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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
Other AURKB 77
TK BMX 422
TK BTK 402
CMGC CDK2 4
CMGC CDK4 6
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
TK FER 563
TK FGFR1 478
CMGC GSK3B 56
TK ITK 363
STE MAP4K2 16
CMGC MAPK10 64
CMGC MAPK8 26
CMGC MAPK9 26
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
Other PLK1 53
Other PLK2 82
TK RET 724
STE SLK 34
TK SYK 371
TK TNK2 150
TK TXK 271
---YTDIKVIGNGSFGVVYQARLA-------ETRELVAIKKVLQD--K-RFK---NR---------------ELQIMRKL--D---HCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ---LVRGEPN--------------VS---YICSRYYRAPEL--IF----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF--
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM----EV---EEFL-K------EAAVMKEI--K---HPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV----KVADFGLSRLM--T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GIDLSQVYELL-EKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
---ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAVKTLK-E--D-TM----EV---EEFL-K------EAAVMKEI--K---HPNLVQLLGVCTL------EPPFY--IVTEYMPYG--NLLDYLR-----EC----------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHVV----KVADFGLSRLM--T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----YNTFSIKSDVWAFGVLLWEIATYGMSPYP-GIDLSQVYDLL-EKGYRMEQPEGCP-----------------------------------------PKVYELMRACWKWSPADRPSFAETHQA--F--
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKA---GV---EHQLRR------EVEIQSHL--R---HPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL----KIADFGWSV----HAPSSRR--------------TT---LCGTLDYLPPEM--IE-----GRMHDEKVDLWSLGVLCYEFLV-GKPPFE-AN---TYQETY-KRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKS--Q-IEK---EG---VEHQLR-----REIEIQAHL--H---HPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL----KIADFGWSV----HAPSLRR--------------KT---MCGTLDYLPPEM--IE-----GRMHNEKVDLWCIGVLCYELLV-GNPPFE-SA---SHNETY-RRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
---ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMIK-E--G-SM----SE---DEFF-Q------EAQTMMKL--S---HPKLVKFYGVCSK------EYPIY--IVTEYISNG--CLLNYLR-----SH-----------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVD-RDLCV----KVSDFGMTRYV--L--DDQY--------------VSSVGTKFPVKWSAPEV--FH-----YFKYSSKSDVWAFGILMWEVFSLGKQPYD-LYDNSQVVLKV-SQGHRLYRPHLAS-----------------------------------------DTIYQIMYSCWHELPEKRPTFQQLLSS--I--
---LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIK-E--G-SM----SE---DEFI-E------EAKVMMNL--S---HEKLVQLYGVCTK------QRPIF--IITEYMANG--CLLNYLR-----EM-----------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN-DQGVV----KVSDFGLSRYV--L--DDEY--------------TSSVGSKFPVRWSPPEV--LM-----YSKFSSKSDIWAFGVLMWEIYSLGKMPYE-RFTNSETAEHI-AQGLRLYRPHLAS-----------------------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I--
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETE---GV---PSTAIR------EISLLKEL--N---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF--GVPVRTY--------------TH---EVVTLWYRAPEI--LL----GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
--Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVP--N-GGGGGGGL---PISTVR------EVALLRRL--EAFEHPNVVRLMDVCATSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV----KLADFGLARI---YSYQMAL--------------TP---VVVTLWYRAPEV--LL-----QSTYATPVDMWSVGCIFAEMFR-RKPLFC-GNSEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
-YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKR--K-FAI---GS---AREADPALNVETEIEILKKL--N---HPCIIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV----GNK-------------------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI---LGETSLM--------------RT---LCGTPTYLAPEV--LVS--VGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH--RTQVSLK-DQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL--
---YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKILKPV--K-KKK---IK---R-----------EIKILENL-RG---GPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------Q-------------------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF---YHPGQEY--------------NV---RVASRYFKGPEL--LV----DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF--
