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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK IGF1R 203
TK ABL1 261
TK ALK 1116
TK AXL 527
TK BLK 241
TK BMX 422
TK BTK 402
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK EPHB6 670
TK ERBB3 709
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FLT4 845
TK HCK 241
TK INSR 1023
TK INSRR 979
TK ITK 363
TK JAK2 849
TK KDR 834
TK LCK 245
TK LTK 510
TK MATK 235
TK MERTK 587
TK MST1R 1082
Other NEK11 29
Other NEK4 6
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PTK2 422
TK PTK2B 425
TK RET 724
AGC RPS6KA2 59
AGC RPS6KA3 68
STE SLK 34
TK SRC 270
STE STK24 24
STE STK39 63
TK TEC 370
TK TEK 824
TK TIE1 839
TK TXK 271
TK TYK2 589
TK TYRO3 518
TK YES1 277
TK ZAP70 338
-------ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPET---RVAIKTVN-E-AAS-MRERIEFL-NEASVMKEF-NCHHVVRLLGVVS--Q-GQP------TLVIMELMTRGDLKSYLR---------SLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI----Y---E--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGVFTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL-SNEQVLRFV----ME----GGL---LDKPDNCP----------DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I--
-------ITMKHKLGGGQYGEVYEGVWK----------------KYSL---TVAVKTLK-E-DTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT--R-EPP------FYIITEFMTYGNLLDYLR---------EC----------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM--------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EK----DYR---MERPEGCP----------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F--
------I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPL---QVAVKTLP-E-VCS-EQDELDFL-MEALIISKF-NHQNIVRCIGVSL--Q-SLP------RFILLELMAGGDLKSFLR---------ETRP-----------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI----Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGIFTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-SNQEVLEFV----TS----GGR---MDPPKNCP----------GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I--
------V-ALGKTLGEGEFGAVMEGQLN--------------QDDSIL---KVAVKTMK-IAICT-RSELEDFL-SEAVCMKEF-DHPNVMRLIGVCF--Q-GSERESFPAPVVILPFMKHGDLHSFLL---------YSRL------------------------------------------------------------GDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNE---NMSVCVADFGLSKKI----Y---N--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRVYTSKSDVWSFGVTMWEIATRGQ-TP---------------YPGV-ENSEIYDYL----RQ----GNR---LKQPADCL----------DGLYA-LMSRCWELNPQDRPS-----FTELREDL----
------L-RLVRKLGSGQFGEVWMGYYK-----------------NNM---KVAIKTLK-E-GTM-SP--EAFL-GEANVMKAL-QHERLVRLYAVVT----KEP------IYIVTEYMARGCLLDFLK---------TD----------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE---ALCCKIADFGLARII-----------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGVFTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-SNPEVIRNL----ER----GYR---MPRPDTCP----------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L--
-------ITLLKELGSGQFGVVQLGKWK-----------------GQY---DVAVKMIK-E-GSM-SE--DEFF-QEAQTMMKL-SHPKLVKFYGVCS--K-EYP------IYIVTEYISNGCLLNYLR---------SH-----------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDR---DLCVKVSDFGMTRYV--------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFKYSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY-DNSQVVLKV----SQ----GHR---LYRPHLAS----------DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I--
-------LTFLKELGTGQFGVVKYGKWR-----------------GQY---DVAIKMIK-E-GSM-SE--DEFI-EEAKVMMNL-SHEKLVQLYGVCT--K-QRP------IFIITEYMANGCLLNYLR---------EM-----------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVVKVSDFGLSRYV--------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSKFSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF-TNSETAEHI----AQ----GLR---LYRPHLAS----------EKVYT-IMYSCWHEKADERPT-----FKILLSN--I--
