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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
TK FER 563
CMGC GSK3B 56
Other IKBKE 9
TK JAK2 849
CAMK MELK 11
CMGC PCTK1 165
AGC PKN1 615
TK SRC 270
CAMK STK17A 61
TK YES1 277
---YTDIKVIGNGSFGVVYQARLA----ETRE-LVAIKKVLQDKRFKNR---------ELQIMRKL-D---HCNIVRLRYFFY--SSG----EKKDELYLNLVLEYVPETVYRVARHFT---KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLL--VDPDTAVL---KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF-------GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF-------------------------------------------------------
---YTKIEKIGEGTYGVVYKGRHK----TTGQ-VVAMKKIRLESEEEGV--PSTAIR-EISLLKEL-R---HPNIVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLL--ID-DKGTI---KLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLL-------GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF-------------------------------------------------------
---FQKVEKIGEGTYGVVYKARNK----LTGE-VVALKKIRLDTETEGV--PSTAIR-EISLLKEL-N---HPNIVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLL--IN-TEGAI---KLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL-------GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-------------------------------------------------------
---YEKLEKIGEGTYGTVFKAKNR----ETHE-IVALKRVRLDDDDEGV--PSSALR-EICLLKEL-K---HKNIVRLHDVLH--S--------DKKLT--LVFEFCDQ---DLKKYFD---SCNG---DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLL--IN-RNGEL---KLADFGLARAF------GIPVRCYSA---EVVTLWYRPPDVLF-------GAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF-------------------------------------------------------
---YECVAEIGEGAYGKVFKARDL----KNGGRFVALKRVRVQTGEEGM--PLSTIR-EVAVLRHL-ETFEHPNVVRLFDVCT--VSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP---GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNIL--VT-SSGQI---KLADFGLARI-------YSFQMALTS---VVVTLWYRAPEVLL--------QSSYATPVDLWSVGCIFAEMFR-RKPL---------------FRGS-SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF-------------------------------------------------------
---YEKLAKIGQGTFGEVFKARHR----KTGQ-KVALKKVLMENEKEGF--PITALR-EIKILQLL-K---HENVVNLIEICR--TKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVL--IT-RDGVL---KLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLL-------GERDYGPPIDLWGAGCIMAEMWT-RSPI---------------MQGN-TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF-------------------------------------------------------
-VI--LGELLGKGNFGEVYKGTLK-----DKT-SVAVKTCK-EDLP-QELKIKFL-Q-EAKILKQY-D---HPNIVKLIGVCT--Q--------RQPVY--IIMELVSGG--DFLTFLR-----RK-KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCL--VG-ENNVL---KISDFGMSRQE------D--GGVYSSSGLKQIPIKWTAPEALN--------YGRYSSESDVWSFGILLWETFSLGVCP---------------YPGM-TNQQAREQVERGYRMSAPQHCP-------------------------------EDISKIMMKCWDYKPENRPK-----FSELQKEL---------------------------------------------------------
---YTDTKVIGNGSFGVVYQAKLC----DSGE-LVAIKKVLQDKRFKNR---------ELQIMRKL-D---HCNIVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLL--LDPDTAVL---KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF-------GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-------------------------------------------------------
--W-HTDDLLGQGATASVYKARNK----KSGE-LVAVKVFNTTSYLRPR--EV-QVR-EFEVLRKL-N---HQNIVKLFAVEE--TG------GSRQKV--LVMEYCSSG--SLLSVLES-PENAF---GLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVG-EEGQSI-YKLTDFGAARE-------LDDDEKFVS---VYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAAT-GSLP---------------FIPFGGPRRNKEIMYRITTEKPAGAIA------------------------------------------------------------------GAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAET
---LKFLQQLGKGNFGSVEMCRYDPLQDNTGE-VVAVKKLQ-HSTE--EHLRDFE-R-EIEILKSL-Q---HDNIVKYKGVCYSAG--------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNIL--VE-NENRV---KIGDFGLTKVL--PQ--D--KEYYKVKEPGESPIFWYAPESLT--------ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP-------------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV-----------------------------------------------------
---YELHETIGTGGFAKVKLACHI----LTGE-MVAIKIMDKNTLGSDL--PRIKT--EIEALKNL-R---HQHICQLYHVLE--T--------ANKIF--MVLEYCPGG--ELFDYII----SQD---RLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLL--FD-EYHKL---KLIDFGLCAKP-----KGNKDYHLQT---CCGSLAYAAPELIQ-------GKSYLGSEADVWSMGILLYVLMC-GFLP---------------FDDD----NVMALYKKIMRGKYDVPKWLS-----------------------------PSSILLLQQMLQVDPKKRIS-----MKNLLNHPWI-------------------------------------------------------
--Y-IKLDKLGEGTYATVYKGKSK----LTDN-LVALKEIRLEHEEGAP--C-TAIR-EVSLLKDL-K---HANIVTLHDIIH--T--------EKSLT--LVFEYLDK---DLKQYLD---DCGN---IINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLL--IN-ERGEL---KLADFGLARAK------SIPTKTYSN---EVVTLWYRPPDILL-------GSTDYSTQIDMWGVGCIFYEMAT-GRPL---------------FPGS-TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR--AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-----AEDAMKHPFF-------------------------------------------------------
--F-KFLAVLGRGHFGKVLLSEFR----PSGE-LFAIKALKKGDIVARD--EVESLMCEKRILAAV-TSAGHPFLVNLFGCFQ--T--------PEHVC--FVMEYSAGG--DLMLHIH-----SD---VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLL--LD-TEGYV---KIADFGLCKEG------MGYGDRTST---FCGTPEFLAPEVLT--------DTSYTRAVDWWGLGVLLYEMLV-GESP---------------FPGD----DEEEVFDSIVNDEVRYPRFLS-----------------------------AEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF-------------------------------------------------------
--L-RLEVKLGQGCFGEVWMGTWN-----GTT-RVAIKTLK-PGTM-SP--EAFL-Q-EAQVMKKL-R---HEKLVQLYAVVS-----------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL--VG-ENLVC---KVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL--------YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-------------------------------------------------------
LCP---GRELGRGKFAVVRKCIKK----DSGK-EFAAKFMRKRRKGQDC--RMEIIH-EIAVLELAQD---NPWVINLHEVYE--T--------ASEMI--LVLEYAAGG--EIFDQCVA--DREE---AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNIL--LT-SESPLGDIKIVDFGLSRI-------LKNSEELRE---IMGTPEYVAPEILS--------YDPISMATDMWSIGVLTYVMLT-GISP---------------FLGN----DKQETFLNISQMNLSYSEEEFDVLS-------------------------ESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL-------------------------------------------------------
--L-RLEVKLGQGCFGEVWMGTWN-----GTT-KVAIKTLK-PGTM-MP--EAFL-Q-EAQIMKKL-R---HDKLVPLYAVVS-----------EEPIY--IVTEFMSKG--SLLDFLK-----EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANIL--VG-ENLVC---KIADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL--------YGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGM-VNREVLEQVERGYRMPCPQGCP-------------------------------ESLHELMNLCWKKDPDERPT-----FEYIQSFL---------------------------------------------------------
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