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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK INSR 203
TK ABL1 261
TK ALK 1116
TK EGFR 712
TK EPHA3 621
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TKL ILK 193
TKL IRAK4 186
TK KIT 589
TK LCK 245
TK MERTK 587
TK MET 1078
TK MST1R 1082
Other PLK1 53
TK PTK2 422
TK PTK2B 425
TK RET 724
AGC RPS6KA1 62
TK SRC 270
STE STK24 24
TK TNK2 150
TK ZAP70 338
----ITLLRELGQGSFGMV---YEGNARD--IIKGEAETRVAVKTVN-E--SAS-LRERI-EFL-N-EASVMKGF-TCHHVVRLLGVVS--KGQP-----TLVVMELMAHGDLKSYLR----SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKK-FVHR-DLAARNCMVAH---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCP--------------ERVTDLMRMCWQFNPKMRPT-----FLEIVNLL-----
----ITMKHKLGGGQYGEV---YEGVWK-------KYSLTVAVKTLK-E--DTM-EV--E-EFL-K-EAAVMKEI-KHPNLVQLLGVCT--REPP-----FYIITEFMTYGNLLDYLR----EC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKN-FIHR-DLAARNCLVGE---NHLVKVADFGLSRLM----T--GDTY--TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCP--------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F---
---I-TLIRGLGHGAFGEV---YEGQVSG--MPNDPSPLQVAVKTLP-E--VCS-EQDEL-DFL-M-EALIISKF-NHQNIVRCIGVSL--QSLP-----RFILLELMAGGDLKSFLR----ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENH-FIHR-DIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYY--RKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFV-TSGGRMDPPKNCP--------------GPVYRIMTQCWQHQPEDRPN-----FAIILER--I---
---F-KKIKVLGSGAFGTV---YKGLWIP---EGEKVKIPVAIKELR-E--ATS-PKANK-EIL-D-EAYVMASV-DNPHVCRLLGICL---TST-----VQLITQLMPFGCLLDYVR----EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRR-LVHR-DLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKE--YHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICT--------------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF-
---I-SIDKVVGAGEFGEV---CSGRLK----LPSKKEISVAIKTLK-V--GYT-EKQRR-DFL-G-EASIMGQF-DHPNIIRLEGVVT--KSKP-----VMIVTEYMENGSLDSFLR----KH---------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMG-YVHR-DLAARNILINS---NLVCKVSDFGLSRVL--E-D--DPEA-AYTTRGGKIPIRWTSPEAIAYRK---FTSASDVWSYGIVLWEVMSYGERPYWEM-SNQDVIKAV-DEGYRLPPPMDCP--------------AALYQLMLDCWQKDRNNRPK-----FEQIVSIL-----
---L-RKLKVLGSGVFGTV---HKGVWIP---EGESIKIPVCIKVIE-D--KSG-RQSFQ-AVT-D-HMLAIGSL-DHAHIVRLLGLCP---GSS-----LQLVTQYLPLGSLLDHVR----QH---------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEHG-MVHR-NLAARNVLLKS---PSQVQVADFGVADLL--P-P--DDKQ--LLYSEAKTPIKWMALESIHFGK---YTHQSDVWSYGVTVWELMTFGAEPYAGL-RLAEVPDLL-EKGERLAQPQICT--------------IDVYMVMVKCWMIDENIRPT-----FKELANE--F---
---L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVTKVAVKMLK-S--DAT-EKDLS-DLI-S-EMEMMKMIGKHKNIINLLGACT--QDGP-----LYVIVEYASKGNLREYLQ----ARRPPGLEY------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK-CIHR-DLAARNVLVTE---DNVMKIADFGLARDI--H-H--IDYY--KKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLL-KEGHRMDKPSNCT--------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-----
----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAVTVAVKMLK-D--DAT-EKDLS-DLV-S-EMEMMKMIGKHKNIINLLGACT--QDGP-----LYVIVEYASKGNLREYLR----ARRPPGMEY------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK-CIHR-DLAARNVLVTE---NNVMKIADFGLARDI--N-N--IDYY--KKTTNGRLPVKWMAPEALFDRV---YTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLL-KEGHRMDKPANCT--------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-----
----LKLEKKLGAGQFGEV---WMATYN--------KHTKVAVKTMK-P--GSM-SV--E-AFL-A-EANVMKTL-QHDKLVKLHAVVT---KEP-----IYIITEFMAKGSLLDFLK----SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRN-YIHR-DLRAANILVSA---SLVCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAINFGS---FTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRAL-ERGYRMPRPENCP--------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L---
