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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
TK ABL1 261
TK ABL2 288
AGC AKT1 150
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
TK BMX 422
CAMK BRSK1 50
CAMK CAMK1G 23
Other CAMKK1 128
CMGC CDC2 4
CMGC CDK11A 438
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
Other CHUK 15
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK3 13
TK DDR1 572
TK DDR2 563
TK EPHB1 619
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FRK 234
TK FYN 271
AGC GRK4 187
CMGC GSK3B 56
TK HCK 241
CAMK HUNK 61
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LYN 247
STE MAP2K1 68
STE MAP2K5 166
STE MAP2K6 53
TKL MAP3K10 98
TKL MAP3K11 117
TKL MAP3K12 125
TKL MAP3K13 168
TKL MAP3K7 36
TKL MAP3K9 144
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK8 26
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK3 56
CAMK MARK4 59
TK MET 1078
TK MUSK 575
Other NEK5 4
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK1 270
STE PAK2 249
STE PAK3 268
CMGC PCTK1 165
CMGC PCTK2 192
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
AGC PKN1 615
AGC PKN2 657
Other PLK1 53
Other PLK2 82
Other PLK3 62
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
CMGC PRPF4B 687
TK PTK6 191
AGC ROCK1 76
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
TK SRC 270
STE STK10 36
CAMK STK17A 61
STE STK24 24
STE STK25 20
CAMK STK33 116
TKL TESK1 57
TK TNK2 150
Other TTK 525
Other ULK3 14
TK YES1 277
TKL ZAK 16
-----YTDIKVIGNGSFGVV---YQARLA----------------E-TRE---LVAIKKV---LQD--K-RFK---NR--------------------------------------ELQIMRKL--D------HCNIVRLRYFFY--SSG----EKKDE------LYLNLVLEYVPETV-YRVARHFT----------------------KAKL--------------------------TIPILYVKVYMYQLFRSLAYIHS-Q-----G---VCHRDIKPQNLLVD--PD--------TA-VL---------KLCDFGSAKQ--------LVRGEPN--------------VS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD-----------SGVDQLVEI----IK----VLG---TPTREQIREMNPNYTEFKFPQIKAH-------------------------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSS--RLS-----PL-EACAHSFF--------------------------------------------------------
-----ITMKHKLGGGQYGEV---YEGVWK----------------K-YSL---TVAVKTL---K-E--D-TM----EV-----E-E-FL-K-------------------------EAAVMKEI--K------HPNLVQLLGVCT--R--------EPP------FY--IITEFMTYG---NLLDYLR------------------------EC----------------------NR-QEVNAVVLLYMATQISSAMEYLEK-K-----N---FIHRDLAARNCLVG---E--------NH-LV---------KVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI-----------DLSQVYELL----EK----DYR---MERPEGCP-----------------------------------------------------------EKVYE-LMRACWQWNPSD--RPS-----FA-EIHQA--F--------------------------------------------------------
-----ITMKHKLGGGQYGEV---YVGVWK----------------K-YSL---TVAVKTL---K-E--D-TM----EV-----E-E-FL-K-------------------------EAAVMKEI--K------HPNLVQLLGVCT--L--------EPP------FY--IVTEYMPYG---NLLDYLR------------------------EC----------------------NR-EEVTAVVLLYMATQISSAMEYLEK-K-----N---FIHRDLAARNCLVG---E--------NH-VV---------KVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----------YNTFSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI-----------DLSQVYDLL----EK----GYR---MEQPEGCP-----------------------------------------------------------PKVYE-LMRACWKWSPAD--RPS-----FA-ETHQA--F--------------------------------------------------------
----F-EYLKLLGKGTFGKV---ILVKEK----------------A-TGR---YYAMKIL---KKE--V-IVA---KD-----E-V-AHTL------------------------TENRVLQNS--R------HPFLTALKYSFQ--T--------HDR------LC--FVMEYANGG---ELFFHLS-----------------------RER--------------------------VFSEDRARFYGAEIVSALDYLHSEK-----N---VVYRDLKLENLMLD---K--------DG-HI---------KITDFGLCKEG-------IKDGATM--------------KT---FCGTPEYLAPEVLE-----------DNDYGRAVDWWGLGVVMYEMMC-GR-LP---------------FY-NQ--------------DHEKLF----EL----ILM---EEIRFPRTLG---------------------------------------------------------PEAKS-LLSGLLKKDPKQ--RLGGGSEDAK-EIMQHRFF--------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLAREK----------------Q-SKF---ILALKVL---FKA--QLEKA---GV-----E-H-QLRR-------------------------EVEIQSHL--R------HPNILRLYGYFH--D--------ATR------VY--LILEYAPLG---TVYRELQ-----------------------KLS--------------------------KFDEQRTATYITELANALSYCHS-K-----R---VIHRDIKPENLLLG---S--------AG-EL---------KIADFGWSV---------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FE-AN--------------TYQETY----KR----ISR---VEFTFPDFVT---------------------------------------------------------EGARD-LISRLLKHNPSQ--RPM-----LR-EVLEHPWI--------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLAREK----------------K-SHF---IVALKVL---FKS--Q-IEK---EG-----V-E-HQLR------------------------REIEIQAHL--H------HPNILRLYNYFY--D--------RRR------IY--LILEYAPRG---ELYKELQ-----------------------KSC--------------------------TFDEQRTATIMEELADALMYCHG-K-----K---VIHRDIKPENLLLG---L--------KG-EL---------KIADFGWSV---------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FE-SA--------------SHNETY----RR----IVK---VDLKFPASVP---------------------------------------------------------MGAQD-LISKLLRHNPSE--RLP-----LA-QVSAHPWV--------------------------------------------------------
-----FEIGRPLGKGKFGNV---YLARLK----------------E-SHF---IVALKVL---FKS--Q-IEK---EG-----L-E-HQLR------------------------REIEIQAHL--Q------HPNILRLYNYFH--D--------ARR------VY--LILEYAPRG---ELYKELQ-----------------------KSE--------------------------KLDEQRTATIIEELADALTYCHD-K-----K---VIHRDIKPENLLLG---F--------RG-EV---------KIADFGWSV---------HTPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRTYDEKVDLWCIGVLCYELLV-GY-PP---------------FE-SA--------------SHSETY----RR----ILK---VDVRFPLSMP---------------------------------------------------------LGARD-LISRLLRYQPLE--RLP-----LA-QILKHPWV--------------------------------------------------------
----V-ALGKTLGEGEFGAV---MEGQLN--------------QDD-SIL---KVAVKTM---K-I-AI-CT----RSE---LE-D-FL-S-------------------------EAVCMKEF--D------HPNVMRLIGVCF--Q--------GSERESFPAPV--VILPFMKHG---DLHSFLL------------------------YSRL------------------GDQP-VYLPTQMLVKFMADIASGMEYLST-K-----R---FIHRDLAARNCMLN---E--------NM-SV---------CVADFGLSKKI----Y--N--GDYY--------------RQGRIAKMPVKWIAIESLA-----------DRVYTSKSDVWSFGVTMWEIATRGQ-TP---------------YP-GV-----------ENSEIYDYL----RQ----GNR---LKQPADCL-----------------------------------------------------------DGLYA-LMSRCWELNPQD--RPS-----FT-ELREDL----------------------------------------------------------
----L-RLVRKLGSGQFGEV---WMGYYK------------------NNM---KVAIKTL---K-E--G-TM----SP-----E-A-FL-G-------------------------EANVMKAL--Q------HERLVRLYAVVT-----------KEP------IY--IVTEYMARG---CLLDFLK------------------------TD----------------------EG-SRLSLPRLIDMSAQIAEGMAYIER-M-----N---SIHRDLRAANILVS---E--------AL-CC---------KIADFGLARII----------DSEY--------------TAQEGAKFPIKWTAPEAIH-----------FGVFTIKADVWSFGVLLMEVVTYGR-VP---------------YP-GM-----------SNPEVIRNL----ER----GYR---MPRPDTCP-----------------------------------------------------------PELYRGVIAECWRSRPEE--RPT-----FE-FLQSV--L--------------------------------------------------------
-----ITLLKELGSGQFGVV---QLGKWK------------------GQY---DVAVKMI---K-E--G-SM----SE-----D-E-FF-Q-------------------------EAQTMMKL--S------HPKLVKFYGVCS--K--------EYP------IY--IVTEYISNG---CLLNYLR------------------------SH-----------------------G-KGLEPSQLLEMCYDVCEGMAFLES-H-----Q---FIHRDLAARNCLVD---R--------DL-CV---------KVSDFGMTRYV-------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----------YFKYSSKSDVWAFGILMWEVFSLGK-QP---------------YD-LY-----------DNSQVVLKV----SQ----GHR---LYRPHLAS-----------------------------------------------------------DTIYQ-IMYSCWHELPEK--RPT-----FQ-QLLSS--I--------------------------------------------------------
-----YRLEKTLGKGQTGLV---KLGVHC----------------I-TGQ---KVAIKIV---NRE--K-LSE---SV-----L-M-KVER-------------------------EIAILKLI--E------HPHVLKLHDVYE--N--------KKY------LY--LVLEHVSGG---ELFDYLV-----------------------KKG--------------------------RLTPKEARKFFRQIVSALDFCHS-Y-----S---ICHRDLKPENLLLD---E--------KN-NI---------RIADFGMASL--------QVGDSLL--------------ET---SCGSPHYACPEVIK----------GEKYDGRRADMWSCGVILFALLV-GA-LP---------------FD-DD--------------NLRQLL----EK----VKR---GVFHMPHFIP---------------------------------------------------------PDCQS-LLRGMIEVEPEK--RLS-----LE-QIQKHPW-Y-------------------------------------------------------
---FI--FMEVLGSGAFSEV---FLVKQR----------------L-TGK---LFALKCI---KKS--P-AFR---DS-----S-L-E--N-------------------------EIAVLKKI--K------HENIVTLEDIYE--S--------TTH------YY--LVMQLVSGG---ELFDRIL-----------------------ERG--------------------------VYTEKDASLVIQQVLSAVKYLHE-N-----G---IVHRDLKPENLLYLTPEE--------NS-KI---------MITDFGLSK---------MEQNGIM--------------ST---ACGTPGYVAPEVLA-----------QKPYSKAVDCWSIGVITYILLC-GY-PP---------------FY-EE--------------TESKLF----EK----IKE---GYYEFESPFWDDIS-----------------------------------------------------ESAKD-FICHLLEKDPNE--RYT-----CE-KALSHPWI--------------------------------------------------------