-------LKLLQTIGKGEFGDVMLGDYR------------------GN---KVAVKCIK-N-DAT-AQ---AFL-AEASVMTQL-RHSNLVQLLGVIV-EE-KGG------LYIVTEYMAKGSLVDYLR---------SR----------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEA--------------S--------------STQDTGKLPVKWTAPEALR-----EKKFSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI-PLKDVVPRV----EK----GYK---MDAPDGCP----------PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL----
-------LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPL---LVAVKILR-P-DAT-KNARNDFL-KEVKIMSRL-KDPNIIRLLGVCV--Q-DDP------LCMITDYMENGDLNQFLS---------AHQLEDKAAE-----------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE---NFTIKIADFGMSRNL----Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGKFTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRD----QGRQVYLSRPPACP----------QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL----
-------LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPV---LVAVKMLR-A-DAN-KNARNDFL-KEIKIMSRL-KDPNIIHLLAVCI--T-DDP------LCMITEYMENGDLNQFLS---------RHEPPN--------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK---NYTIKIADFGMSRNL----Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGKFTTASDVWAFGVTLWETFTFCQEQP---------------YSQL-SDEQVIENT----GEFFRDQGRQTYLPQPAICP----------DSVYK-LMLSCWRRDTKNRPS-----FQEIHL---LL-
------F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKI---PVAIKELR-E-ATS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL----TST------VQLITQLMPFGCLLDYVR---------EH-----------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL----G---A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRIYTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-PASEISSIL----EK----GER---LPQPPICT----------IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF
-----LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCK---TVAIKTLK-D-TSP-GGQWWNFL-REATIMGQF-SHPHILHLEGVVT--K-RKP------IMIITEFMENGALDAFLR---------ER-----------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQ---NLCCKVSDFGLTRLL----D---D--FDGT--------------YETQGGKIPIRWTAPEAIA-----HRIFTTASDVWSFGIVMWEVLSFGD-KP---------------YGEM-SNQEVMKSI----ED----GYR---LPPPVDCP----------APLYE-LMKNCWAYDRARRPH-----FQKLQAHL----
------I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEI---SVAIKTLK-V-GYT-EKQRRDFL-GEASIMGQF-DHPNIIRLEGVVT--K-SKP------VMIVTEYMENGSLDSFLR---------KH-----------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL----E---D--DPEA-------------AYTTRGGKIPIRWTSPEAIA-----YRKFTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM-SNQDVIKAV----DE----GYR---LPPPMDCP----------AALYQ-LMLDCWQKDRNNRPK-----FEQIVSIL----
-------IKIEKVIGVGEFGEVCSGRLK-------------VPGKREI---CVAIKTLK-A-GYT-DKQRRDFL-SEASIMGQF-DHPNIIHLEGVVT--K-CKP------VMIITEYMENGSLDAFLR---------KN-----------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNS---NLVCKVSDFGMSRVL----E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----YRKFTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-SNQDVIKAI----EE----GYR---LPPPMDCP----------IALHQ-LMLDCWQKERSDRPK-----FGQIVNML----
-------ITIERVIGAGEFGEVCSGRLK-------------LPGKREL---PVAIKTLK-V-GYT-EKQRRDFL-GEASIMGQF-DHPNIIHLEGVVT--K-SKP------VMIVTEYMENGSLDTFLK---------KN-----------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL----E---D--DPEA-------------AYTTRGGKIPIRWTAPEAIA-----FRKFTSASDVWSYGIVMWEVVSYGE-RP---------------YWEM-TNQDVIKAV----EE----GYR---LPSPMDCP----------AALYQ-LMLDCWQKERNSRPK-----FDEIVNML----
LPPRIPA-----------------------------------------------------------------------------------------------GRP------VMIVVEYMENGSLDSFLR---------KH-----------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNS---NLVCKVSDFGLSRVL----E---D--DPEA-------------AYTTTGGKIPIRWTAPEAIA-----YRKFSSASDAWSYGIVMWEVMSYGE-RP---------------YWEM-SNQDVILSI----EE----GYR---LPAPMGCP----------ASLHQ-LMLHCWQKERNHRPK-----FTDIVSFL----
