGDGAFGKV---YKAQN---K-------ETSV---LAAAKVIDTKS-EEELE--D-Y-M--V-------------------------EIDILASC--D---HPN-----IVKLLDAFY--Y-----------------------------ENNLW--ILIEFCAGG--AVDAVML--ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--N--KIIHRDLKAGNILFT--L-----DGDI---------KLADFGVSAKN---------TRTIQ-RR--------------DS---FIGTPYWMAPEVVMCE--TSKDRP--YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL------------NPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------------------------------SNFKDFLKKCLEKNVDARWT-------TS-QLLQHPFV--------------
-----WEIVGELGDGAFGKV---YKAKN---K-------ETGA---LAAAKVIETKS-EEELE--D-Y-I--V-------------------------EIEILATC--D---HPY-----IVKLLGAYY--H-----------------------------DGKLW--IMIEFCPGG--AVDAIML--ELDR-------------------------GL---TEPQIQVVCRQMLEALNFLHS--K--RIIHRDLKAGNVLMT--L-----EGDI---------RLADFGVSAKN---------LKTLQ-KR--------------DS---FIGTPYWMAPEVVMCE--TMKDTP--YDYKADIWSLGITLIEMAQ-IE-PP---------------HHEL------------NPMRVLLKIAKSDPPTLLTPSKWS---------------------------------------------------------------VEFRDFLKIALDKNPETRPS-------AA-QLLEHPFV--------------
--LCP---GRELGRGKFAVV---RKCIK---K-------DSGK---EFAAKFMRKRR-KGQDC--R-M-EIIH-------------------------EIAVLELA-QD---NPW-----VINLHEVYE--T-----------------------------ASEMI--LVLEYAAGG--EIFDQCVA-DREE-------------------------AF---KEKDVQRLMRQILEGVHFLHT--R--DVVHLDLKPQNILLT--S-----ESPLG------DIKIVDFGLSRI----------LKNSE-EL--------------RE---IMGTPEYVAPEILS-------YDP--ISMATDMWSIGVLTYVMLT-GI-SP---------------FLGN---------------DKQETFLNISQMNLSYSEEEF-DV-LS---------------------------------------------------------ESAVDFIRTLLVKKPEDRAT-------AE-ECLKHPWL--------------
-----FTKLEKIGKGSFGEV---FKGID---N-------RTQK---VVAIKIIDLEE-AEDEI--E-D-IQ-Q-------------------------EITVLSQC--D---SPY-----VTKYYGSYL--K-----------------------------DTKLW--IIMEYLGGG--SALDLLE----PG-------------------------PL---DETQIATILREILKGLDYLHS--E--KKIHRDIKAANVLLS--E-----HGEV---------KLADFGVAGQL---------TDTQI-KR--------------NT---FVGTPFWMAPEVIK-------QSA--YDSKADIWSLGITAIELAR-GE-PP---------------HSEL------------HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------------------------------KPLKEFVEACLNKEPSFRPT-------AK-ELLKHKFI--------------
----F-TKLDRIGKGSFGEV---YKGID---N-------HTKE---VVAIKIIDLEE-AEDEI--E-D-IQ-Q-------------------------EITVLSQC--D---SPY-----ITRYFGSYL--K-----------------------------STKLW--IIMEYLGGG--SALDLLK----PG-------------------------PL---EETYIATILREILKGLDYLHS--E--RKIHRDIKAANVLLS--E-----QGDV---------KLADFGVAGQL---------TDTQI-KR--------------NT---FVGTPFWMAPEVIK-------QSA--YDFKADIWSLGITAIELAK-GE-PP---------------NSDL------------HPMRVLFLIPKNSPPTLEGQHS-----------------------------------------------------------------KPFKEFVEACLNKDPRFRPT-------AK-ELLKHKFI--------------
