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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK IGF1R 203
TK ABL1 261
TK ALK 1116
TK EGFR 712
TK EPHA3 621
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK INSR 1023
TK LCK 245
TK MERTK 587
TK MST1R 1082
STE OXSR1 17
TK PTK2 422
TK PTK2B 425
TK RET 724
AGC RPS6KA1 62
TK SRC 270
STE STK24 24
TK ZAP70 338
----ITMSRELGQGSFGMV---YEGVAKG--VVKDEPETRVAIKTVN-EAAS-MRERIEFL-NEASVMKEF-NCHHVVRLLGVVS-QGQP-----TLVIMELMTRGDLKSYLR---------SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y---E--TDYY--RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP---------DMLFELMRMCWQYNPKMRPS-----FLEIISS--I--
----ITMKHKLGGGQYGEV---YEGVWK-------KYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-REPP-----FYIITEFMTYGNLLDYLR---------EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-------T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP---------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F--
---I-TLIRGLGHGAFGEV---YEGQVSG--MPNDPSPLQVAVKTLP-EVCS-EQDELDFL-MEALIISKF-NHQNIVRCIGVSL-QSLP-----RFILLELMAGGDLKSFLR---------ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y---R--ASYY--RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP---------GPVYRIMTQCWQHQPEDRPN-----FAIILER--I--
---F-KKIKVLGSGAFGTV---YKGLWIP---EGEKVKIPVAIKELR-EATS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL--TST-----VQLITQLMPFGCLLDYVR---------EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G---A--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT---------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF
---I-SIDKVVGAGEFGEV---CSGRLK----LPSKKEISVAIKTLK-VGYT-EKQRRDFL-GEASIMGQF-DHPNIIRLEGVVT-KSKP-----VMIVTEYMENGSLDSFLR---------KH-----------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL---E---D--DPEA-AYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCP---------AALYQLMLDCWQKDRNNRPK-----FEQIVSIL----
---L-RKLKVLGSGVFGTV---HKGVWIP---EGESIKIPVCIKVIE-DKSG-RQSFQAVT-DHMLAIGSL-DHAHIVRLLGLCP--GSS-----LQLVTQYLPLGSLLDHVR---------QH-----------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL---P---P--DDKQ--LLYSEAKTPIKWMALESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICT---------IDVYMVMVKCWMIDENIRPT-----FKELANE--F--
---L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLQ---------ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---H---H--IDYY--KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT---------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL----
----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAVTVAVKMLK-DDAT-EKDLSDLV-SEMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLR---------ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI---N---N--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT---------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL----
----LKLEKKLGAGQFGEV---WMATYN--------KHTKVAVKTMK-PGSM-SV--EAFL-AEANVMKTL-QHDKLVKLHAVVT--KEP-----IYIITEFMAKGSLLDFLK---------SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI-------E--DNEY--TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP---------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L--
----ITLLRELGQGSFGMV---YEGNARD--IIKGEAETRVAVKTVN-ESAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS-KGQP-----TLVVMELMAHGDLKSYLR---------SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---Y---E--TDYY--RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP---------ERVTDLMRMCWQFNPKMRPT-----FLEIVNLL----
----LKLVERLGAGQFGEV---WMGYYN--------GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT--QEP-----IYIITEYMENGSLVDFLK---------TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI-------E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP---------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L--
---L-ILGKILGEGEFGSV---MEGNLK----QEDGTSLKVAVKTMKLDNSS-QREIEEFL-SEAACMKDF-SHPNVIRLLGVCI-EMSSQGIPKPMVILPFMKYGDLHTYLL---------YSRL------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKI---Y---S--GDYY--RQGRIAKMPVKWIAIESLA-DRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL---------DELYEIMYSCWRTDPLDRPT-----FSVLRLQ--L--
-THS---DRVIGKGHFGVV---YHGEYI----DQAQNRIQCAIKSLS-RITE-MQQVEAFL-REGLLMRGL-NHPNVLALIGIMLPPEGL-----PHVLLPYMCHGDLLQFIR---------SP-----------------------QRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDE---SFTVKVADFGLARDI---L---D--REYYSVQQHRHARLPVKWMALESLQ-TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCP---------DSLYQVMQQCWEADPAVRPT-----FRVLV----GEV
----YELQEVIGSGATAVV---QAAYCA-------PKKEKVAIKRINLEKCQTSM--DE-LLKEIQAMSQC-HHPNIVSYYTSFV-VKDE-----LWLVMKLLSGGSVLDIIKHIVAKGEHKSG-------------------------VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGE---DGSVQIADFGVSAFLAT--GGDITRNKVR--KT---FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPT-----AAELLRHKFF--
----IELGRCIGEGQFGDV---HQGIYM----SPENPALAVAIKTCK-NCTS-DSVREKFL-QEALTMRQF-DHPHIVKLIGVIT--ENP-----VWIIMELCTLGELRSFLQ---------VR-----------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM-------E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP---------PTLYSLMTKCWAYDPSRRPR-----FTELKAQL----
---V-VLNRILGEGFFGEV---YEGVYT----NHKGEKINVAVKTCK-KDCT-LDNKEKFM-SEAVIMKNL-DHPHIVKLIGIIE--EEP-----TWIIMELYPYGELGHYLE---------RN-----------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS---PECVKLGDFGLSRYI-------E--DEDY--YKASVTRLPIKWMSPESIN-FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP---------PVLYTLMTRCWDYDPSDRPR-----FTELVCS--L--
---L-VLGKTLGEGEFGKV---VKATAFH--LKGRAGYTTVAVKMLK-ENAS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACS-QDGP-----LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV---Y---E--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS---------EEMYRLMLQCWKQEPDKRPV-----FADISKDL----
----FELLKVLGQGSFGKVFLVRKVTRP-------DSGHLYAMKVLKKATLKVRD--RVRTKMERDILADV-NHPFVVKLHYAFQ-TEGK-----LYLILDFLRGGDLFTRLS--------KEV-------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKEA-------IDHEKKA--YS---FCGTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK---DRKETMTLILKAKLGMPQFLS-------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY
---L-RLEVKLGQGCFGEV---WMGTWN--------GTTRVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS--EEP-----IYIVTEYMSKGSLLDFLK---------GE----------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI-------E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP---------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L--
----FTKLEKIGKGSFGEV---FKGIDN-------RTQKVVAIKIIDLEEAEDEI--EDIQ-QEITVLSQC-DSPYVTKYYGSYL-KDTK-----LWIIMEYLGGGSALDLLE---------PG-------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL-------TDTQIKR--NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLIPKNNPPTLEGNYS---------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI--
LIAD----IELGCGNFGSV---RQGVYR-----MRKKQIDVAIKVLK-QGTE-KADTEEMM-REAQIMHQL-DNPYIVRLIGVCQ--AEA-----LMLVMEMAGGGPLHKFLV---------GK-----------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL--GA---D--DSYY--TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP---------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M--
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