---YQLVRKLGRGKYSEVFEAINI-------TNNERVVVKILKPV--K-KKK---IK---R-----------EVKILENL-RG---GTNIIKLIDTVKDP----VSKTPA--LVFEYINNT--DFKQLY-------Q-------------------------ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL----RLIDWGLAEF---YHPAQEY--------------NV---RVASRYFKGPEL--LV----DYQMYDYSLDMWSLGCMLASMIF-RREPFFHGQDNYDQLVRI-AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-----RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF--
---YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKR--R-TKS---SR---RGVSREDI--EREVSILKEI--Q---HPNVITLHEVYEN------KTDVI--LILELVAGG--ELFDFLA----EKE-------------------------SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK---IDFGNEF--------------KN---IFGTPEFVAPEI--VN-----YEPLGLEADMWSIGVITYILLS-GASPFL-GD---TKQETL-ANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI--
-VI--LGELLGKGNFGEVYKGTLK--------DKTSVAVKTCK-E--D-LP----QEL-KIKFL-Q------EAKILKQY--D---HPNIVKLIGVCTQ------RQPVY--IIMELVSGG--DFLTFLR-----RK-----------------------KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVG-ENNVL----KISDFGMSRQE--D--GGVY--------------SSSGLKQIPIKWTAPEA--LN-----YGRYSSESDVWSFGILLWETFSLGVCPYP-GMTNQQAREQV-ERGYRMSAPQHCP-----------------------------------------EDISKIMMKCWDYKPENRPKFSELQKEL----
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT----EKD-LSDLI-S------EMEMMKMIG-K---HKNIINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM----KIADFGLARDI-HH--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----DRIYTHQSDVWSFGVLLWEIFTLGGSPYP-GVPVEELFKLL-KEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
---YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQD--K-RFK---NR---------------ELQIMRKL--D---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ---LVRGEPN--------------VS---YICSRYYRAPEL--IF----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--
---LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-E--G-AM----SE---EDFI-E------EAEVMMKL--S---HPKLVQLYGVCLE------QAPIC--LVFEFMEHG--CLSDYLR-----TQ-----------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVI----KVSDFGMTRFV--L--DDQY--------------TSSTGTKFPVKWASPEV--FS-----FSRYSSKSDVWSFGVLMWEVFSEGKIPYE-NRSNSEVVEDI-STGFRLYKPRLAS-----------------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----
---FELLQRVGAGTYGDVYKARDT-------VTSELAAVKIVKLD--P-GDD---IS---SL--QQ------EITILREC--R---HPNVVAYIGSYLR------NDRLW--ICMEFCGGG--SLQEIYH----ATG-------------------------PLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLT-LQGDV----KLADFGVSGEL--TASVAKR--------------RS---FIGTPYWMAPEVAAVE----RKGGYNELCDVWALGITAIELGE-LQPPLF-HLHPMRALMLM-SKSSFQPPKLRDKTR--WT-----------------------------------QNFHHFLKLALTKNPKKRPTAEKLLQHPF-T-
---YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRP--F-QNQ---TH---AKRAYR------ELVLMKCV--N---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-------------------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL----KILDFGLART---AGTSFMM--------------TP---YVVTRYYRAPEV--IL-----GMGYKENVDIWSVGCIMGEMVR-HKILFP-GRDYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI--
---YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKLSRP--F-QNQ---TH---AKRAYR------ELVLMKCV--N---HKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-------------------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL----KILDFGLART---AGTSFMM--------------TP---YVVTRYYRAPEV--IL-----GMGYKENVDLWSVGCIMGEMVC-HKILFP-GRDYIDQWNKV-IEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI--
---YQQLKPIGSGAQGIVCAAFDT-------VLGINVAVKKLSRP--F-QNQ---TH---AKRAYR------ELVLLKCV--N---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M-------------------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL----KILDFGLART---ACTNFMM--------------TP---YVVTRYYRAPEV--IL-----GMGYKENVDIWSVGCIMGELVK-GCVIFQ-GTDHIDQWNKV-IEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI--
-IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-E--A-SE----SA--RQDFQ-R------EAELLTML--Q---HQHIVRFFGVCTE------GRPLL--MVFEYMRHG--DLNRFLR-----SHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-QGLVV----KIGDFGMSRDI-YS--TDYY--------------RVGGRTMLPIRWMPPES--IL-----YRKFTTESDVWSFGVVLWEIFTYGKQPWY-QLSNTEAIDCI-TQGRELERPRACP-----------------------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL----