------V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREI---YVAIKTLK-A-GYS-EKQRRDFL-SEASIMGQF-DHPNIIRLEGVVT--K-SRP------VMIITEFMENGALDSFLR---------QN-----------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRYLQ-DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRKFTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQ----DYR---LPPPMDCP----------AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL----
------V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREI---FVAIKTLK-S-GYT-EKQRRDFL-SEASIMGQF-DHPNVIHLEGVVT--K-STP------VMIITEFMENGSLDSFLR---------QN-----------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS---NLVCKVSDFGLSRFLE-DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRKFTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-TNQDVINAI----EQ----DYR---LPPPMDCP----------SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL----
------V-KIEEVIGAGEFGEVCRGRLK-------------QPGRREV---FVAIKTLK-V-GYT-ERQRRDFL-SEASIMGQF-DHPNIIRLEGVVT--K-SRP------VMILTEFMENCALDSFLR---------LN-----------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRFLE-DDP---S--DPTY--------------TSSLGGKIPIRWTAPEAIA-----YRKFTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-SNQDVINAV----EQ----DYR---LPPPMDCP----------TALHQ-LMLDCWVRDRNLRPK-----FSQIVNTL----
------V-KIEEVIGAGEFGEVCRGRLK-------------APGKKES---CVAIKTLK-G-GYT-ERQRREFL-SEASIMGQF-EHPNIIRLEGVVT--N-SMP------VMILTEFMENGALDSFLR---------LN-----------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLE-ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA-----FRKFTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQ----DYR---LPPPPDCP----------TSLHQ-LMLDCWQKDRNARPR-----FPQVVSAL----
-------IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQ---TVAIQALW-A-GGA-ESLQMTFL-GRAAVLGQF-QHPNILRLEGVVT--K-SRP------LMVLTEFMELGPLDSFLR---------QR-----------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNS---HLVCKVARLGHSPQG----------------------------------PSCLLRWAAPEVIA-----HGKHTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM-SEQEVLNAI----EQ----EFR---LPPPPGCP----------PGLHL-LMLDTWQKDRARRPH-----FDQLVA---AF-
------L-RKLKVLGSGVFGTVHKGVWIP------------EGESIKI---PVCIKVIE-D-KSG-RQSFQAVT-DHMLAIGSL-DHAHIVRLLGLCP----GSS------LQLVTQYLPLGSLLDHVR---------QH-----------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL----P---P--DDKQ--------------LLYSEAKTPIKWMALESIH-----FGKYTHQSDVWSYGVTVWELMTFGA-EP---------------YAGL-RLAEVPDLL----EK----GER---LAQPQICT----------IDVYM-VMVKCWMIDENIRPT-----FKELANE--F--
------L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKI---PVAIKILN-E-TTG-PKANVEFM-DEALIMASM-DHPHLVRLLGVCL----SPT------IQLVTQLMPHGCLLEYVH---------EH-----------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKS---PNHVKITDFGLARLL----E---G--DEKE--------------YNADGGKMPIKWMALECIH-----YRKFTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI-PTREIPDLL----EK----GER---LPQPPICT----------IDVYM-VMVKCWMIDADSRPK-----FKELAAE--F--
-----VI--LGELLGKGNFGEVYKGTLK-----------------DKT---SVAVKTCK-E-DLP-QELKIKFL-QEAKILKQY-DHPNIVKLIGVCT--Q-RQP------VYIIMELVSGGDFLTFLR---------RK-----------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGE---NNVLKISDFGMSRQE--------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGRYSSESDVWSFGILLWETFSLGV-CP---------------YPGM-TNQQAREQV----ER----GYR---MSAPQHCP----------EDISK-IMMKCWDYKPENRPK-----FSELQKEL----
