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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3B 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK2D 14
CAMK CAMK2G 14
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CMGC DYRK2 222
Other EIF2AK2 267
CMGC GSK3A 119
CMGC MAPK10 64
CAMK NUAK1 55
AGC PDPK1 82
CAMK PHKG1 20
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA6 73
CAMK SIK2 20
CAMK STK11 49
---YTDTKVIGNGSFGVV---YQAKLCDSGE---LVAIKKVLQDK-RFKNR--------------ELQIMRKL-D------HCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
---FEIGRPLGKGKFGNV---YLAREKQSKF---ILALKVLFKAQLEKAGVEH-QLRR-------EVEIQSHL-R------HPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV------HAPSSRRTTLCGTLDYLPPEMIE------GRMHDEKVDLWSLGVLCYEFLV-GK-PPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
---FEIGRPLGKGKFGNV---YLAREKKSHF---IVALKVLFKSQ-IEKEGVE-HQLR------REIEIQAHL-H------HPNILRLYNYFYD-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV------HAPSLRRKTMCGTLDYLPPEMIE------GRMHNEKVDLWCIGVLCYELLV-GN-PPFESA---SHNETYRRIVKVDLKFPASVP--------------------------------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV-----------
---FEIGRPLGKGKFGNV---YLARLKESHF---IVALKVLFKSQ-IEKEGLE-HQLR------REIEIQAHL-Q------HPNILRLYNYFHD-----------------------------ARRVY--LILEYAPRG--ELYKELQ----KSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEV---KIADFGWSV------HTPSLRRKTMCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GY-PPFESA---SHSETYRRILKVDVRFPLSMP--------------------------------------------------------LGARDLISRLLRYQPLERLP-----LAQILKHPWV-----------
---YRLEKTLGKGQTGLV---KLGVHCITGQ---KVAIKIVNREK-LSESVLM-KVER-------EIAILKLI-E------HPHVLKLHDVYEN-----------------------------KKYLY--LVLEHVSGG--ELFDYLV----KKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLD-EKNNI---RIADFGMASL-----QVGDSLLETSCGSPHYACPEVIK-----GEKYDGRRADMWSCGVILFALLV-GA-LPFDDD---NLRQLLEKVKRGVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
---YRLEKTLGKGQTGLV---KLGVHCVTCQ---KVAIKIVNREK-LSESVLM-KVER-------EIAILKLI-E------HPHVLKLHDVYEN-----------------------------KKYLY--LVLEHVSGG--ELFDYLV----KKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLD-EKNNI---RIADFGMASL-----QVGDSLLETSCGSPHYACPEVIR-----GEKYDGRKADVWSCGVILFALLV-GA-LPFDDD---NLRQLLEKVKRGVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
---YQLFEELGKGAFSVV---RRCMKIPTGQ---EYAAKIINTKK-LSARDHQ-KLER-------EARICRLL-K------HPNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----AREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLA-SKSKGAAVKLADFGLAIEV----QGDQQAWFGFAGTPGYLSPEVLR------KDPYGKPVDMWACGVILYILLV-GY-PPFWDE---DQHRLYQQIKAGAYDFPSPEWDTVT----------------------------------------------------PEAKDLINKMLTINPAKRIT-----ASEALKHPWI-----------
---YQLFEELGKGAFSVV---RRCVKKTSTQ---EYAAKIINTKK-LSARDHQ-KLER-------EARICRLL-K------HPNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----AREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA-SKCKGAAVKLADFGLAIEV----QGEQQAWFGFAGTPGYLSPEVLR------KDPYGKPVDIWACGVILYILLV-GY-PPFWDE---DQHKLYQQIKAGAYDFPSPEWDTVT----------------------------------------------------PEAKNLINQMLTINPAKRIT-----ADQALKHPWV-----------
---YTKIEKIGEGTYGVV---YKGRHKTTGQ---VVAMKKIRLES-EEEGVPS-TAIR-------EISLLKEL-R------HPNIVSLQDVLMQ-----------------------------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF-----------
---FQKVEKIGEGTYGVV---YKARNKLTGE---VVALKKIRLDT-ETEGVPS-TAIR-------EISLLKEL-N------HPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
---FQKVEKIGEGTYGVV---YKAKNRETGQ---LVALKKIRLDL-EMEGVPS-TAIR-------EISLLKEL-K------HPNIVRLLDVVHN-----------------------------ERKLY--LVFEFLSQ---DLKKYMDS--TPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAI---KLADFGLARAF----GVPLRTYTHEVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RK-ALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF-----------
---YEKLEKIGEGTYGTV---FKAKNRETHE---IVALKRVRLDD-DDEGVPS-SALR-------EICLLKEL-K------HKNIVRLHDVLHS-----------------------------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGR-PLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF-----------
---YECVAEIGEGAYGKV---FKARDLKNGG--RFVALKRVRVQT-GEEGMPL-STIR-------EVAVLRHL-ET---FEHPNVVRLFDVCTVSR------------------------TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQI---KLADFGLARI-----YSFQMALTSVVVTLWYRAPEVLL------QSSYATPVDLWSVGCIFAEMFR-RK-PLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ--------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF-----------
---YEKLAKIGQGTFGEV---FKARHRKTGQ---KVALKKVLMEN-EKEGFPI-TALR-------EIKILQLL-K------HENVVNLIEICRTKASP---------------------YNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL---KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL-----GERDYGPPIDLWGAGCIMAEMWT-RS-PIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK---------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF-----------
