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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
TK FGFR1 478
TK LCK 245
CMGC MAPK11 24
CMGC MAPK12 27
CMGC MAPK13 25
CMGC MAPK14 24
TK SRC 270
----YTDIKVIGNGSFGVVYQARLA-------ETRELVAIKKVLQDKRFKNR--------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT--KAKL-----------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ--LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKEL-RHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF-GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PSTAIREISLLKEL-NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDIHH--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL--
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI-E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
-LQG---LRPVGSGAYGSVCSAYDA-------RLRQKVAVKKLSRPFQSLIH--ARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK----CQ-----------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR----QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
----YRDLQPVGSGAYGAVCSAVDG-------RTGAKVAIKKLYRPFQSELF--AKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFY--LVMPFMGT---DLGKLMK----HE-----------------KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR----QADSEMTG---YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF
YVSP----THVGSGAYGSVCSAIDK-------RSGEKVAIKKLSRPFQSEIF--AKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFY--LVMPFMQT---DLQKIM-----GM-----------------EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR----HADAEMTG---YVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF
----YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPFQSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI-E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
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