------L-VLGEQIGRGNFGEVFSGRLR----------------ADNT---LVAVKSCR-E-TLP-PDLKAKFL-QEARILKQY-SHPNIVRLIGVCT--Q-KQP------IYIVMELVQGGDFLTFLR---------TE-----------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTE---KNVLKISDFGMSREE----A---D--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGRYSSESDVWSFGILLWETFSLGA-SP---------------YPNL-SNQQTREFV----EK----GGR---LPCPELCP----------DAVFR-LMEQCWAYEPGQRPS-----FSTIYQEL----
------L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVT---KVAVKMLK-S-DAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT--Q-DGP------LYVIVEYASKGNLREYLQ---------ARRPPGLEY--------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI----H---H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRIYTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-PVEELFKLL----KE----GHR---MDKPSNCT----------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----
-------LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCD---TVAVKMLK-E-GAT-ASEHRALM-SELKILIHIGNHLNVVNLLGACT-KP-QGP------LMVIVEFCKYGNLSNFLR---------AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR--PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSE---SDVVKICDFGLARDI----Y---K--DPDY--------------VRKGSARLPLKWMAPESIF-----DKVYTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGVQINEEFCQRL----RD----GTR---MRAPELAT----------PAIRR-IMLNCWSGDPKARPA-----FSELVEIL----
-------LKLEKKLGAGQFGEVWMATYN-----------------KHT---KVAVKTMK-P-GSM-SV--EAFL-AEANVMKTL-QHDKLVKLHAVVT----KEP------IYIITEFMAKGSLLDFLK---------SD----------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGSFTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-SNPEVIRAL----ER----GYR---MPRPENCP----------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L--
-------ITLLRELGQGSFGMVYEGNARD-----------IIKGEAET---RVAVKTVN-E-SAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS--K-GQP------TLVVMELMAHGDLKSYLR---------SLRPEA--------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGVFTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-SNEQVLKFV----MD----GGY---LDQPDNCP----------ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL----
------I-SIIRELGQGSFGMVYEGLARG-----------LEAGEEST---PVALKTVN-E-LAS-PRECIEFL-KEASVMKAF-KCHHVVRLLGVVS--Q-GQP------TLVIMELMTRGDLKSHLR---------SLRPEA--------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ---DFTVKIGDFGMTRDV----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGIFTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL-SNEQVLKFV----MD----GGV---LEELEGCP----------LQLQE-LMSRCWQPNPRLRPS-----FTHILD---SI-
-------LTFVQEIGSGQFGLVHLGYWL-----------------NKD---KVAIKTIR-E-GAM-SE--EDFI-EEAEVMMKL-SHPKLVQLYGVCL--E-QAP------ICLVFEFMEHGCLSDYLR---------TQ-----------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE---NQVIKVSDFGMTRFV--------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSRYSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR-SNSEVVEDI----ST----GFR---LYKPRLAS----------THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL----
-------LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGE---VVAVKKLQ-H-STE--EHLRDFE-REIEILKSL-QHDNIVKYKGVCYSAG-RRN------LKLIMEYLPYGSLRDYLQ---------KH-----------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL---PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KN----NGR---LPRPDGCP----------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV
-------LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCR---TVAVKMLK-E-GAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACT-KP-GGP------LMVIVEFCKFGNLSTYLR---------SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE---KNVVKICDFGLARDI----Y---K--DPDY--------------VRKGDARLPLKWMAPETIF-----DRVYTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGVKIDEEFCRRL----KE----GTR---MRAPDYTT----------PEMYQ-TMLDCWHGEPSQRPT-----FSELVEHL----