-----YKLQSEIGKGAYGVV---RLAYNE----------------S-EDR---HYAMKVL---SKK--K-LLK---QY-----G-F-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D------HVNVVKLIEVLD--DP------AEDN------LY--LVFDLLRKG---PVMEVPC------------------------DK--------------------------PFSEEQARLYLRDVILGLEYLHC-Q-----K---IVHRDIKPSNLLLG---D--------DG-HV---------KIADFGVSNQF-------EGNDAQL--------------SS---TAGTPAFMAPEAISD--------SGQSFSGKALDVWATGVTLYCFVY-GK-CP---------------FI-DD--------------FILALH----RK----IKN---EPVVFPEEPEIS-------------------------------------------------------EELKD-LILKMLDKNPET--RIG-----VP-DIKLHPWV--------------------------------------------------------
-----YTKIEKIGEGTYGVV---YKGRHK----------------T-TGQ---VVAMKKI---RLE--S-EEE---GV-----P-S-TAIR-------------------------EISLLKEL--R------HPNIVSLQDVLM--Q--------DSR------LY--LIFEFLSM----DLKKYLDS--------------------IPPGQ--------------------------YMDSSLVKSYLYQILQGIVFCHS-R-----R---VLHRDLKPQNLLID---D--------KG-TI---------KLADFGLARAF-------GIPIRVY--------------TH---EVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FH-GD-----------SEIDQLFRI----FR----ALG---TPNNEVWPEVESLQDYKNTFPKWKP-------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAK--RIS-----GK-MALNHPYF--------------------------------------------------------
-----FQCLNRIEEGTYGVV---YRAKDK----------------K-TDE---IVALKRL---KME--K-EKE---GF-----P-I-TSLR-------------------------EINTILKA--Q------HPNIVTVREIVV--GS------NMDK------IY--IVMNYVEH----DLKSLME----------------------TMKQ--------------------------PFLPGEVKTLMIQLLRGVKHLHD-N-----W---ILHRDLKTSNLLLS---H--------AG-IL---------KVGDFGLAREY-------GSPLKAY--------------TP---VVVTLWYRAPELLL----------GAKEYSTAVDMWSVGCIFGELLT-QK-PL---------------FP-GK-----------SEIDQINKV----FK----DLG---TPSEKIWPGYSELPAVKKMTFSEHPY-----------------------------NNLRKRFGALLSDQGFD-LMNKFLTYFPGR--RIS-----AE-DGLKHEYF--------------------------------------------------------
-----FQKVEKIGEGTYGVV---YKARNK----------------L-TGE---VVALKKI---RLD--T-ETE---GV-----P-S-TAIR-------------------------EISLLKEL--N------HPNIVKLLDVIH--T--------ENK------LY--LVFEFLHQ----DLKKFMDA---------------------SALT--------------------------GIPLPLIKSYLFQLLQGLAFCHS-H-----R---VLHRDLKPQNLLIN---T--------EG-AI---------KLADFGLARAF-------GVPVRTY--------------TH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FP-GD-----------SEIDQLFRI----FR----TLG---TPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNK--RIS-----AK-AALAHPFF--------------------------------------------------------
----Y-EPVAEIGVGAYGTV---YKARDP----------------H-SGH---FVALKSV---RVP--N-GGGGGGGL-----P-I-STVR-------------------------EVALLRRL--EA---FEHPNVVRLMDVCA--TSR---TDREIK------VT--LVFEHVDQ----DLRTYLDK---------------------APPP--------------------------GLPAETIKDLMRQFLRGLDFLHA-N-----C---IVHRDLKPENILVT---S--------GG-TV---------KLADFGLARI--------YSYQMAL--------------TP---VVVTLWYRAPEVLL-----------QSTYATPVDMWSVGCIFAEMFR-RK-PL---------------FC-GN-----------SEADQLGKI----FD----LIG---LPPEDDWPRDVSLPRGAFPPRGPR---------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHK--RIS-----AF-RALQHSYL--------------------------------------------------------
-----YEKLEKIGEGTYGTV---FKAKNR----------------E-THE---IVALKRV---RLD--D-DDE---GV-----P-S-SALR-------------------------EICLLKEL--K------HKNIVRLHDVLH--S--------DKK------LT--LVFEFCDQ----DLKKYFD----------------------SCNG--------------------------DLDPEIVKSFLFQLLKGLGFCHS-R-----N---VLHRDLKPQNLLIN---R--------NG-EL---------KLADFGLARAF-------GIPVRCY--------------SA---EVVTLWYRPPDVLF----------GAKLYSTSIDMWSAGCIFAELANAGR-PL---------------FP-GN-----------DVDDQLKRI----FR----LLG---TPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQ--RIS-----AE-EALQHPYF--------------------------------------------------------
-----YEKLAKIGQGTFGEV---FKARHR----------------K-TGQ---KVALKKV---LME--N-EKE---GF-----P-I-TALR-------------------------EIKILQLL--K------HENVVNLIEICR--TKASPYNRCKGS------IY--LVFDFCEH----DLAGLLS----------------------NVLV--------------------------KFTLSEIKRVMQMLLNGLYYIHR-N-----K---ILHRDMKAANVLIT---R--------DG-VL---------KLADFGLARAFSL---AKNSQPNRY--------------TN---RVVTLWYRPPELLL----------GERDYGPPIDLWGAGCIMAEMWT-RS-PI---------------MQ-GN-----------TEQHQLALI----SQ----LCG---SITPEVWPNVDNYELYEKLELVKGQK----------------------------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQ--RID-----SD-DALNHDFF--------------------------------------------------------
-----YENLGLVGEGSYGMV---MKCRNK----------------D-TGR---IVAIKKF---LES--D-DDK---MV-----K-K-IAMR-------------------------EIKLLKQL--R------HENLVNLLEVCK--K--------KKR------WY--LVFEFVDHT---ILDDLEL-----------------------FPN--------------------------GLDYQVVQKYLFQIINGIGFCHS-H-----N---IIHRDIKPENILVS---Q--------SG-VV---------KLCDFGFARTL-------AAPGEVY--------------TD---YVATRWYRAPELLV----------GDVKYGKAVDVWAIGCLVTEMFM-GE-PL---------------FP-GD-----------SDIDQLYHI----MM----CLG---NLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDK--RPF-----CA-ELLHHDFF--------------------------------------------------------
-----YETLGKVGEGSYGTV---MKCKHK----------------N-TGQ---IVAIKIF---YER--P-EQS---VN-----K---IAMR-------------------------EIKFLKQF--H------HENLVNLIEVFR--Q--------KKK------IH--LVFEFIDHT---VLDELQH-----------------------YCH--------------------------GLESKRLRKYLFQILRAIDYLHS-N-----N---IIHRDIKPENILVS---Q--------SG-IT---------KLCDFGFARTL-------AAPGDIY--------------TD---YVATRWYRAPELVL----------KDTSYGKPVDIWALGCMIIEMAT-GN-PY---------------LP-SS-----------SDLDLLHKI----VL----KVG---N-LSPHLQNIFSKSPIFAGVVLPQVQ----------------------------HPKNARKKYPKLNGLLAD-IVHACLQIDPAD--RIS-----SS-DLLHHEYF--------------------------------------------------------
-----FEILGVVGEGAYGVV---LKCRHK----------------E-THE---IVAIKKF---KDS--E-ENE---EV-----K-E-TTLR-------------------------ELKMLRTL--K------QENIVELKEAFR--R--------RGK------LY--LVFEYVEK----NMLELLE----------------------EMPN--------------------------GVPPEKVKSYIYQLIKAIHWCHK-N-----D---IVHRDIKPENLLIS---H--------ND-VL---------KLCDFGFARNL------SEGNNANY--------------TE---YVATRWYRSPELLL-----------GAPYGKSVDMWSVGCILGELSD-GQ-PL---------------FP-GE-----------SEIDQLFTI----QK----VLG---PLPSEQMKLFYSNPRFHGLRFPAVNH----------------------------PQSLERRYLGILNSVLLD-LMKNLLKLDPAD--RYL-----TE-QCLNHPTF--------------------------------------------------------
----W-DLVQTLGEGAYGEV---QLAVNR----------------V-TEE---AVAVKIV---DMK--R-AVD---CP-----E-N-I-KK-------------------------EICINKML--N------HENVVKFYGHRR--E--------GNI------QY--LFLEYCSGG---ELFDRIE-----------------------PDI--------------------------GMPEPDAQRFFHQLMAGVVYLHG-I-----G---ITHRDIKPENLLLD---E--------RD-NL---------KISDFGLATVFR-----YNNRERLL--------------NK---MCGTLPYVAPELLK----------RREFHAEPVDVWSCGIVLTAMLA-GE-LP---------------WD-QP-------------SDSCQEY----SD----WKE---KKTYLNPWKKI--D-----------------------------------------------------SAPLA-LLHKILVENPSA--RIT-----IP-DIKKDRW-Y-------------------------------------------------------
----W-EMRERLGTGGFGNV---CLYQHR----------------E-LDL---KIAIKSC---RLE--L-STK---NR-----E-R--WCH-------------------------EIQIMKKL--N------HANVVKACDVPE--ELN---ILIHDV------PL--LAMEYCSGG---DLRKLLNK--------------------PENCC--------------------------GLKESQILSLLSDIGSGIRYLHE-N-----K---IIHRDLKPENIVLQ---D--------VG-GKI------IHKIIDLGYAKD--------VDQGSLC--------------TS---FVGTLQYLAPELFE-----------NKPYTATVDYWSFGTMVFECIA-GY-RP---------------FL-HHLQPFTWHEKIKKKDPKCIFA----CE----EMS---GEVRFSSHLPQPNSLCS-----------------------------------------------LVVEPMEN-WLQLMLNWDPQQ--RG-----------------GPVDLTLKQ-----------------------------------------------
-----YQLVRKLGRGKYSEV---FEAINI----------------T-NNE---KVVVKIL---KPV--K-KKK---IK-----R--------------------------------EIKILENL-RG------GPNIITLADIVK--DP------VSRT------PA--LVFEHVNNT---DFKQLY--------------------------Q--------------------------TLTDYDIRFYMYEILKALDYCHS-M-----G---IMHRDVKPHNVMID--HE--------HR-KL---------RLIDWGLAEF--------YHPGQEY--------------NV---RVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIF-RK-EP---------------FFHGH-----------DNYDQLVRI----AK----VLG---TEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------RWERFVHSENQHLVSPEALD-FLDKLLRYDHQS--RLT-----AR-EAMEHPYF--------------------------------------------------------
-----YQLVRKLGRGKYSEV---FEAINI----------------T-NNE---RVVVKIL---KPV--K-KKK---IK-----R--------------------------------EVKILENL-RG------GTNIIKLIDTVK--DP------VSKT------PA--LVFEYINNT---DFKQLY--------------------------Q--------------------------ILTDFDIRFYMYELLKALDYCHS-K-----G---IMHRDVKPHNVMID--HQ--------QK-KL---------RLIDWGLAEF--------YHPAQEY--------------NV---RVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIF-RR-EP---------------FFHGQ-----------DNYDQLVRI----AK----VLG---TEELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQ--RLT-----AK-EAMEHPYF--------------------------------------------------------
