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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK HCK 203
TK ABL1 261
TK BMX 422
TK BTK 402
CAMK CHEK1 9
TK CSK 195
TK EGFR 712
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK ERBB2 720
TK FYN 271
TK IGF1R 999
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
CMGC MAPK1 13
CMGC MAPK14 24
TK PDGFRB 600
TK PTK6 191
TK RET 724
AGC RPS6KA1 62
AGC RPS6KA6 73
TK SRC 270
TK SYK 371
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
---LKLEKKLGAGQFGEV---WMATYN------KHT---KVAVKTMK-P--GSM-SV---EAFL-AEANVMKTL-QHDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK-SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI------E--DNEY-TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRAL-ERGYRMPRPENCP------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L--
---ITMKHKLGGGQYGEV---YEGVWK-----KYSL---TVAVKTLK-E--DTM-EV---EEFL-KEAAVMKEI-KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR-EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM------T--GDTY-TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELL-EKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F--
---ITLLKELGSGQFGVV---QLGKWK------GQY---DVAVKMIK-E--GSM-SE---DEFF-QEAQTMMKL-SHPKLVKFYGVCS--K------EYPIYIVTEYISNGCLLNYLR-SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYV------L--DDQY-VSSVGTKFPVKWSAPEVFH-YFKYSSKSDVWAFGILMWEVFSLGKQP---------------YDLY-DNSQVVLKV-SQGHRLYRPHLAS------------------------------DTIYQIMYSCWHELPEKRPT-----FQQLLSS--I--
---LTFLKELGTGQFGVV---KYGKWR------GQY---DVAIKMIK-E--GSM-SE---DEFI-EEAKVMMNL-SHEKLVQLYGVCT--K------QRPIFIITEYMANGCLLNYLR-EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV------L--DDEY-TSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMP---------------YERF-TNSETAEHI-AQGLRLYRPHLAS------------------------------EKVYTIMYSCWHEKADERPT-----FKILLSN--I--
--W-DLVQTLGEGAYGEV---QLAVNR-----VTEE---AVAVKIVDMK--RAVDCP---ENI-KKEICINKML-NHENVVKFYGHRR--E------GNIQYLFLEYCSGGELFDRIEPDI----------------------------------------------------------------------------------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFR----YNNRERLL-NK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP---SDSCQEY-SDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-
---LKLLQTIGKGEFGDV---MLGDYR-------GN---KVAVKCIK-N--DAT-AQ----AFL-AEASVMTQL-RHSNLVQLLGVIV-EE------KGGLYIVTEYMAKGSLVDYLR-SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA------------S-STQDTGKLPVKWTAPEALR-EKKFSTKSDVWSFGILLWEIYSFGRVP---------------YPRI-PLKDVVPRV-EKGYKMDAPDGCP------------------------------PAVYEVMKNCWHLDAAMRPS-----FLQLREQL----
--F-KKIKVLGSGAFGTV---YKGLWIP-EGEKVKI---PVAIKELR-E--ATS-PKA-NKEIL-DEAYVMASV-DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR-EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL---G--A--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGERLPQPPICT------------------------------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF
--V-KIEEVIGAGEFGEV---YKGRLK--LPGKREI---YVAIKTLK-A--GYS-EKQ-RRDFL-SEASIMGQF-DHPNIIRLEGVVT--K------SRPVMIITEFMENGALDSFLR-QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDT--S--DPTY-TSSLGGKIPVRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAI-EQDYRLPPPMDCP------------------------------AALHQLMLDCWQKDRNSRPR-----FAEIVNTL----
--V-KIEQVIGAGEFGEV---CSGHLK--LPGKREI---FVAIKTLK-S--GYT-EKQ-RRDFL-SEASIMGQF-DHPNVIHLEGVVT--K------STPVMIITEFMENGSLDSFLR-QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDT--S--DPTY-TSALGGKIPIRWTAPEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERP---------------YWDM-TNQDVINAI-EQDYRLPPPMDCP------------------------------SALHQLMLDCWQKDRNHRPK-----FGQIVNTL----