-------LKLVERLGAGQFGEVWMGYYN-----------------GHT---KVAVKSLK-Q-GSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT----QEP------IYIITEYMENGSLVDFLK---------TP----------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ER----GYR---MVRPDNCP----------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L--
------V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPL---QVAIKTLP-E-LCS-PQDELDFL-MEALIISKF-RHQNIVRCVGLSL--R-ATP------RLILLELMSGGDMKSFLR---------HSRP-----------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI----Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGIFTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR-TNQEVLDFV----VG----GGR---MDPPRGCP----------GPVYR-IMTQCWQHEPELRPS-----FASILERL----
-------LTLGAQIGEGEFGAVLQGEYL------------------GQ---KVAVKNIK-C-DVT-AQ---AFL-DETAVMTKM-QHENLVRLLGVIL----HQG------LYIVMEHVSKGNLVNFLR---------TR----------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSE---DLVAKVSDFGLAKAE--------------R--------------KGLDSSRLPVKWTAPEALK-----HGKFTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM-SLKEVSEAV----EK----GYR---MEPPEGCP----------GPVHV-LMSSCWEAEPARRPP-----FRKLAEKL----
------L-ILGKILGEGEFGSVMEGNLK-------------QEDGTSL---KVAVKTMKLD-NSS-QREIEEFL-SEAACMKDF-SHPNVIRLLGVCI--E-MSSQG-IPKPMVILPFMKYGDLHTYLL---------YSRL------------------------------------------------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKI----Y---S--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRVYTSKSDVWAFGVTMWEIATRGM-TP---------------YPGV-QNHEMYDYL----LH----GHR---LKQPEDCL----------DELYE-IMYSCWRTDPLDRPT-----FSVLRLQ--L--
----THS---DRVIGKGHFGVVYHGEYI-------------DQAQNRI---QCAIKSLS-R-ITE-MQQVEAFL-REGLLMRGL-NHPNVLALIGIML-PP-EGL------PHVLLPYMCHGDLLQFIR---------SP-----------------------------------------------------------------QRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDE---SFTVKVADFGLARDI----L---D--REYYS------------VQQHRHARLPVKWMALESLQ-----TYRFTTKSDVWSFGVLLWELLTRGA-PP---------------YRHI-DPFDLTHFL----AQ----GRR---LPQPEYCP----------DSLYQ-VMQQCWEADPAVRPT-----FRVLV----GEV
-------YVLQQKLGSGSFGTVYLVSDK----------------KAKRGEELKVLKEISVG-ELNPNE--TVQANLEAQLLSKL-DHPAIVKFHASFV--E-QDN------FCIITEYCEGRDLDDKIQEY----KQAGK-------------------------------------------------------------------IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLK----NNLLKIGDFGVSRLL--------MGSCDLA--------------TT---LTGTPHYMSPEALK-----HQGYDTKSDIWSLACILYEMCC-MN-HA---------------FAGS----NFLSIV----LK----IVE---GDTPSLPERY-P------KELNA-IMESMLNKNPSLRPS-----AIEILKIPYL--
------Y-CYLRVVGKGSYGEVTLVKHR----------------RDGK---QYVIKKLNLR-NASSRE--RRAAEQEAQLLSQL-KHPNIVTYKESWE--GGDGL------LYIVMGFCEGGDLYRKLKE------QKGQ-------------------------------------------------------------------LLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTR---TNIIKVGDLGIARVL--------ENHCDMA--------------ST---LIGTPYYMSPELFS-----NKPYNYKSDVWALGCCVYEMAT-LK-HA---------------FNAK----DMNSLV----YR----IIE---GKLPPMPRDY--S-----PELAE-LIRTMLSKRPEERPS-----VRSILRQPYI--
-----IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKM---LVAVKALK-E-ASE-SA-RQDFQ-REAELLTML-QHQHIVRFFGVCT--E-GRP------LLMVFEYMRHGDLNRFLR---------SHGPDAKL---------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI----Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRKFTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL-SNTEAIDCI----TQ----GRE---LERPRACP----------PEVYA-IMRGCWQREPQQRHS-----IKDVHARL----
------I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKI---LVAVKTLK-D-ASD-NA-RKDFH-REAELLTNL-QHEHIVKFYGVCV--E-GDP------LIMVFEYMKHGDLNKFLR---------AHGPDAV-----------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE---NLLVKIGDFGMSRDV----Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRKFTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-SNNEVIECI----TQ----GRV---LQRPRTCP----------QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L--