-----YEMGEELGSGQFAIV---RKCRQK----------------G-TGK---EYAAKFI---KKR--R-LSS---SR-----R-G-VSREEI---------------------EREVNILREI--R------HPNIITLHDIFE--N--------KTD------VV--LILELVSGG---ELFDFLA-----------------------EKE--------------------------SLTEDEATQFLKQILDGVHYLHS-K-----R---IAHFDLKPENIMLL---D--------KN-VPNP-----RIKLIDFGIAHK--------IEAGNEF--------------KN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GA-SP---------------FL-GE--------------TKQETL----TN----ISA---VNYDFDEEYFSNTS-----------------------------------------------------ELAKD-FIRRLLVKDPKR--RMT-----IA-QSLEHSWI--------------------------------------------------------
-----LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKG-HPL---LVAVKIL---R-P--D-AT----KNA---RN-D-FL-K-------------------------EVKIMSRL--K------DPNIIRLLGVCV--Q--------DDP------LC--MITDYMENG---DLNQFLS------------------------AHQLEDKAAE-----GAPGDGQAAQG-PTISYPMLLHVAAQIASGMRYLAT-L-----N---FVHRDLATRNCLVG---E--------NF-TI---------KIADFGMSRNL----Y--A--GDYY--------------RVQGRAVLPIRWMAWECIL-----------MGKFTTASDVWAFGVTLWEVLMLCRAQP---------------FG-QL-----------TDEQVIENAGEFFRD----QGRQVYLSRPPACP-----------------------------------------------------------QGLYE-LMLRCWSRESEQ--RPP-----FS-QLHRFL----------------------------------------------------------
-----LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSAN-QPV---LVAVKML---R-A--D-AN----KNA---RN-D-FL-K-------------------------EIKIMSRL--K------DPNIIHLLAVCI--T--------DDP------LC--MITEYMENG---DLNQFLS------------------------RHEPPN--------------SSSSDV-RTVSYTNLKFMATQIASGMKYLSS-L-----N---FVHRDLATRNCLVG---K--------NY-TI---------KIADFGMSRNL----Y--S--GDYY--------------RIQGRAVLPIRWMSWESIL-----------LGKFTTASDVWAFGVTLWETFTFCQEQP---------------YS-QL-----------SDEQVIENT----GEFFRDQGRQTYLPQPAICP-----------------------------------------------------------DSVYK-LMLSCWRRDTKN--RPS-----FQ-EIHL---LL-------------------------------------------------------
----V-KIEEVIGAGEFGEV---YKGRLK-------------LPGK-REI---YVAIKTL---K-A--G-YS----EKQ---RR-D-FL-S-------------------------EASIMGQF--D------HPNIIRLEGVVT--K--------SRP------VM--IITEFMENG---ALDSFLR------------------------QN-----------------------D-GQFTVIQLVGMLRGIAAGMKYLAE-M-----N---YVHRDLAARNILVN---S--------NL-VC---------KVSDFGLSRYLQ-DDT--S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----------YRKFTSASDVWSYGIVMWEVMSFGE-RP---------------YW-DM-----------SNQDVINAI----EQ----DYR---LPPPMDCP-----------------------------------------------------------AALHQ-LMLDCWQKDRNS--RPR-----FA-EIVNTL----------------------------------------------------------
---VI--LGELLGKGNFGEV---YKGTLK------------------DKT---SVAVKTC---K-E--D-LP----QEL---KI-K-FL-Q-------------------------EAKILKQY--D------HPNIVKLIGVCT--Q--------RQP------VY--IIMELVSGG---DFLTFLR------------------------RK-----------------------K-DELKLKQLVKFSLDAAAGMLYLES-K-----N---CIHRDLAARNCLVG---E--------NN-VL---------KISDFGMSRQE-------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----------YGRYSSESDVWSFGILLWETFSLGV-CP---------------YP-GM-----------TNQQAREQV----ER----GYR---MSAPQHCP-----------------------------------------------------------EDISK-IMMKCWDYKPEN--RPK-----FS-ELQKEL----------------------------------------------------------
----L-VLGEQIGRGNFGEV---FSGRLR----------------A-DNT---LVAVKSC---R-E--T-LP----PDL---KA-K-FL-Q-------------------------EARILKQY--S------HPNIVRLIGVCT--Q--------KQP------IY--IVMELVQGG---DFLTFLR------------------------TE-----------------------G-ARLRVKTLLQMVGDAAAGMEYLES-K-----C---CIHRDLAARNCLVT---E--------KN-VL---------KISDFGMSREE----A--D--GVYA--------------ASGGLRQVPVKWTAPEALN-----------YGRYSSESDVWSFGILLWETFSLGA-SP---------------YP-NL-----------SNQQTREFV----EK----GGR---LPCPELCP-----------------------------------------------------------DAVFR-LMEQCWAYEPGQ--RPS-----FS-TIYQEL----------------------------------------------------------
----L-VLGKPLGEGCFGQV---VLAEAIGL---------DKDKPN-RVT---KVAVKML---K-S--D-AT----EKD---LS-D-LI-S-------------------------EMEMMKMIG-K------HKNIINLLGACT--Q--------DGP------LY--VIVEYASKG---NLREYLQ------------------------ARRPPGLEY--------CYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLAS-K-----K---CIHRDLAARNVLVT---E--------DN-VM---------KIADFGLARDI----H--H--IDYY--------------KKTTNGRLPVKWMAPEALF-----------DRIYTHQSDVWSFGVLLWEIFTLGG-SP---------------YP-GV-----------PVEELFKLL----KE----GHR---MDKPSNCT-----------------------------------------------------------NELYM-MMRDCWHAVPSQ--RPT-----FK-QLVEDL----------------------------------------------------------
-----LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPK-EAV---TVAVKML---K-D--D-AT----EKD---LS-D-LV-S-------------------------EMEMMKMIG-K------HKNIINLLGACT--Q--------DGP------LY--VIVEYASKG---NLREYLR------------------------ARRPPGMEY--------SYDINRVPE-EQMTFKDLVSCTYQLARGMEYLAS-Q-----K---CIHRDLAARNVLVT---E--------NN-VM---------KIADFGLARDI----N--N--IDYY--------------KKTTNGRLPVKWMAPEALF-----------DRVYTHQSDVWSFGVLMWEIFTLGG-SP---------------YP-GI-----------PVEELFKLL----KE----GHR---MDKPANCT-----------------------------------------------------------NELYM-MMRDCWHAVPSQ--RPT-----FK-QLVEDL----------------------------------------------------------
-----LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAA-KPV---TVAVKML---K-D--D-AT----DKD---LS-D-LV-S-------------------------EMEMMKMIG-K------HKNIINLLGACT--Q--------GGP------LY--VLVEYAAKG---NLREFLR------------------------ARRPPGLDY--------SFDTCKPPE-EQLTFKDLVSCAYQVARGMEYLAS-Q-----K---CIHRDLAARNVLVT---E--------DN-VM---------KIADFGLARDV----H--N--LDYY--------------KKTTNGRLPVKWMAPEALF-----------DRVYTHQSDVWSFGVLLWEIFTLGG-SP---------------YP-GI-----------PVEELFKLL----KE----GHR---MDKPANCT-----------------------------------------------------------HDLYM-IMRECWHAAPSQ--RPT-----FK-QLVEDL----------------------------------------------------------
----L-VLGKPLGEGCFGQV---VRAEAFGM---------DPARPD-QAS---TVAVKML---K-D--N-AS----DKD---LA-D-LV-S-------------------------EMEVMKLIG-R------HKNIINLLGVCT--Q--------EGP------LY--VIVECAAKG---NLREFLR------------------------ARRPPGPDL--------SPDGPRSSE-GPLSFPVLVSCAYQVARGMQYLES-R-----K---CIHRDLAARNVLVT---E--------DN-VM---------KIADFGLARGV----H--H--IDYY--------------KKTSNGRLPVKWMAPEALF-----------DRVYTHQSDVWSFGILLWEIFTLGG-SP---------------YP-GI-----------PVEELFSLL----RE----GHR---MDRPPHCP-----------------------------------------------------------PELYG-LMRECWHAAPSQ--RPT-----FK-QLVEAL----------------------------------------------------------
-----ITLERRLGTGCFGDV---WLGTWN------------------GST---KVAVKTL---K-P--G-TM----SP-----K-A-FL-E-------------------------EAQVMKLL--R------HDKLVQLYAVVS-----------EEP------IY--IVTEFMCHG---SLLDFLK------------------------NP----------------------EG-QDLRLPQLVDMAAQVAEGMAYMER-M-----N---YIHRDLRAANILVG---E--------RL-AC---------KIADFGLARLI-------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----------FGRFTIKSDVWSFGILLTELITKGR-IP---------------YP-GM-----------NKREVLEQV----EQ----GYH---MPCPPGCP-----------------------------------------------------------ASLYE-AMEQTWRLDPEE--RPT-----FE-YLQSFL----------------------------------------------------------
-----IQLLKRLGSGQFGEV---WEGLWN------------------NTT---PVAVKTL---K-P--G-SM----DP-----N-D-FL-R-------------------------EAQIMKNL--R------HPKLIQLYAVCT--L--------EDP------IY--IITELMRHG---SLQEYLQ------------------------ND----------------------TG-SKIHLTQQVDMAAQVASGMAYLES-R-----N---YIHRDLAARNVLVG---E--------HN-IY---------KVADFGLARVFK--VD--N--EDIY--------------ESRHEIKLPVKWTAPEAIR-----------SNKFSIKSDVWSFGILLYEIITYGK-MP---------------YS-GM-----------TGAQVIQML----AQ----NYR---LPQPSNCP-----------------------------------------------------------QQFYN-IMLECWNAEPKE--RPT-----FE-TLRWK--L--------------------------------------------------------
-----LQLIKRLGNGQFGEV---WMGTWN------------------GNT---KVAIKTL---K-P--G-TM----SP-----E-S-FL-E-------------------------EAQIMKKL--K------HDKLVQLYAVVS-----------EEP------IY--IVTEYMNKG---SLLDFLK------------------------DG----------------------EG-RALKLPNLVDMAAQVAAGMAYIER-M-----N---YIHRDLRSANILVG---N--------GL-IC---------KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELVTKGR-VP---------------YP-GM-----------NNREVLEQV----ER----GYR---MPCPQDCP-----------------------------------------------------------ISLHE-LMIHCWKKDPEE--RPT-----FE-YLQSFL----------------------------------------------------------
---FR--HYRVLGKGGFGEV---CACQVR----------------A-TGK---MYACKKL---QKK--R-IKK---RK-----G-E-AMAL------------------------NEKRILEKV--Q------SRFVVSLAYAYE--T--------KDA------LC--LVLTIMNGG---DLKFHIYN---------------------LGNP--------------------------GFDEQRAVFYAAELCCGLEDLQR-E-----R---IVYRDLKPENILLD---D--------RG-HI---------RISDLGLATE--------IPEGQRV--------------RG---RVGTVGYMAPEVVN-----------NEKYTFSPDWWGLGCLIYEMIQ-GH-SP---------------FK-KY-----------KEKVKWEEV----DQ----RIK---NDTEEYSE---KFS-----------------------------------------------------EDAKS-ICRMLLTKNPSK--RLGCRGEGAA-GVKQHPV-F-------------------------------------------------------
