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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3B 203
CMGC CDK2 4
AGC PRKCA 339
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKL-DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--------------
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKEL-NHPNIVKLLDVIHT----ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQT----VDRLY--FVMEYVNGG--DLMYHIQ----QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLAGQPPFDGE---DEDELFQSIMEHNVSYPKSLS--------------------------KEAVSVCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
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