------I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKM---LVAVKALK-D-PTL-AA-RKDFQ-REAELLTNL-QHEHIVKFYGVCG--D-GDP------LIMVFEYMKHGDLNKFLR---------AHGPDAMIL--------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA---NLLVKIGDFGMSRDV----Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRKFTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-SNTEVIECI----TQ----GRV---LERPRVCP----------KEVYD-VMLGCWQREPQQRLN-----IKEIYKIL----
-------IELGRCIGEGQFGDVHQGIYM-------------SPENPAL---AVAIKTCK-N-CTS-DSVREKFL-QEALTMRQF-DHPHIVKLIGVIT----ENP------VWIIMELCTLGELRSFLQ---------VR-----------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM--------E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRRFTSASDVWMFGVCMWEILMHGV-KP---------------FQGV-KNNDVIGRI----EN----GER---LPMPPNCP----------PTLYS-LMTKCWAYDPSRRPR-----FTELKAQL----
------V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKI---NVAVKTCK-K-DCT-LDNKEKFM-SEAVIMKNL-DHPHIVKLIGIIE----EEP------TWIIMELYPYGELGHYLE---------RN-----------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS---PECVKLGDFGLSRYI--------E--DEDY--------------YKASVTRLPIKWMSPESIN-----FRRFTTASDVWMFAVCMWEILSFGK-QP---------------FFWL-ENKDVIGVL----EK----GDR---LPKPDLCP----------PVLYT-LMTRCWDYDPSDRPR-----FTELVCS--L--
------L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYT---TVAVKMLK-E-NAS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACS--Q-DGP------LLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV----Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHIYTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-PPERLFNLL----KT----GHR---MERPDNCS----------EEMYR-LMLQCWKQEPDKRPV-----FADISKDL----
-------FELLKVLGQGSYGKVFLVRKV----------------KGSDAGQLYAMKVLKKA-TLKVRD--RVRSKMERDILAEV-NHPFIVKLHYAFQ--T-EGK------LYLILDFLRGGDLFTRLS--------KEV-------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE---EGHIKITDFGLSKEA--------IDHDKRA--------------YS---FCGTIEYMAPEVVN-----RRGHTQSADWWSFGVLMFEMLT-GS-LP---------------FQGK----DRKETM----AL----ILK---AKLGMPQFLS--------GEAQS-LLRALFKRNPCNRLGAGIDGVEEIKRHPFF--
-------FELLKVLGQGSFGKVFLVKKI----------------SGSDARQLYAMKVLKKA-TLKVRD--RVRTKMERDILVEV-NHPFIVKLHYAFQ--T-EGK------LYLILDFLRGGDLFTRLS--------KEV-------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKES--------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----RRGHTQSADWWSFGVLMFEMLT-GT-LP---------------FQGK----DRKETM----TM----ILK---AKLGMPQFLS--------PEAQS-LLRMLFKRNPANRLGAGPDGVEEIKRHSFF--
-------WEIIGELGDGAFGKVYKAQNK----------------ETSV---LAAAKVIDTK-SEEELE--DYM--VEIDILASC-DHPNIVKLLDAFY--Y-ENN------LWILIEFCAGGAVDAVML-------ELER-------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTL---DGDIKLADFGVSAKN--------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IE-PP---------------HHEL-NPMRVLLKI----AK----SEP---PTLAQPSRWS--------SNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV--
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTT---RVAIKTLK-P-GTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS----EEP------IYIVTEYMSKGSLLDFLK---------GE----------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ER----GYR---MPCPPECP----------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L--
-------FTKLEKIGKGSFGEVFKGIDN----------------RTQK---VVAIKIIDLE-EAEDEI--EDIQ-QEITVLSQC-DSPYVTKYYGSYL--K-DTK------LWIIMEYLGGGSALDLLE---------PG-------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL--------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSAYDSKADIWSLGITAIELAR-GE-PP---------------HSEL-HPMKVLFLI----PK----NNP---PTLEGNYS----------KPLKE-FVEACLNKEPSFRPT-----AKELLKHKFI--