-----YTDTKVIGNGSFGVV---YQAKLC----------------D-SGE---LVAIKKV---LQD--K-RFK---NR--------------------------------------ELQIMRKL--D------HCNIVRLRYFFY--SSG----EKKDE------VYLNLVLDYVPETV-YRVA---RHY-------------------SRAKQ--------------------------TLPVIYVKLYMYQLFRSLAYIHS-F-----G---ICHRDIKPQNLLLD--PD--------TA-VL---------KLCDFGSAKQ--------LVRGEPN--------------VS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD-----------SGVDQLVEI----IK----VLG---TPTREQIREMNPNYTEFKFPQIKAH-------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTA--RLT-----PL-EACAHSFF--------------------------------------------------------
-----LKLEKKLGAGQFGEV---WMATYN------------------KHT---KVAVKTM---K-P--G-SM----SV-----E-A-FL-A-------------------------EANVMKTL--Q------HDKLVKLHAVVT-----------KEP------IY--IITEFMAKG---SLLDFLK------------------------SD----------------------EG-SKQPLPKLIDFSAQIAEGMAFIEQ-R-----N---YIHRDLRAANILVS---A--------SL-VC---------KIADFGLARVI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------FGSFTIKSDVWSFGILLMEIVTYGR-IP---------------YP-GM-----------SNPEVIRAL----ER----GYR---MPRPENCP-----------------------------------------------------------EELYN-IMMRCWKNRPEE--RPT-----FE-YIQSV--L--------------------------------------------------------
--IGS----RKLGEGSFAKV---REGLHV----------------L-TGE---KVAIKVI---DKK--R-AKK---DT-----Y-V-TKNLR-----------------------REGQIQQMI--R------HPNITQLLDILE--T--------ENS------YY--LVMELCPGG---NLMHKIY-----------------------EKK--------------------------RLEESEARRYIRQLISAVEHLHR-A-----G---VVHRDLKIENLLLD---E--------DN-NI---------KLIDFGLSNCAG-----ILGYSDPF--------------ST---QCGSPAYAAPELLA-----------RKKYGPKIDVWSIGVNMYAMLT-GT-LP---------------FT-VE------------PFSLRALY----QK----MVD----KEMNPLPTQ--LS-----------------------------------------------------TGAIS-FLRSLLEPDPVK--RPN-----IQ-QALANRWL--------------------------------------------------------
--VGG----NKMGEGGFGVV---YKGYVN----------------N-TT-----VAVKKL---AAM--V-DIT---TE-----ELK-QQFD------------------------QEIKVMAKC--Q------HENLVELLGFSS--D--------GDD------LC--LVYVYMPNG---SLLDRLSC--------------------LDGTP--------------------------PLSWHMRCKIAQGAANGINFLHE-N-----H---HIHRDIKSANILLD---E--------AF-TA---------KISDFGLARASE-----KFAQTVMT--------------SR---IVGTTAYMAPEALR------------GEITPKSDIYSFGVVLLEIIT-GL-PA---------------VD-EH-----------REPQLLLDI----KE----EIE---DEEKTIEDYIDKKMNDAD---------------------------------------------STSVEAMYS-VASQCLHEKKNK--RPD-----IK-KVQQ----LLQ-----------------------------------------------------
-----LTFVQEIGSGQFGLV---HLGYWL------------------NKD---KVAIKTI---R-E--G-AM----SE-----E-D-FI-E-------------------------EAEVMMKL--S------HPKLVQLYGVCL--E--------QAP------IC--LVFEFMEHG---CLSDYLR------------------------TQ-----------------------R-GLFAAETLLGMCLDVCEGMAYLEE-A-----C---VIHRDLAARNCLVG---E--------NQ-VI---------KVSDFGMTRFV-------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----------FSRYSSKSDVWSFGVLMWEVFSEGK-IP---------------YE-NR-----------SNSEVVEDI----ST----GFR---LYKPRLAS-----------------------------------------------------------THVYQ-IMNHCWKERPED--RPA-----FS-RLLRQL----------------------------------------------------------
----L-KRIRDLGEGHFGKV---ELCRYDP------------EGDN-TGE---QVAVKSL---K-P--E-SG----GNH---IA-D-LK-K-------------------------EIEILRNL--Y------HENIVKYKGICT-ED---------GGN----GIK--LIMEFLPSG---SLKEYLP------------------------KN-----------------------K-NKINLKQQLKYAVQICKGMDYLGS-R-----Q---YVHRDLAARNVLVE---S--------EH-QV---------KIGDFGLTKAI---ET--D--KEYY--------------TVKDDRDSPVFWYAPECLM-----------QSKFYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHG-QM-----------TVTRLVNTL----KE----GKR---LPCPPNCP-----------------------------------------------------------DEVYQ-LMRKCWEFQPSN--RTS-----FQ-NLIE---GF-------------------------------------------------------
-----LKFLQQLGKGNFGSV---EMCRYDP------------LQDN-TGE---VVAVKKL---Q-H--S-TE-----EH---LR-D-FE-R-------------------------EIEILKSL--Q------HDNIVKYKGVCYSAG--------RRN------LK--LIMEYLPYG---SLRDYLQ------------------------KH-----------------------K-ERIDHIKLLQYTSQICKGMEYLGT-K-----R---YIHRDLATRNILVE---N--------EN-RV---------KIGDFGLTKVL---PQ--D--KEYY--------------KVKEPGESPIFWYAPESLT-----------ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQG-QM-----------IVFHLIELL----KN----NGR---LPRPDGCP-----------------------------------------------------------DEIYM-IMTECWNNNVNQ--RPS-----FR-DLA----LRV------------------------------------------------------
----L-KYISQLGKGNFGSV---ELCRYDP------------LGDN-TGA---LVAVKQL---Q-H--S-GP----DQ----QR-D-FQ-R-------------------------EIQILKAL--H------SDFIVKYRGVSYGPG--------RQS------LR--LVMEYLPSG---CLRDFLQ------------------------RH-----------------------R-ARLDASRLLLYSSQICKGMEYLGS-R-----R---CVHRDLAARNILVE---S--------EA-HV---------KIADFGLAKLL---PL--D--KDYY--------------VVREPGQSPIFWYAPESLS-----------DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCER-DV-P---------ALCRLLELL----EE----GQR---LPAPPACP-----------------------------------------------------------AEVHE-LMKLCWAPSPQD--RPS-----FS-ALGP---QL-------------------------------------------------------
-----LKLVERLGAGQFGEV---WMGYYN------------------GHT---KVAVKSL---K-Q--G-SM----SP-----D-A-FL-A-------------------------EANLMKQL--Q------HQRLVRLYAVVT-----------QEP------IY--IITEYMENG---SLVDFLK------------------------TP----------------------SG-IKLTINKLLDMAAQIAEGMAFIEE-R-----N---YIHRDLRAANILVS---D--------TL-SC---------KIADFGLARLI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YP-GM-----------TNPEVIQNL----ER----GYR---MVRPDNCP-----------------------------------------------------------EELYQ-LMRLCWKERPED--RPT-----FD-YLRSV--L--------------------------------------------------------
-----IKLVKRLGAGQFGEV---WMGYYN------------------NST---KVAVKTL---K-P--G-TM----SV-----Q-A-FL-E-------------------------EANLMKTL--Q------HDKLVRLYAVVT--R--------EEP------IY--IITEYMAKG---SLLDFLK------------------------SD----------------------EG-GKVLLPKLIDFSAQIAEGMAYIER-K-----N---YIHRDLRAANVLVS---E--------SL-MC---------KIADFGLARVI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------FGCFTIKSDVWSFGILLYEIVTYGK-IP---------------YP-GR-----------TNADVMTAL----SQ----GYR---MPRVENCP-----------------------------------------------------------DELYD-IMKMCWKEKAEE--RPT-----FD-YLQSV--L--------------------------------------------------------
-----FEKISELGAGNGGVV---FKVSHK----------------P-SGL----VMARKL---IHL--E-IKP---AI-----R-N-QIIR-------------------------ELQVLHEC--N------SPYIVGFYGAFY--S--------DGE------IS--ICMEHMDGG---SLDQVLK-----------------------KAG--------------------------RIPEQILGKVSIAVIKGLTYLREKH-----K---IMHRDVKPSNILVN---S--------RG-EI---------KLCDFGVSG---------QLIDSMA--------------NS---FVGTRSYMSPERLQ-----------GTHYSVQSDIWSMGLSLVEMAV-GR-YP---------------IP-PP-----------DAKELELMF----GC----QVE---GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE----------------LLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAE--RAD-----LK-QLMVHAFI--------------------------------------------------------
--IRY---RDTLGHGNGGTV---YKAYHV----------------P-SGK---ILAVKVI---LLD--I-TLE---LQ-----K-Q-I-MS-------------------------ELEILYKC--D------SSYIIGFYGAFF--V--------ENR------IS--ICTEFMDGG---SLD---------------------------VYR--------------------------KMPEHVLGRIAVAVVKGLTYLWS-L-----K---ILHRDVKPSNMLVN---T--------RG-QV---------KLCDFGVST---------QLVNSIA--------------KT---YVGTNAYMAPERIS-----------GEQYGIHSDVWSLGISFMELAL-GR-FP---------------YP-QI-----------QKNQGSLMP----LQ----LLQ---CIVDEDSPVLPVGEF---------------------------------------------------SEPFVH-FITQCMRKQPKE--RPA-----PE-ELMGHPFI--------------------------------------------------------
-LEPI----MELGRGAYGVV---EKMRHV----------------P-SGQ---IMAVKRI---RAT--V-NSQ---EQ-----K-R-L-LM-------------------------DLDISMRT-VD------CPFTVTFYGALF--R--------EGD------VW--ICMELMDTSLDKFYKQVID-----------------------KGQ--------------------------TIPEDILGKIAVSIVKALEHLHS-K----LS---VIHRDVKPSNVLIN---A--------LG-QV---------KMCDFGISGY--------LVDSVAK--------------TI---DAGCKPYMAPERINP-------ELNQKGYSVKSDIWSLGITMIELAI-LR-FP---------------YD-SW----------GTPFQQLKQV----VE----EPS---PQLPADKF-----S-----------------------------------------------------AEFVD-FTSQCLKKNSKE--RPT-----YP-ELMQHPFF--------------------------------------------------------
-----LQLEEIIGVGGFGKV---YRALWR-------------------GE---EVAVKAARLDP-E--K-DP----AVT---AE-Q-VC-Q-------------------------EARLFGAL--Q------HPNIIALRGACL--N--------PPH------LC--LVMEYARGG---ALSRVLA------------------------GR--------------------------RVPPHVLVNWAVQVARGMNYLHN-D-----APVPIIHRDLKSINILIL---EAIENHNLADT-VL---------KITDFGLAREW------------HK--------------TTKMSAAGTYAWMAPEVIR-----------LSLFSKSSDVWSFGVLLWELLT-GE-VP---------------YR-EI-----------DALAVAYGV---AMN----KLT---LPIPSTCP-----------------------------------------------------------EPFAR-LLEECWDPDPHG--RPD-----FG-SILKRL----------------------------------------------------------