--V-KIEEVIGAGEFGEV---CRGRLK--QPGRREV---FVAIKTLK-V--GYT-ERQ-RRDFL-SEASIMGQF-DHPNIIRLEGVVT--K------SRPVMILTEFMENCALDSFLR-LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDP--S--DPTY-TSSLGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERP---------------YWDM-SNQDVINAV-EQDYRLPPPMDCP------------------------------TALHQLMLDCWVRDRNLRPK-----FSQIVNTL----
--V-KIEEVIGAGEFGEV---CRGRLK--APGKKES---CVAIKTLK-G--GYT-ERQ-RREFL-SEASIMGQF-EHPNIIRLEGVVT--N------SMPVMILTEFMENGALDSFLR-LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENS--S--DPTY-TSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAI-EQDYRLPPPPDCP------------------------------TSLHQLMLDCWQKDRNARPR-----FPQVVSAL----
--L-RKVKVLGSGAFGTV---YKGIWIP-DGENVKI---PVAIKVLR-E--NTS-PKA-NKEIL-DEAYVMAGV-GSPYVSRLLGICL---------TSTVQLVTQLMPYGCLLDHVR-EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL---D--I--DETE-YHADGGKVPIKWMALESIL-RRRFTHQSDVWSYGVTVWELMTFGAKP---------------YDGI-PAREIPDLL-EKGERLPQPPICT------------------------------IDVYMIMVKCWMIDSECRPR-----FRELVSE--F--
---LQLIKRLGNGQFGEV---WMGTWN------GNT---KVAIKTLK-P--GTM-SP---ESFL-EEAQIMKKL-KHDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK-DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI------E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQV-ERGYRMPCPQDCP------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL----
---ITMSRELGQGSFGMV---YEGVAKGVVKDEPET---RVAIKTVN-E--AAS-MRE-RIEFL-NEASVMKEF-NCHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSYLR-SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI---Y--E--TDYY-RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFV-MEGGLLDKPDNCP------------------------------DMLFELMRMCWQYNPKMRPS-----FLEIISS--I--
---LKFLQQLGKGNFGSV---EMCRYDP-LQDNTGE---VVAVKKLQ-H--STE--EH-LRDFE-REIEILKSL-QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ-KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL--PQ--D--KEYY-KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV
--L-KYISQLGKGNFGSV---ELCRYDP-LGDNTGA---LVAVKQLQ-H--SGP-DQ--QRDFQ-REIQILKAL-HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ-RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL--PL--D--KDYY-VVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP------------------------------AEVHELMKLCWAPSPQDRPS-----FSALGP---QL-
---LSFGKTLGAGAFGKV---VEATAYGLIKSDAAM---TVAVKMLK-P--SAH-LTE-REALM-SELKVLSYLGNHMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR-RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI---K--N--DSNY-VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMI-KEGFRMLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I--
---LKLVERLGAGQFGEV---WMGYYN------GHT---KVAVKSLK-Q--GSM-SP---DAFL-AEANLMKQL-QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK-TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI------E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L--
---YTNLSYIGEGAYGMV---CSAYDN-----VNKV---RVAIKKISPF--EHQTYC---QRT-LREIKILLRF-RHENIIGINDIIR--APT-IEQMKDVYIVQDLMET-DLYKLLK-TQ----------------------------------------------------------------------------------------------------HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD---PDHDHTGFL-TE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FPGK-HYLDQLNHI-LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL--
---YQNLSPVGSGAYGSV---CAAFDT-----KTGL---RVAVKKLSRP--FQSIIH---AKRTYRELRLLKHM-KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK-CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---------HTDDEM-TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF--