--I-VLKRELGEGAFGKVFLAECYN--LCPEQDKILVAVKTLK-D--A-SD----NA--RKDFH-R------EAELLTNL--Q---HEHIVKFYGVCVE------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV-----------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLV----KIGDFGMSRDV-YS--TDYY--------------RVGGHTMLPIRWMPPES--IM-----YRKFTTESDVWSLGVVLWEIFTYGKQPWY-QLSNNEVIECI-TQGRVLQRPRTCP-----------------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L--
--I-VLKRELGEGAFGKVFLAECYN--LSPTKDKMLVAVKALK-D--P-TL----AA--RKDFQ-R------EAELLTNL--Q---HEHIVKFYGVCGD------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMIL--------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-ANLLV----KIGDFGMSRDV-YS--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM-----YRKFTTESDVWSFGVILWEIFTYGKQPWF-QLSNTEVIECI-TQGRVLERPRVCP-----------------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL----
---YELQETLGKGTYGKVKRATER-------FSGRVVAIKSIRKD--K-IKD---EQ---DMVHIR-----REIEIMSSL--N---HPHIISIYEVFEN------KDKIV--IIMEYASKG--ELYDYIS----ERR-------------------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI----KIADFGLSNL---YQKDKFL--------------QT---FCGSPLYASPEI--VN----GRPYRGPEVDSWALGVLLYTLVY-GTMPFD-GF---DHKNLI-RQISSGEYREPTQP----------------------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V-
-YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKS--L-LLK---PH---QREKMS-----MEISIHRSL--A---HQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRK-------------------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV--EYDGERK--------------KT---LCGTPNYIAPEV--LS-----KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS---CLKETY-LRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF--
--Y-CRGKVLGKGGFAKCYEMTDL-------TNNKVYAAKIIPHS--R-VAK---PH---QREKID-----KEIELHRIL--H---HKHVVQFYHYFED------KENIY--ILLEYCSRR--SMAHILK----ARK-------------------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN-EAMEL----KVGDFGLAARL--EPLEHRR--------------RT---ICGTPNYLSPEV--LN-----KQGHGCESDIWALGCVMYTMLL-GRPPFE-TT---NLKETY-RCIREARYTMPSSLL---------------------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF--
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS----PSE-LRDLL-S------EFNVLKQV--N---HPHVIKLYGACSQ------DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRKM----KISDFGLSRDV-YE--EDSY--------------VKRSQGRIPVKWMAIES--LF-----DHIYTTQSDVWSFGVLLWEIVTLGGNPYP-GIPPERLFNLL-KTGHRMERPDNCS-----------------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
---WEIIGELGDGAFGKVYKAQNK-------ETSVLAAAKVIDTK--S-EEE---LE---DYM--V------EIDILASC--D---HPNIVKLLDAFYY------ENNLW--ILIEFCAGG--AVDAVML---ELER-------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDI----KLADFGVSAKN--TRTIQRR--------------DS---FIGTPYWMAPEV--VMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHH-ELNPMRVLLKI-AKSEPPTLAQPSRWS---------------------------------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV--
TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-N--E-AN----DPALKDELL-A------EANVMQQL--D---NPYIVRMIGICE-------AESWM--LVMEMAELG--PLNKYLQ-----QN------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-TQHYA----KISDFGLSKAL-RA--DENY-------------YKAQTHGKWPVKWYAPEC--IN-----YYKFSSKSDVWSFGVLMWEAFSYGQKPYR-GMKGSEVTAML-EKGERMGCPAGCP-----------------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL
--L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ----PEA-MDDFI-R------EVNAMHSL--D---HRNLIRLYGVVL-------TPPMK--MVTELAPLG--SLLDRLR-----KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA-TRDLV----KIGDFGLMRALPQN--DDHY--------------VMQEHRKVPFAWCAPES--LK-----TRTFSHASDTWMFGVTLWEMFTYGQEPWI-GLNGSQILHKIDKEGERLPRPEDCP-----------------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
--L-AFIKEIGSGQFGVVHLGEWR--------SHIQVAIKAIN-E--G-SM----SE---EDFI-E------EAKVMMKL--S---HSKLVQLYGVCIQ------RKPLY--IVTEFMENG--CLLNYLR-----EN-----------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVS-STCIV----KISDFGMTRYV--L--DDEY--------------VSSFGAKFPIKWSPPEV--FL-----FNKYSSKSDVWSFGVLMWEVFTEGKMPFE-NKSNLQVVEAI-SEGFRLYRPHLAP-----------------------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV-
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