-----LRLEEVIGIGGFGKV---YRGSWR-------------------GE---LVAVKAA---R-Q--D-PD----EDISVTAE-S-VR-Q-------------------------EARLFAML--A------HPNIIALKAVCL--E--------EPN------LC--LVMEYAAGG---PLSRALA------------------------GR--------------------------RVPPHVLVNWAVQIARGMHYLHC-E-----ALVPVIHRDLKSNNILLL---QPIESDDMEHK-TL---------KITDFGLAREW------------HK--------------TTQMSAAGTYAWMAPEVIK-----------ASTFSKGSDVWSFGVLLWELLT-GE-VP---------------YR-GI-----------DCLAVAYGV---AVN----KLT---LPIPSTCP-----------------------------------------------------------EPFAQ-LMADCWAQDPHR--RPD-----FA-SILQQL----------------------------------------------------------
LDLQW------VGSGAQGAV---FLGRFH-------------------GE---EVAVKKV---R-D--L-KE----T---------------------------------------DIKHLRKL--K------HPNIITFKGVCT--Q--------APC------YC--ILMEFCAQG---QLYEVLR------------------------AG-------------------------RPVTPSLLVDWSMGIAGGMNYLHL-H-----K---IIHRDLKSPNMLIT---Y--------DD-VV---------KISDFGTSKEL-----------SDK--------------STKMSFAGTVAWMAPEVIR-----------NEPVSEKVDIWSFGVVLWELLT-GE-IP---------------YK-DV-----------DSSAIIWGV---GSN----SLH---LPVPSSCP-----------------------------------------------------------DGFKI-LLRQCWNSKPRN--RPS-----FR-QILLH--L--------------------------------------------------------
-ISEL----QWLGSGAQGAV---FLGKFR-------------------AE---EVAIKKV---R-E--Q-NE----TD---------------------------------------IKHLRKL--K------HPNIIAFKGVCT--Q--------APC------YC--IIMEYCAHG---QLYEVLR------------------------AG-------------------------RKITPRLLVDWSTGIASGMNYLHL-H-----K---IIHRDLKSPNVLVT---H--------TD-AV---------KISDFGTSKEL-----------SDK--------------STKMSFAGTVAWMAPEVIR-----------NEPVSEKVDIWSFGVVLWELLT-GE-IP---------------YK-DV-----------DSSAIIWGV---GSN----SLH---LPVPSTCP-----------------------------------------------------------DGFKI-LMKQTWQSKPRN--RPS-----FR-QTLMH--L--------------------------------------------------------
-----IEVEEVVGRGAFGVV---CKAKWR-------------------AK---DVAIKQI---E-------S----ESE---RK-A-FI-V-------------------------ELRQLSRV--N------HPNIVKLYGACL------------NP------VC--LVMEYAEGG---SLYNVLH------------------------GA----------------------EPLPYYTAAHAMSWCLQCSQGVAYLHS-M-----QPKALIHRDLKPPNLLLV---A--------GGTVL---------KICDFGTACDI-------------Q--------------THMTNNKGSAAWMAPEVFE-----------GSNYSEKCDVFSWGIILWEVITR-R-KP---------------FD-EIGG---------PAFRIMWAV----HN----GTR---PPLIKNLP-----------------------------------------------------------KPIES-LMTRCWSKDPSQ--RPS-----ME-EIVKI--M--------------------------------------------------------
----L-TLEEIIGIGGFGKV---YRAFWI----------------G-DE-----VAVKAA---RHDP-D-EDI---SQ-----T-I-ENVR------------------------QEAKLFAML--K------HPNIIALRGVCL--K--------EPN------LC--LVMEFARGG---PLNRVLS------------------------GK--------------------------RIPPDILVNWAVQIARGMNYLHD-EA--IVP---IIHRDLKSSNILIL---Q--------KV-ENGDLS-NKILKITDFGLAR---------EWHRTTK--------------MS---AAGTYAWMAPEVIR-----------ASMFSKGSDVWSYGVLLWELLT-GE-VP---------------FR-GI--------------DGLAVA----YG----VAM---NKLALPIPSTCP-------------------------------------------------------EPFAK-LMEDCWNPDPHS--RPS-----FT-NILDQ---LT------------------------------------------------------
-----YQNLKPIGSGAQGIV---CAAYDA----------------V-LDR---NVAIKKL---SRP--F-QNQ---TH-----A-K-RAYR-------------------------ELVLMKCV--N------HKNIISLLNVFT--PQKT--LEEFQD------VY--LVMELMDA----NLCQVIQ-------------------------M--------------------------ELDHERMSYLLYQMLCGIKHLHS-A-----G---IIHRDLKPSNIVVK---S--------DC-TL---------KILDFGLART--------AGTSFMM--------------TP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVR-HK-IL---------------FP-GR-----------DYIDQWNKV----IE----QLG---TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAK--RIS-----VD-DALQHPYI--------------------------------------------------------
-----YQNLSPVGSGAYGSV---CAAFDT----------------K-TGL---RVAVKKL---SRP--F-QSI---IH-----A-K-RTYR-------------------------ELRLLKHM--K------HENVIGLLDVFT--PARS--LEEFND------VY--LVTHLMGA----DLNNIVK------------------------CQ--------------------------KLTDDHVQFLIYQILRGLKYIHS-A-----D---IIHRDLKPSNLAVN---E--------DC-EL---------KILDFGLAR----------HTDDEM--------------TG---YVATRWYRAPEIML----------NWMHYNQTVDIWSVGCIMAELLT-GR-TL---------------FP-GT-----------DHIDQLKLI----LR----LVG---TPGAELLKKISSESARNYIQSLTQMP-----------------------------KMNFANVFIGANPLAVD-LLEKMLVLDSDK--RIT-----AA-QALAHAYF--------------------------------------------------------
-----YQNLKPIGSGAQGIV---CAAYDA----------------I-LER---NVAIKKL---SRP--F-QNQ---TH-----A-K-RAYR-------------------------ELVLMKCV--N------HKNIIGLLNVFT--PQKS--LEEFQD------VY--IVMELMDA----NLCQVIQ-------------------------M--------------------------ELDHERMSYLLYQMLCGIKHLHS-A-----G---IIHRDLKPSNIVVK---S--------DC-TL---------KILDFGLART--------AGTSFMM--------------TP---YVVTRYYRAPEVIL-----------GMGYKENVDLWSVGCIMGEMVC-HK-IL---------------FP-GR-----------DYIDQWNKV----IE----QLG---TPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASK--RIS-----VD-EALQHPYI--------------------------------------------------------
-----YRLQKTIGKGNFAKV---KLARHV----------------L-TGR---EVAVKII---DKT--Q-LNP---TS-----L-Q-KLFR-------------------------EVRIMKIL--N------HPNIVKLFEVIE--T--------EKT------LY--LVMEYASGG---EVFDYLV-----------------------AHG--------------------------RMKEKEARAKFRQIVSAVQYCHQ-K-----Y---IVHRDLKAENLLLD---G--------DM-NI---------KIADFGFSNE--------FTVGNKL--------------DT---FCGSPPYAAPELFQ----------GKKYDGPEVDVWSLGVILYTLVS-GS-LP---------------FD-GQ--------------NLKELR----ER----VLR---GKYRIPFYMS---------------------------------------------------------TDCEN-LLKKLLVLNPIK--RGS-----LE-QIMKDRWM--------------------------------------------------------
-----YRLLKTIGKGNFAKV---KLARHI----------------L-TGK---EVAVKII---DKT--Q-LNS---SS-----L-Q-KLFR-------------------------EVRIMKVL--N------HPNIVKLFEVIE--T--------EKT------LY--LVMEYASGG---EVFDYLV-----------------------AHG--------------------------RMKEKEARAKFRQIVSAVQYCHQ-K-----F---IVHRDLKAENLLLD---A--------DM-NI---------KIADFGFSNE--------FTFGNKL--------------DT---FCGSPPYAAPELFQ----------GKKYDGPEVDVWSLGVILYTLVS-GS-LP---------------FD-GQ--------------NLKELR----ER----VLR---GKYRIPFYMS---------------------------------------------------------TDCEN-LLKKFLILNPSK--RGT-----LE-QIMKDRWM--------------------------------------------------------
-----YRLLKTIGKGNFAKV---KLARHI----------------L-TGR---EVAIKII---DKT--Q-LNP---TS-----L-Q-KLFR-------------------------EVRIMKIL--N------HPNIVKLFEVIE--T--------EKT------LY--LIMEYASGG---EVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV--------------------------QVSFDLLSLMFTFIVSAVQYCHQ-K-----R---IVHRDLKAENLLLD---A--------DM-NI---------KIADFGFSNE--------FTVGGKL--------------DT---FCGSPPYAAPELFQ----------GKKYDGPEVDVWSLGVILYTLVS-GS-LP---------------FD-GQ--------------NLKELR----ER----VLR---GKYRIPFYMS---------------------------------------------------------TDCEN-LLKRFLVLNPIK--RGT-----LE-QIMKDRWI--------------------------------------------------------
-----YRLLRTIGKGNFAKV---KLARHI----------------L-TGR---EVAIKII---DKT--Q-LNP---SS-----L-Q-KLFR-------------------------EVRIMKGL--N------HPNIVKLFEVIE--T--------EKT------LY--LVMEYASAG---EVFDYLV-----------------------SHG--------------------------RMKEKEARAKFRQIVSAVHYCHQ-K-----N---IVHRDLKAENLLLD---A--------EA-NI---------KIADFGFSNE--------FTLGSKL--------------DT---FCGSPPYAAPELFQ----------GKKYDGPEVDIWSLGVILYTLVS-GS-LP---------------FD-GH--------------NLKELR----ER----VLR---GKYRVPFYMS---------------------------------------------------------TDCES-ILRRFLVLNPAK--RCT-----LE-QIMKDKWI--------------------------------------------------------
-----VHFNEVIGRGHFGCV---YHGTLL-------------DNDG-KKI---HCAVKSL---N-R--I-TD----IGE---VS-Q-FL-T-------------------------EGIIMKDF--S------HPNVLSLLGICL-RS--------EGS------PL--VVLPYMKHG---DLRNFIR------------------------NE-----------------------T-HNPTVKDLIGFGLQVAKGMKYLAS-K-----K---FVHRDLAARNCMLD---E--------KF-TV---------KVADFGLARDM----Y--D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----------TQKFTTKSDVWSFGVLLWELMTRGA-PP---------------YP-DV-----------NTFDITVYL----LQ----GRR---LLQPEYCP-----------------------------------------------------------DPLYE-VMLKCWHPKAEM--RPS-----FS-ELVSR--I--------------------------------------------------------
----I-EYVRDIGEGAFGRV---FQARAPG-----------LLPYE-PFT---MVAVKML---K-E--E-AS----ADM---QA-D-FQ-R-------------------------EAALMAEF--D------NPNIVKLLGVCA--V--------GKP------MC--LLFEYMAYG---DLNEFLR------------------------SMSPHTVCSLSHSDLSMRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSE-R-----K---FVHRDLATRNCLVG---E--------NM-VV---------KIADFGLSRNI----Y--S--ADYY--------------KANENDAIPIRWMPPESIF-----------YNRYTTESDVWAYGVVLWEIFSYGL-QP---------------YY-GM-----------AHEEVIYYV----RD----GNI---LSCPENCP-----------------------------------------------------------VELYN-LMRLCWSKLPAD--RPS-----FT-SIHRIL----------------------------------------------------------