-------YELQEVIGSGATAVVQAALCK----------------PRQE---RVAIKRINLE-KCQTSM--DE-LLKEIQAMSQC-SHPNVVTYYTSFV--V-KDE------LWLVMKLLSGGSMLDIIKYIVNRGEHKNG-------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGE---DGSVQIADFGVSAFLAT---GGDVTRNKVR--------------KT---FVGTPCWMAPEVME----QVRGYDFKADMWSFGITAIELAT-GA-AP---------------YHKY-PPMKVLMLT----LQ----NDP---PTLETGVEDKE-MMKKYGKSFRK-LLSLCLQKDPSKRPT-----AAELLKCKFF--
-------LTFMRELGSGLFGVVRLGKWR-----------------AQY---KVAIKAIR-E-GAM-CE--EDFI-EEAKVMMKL-THPKLVQLYGVCT--Q-QKP------IYIVTEFMERGCLLNFLR---------QR-----------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSE---AGVVKVSDFGMARYV--------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSRFSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY-TNYEVVTMV----TR----GHR---LYQPKLAS----------NYVYE-VMLRCWQEKPEGRPS-----FEDLLRT--I--
-------IKFQDVIGEGNFGQVLKARIK--------------KDGLRM---DAAIKRMK-E-YAS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE--H-RGY------LYLAIEYAPHGNLLDFLR---------KSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ------------EVY--------------VKKTMGRLPVRWMAIESLN-----YSVYTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM-TCAELYEKL----PQ----GYR---LEKPLNCD----------DEVYD-LMRQCWREKPYERPS-----FAQILV---SL-
-------ITFEDLIGEGNFGQVIRAMIK--------------KDGLKM---NAAIKMLK-E-YAS-ENDHRDFA-GELEVLCKLGHHPNIINLLGACK--N-RGY------LYIAIEYAPYGNLLDFLR---------KSRVLETDP--------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGE---NLASKIADFGLSRGE------------EVY--------------VKKTMGRLPVRWMAIESLN-----YSVYTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM-TCAELYEKL----PQ----GYR---MEQPRNCD----------DEVYE-LMRQCWRDRPYERPP-----FAQIALQ--L--
------L-AFIKEIGSGQFGVVHLGEWR-----------------SHI---QVAIKAIN-E-GSM-SE--EDFI-EEAKVMMKL-SHSKLVQLYGVCI--Q-RKP------LYIVTEFMENGCLLNYLR---------EN-----------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSS---TCIVKISDFGMTRYV--------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNKYSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK-SNLQVVEAI----SE----GFR---LYRPHLAP----------MSIYE-VMYSCWHEKPEGRPT-----FAELLR---AV-
------L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGE---MVAVKALK-A-DCG-PQHRSGWK-QEIDILRTL-YHEHIIKYKGCCEDQG-EKS------LQLVMEYVPLGSLRDYLP---------RH-------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDN---DRLVKIGDFGLAKAV---PE---G--HEYY--------------RVREDGDSPVFWYAPECLK-----EYKFYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM-TVLRLTELL----ER----GER---LPRPDKCP----------CEVYH-LMKNCWETEASFRPT-----FENLIP---IL-
------F-TLGRMLGKGEFGSVREAQLK-------------QEDGSFV---KVAVKMLK-ADIIA-SSDIEEFL-REAACMKEF-DHPHVAKLVGVSL--R-SRAKGRLPIPMVILPFMKHGDLHAFLL---------ASRI------------------------------------------------------------GENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAE---DMTVCVADFGLSRKI----Y---S--GDYY--------------RQGCASKLPVKWLALESLA-----DNLYTVQSDVWAFGVTMWEIMTRGQ-TP---------------YAGI-ENAEIYNYL----IG----GNR---LKQPPECM----------EDVYD-LMYQCWSADPKQRPS-----FTCLRME--L--
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTT---KVAIKTLK-P-GTM-MP--EAFL-QEAQIMKKL-RHDKLVPLYAVVS----EEP------IYIVTEFMSKGSLLDFLK---------EG----------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE---NLVCKIADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ER----GYR---MPCPQGCP----------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL----
---LIAD----IELGCGNFGSVRQGVYR--------------MRKKQI---DVAIKVLK-Q-GTE-KADTEEMM-REAQIMHQL-DNPYIVRLIGVCQ----AEA------LMLVMEMAGGGPLHKFLV---------GK-----------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL---GA---D--DSYY--------------TARSAGKWPLKWYAPECIN-----FRKFSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM-KGPEVMAFI----EQ----GKR---MECPPECP----------PELYA-LMSDCWIYKWEDRPD-----FLTVEQR--M--
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