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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3B 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
AGC PRKCA 339
-YTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQDK-RFKNR-------ELQIMRKL-D---HCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--------------
-FEIGRPLGKGKFGNVYLAREKQSKF-ILALKVLFKAQLEKAGVEHQLRR-EVEIQSHL-R---HPNILRLYGYFHD--------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV------HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--------------
-YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLES-EEEGVPSTAIR-EISLLKEL-R---HPNIVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
-FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDT-ETEGVPSTAIR-EISLLKEL-N---HPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
-FQKVEKIGEGTYGVVYKAKNRETGQ-LVALKKIRLDL-EMEGVPSTAIR-EISLLKEL-K---HPNIVRLLDVVHN--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLARAF----GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF--------------
-YEKLEKIGEGTYGTVFKAKNRETHE-IVALKRVRLDD-DDEGVPSSALR-EICLLKEL-K---HKNIVRLHDVLHS--------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--------------
-YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPLSTIR-EVAVLRHL-ETFEHPNVVRLFDVCTVSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARI-----YSFQMALTSVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF--------------
-YEKLAKIGQGTFGEVFKARHRKTGQ-KVALKKVLMEN-EKEGFPITALR-EIKILQLL-K---HENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF--------------
F-NFLMVLGKGSFGKVMLADRKGTEE-LYAIKILKKDV-VIQDDDVECTMVEKRVLALLDK---PPFLTQLHSCFQT--------VDRLY--FVMEYVNGG--DLMYHIQ----QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHIKIADFGMCKEH----MMDGVTTRTFCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLA-GQPPFDGE---DEDELFQSIMEHNVSYPKSLS-----------------------------KEAVSVCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
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