-----YDVIKAIGQGAFGKA---YLAKGK----------------S-DSK---HCVIKEI---NFE--K-MPI---QE-----K-E-ASKK-------------------------EVILLEKM--K------HPNIVAFFNSFQ--E--------NGR------LF--IVMEYCDGG---DLMKRINR---------------------QRGV--------------------------LFSEDQILGWFVQISLGLKHIHD-R-----K---ILHRDIKAQNIFLS---K--------NG-MV--------AKLGDFGIARVL-------NNSMELA--------------RT---CIGTPYYLSPEICQ-----------NKPYNNKTDIWSLGCVLYELCT-LK-HP---------------FE-GN--------------NLQQLV----LK----ICQ---AHFAPISPGF---S-----------------------------------------------------RELHS-LISQLFQVSPRD--RPS-----IN-SILKRPFL--------------------------------------------------------
----I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQ-DKI---LVAVKTL---K-D--A-SD----NA----RK-D-FH-R-------------------------EAELLTNL--Q------HEHIVKFYGVCV--E--------GDP------LI--MVFEYMKHG---DLNKFLR------------------------AHGPDAV-----------LMAEGNPP-TELTQSQMLHIAQQIAAGMVYLAS-Q-----H---FVHRDLATRNCLVG---E--------NL-LV---------KIGDFGMSRDV----Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM-----------YRKFTTESDVWSLGVVLWEIFTYGK-QP---------------WY-QL-----------SNNEVIECI----TQ----GRV---LQRPRTCP-----------------------------------------------------------QEVYE-LMLGCWQREPHM--RKN-----IK-GIHTL--L--------------------------------------------------------
----I-VLKRELGEGAFGKV---FLAECYN-----------LSPTK-DKM---LVAVKAL---K-D--P-TL----AA----RK-D-FQ-R-------------------------EAELLTNL--Q------HEHIVKFYGVCG--D--------GDP------LI--MVFEYMKHG---DLNKFLR------------------------AHGPDAMIL--------VDGQPRQAK-GELGLSQMLHIASQIASGMVYLAS-Q-----H---FVHRDLATRNCLVG---A--------NL-LV---------KIGDFGMSRDV----Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----------YRKFTTESDVWSFGVILWEIFTYGK-QP---------------WF-QL-----------SNTEVIECI----TQ----GRV---LERPRVCP-----------------------------------------------------------KEVYD-VMLGCWQREPQQ--RLN-----IK-EIYKIL----------------------------------------------------------
-----YELQETLGKGTYGKV---KRATER----------------F-SGR---VVAIKSI---RKD--K-IKD---EQ-----D-M-VHIR------------------------REIEIMSSL--N------HPHIISIYEVFE--N--------KDK------IV--IIMEYASKG---ELYDYIS-----------------------ERR--------------------------RLSERETRHFFRQIVSAVHYCHK-N-----G---VVHRDLKLENILLD---D--------NC-NI---------KIADFGLSNL--------YQKDKFL--------------QT---FCGSPLYASPEIVN----------GRPYRGPEVDSWALGVLLYTLVY-GT-MP---------------FD-GF--------------DHKNLI----RQ----ISS---GEYREPTQP----------------------------------------------------------SDARG-LIRWMLMVNPDR--RAT-----IE-DIANHWW-V-------------------------------------------------------
-----YEFLETLGKGTYGKV---KKARES----------------S-GR----LVAIKSI---RKD--K-IKD---EQ-----D-L-MHIR------------------------REIEIMSSL--N------HPHIIAIHEVFE--N--------SSK------IV--IVMEYASRG---DLYDYIS-----------------------ERQ--------------------------QLSEREARHFFRQIVSAVHYCHQ-N-----R---VVHRDLKLENILLD---A--------NG-NI---------KIADFGLSNL--------YHQGKFL--------------QT---FCGSPLYASPEIVN----------GKPYTGPEVDSWSLGVLLYILVH-GT-MP---------------FD-GH--------------DHKILV----KQ----ISN---GAYREPPK-----P-----------------------------------------------------SDACG-LIRWLLMVNPTR--RAT-----LE-DVASHWW-V-------------------------------------------------------
-----YTRFEKIGQGASGTV---YTAMDV----------------A-TGQ---EVAIKQM---NLQ--Q-QPK---KE-----L-I-I--N-------------------------EILVMREN--K------NPNIVNYLDSYL--V--------GDE------LW--VVMEYLAGG---SLTDVVT------------------------ET--------------------------CMDEGQIAAVCRECLQALEFLHS-N-----Q---VIHRDIKSDNILLG---M--------DG-SV---------KLTDFGFCAQI-------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----------RKAYGPKVDIWSLGIMAIEMIE-GE-PP---------------YL-NE-----------NPLRALYLI----AT----NGT---PELQNPEKLS---------------------------------------------------------AIFRD-FLNRCLEMDVEK--RGS-----AK-ELLQHQFL--------------------------------------------------------
-----YTRYEKIGQGASGTV---FTATDV----------------A-LGQ---EVAIKQI---NLQ--K-QPK---KE-----L-I-I--N-------------------------EILVMKEL--K------NPNIVNFLDSYL--V--------GDE------LF--VVMEYLAGG---SLTDVVT------------------------ET--------------------------CMDEAQIAAVCRECLQALEFLHA-N-----Q---VIHRDIKSDNVLLG---M--------EG-SV---------KLTDFGFCAQI-------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----------RKAYGPKVDIWSLGIMAIEMVE-GE-PP---------------YL-NE-----------NPLRALYLI----AT----NGT---PELQNPEKLS---------------------------------------------------------PIFRD-FLNRCLEMDVEK--RGS-----AK-ELLQHPFL--------------------------------------------------------
-----YTRFEKIGQGASGTV---YTALDI----------------A-TGQ---EVAIKQM---NLQ--Q-QPK---KE-----L-I-I--N-------------------------EILVMREN--K------NPNIVNYLDSYL--V--------GDE------LW--VVMEYLAGG---SLTDVVT------------------------ET--------------------------CMDEGQIAAVCRECLQALDFLHS-N-----Q---VIHRDIKSDNILLG---M--------DG-SV---------KLTDFGFCAQI-------TPEQSKR--------------ST---MVGTPYWMAPEVVT-----------RKAYGPKVDIWSLGIMAIEMVE-GE-PP---------------YL-NE-----------NPLRALYLI----AT----NGT---PELQNPERLS---------------------------------------------------------AVFRD-FLNRCLEMDVDR--RGS-----AK-ELLQHPFL--------------------------------------------------------
----Y-IKLDKLGEGTYATV---YKGKSK----------------L-TDN---LVALKEI---RLE--H-EEG---AP-----C---TAIR-------------------------EVSLLKDL--K------HANIVTLHDIIH--T--------EKS------LT--LVFEYLDK----DLKQYLD----------------------DCGN--------------------------IINMHNVKLFLFQLLRGLAYCHR-Q-----K---VLHRDLKPQNLLIN---E--------RG-EL---------KLADFGLARAK-------SIPTKTY--------------SN---EVVTLWYRPPDILL----------GSTDYSTQIDMWGVGCIFYEMAT-GR-PL---------------FP-GS-----------TVEEQLHFI----FR----ILG---TPTEETWPGILSNEEFKTYNYPKYR------------------------------AEALLSHAPRLDSDGAD-LLTKLLQFEGRN--RIS-----AE-DAMKHPFF--------------------------------------------------------
----Y-IKLEKLGEGTYATV---YKGRSK----------------L-TEN---LVALKEI---RLE--H-EEG---AP-----C---TAIR-------------------------EVSLLKDL--K------HANIVTLHDIVH--T--------DKS------LT--LVFEYLDK----DLKQYMD----------------------DCGN--------------------------IMSMHNVKLFLYQILRGLAYCHR-R-----K---VLHRDLKPQNLLIN---E--------KG-EL---------KLADFGLARAK-------SVPTKTY--------------SN---EVVTLWYRPPDVLL----------GSSEYSTQIDMWGVGCIFFEMAS-GR-PL---------------FP-GS-----------TVEDELHLI----FR----LLG---TPSQETWPGISSNEEFKNYNFPKYK------------------------------PQPLINHAPRLDSEGIE-LITKFLQYESKK--RVS-----AE-EAMKHVYF--------------------------------------------------------
----F-KFGKILGEGSFSTV---VLAREL----------------A-TSR---EYAIKIL---EKR--H-IIK---EN-----K-VPYVTR-------------------------ERDVMSRL--D------HPFFVKLYFTFQ--D--------DEK------LY--FGLSYAKNG---ELLKYIR-----------------------KIG--------------------------SFDETCTRFYTAEIVSALEYLHG-K-----G---IIHRDLKPENILLN---E--------DM-HI---------QITDFGTAKVLS-----PESKQARA--------------NS---FVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVA-GL-PP---------------FR-AG--------------NEYLIF----QK----IIK---LEYDFPEKFF---------------------------------------------------------PKARD-LVEKLLVLDATK--RLG-----CE-EM------EGYGPLKAHPF---------------------------------------------
-----YEPKEILGRGVSSVV---RRCIHK----------------P-TSQ---EYAVKVI---DVT--G-GGS---FS-----P-E-EVRELRE------------------ATLKEVDILRKV-SG------HPNIIQLKDTYE--T--------NTF------FF--LVFDLMKRG---ELFDYLT-----------------------EKV--------------------------TLSEKETRKIMRALLEVICTLHK-L-----N---IVHRDLKPENILLD---D--------NM-NI---------KLTDFGFSCQ--------LEPGERL--------------RE---VCGTPSYLAPEIIECS-----MNEDHPGYGKEVDMWSTGVIMYTLLA-GS-PP---------------FW-HR--------------KQMLML----RM----IMS---GNYQFGSPEWDDYS-----------------------------------------------------DTVKD-LVSRFLVVQPQN--RYT-----AE-EALAHPFF--------------------------------------------------------
--YDP---KDVIGRGVSSVV---RRCVHR----------------A-TGH---EFAVKIM---EVT--A-ERL---SP-----E-Q-LEEVREA-------------------TRRETHILRQV-AG------HPHIITLIDSYE--S--------SSF------MF--LVFDLMRKG---ELFDYLT-----------------------EKV--------------------------ALSEKETRSIMRSLLEAVSFLHA-N-----N---IVHRDLKPENILLD---D--------NM-QI---------RLSDFGFSCH--------LEPGEKL--------------RE---LCGTPGYLAPEILKCS-----MDETHPGYGKEVDLWACGVILFTLLA-GS-PP---------------FW-HR--------------RQILML----RM----IME---GQYQFSSPEWDDRS-----------------------------------------------------STVKD-LISRLLQVDPEA--RLT-----AE-QALQHPFF--------------------------------------------------------
----F-KFLAVLGRGHFGKV---LLSEFR----------------P-SGE---LFAIKAL---KKG--D-IVA---RD-----E-V-ESLM------------------------CEKRILAAV--TS---AGHPFLVNLFGCFQ--T--------PEH------VC--FVMEYSAGG---DLMLHIH------------------------SD--------------------------VFSEPRAIFYSACVVLGLQFLHE-H-----K---IVYRDLKLDNLLLD---T--------EG-YV---------KIADFGLCKEG-------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----------DTSYTRAVDWWGLGVLLYEMLV-GE-SP---------------FP-GD--------------DEEEVF----DS----IVN---DEVRYPRFLS---------------------------------------------------------AEAIG-IMRRLLRRNPER--RLGSSERDAE-DVKKQPFF--------------------------------------------------------