--L-VLGRTLGSGAFGQV---VEATAHGLSHSQATM---KVAVKMLK-S--TAR-SSE-KQALM-SELKIMSHLGPHLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH-RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI---M--R--DSNY-ISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAI-KRGYRMAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPP-----FSQLVL---LL-
--F-TLCRKLGSGYFGEV---FEGLWK------DRV---QVAIKVIS-R--DNL-LH--QQMLQ-SEIQAMKKL-RHKHILALYAVVS--V------GDPVYIITELMAKGSLLELLR-DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLI---------KEDV-YLSHDHNIPYKWTAPEALS-RGHYSTKSDVWSFGILLHEMFSRGQVP---------------YPGM-SNHEAFLRV-DAGYRMPCPLECP------------------------------PSVHKLMLTCWCRDPEQRPC-----FKALRERL----
--L-VLGKTLGEGEFGKV---VKATAFHLKGRAGYT---TVAVKMLK-E--NAS-PSE-LRDLL-SEFNVLKQV-NHPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV---Y--E--EDSY-VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLL-KTGHRMERPDNCS------------------------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL----
---FELLKVLGQGSFGKVFLVRKVTRP-----DSGH---LYAMKVLKKA--TLKVRD---RVRTKMERDILADV-NHPFVVKLHYAFQ--T------EGKLYLILDFLRGGDLFTRLSKEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA------IDHEKKA-YS---FCGTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEMLT-GSLP---------------FQGK----DRKETM-TLILKAKLGMPQFLS----------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY
---FELLKVLGQGSFGKV---FLVRKK-----TGPDAGQLYAMKVLKKA--SLKVRD---RVRTKMERDILVEV-NHPFIVKLHYAFQ--T------EGKLYLILDFLRGGDVFTRLSKEV----------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKES------VDQEKKA-YS---FCGTVEYMAPEVVN-RRGHSQSADWWSYGVLMFEMLT-GTLP---------------FQGK----DRNETM-NMILKAKLGMPQFLS----------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF--
--L-RLEVKLGQGCFGEV---WMGTWN------GTT---RVAIKTLK-P--GTM-SP---EAFL-QEAQVMKKL-RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK-GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI------E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQV-ERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L--
TLE---DKELGSGNFGTV---KKGYYQ---MKKVVK---TVAVKILK-N--EAN-DPALKDELL-AEANVMQQL-DNPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ-QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL---R--A--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAML-EKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPG-----FAAVE----LRL
--L-RLLEKLGDGSFGVV---RRGEWD--APSGKTV---SVAVKCLK-PDVLSQ-PEA-MDDFI-REVNAMHSL-DHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR-KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRAL--PQ--N--DDHY-VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP------------------------------QDIYNVMVQCWAHKPEDRPT-----FVALRDF--L--
--L-AFIKEIGSGQFGVV---HLGEWR------SHI---QVAIKAIN-E--GSM-SE---EDFI-EEAKVMMKL-SHSKLVQLYGVCI--Q------RKPLYIVTEFMENGCLLNYLR-EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYV------L--DDEY-VSSFGAKFPIKWSPPEVFL-FNKYSSKSDVWSFGVLMWEVFTEGKMP---------------FENK-SNLQVVEAI-SEGFRLYRPHLAP------------------------------MSIYEVMYSCWHEKPEGRPT-----FAELLR---AV-
--L-KKIRDLGEGHFGKV---SLYCYDP-TNDGTGE---MVAVKALK-A--DCG-PQH-RSGWK-QEIDILRTL-YHEHIIKYKGCCEDQG------EKSLQLVMEYVPLGSLRDYLP-RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAV--PE--G--HEYY-RVREDGDSPVFWYAPECLK-EYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKF-LELIGIAQGQM-TVLRLTELL-ERGERLPRPDKCP------------------------------CEVYHLMKNCWETEASFRPT-----FENLIP---IL-
--L-RLEVKLGQGCFGEV---WMGTWN------GTT---KVAIKTLK-P--GTM-MP---EAFL-QEAQIMKKL-RHDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK-EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI------E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGM-VNREVLEQV-ERGYRMPCPQGCP------------------------------ESLHELMNLCWKKDPDERPT-----FEYIQSFL----
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