---YL--LLHLLGRGGFSEV---YKAFD---L-------YEQR---YAAVKIHQLNK-SWRDE--K-K-ENYHKH--------------------ACREYRIHKEL--D---HPR-----IVKLYDYFS--L----------------------------DTDTFC--TVLEYCEGN--DLDFYLK---QHK-------------------------LM---SEKEARSIVMQIVNALRYLNE--IKPPIIHYDLKPGNILLV--D-----GTACG------EIKITDFGLSKIMDDD---SYGVDGMD-LT--------------SQ---GAGTYWYLPPECFVV---GKEPPK--ISNKVDVWSVGVIFFQCLY-GR-KP---------------FGHN-------------QSQQDILQENTILKATEVQFPVK-PV-VS---------------------------------------------------------SEAKAFIRRCLAYRKEDRFD-------VH-QLANDPYL--------------
---YL--LLHLLGRGGFSEV---YKAFD---L-------TEQR---YVAVKIHQLNK-NWRDE--K-K-ENYHKH--------------------ACREYRIHKEL--D---HPR-----IVKLYDYFS--L----------------------------DTDSFC--TVLEYCEGN--DLDFYLK---QHK-------------------------LM---SEKEARSIIMQIVNALKYLNE--IKPPIIHYDLKPGNILLV--N-----GTACG------EIKITDFGLSKIMDDD--SYNSVDGME-LT--------------SQ---GAGTYWYLPPECFVV---GKEPPK--ISNKVDVWSVGVIFYQCLY-GR-KP---------------FGHN-------------QSQQDILQENTILKATEVQFPPK-PV-VT---------------------------------------------------------PEAKAFIRRCLAYRKEDRID-------VQ-QLACDPYL--------------
YLLGI-----NLGEGSYAKV---KSAYS---E-------RLKF---NVAIKIIDRKK-APADF--L-E-KFLP------------------------REIEILAML--N---HCS-----IIKTYEIFE--T----------------------------SHGKVY--IVMELAVQG--DLLELIK---TRG-------------------------AL---HEDEARKKFHQLSLAIKYCHD--L--DVVHRDLKCDNLLLD--K-----DFNI---------KLSDFSFSKRCLR-----DDSGRMA-LS--------------KT---FCGSPAYAAPEVLQ------GIPY--QPKVYDIWSLGVILYIMVC-GS-MP---------------YDDS---------------NIKKMLRIQKEHRVNFPRSKH-LT------------------------------------------------------------GECKDLIYHMLQPDVNRRLH-------ID-EILSHCWM--------------
---FS--RKDLIGHGAFAVV---FKGRH---R-------EKHD--LEVAVKCINKKN-LAKSQ--T---LLGK-------------------------EIKILKEL--K---HEN-----IVALYDFQE--M-----------------------------ANSVY--LVMEYCNGG--DLADYLH---AMR-------------------------TL---SEDTIRLFLQQIAGAMRLLHS--K--GIIHRDLKPQNILLS--N-----PAGRRANPNSIRVKIADFGFARY----------LQSNM-MA--------------AT---LCGSPMYMAPEVIM-------SQH--YDGKADLWSIGTIVYQCLT-GK-AP---------------FQAS------------SPQDLRLFYEKNKTLVPTIPRETS---------------------------------------------------------------APLRQLLLALLQRNHKDRMD-------FD-EFFHHPFL--------------
----Y-SKRDLVGHGAFAVV---FRGRH---R-------QKTD--WEVAIKSINKKN-LSKSQ----I-LLGK-------------------------EIKILKEL--Q---HEN-----IVALYDVQE--L-----------------------------PNSVF--LVMEYCNGG--DLADYLQ---AKG-------------------------TL---SEDTIRVFLHQIAAAMRILHS--K--GIIHRDLKPQNILLS--Y-----ANRRKSSVSGIRIKIADFGFARY----------LHSNM-MA--------------AT---LCGSPMYMAPEVIM-------SQH--YDAKADLWSIGTVIYQCLV-GK-PP---------------FQAN------------SPQDLRMFYEKNRS--LMPSIPRE-TS------------------------------------------------------------PYLANLLLGLLQRNQKDRMD-------FE-AFFSHPFL--------------
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