---FR--CCAVLGRGHFGKV---LLAEYK----------------N-TNE---MFAIKAL---KKG--D-IVA---RD-----E-V-DSLM------------------------CEKRIFETV--NS---VRHPFLVNLFACFQ--T--------KEH------VC--FVMEYAAGG---DLMMHIH------------------------TD--------------------------VFSEPRAVFYAACVVLGLQYLHE-H-----K---IVYRDLKLDNLLLD---T--------EG-FV---------KIADFGLCKEG-------MGYGDRT--------------ST---FCGTPEFLAPEVLT-----------ETSYTRAVDWWGLGVLIYEMLV-GE-SP---------------FP-GD--------------DEEEVF----DS----IVN---DEVRYPRFLS---------------------------------------------------------TEAIS-IMRRLLRRNPER--RLGASEKDAE-DVKKHPFF--------------------------------------------------------
---YV--RGRFLGKGGFAKC---FEISDA----------------D-TKE---VFAGKIV---PKS--L-LLK---PH-----Q-R-EKMS------------------------MEISIHRSL--A------HQHVVGFHGFFE--D--------NDF------VF--VVLELCRRR---SLLELHK-----------------------RRK--------------------------ALTEPEARYYLRQIVLGCQYLHR-N-----R---VIHRDLKLGNLFLN---E--------DL-EV---------KIGDFGLATKV-------EYDGERK--------------KT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GK-PP---------------FE-TS--------------CLKETY----LR----IKK---NEYSIPKHIN---------------------------------------------------------PVAAS-LIQKMLQTDPTA--RPT-----IN-ELLNDEFF--------------------------------------------------------
----Y-CRGKVLGKGGFAKC---YEMTDL----------------T-NNK---VYAAKII---PHS--R-VAK---PH-----Q-R-EKID------------------------KEIELHRIL--H------HKHVVQFYHYFE--D--------KEN------IY--ILLEYCSRR---SMAHILK-----------------------ARK--------------------------VLTEPEVRYYLRQIVSGLKYLHE-Q-----E---ILHRDLKLGNFFIN---E--------AM-EL---------KVGDFGLAARL-------EPLEHRR--------------RT---ICGTPNYLSPEVLN-----------KQGHGCESDIWALGCVMYTMLL-GR-PP---------------FE-TT--------------NLKETY----RC----IRE---ARYTMPSSLL---------------------------------------------------------APAKH-LIASMLSKNPED--RPS-----LD-DIIRHDFF--------------------------------------------------------
---YL--KGRLLGKGGFARC---YEATDT----------------E-TGS---AYAVKVI---PQS--R-VAK---PH-----Q-R-EKIL------------------------NEIELHRDL--Q------HRHIVRFSHHFE--D--------ADN------IY--IFLELCSRK---SLAHIWK-----------------------ARH--------------------------TLLEPEVRYYLRQILSGLKYLHQ-R-----G---ILHRDLKLGNFFIT---E--------NM-EL---------KVGDFGLAARL-------EPPEQRK--------------KT---ICGTPNYVAPEVLL-----------RQGHGPEADVWSLGCVMYTLLC-GS-PP---------------FE-TA--------------DLKETY----RC----IKQ---VHYTLPASLS---------------------------------------------------------LPARQ-LLAAILRASPRD--RPS-----ID-QILRHDFF--------------------------------------------------------
----F-NFLMVLGKGSFGKV---MLADRK----------------G-TEE---LYAIKIL---KKD--V-VIQ---DD-----D-V-ECTM------------------------VEKRVLALL-DK------PPFLTQLHSCFQ--T--------VDR------LY--FVMEYVNGG---DLMYHIQ-----------------------QVG--------------------------KFKEPQAVFYAAEISIGLFFLHK-R-----G---IIYRDLKLDNVMLD---S--------EG-HI---------KIADFGMCKEH-------MMDGVTT--------------RT---FCGTPDYIAPEIIA-----------YQPYGKSVDWWAYGVLLYEMLA-GQ-PP---------------FD-GE--------------DEDELF----QS----IME---HNVSYPKSLS---------------------------------------------------------KEAVS-VCKGLMTKHPAK--RLG-----C----------GPEGERDVREHAFF------------------------------------------
---FI--FHKVLGKGSFGKV---LLGELK----------------G-RGE---YFAIKAL---KKD--V-VLI---DD-----D-V-ECTM------------------------VEKRVLTLA-AE------NPFLTHLICTFQ--T--------KDH------LF--FVMEFLNGG---DLMYHIQ-----------------------DKG--------------------------RFELYRATFYAAEIMCGLQFLHS-K-----G---IIYRDLKLDNVLLD---R--------DG-HI---------KIADFGMCKEN-------IFGESRA--------------ST---FCGTPDYIAPEILQ-----------GLKYTFSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GD--------------DEDELF----ES----IRV---DTPHYPRWIT---------------------------------------------------------KESKD-ILEKLFEREPTK--RLG----VTG-NIKIHPFF--------------------------------------------------------
---FI--LHKMLGKGSFGKV---FLAEFK----------------K-TNQ---FFAIKAL---KKD--V-VLM---DD-----D-V-ECTM------------------------VEKRVLSLA-WE------HPFLTHMFCTFQ--T--------KEN------LF--FVMEYLNGG---DLMYHIQ-----------------------SCH--------------------------KFDLSRATFYAAEIILGLQFLHS-K-----G---IVYRDLKLDNILLD---K--------DG-HI---------KIADFGMCKEN-------MLGDAKT--------------NT---FCGTPDYIAPEILL-----------GQKYNHSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GQ--------------DEEELF----HS----IRM---DNPFYPRWLE---------------------------------------------------------KEAKD-LLVKLFVREPEK--RLG-----VRGDIRQHPLF--------------------------------------------------------
-YNVY----GYTGQGVFSNV---VRARDN----------------ARANQ---EVAVKII---RNN--E-LMQ---KT-----G-----LK-------------------------ELEFLKKL--NDADPDDKFHCLRLFRHFY--H--------KQH------LC--LVFEPLSM----NLREVLKK--------------------YGKDV--------------------------GLHIKAVRSYSQQLFLALKLLKR-C-----N---ILHADIKPDNILVN---E--------SK-TI--------LKLCDFGSAS---------HVADNDI--------------TP---YLVSRFYRAPEIII-----------GKSYDYGIDMWSVGCTLYELYT-GK-IL---------------FP-GK-----------TNNHMLKLA----MD----LKG---KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKD-LLDQILMLDPAK--RIS-----IN-QALQHAFI--------------------------------------------------------
----F-TLCRKLGSGYFGEV---FEGLWK------------------DRV---QVAIKVI---S-R--D-NL----LH----QQ-M-LQ-S-------------------------EIQAMKKL--R------HKHILALYAVVS--V--------GDP------VY--IITELMAKG---SLLELLR------------------------DS----------------------DE-KVLPVSELLDIAWQVAEGMCYLES-Q-----N---YIHRDLAARNILVG---E--------NT-LC---------KVGDFGLARLI----------KEDV--------------YLSHDHNIPYKWTAPEALS-----------RGHYSTKSDVWSFGILLHEMFSRGQ-VP---------------YP-GM-----------SNHEAFLRV----DA----GYR---MPCPLECP-----------------------------------------------------------PSVHK-LMLTCWCRDPEQ--RPC-----FK-ALRERL----------------------------------------------------------
-----YEVVKVIGRGAFGEV---QLVRHK----------------S-TRK---VYAMKLL---SKF--E-MIK---RS-----D-S-AFFW------------------------EERDIMAFA--N------SPWVVQLFYAFQ--D--------DRY------LY--MVMEYMPGG---DLVNLMS------------------------NY--------------------------DVPEKWARFYTAEVVLALDAIHS-M-----G---FIHRDVKPDNMLLD---K--------SG-HL---------KLADFGTCMKM------NKEGMVRC--------------DT---AVGTPDYISPEVLKS-------QGGDGYYGRECDWWSVGVFLYEMLV-GD-TP---------------FY-AD--------------SLVGTY----SK----IMN---HKNSLTFPDDNDIS-----------------------------------------------------KEAKN-LICAFLTDREVRLGRNG-----VE-EIKRHLFF--------------------------------------------------------
-----FELLKVLGQGSFGKVFLVRKVTRP----------------D-SGH---LYAMKVL---KKA--T-LKV---RD-----R-V-RTKM-------------------------ERDILADV--N------HPFVVKLHYAFQ--T--------EGK------LY--LILDFLRGG---DLFTRLS-----------------------KEV--------------------------MFTEEDVKFYLAELALGLDHLHS-L-----G---IIYRDLKPENILLD---E--------EG-HI---------KLTDFGLSKEA-------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----------RQGHSHSADWWSYGVLMFEMLT-GS-LP---------------FQ-GK--------------DRKETM----TL----ILK---AKLGMPQFLS---------------------------------------------------------TEAQS-LLRALFKRNPAN--RLGSGPDGAE-EIKRHV--FY------------------------------------------------------
-----FELLKVLGQGSYGKV---FLVRKV----------------K-GSDAGQLYAMKVL---KKA--T-LKV---RD-----R-V-RSKM-------------------------ERDILAEV--N------HPFIVKLHYAFQ--T--------EGK------LY--LILDFLRGG---DLFTRLS-----------------------KEV--------------------------MFTEEDVKFYLAELALALDHLHS-L-----G---IIYRDLKPENILLD---E--------EG-HI---------KITDFGLSKEA-------IDHDKRA--------------YS---FCGTIEYMAPEVVN-----------RRGHTQSADWWSFGVLMFEMLT-GS-LP---------------FQ-GK--------------DRKETM----AL----ILK---AKLGMPQFLS---------------------------------------------------------GEAQS-LLRALFKRNPCN--RLGAGIDGVE-EIKRHPFF--------------------------------------------------------
-----FELLKVLGQGSFGKV---FLVKKI----------------S-GSDARQLYAMKVL---KKA--T-LKV---RD-----R-V-RTKM-------------------------ERDILVEV--N------HPFIVKLHYAFQ--T--------EGK------LY--LILDFLRGG---DLFTRLS-----------------------KEV--------------------------MFTEEDVKFYLAELALALDHLHS-L-----G---IIYRDLKPENILLD---E--------EG-HI---------KLTDFGLSKES-------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----------RRGHTQSADWWSFGVLMFEMLT-GT-LP---------------FQ-GK--------------DRKETM----TM----ILK---AKLGMPQFLS---------------------------------------------------------PEAQS-LLRMLFKRNPAN--RLGAGPDGVE-EIKRHSFF--------------------------------------------------------
-----YDIERTLGKGNFAVV---KLARHR----------------V-TKT---QVAIKII---DKT--R-LDS---SN-----L-E-KIYR-------------------------EVQLMKLL--N------HPHIIKLYQVME--T--------KDM------LY--IVTEFAKNG---EMFDYLT-----------------------SNG--------------------------HLSENEARKKFWQILSAVEYCHD-H-----H---IVHRDLKTENLLLD---G--------NM-DI---------KLADFGFGNF--------YKSGEPL--------------ST---WCGSPPYAAPEVFE----------GKEYEGPQLDIWSLGVVLYVLVC-GS-LP---------------FD-GP--------------NLPTLR----QR----VLE---GRFRIPFFMS---------------------------------------------------------QDCES-LIRRMLVVDPAR--RIT-----IA-QIRQHRWM--------------------------------------------------------