-YI--MSKTLGSGACGEV---KLAFERKTCK---KVAIKIISKRK-FAIGSAR-EADPALN-VETEIEILKKL-N------HPCIIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI-----LGETSLMRTLCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GY-PPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS----------------------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
---YEVLKVIGKGSFGQV---VKAYDHKVHQ---HVALKMVRNEK-RFHRQAA-E----------EIRILEHL-RKQDKDNTMNVIHMLENFTF-----------------------------RNHIC--MTFELLSM---NLYELIKK--NKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLK-QQGRSG-IKVIDFGSSC-------YEHQRVYTYIQSRFYRAPEVIL------GARYGMPIDMWSLGCILAELLT-GY-PLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT-----PGQALRHPWL-----------
--F-KEIELIGSGGFGQV---FKAKHRIDGK---TYVIKRVKYNN-EKAER--------------EVKALAKL-D------HVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV-DTKQV---KIGDFGLVTS-----LKNDGKRTRSKGTLRYMSPEQIS------SQDYGKEVDLYALGLILAELLH-VCDTAFET-------SKFFTDLRDGIISDIFDK---------------------------------------------------------KEKTLLQKLLSKKPEDRPN-----TSEILR----TLT--------
---YTDIKVIGNGSFGVV---YQARLAETRE---LVAIKKVLQDK-RFKNR--------------ELQIMRKL-D------HCNIVRLRYFFYSSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF-----------
---YQNLKPIGSGAQGIV---CAAYDAVLDR---NVAIKKLSRPF-QNQTHAK-RAYR-------ELVLMKCV-N------HKNIISLLNVFTPQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGEMVR-HK-ILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK-----------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
---YELQETLGKGTYGKV---KRATERFSGR---VVAIKSIRKDK-IKDEQDM-VHIR------REIEIMSSL-N------HPHIISIYEVFEN-----------------------------KDKIV--IIMEYASKG--ELYDYIS----ERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI---KIADFGLSNL-----YQKDKFLQTFCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GT-MPFDGF---DHKNLIRQISSGEYREPTQP---------------------------------------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V----------
--F-KFGKILGEGSFSTV---VLARELATSR---EYAIKILEKRH-IIKENKVPYVTR-------ERDVMSRL-D------HPFFVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS--PESKQARANSFVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GL-PPFRAG---NEYLIFQKIIKLEYDFPEKFF--------------------------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
---YEPKEILGRGVSSVV---RRCIHKPTSQ---EYAVKVIDVTG-GGSFSPE-EVRELREATLKEVDILRKVSG------HPNIIQLKDTYET-----------------------------NTFFF--LVFDLMKRG--ELFDYLT----EKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLD-DNMNI---KLTDFGFSCQ-----LEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GS-PPFWHR---KQMLMLRMIMSGNYQFGSPEWDDYS----------------------------------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF-----------
---FELLKVLGQGSFGKVFLVRKVTRPDSGH---LYAMKVLKKAT-LKVRDRV-RTKM-------ERDILADV-N------HPFVVKLHYAFQT-----------------------------EGKLY--LILDFLRGG--DLFTRLS----KEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHI---KLTDFGLSKEA----IDHEKKAYSFCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GS-LPFQGK---DRKETMTLILKAKLGMPQFLS--------------------------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
---FELLKVLGQGSYGKV---FLVRKVKGSDAGQLYAMKVLKKAT-LKVRDRV-RSKM-------ERDILAEV-N------HPFIVKLHYAFQT-----------------------------EGKLY--LILDFLRGG--DLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI---KITDFGLSKEA----IDHDKRAYSFCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GS-LPFQGK---DRKETMALILKAKLGMPQFLS--------------------------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
---FELLKVLGQGSFGKV---FLVRKKTGPDAGQLYAMKVLKKAS-LKVRDRV-RTKM-------ERDILVEV-N------HPFIVKLHYAFQT-----------------------------EGKLY--LILDFLRGG--DVFTRLS----KEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHI---KLTDFGLSKES----VDQEKKAYSFCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GT-LPFQGK---DRNETMNMILKAKLGMPQFLS--------------------------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
---YDIEGTLGKGNFAVV---KLGRHRITKT---EVAIKIIDKSQ-LDAVNLE-KIYR-------EVQIMKML-D------HPHIIKLYQVMET-----------------------------KSMLY--LVTEYAKNG--EIFDYLA----NHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLD-NNMNI---KIADFGFGNF-----FKSGELLATWCGSPPYAAPEVFE-----GQQYEGPQLDIWSMGVVLYVLVC-GA-LPFDGP---TLPILRQRVLEGRFRIPYFMS--------------------------------------------------------EDCEHLIRRMLVLDPSKRLT-----IAQIKEHKWM-----------
YLM---GDLLGEGSYGKV---KEVLDSETLC---RRAVKILKKKK-LRRIPNG-EANVK-----KEIQLLRRL-R------HKNVIQLVDVLYNE---------------------------EKQKMY--MVMEYCVCGMQEMLDSVP-----EKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLT-TGGTL---KISDLGVAEALH--PFAADDTCRTSQGSPAFQPPEIAN----GLDTFSGFKVDIWSAGVTLYNITT-GL-YPFEGD---NIYKLFENIGKGSYAIPGDCG--------------------------------------------------------PPLSDLLKGMLEYEPAKRFS-----IRQIRQHSWF-----------
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