-----YDIEGTLGKGNFAVV---KLGRHR----------------I-TKT---EVAIKII---DKS--Q-LDA---VN-----L-E-KIYR-------------------------EVQIMKML--D------HPHIIKLYQVME--T--------KSM------LY--LVTEYAKNG---EIFDYLA-----------------------NHG--------------------------RLNESEARRKFWQILSAVDYCHG-R-----K---IVHRDLKAENLLLD---N--------NM-NI---------KIADFGFGNF--------FKSGELL--------------AT---WCGSPPYAAPEVFE----------GQQYEGPQLDIWSMGVVLYVLVC-GA-LP---------------FD-GP--------------TLPILR----QR----VLE---GRFRIPYFMS---------------------------------------------------------EDCEH-LIRRMLVLDPSK--RLT-----IA-QIKEHKWM--------------------------------------------------------
-----WEIIGELGDGAFGKV---YKAQNK----------------E-TSV---LAAAKVI---DTK--S-EEE---LE-----D-Y-M--V-------------------------EIDILASC--D------HPNIVKLLDAFY--Y--------ENN------LW--ILIEFCAGG---AVDAVML----------------------ELER--------------------------PLTESQIQVVCKQTLDALNYLHD-N-----K---IIHRDLKAGNILFT---L--------DG-DI---------KLADFGVSAKN-------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE------TSKDRPYDYKADVWSLGITLIEMAE-IE-PP---------------HH-EL-----------NPMRVLLKI----AK----SEP---PTLAQPSRWS---------------------------------------------------------SNFKD-FLKKCLEKNVDA--RWT-----TS-QLLQHPFV--------------------------------------------------------
----L-RLEVKLGQGCFGEV---WMGTWN------------------GTT---RVAIKTL---K-P--G-TM----SP-----E-A-FL-Q-------------------------EAQVMKKL--R------HEKLVQLYAVVS-----------EEP------IY--IVTEYMSKG---SLLDFLK------------------------GE----------------------TG-KYLRLPQLVDMAAQIASGMAYVER-M-----N---YVHRDLRAANILVG---E--------NL-VC---------KVADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELTTKGR-VP---------------YP-GM-----------VNREVLDQV----ER----GYR---MPCPPECP-----------------------------------------------------------ESLHD-LMCQCWRKEPEE--RPT-----FE-YLQAF--L--------------------------------------------------------
-----WEIVGELGDGAFGKV---YKAKNK----------------E-TGA---LAAAKVI---ETK--S-EEE---LE-----D-Y-I--V-------------------------EIEILATC--D------HPYIVKLLGAYY--H--------DGK------LW--IMIEFCPGG---AVDAIML----------------------ELDR--------------------------GLTEPQIQVVCRQMLEALNFLHS-K-----R---IIHRDLKAGNVLMT---L--------EG-DI---------RLADFGVSAKN-------LKTLQKR--------------DS---FIGTPYWMAPEVVMCE------TMKDTPYDYKADIWSLGITLIEMAQ-IE-PP---------------HH-EL-----------NPMRVLLKI----AK----SDP---PTLLTPSKWS---------------------------------------------------------VEFRD-FLKIALDKNPET--RPS-----AA-QLLEHPFV--------------------------------------------------------
--LCP---GRELGRGKFAVV---RKCIKK----------------D-SGK---EFAAKFM---RKR--R-KGQ---DC-----R-M-EIIH-------------------------EIAVLELA-QD------NPWVINLHEVYE--T--------ASE------MI--LVLEYAAGG---EIFDQCVA---------------------DREE--------------------------AFKEKDVQRLMRQILEGVHFLHT-R-----D---VVHLDLKPQNILLT---S--------ES-PLG------DIKIVDFGLSRI--------LKNSEEL--------------RE---IMGTPEYVAPEILS-----------YDPISMATDMWSIGVLTYVMLT-GI-SP---------------FL-GN--------------DKQETF----LN----ISQ---MNLSYSEEEFDVLS-----------------------------------------------------ESAVD-FIRTLLVKKPED--RAT-----AE-ECLKHPWL--------------------------------------------------------
-----FTKLEKIGKGSFGEV---FKGIDN----------------R-TQK---VVAIKII---DLE--E-AED---EI-----E-D-IQ-Q-------------------------EITVLSQC--D------SPYVTKYYGSYL--K--------DTK------LW--IIMEYLGGG---SALDLLE------------------------PG--------------------------PLDETQIATILREILKGLDYLHS-E-----K---KIHRDIKAANVLLS---E--------HG-EV---------KLADFGVAGQL-------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELAR-GE-PP---------------HS-EL-----------HPMKVLFLI----PK----NNP---PTLEGNYS-----------------------------------------------------------KPLKE-FVEACLNKEPSF--RPT-----AK-ELLKHKFI--------------------------------------------------------
----F-TKLDRIGKGSFGEV---YKGIDN----------------H-TKE---VVAIKII---DLE--E-AED---EI-----E-D-IQ-Q-------------------------EITVLSQC--D------SPYITRYFGSYL--K--------STK------LW--IIMEYLGGG---SALDLLK------------------------PG--------------------------PLEETYIATILREILKGLDYLHS-E-----R---KIHRDIKAANVLLS---E--------QG-DV---------KLADFGVAGQL-------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----------QSAYDFKADIWSLGITAIELAK-GE-PP---------------NS-DL-----------HPMRVLFLI----PK----NSP---PTLEGQHS-----------------------------------------------------------KPFKE-FVEACLNKDPRF--RPT-----AK-ELLKHKFI--------------------------------------------------------
-----YTFGRILGKGSFGIV---IEATDK----------------E-TET---KWAIKKV---NKE--K-AGS---SA-----V-K-LLER-------------------------EVNILKSV--K------HEHIIHLEQVFE--T--------PKK------MY--LVMELCEDG---ELKEILD-----------------------RKG--------------------------HFSENETRWIIQSLASAIAYLHN-N-----D---IVHRDLKLENIMVK---S--------SL-IDDNNEINLNIKVTDFGLAVKK------QSRSEAML--------------QA---TCGTPIYMAPEVIS-----------AHDYSQQCDIWSIGVVMYMLLR-GE-PP---------------FL-AS--------------SEEKLF----EL----IRK---GELHFENAVWNSIS-----------------------------------------------------DCAKS-VLKQLMKVDPAH--RIT-----AK-ELLDNQWL--------------------------------------------------------
----F-HCAEKIGAGFFSEV---YKVRHR----------------Q-SGQ---VMVLKMN---KLP--S-NRG---NT-----------LR-------------------------EVQLMNRL--R------HPNILRFMGVCV--H--------QGQ------LH--ALTEYMNGG---TLEQLLS-----------------------SPE--------------------------PLSWPVRLHLALDIARGLRYLHS-K-----G---VFHRDLTSKNCLVR---R--------ED-RGF------TAVVGDFGLAEKIPV---YREGARKEP--------------LA---VVGSPYWMAPEVLR-----------GELYDEKADVFAFGIVLCELIA-R--VP------------------------------------------------------------------------------------------------------------------------------------------------------------------ADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHL
----L-RLLEKLGDGSFGVV---RRGEWD-------------APSG-KTV---SVAVKCL---K-PDVL-SQ----PEA---MD-D-FI-R-------------------------EVNAMHSL--D------HRNLIRLYGVVL-----------TPP------MK--MVTELAPLG---SLLDRLR------------------------KH-----------------------Q-GHFLLGTLSRYAVQVAEGMGYLES-K-----R---FIHRDLAARNLLLA---T--------RD-LV---------KIGDFGLMRAL---PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK-----------TRTFSHASDTWMFGVTLWEMFTYGQ-EP---------------WI-GL-----------NGSQILHKI---DKE----GER---LPRPEDCP-----------------------------------------------------------QDIYN-VMVQCWAHKPED--RPT-----FV-ALRDF--L--------------------------------------------------------
-----YSILKQIGSGGSSKV---FQVLNE----------------K-KQ----IYAIKYV---NLE--E-ADN---QT-----L-D-SYRN-------------------------EIAYLNKL-QQ-----HSDKIIRLYDYEI--T--------DQY------IY--MVMECGNI----DLNSWLK-----------------------KKK--------------------------SIDPWERKSYWKNMLEAVHTIHQ-H-----G---IVHSDLKPANFLIV------------DG-ML---------KLIDFGIANQMQ-----PDTTSVVK--------------DS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TP---------------FQ-QI-------------INQISKL----HA----IID---PNHEIEFPDIPE-------------------------------------------------------KDLQD-VLKCCLKRDPKQ--RIS-----IP-ELLAHPYV--------------------------------------------------------
---FI--LTERLGSGTYATV---YKAYAKK---------------D-TRE---VVAIKCV---AKK--S-LNK---AS-----V-E-NLLT-------------------------EIEILKGI--R------HPHIVQLKDFQW--D--------SDN------IY--LIMEFCAGG---DLSRFIH-----------------------TRR--------------------------ILPEKVARVFMQQLASALQFLHE-R-----N---ISHLDLKPQNILLSS-LE--------KP-HL---------KLADFGFAQH--------MSPWDEK--------------HV---LRGSPLYMAPEMVC-----------QRQYDARVDLWSMGVILYEALF-GQ-PP---------------FA-SR-----------SFSELEEKI----RS----NRV---IELPLRPLLS---------------------------------------------------------RDCRD-LLQRLLERDPSR--RIS-----FQ-DFFAHPWV--------------------------------------------------------
----L-RLEVKLGQGCFGEV---WMGTWN------------------GTT---KVAIKTL---K-P--G-TM----MP-----E-A-FL-Q-------------------------EAQIMKKL--R------HDKLVPLYAVVS-----------EEP------IY--IVTEFMSKG---SLLDFLK------------------------EG----------------------DG-KYLKLPQLVDMAAQIADGMAYIER-M-----N---YIHRDLRAANILVG---E--------NL-VC---------KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILQTELVTKGR-VP---------------YP-GM-----------VNREVLEQV----ER----GYR---MPCPQGCP-----------------------------------------------------------ESLHE-LMNLCWKKDPDE--RPT-----FE-YIQSFL----------------------------------------------------------
----L-QFFENCGGGSFGSV---YRAKWI----------------S-QDK---EVAVKKL-----------------------L-K-IE-K-------------------------EAEILSVL--S------HRNIIQFYGVIL--E--------PPN------YG--IVTEYASLG---SLYDYIN------------------------SN----------------------RS-EEMDMDHIMTWATDVAKGMHYLHM-EAPV--K---VIHRDLKSRNVVIA---A--------DG-VL---------KICDFGASRFH------------NH--------------TTHMSLVGTFPWMAPEVIQ-----------SLPVSETCDTYSYGVVLWEMLTR-E-VP---------------FK-GL-----------EGLQVAWLV---VEK----NER---LTIPSSCP-----------------------------------------------------------RSFAE-LLHQCWEADAKK--RPS-----FK-QIISIL----------------------------------------------------------
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