----ITMSRELGQGSFGMV---YEGVAKG--VVKDEPETRVAIKTVN-E--AAS-MRERI-EFL-N-EASVMKEF-NCHHVVRLLGVVS--QGQP-----TLVIMELMTRGDLKSYLR----SLRPEM------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANK-FVHR-DLAARNCMVAE---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMSPESLKDGV---FTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFV-MEGGLLDKPDNCP--------------DMLFELMRMCWQYNPKMRPS-----FLEIISS--I---
---L-NFLTKLNENHSGEL---WKGRWQ---------GNDIVVKVLK-V-RDWS-TRKSR-DFN-E-ECPRLRIF-SHPNVLPVLGACQSPPAPH-----PTLITHWMPYGSLYNVLH----EG--------------------------------------------------------------------------TNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDE---DMTARISMADVKFSF--------------QCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTR-EVPFADL-SNMEIGMKVALEGLRPTIPPGIS--------------PHVCKLMKICMNEDPAKRPK-----FDMIVPI--L---
-VGG----NKMGEGGFGVV---YKGYVN-------NTT--VAVKKLAAM--VDITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSS--DGDD-----LCLVYVYMPNGSLLDRLSCLDGTP-----------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENH-HIHR-DIKSANILLDE---AFTAKISDFGLARASE--KFAQTVMT--SR---IVGTTAYMAPEALR-GE---ITPKSDIYSFGVVLLEIIT-GLPAVDEH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ
----LSFGKTLGAGAFGKV---VEATAYG--LIKSDAAMTVAVKMLK-P--SAH-LTERE-ALM-S-ELKVLSYLGNHMNIVNLLGACT--IGGP-----TLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKN-CIHR-DLAARNILLTH---GRITKICDFGLARDI--K-N--DSNY--VVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAP--------------AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I---
----LKLVERLGAGQFGEV---WMGYYN--------GHTKVAVKSLK-Q--GSM-SP--D-AFL-A-EANLMKQL-QHQRLVRLYAVVT---QEP-----IYIITEYMENGSLVDFLK----TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERN-YIHR-DLRAANILVSD---TLSCKIADFGLARLI----E--DNEY--TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP--------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L---
---L-ILGKILGEGEFGSV---MEGNLK----QEDGTSLKVAVKTMKLD--NSS-QREIE-EFL-S-EAACMKDF-SHPNVIRLLGVCI--EMSSQGIPKPMVILPFMKYGDLHTYLL----YSRL----------------------------------------------------------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRN-FLHR-DLAARNCMLRD---DMTVCVADFGLSKKI--Y-S--GDYY--RQGRIAKMPVKWIAIESLADRV---YTSKSDVWAFGVTMWEIATRGMTPYPGV-QNHEMYDYL-LHGHRLKQPEDCL--------------DELYEIMYSCWRTDPLDRPT-----FSVLRLQ--L---
----VHFNEVIGRGHFGCV---YHGTLL----DNDGKKIHCAVKSLN-R--ITD-IGEVS-QFL-T-EGIIMKDF-SHPNVLSLLGICL-RSEGS-----PLVVLPYMKHGDLRNFIR----NE---------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKK-FVHR-DLAARNCMLDE---KFTVKVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQTQK---FTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYL-LQGRRLLQPEYCP--------------DPLYEVMLKCWHPKAEMRPS-----FSELVSR--I---
-THS---DRVIGKGHFGVV---YHGEYI----DQAQNRIQCAIKSLS-R--ITE-MQQVE-AFL-R-EGLLMRGL-NHPNVLALIGIML-PPEGL-----PHVLLPYMCHGDLLQFIR----SP---------------------------------------------------------------------------QRNPTVKDLISFGLQVARSMEYLAEQK-FVHR-DLAARNCMLDE---SFTVKVADFGLARDI--L-D--REYYSVQQHRHARLPVKWMALESLQTYR---FTTKSDVWSFGVLLWELLTRGAPPYRHI-DPFDLTHFL-AQGRRLPQPEYCP--------------DSLYQVMQQCWEADPAVRPT-----FRVLV----GEV-
--YV--RGRFLGKGGFAKC---FEISDA-------DTKEVFAGKIVPKS--LLLKPH--Q-REKMSMEISIHRSL-AHQHVVGFHGFFE--DNDF-----VFVVLELCRRRSLLELHK---RRK-----------------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRNR-VIHR-DLKLGNLFLNE---DLEVKIGDFGLATKV----EYDGERK--KT---LCGTPNYIAPEVLSKKG---HSFEVDVWSIGCIMYTLLV-GKPPFETS----CLKETY-LRIKKNEYSIPKHIN------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF---
----IELGRCIGEGQFGDV---HQGIYM----SPENPALAVAIKTCK-N--CTS-DSVRE-KFL-Q-EALTMRQF-DHPHIVKLIGVIT---ENP-----VWIIMELCTLGELRSFLQ----VR---------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKR-FVHR-DIAARNVLVSS---NDCVKLGDFGLSRYM----E--DSTY--YKASKGKLPIKWMAPESINFRR---FTSASDVWMFGVCMWEILMHGVKPFQGV-KNNDVIGRI-ENGERLPMPPNCP--------------PTLYSLMTKCWAYDPSRRPR-----FTELKAQL-----
---V-VLNRILGEGFFGEV---YEGVYT----NHKGEKINVAVKTCK-K--DCT-LDNKE-KFM-S-EAVIMKNL-DHPHIVKLIGIIE---EEP-----TWIIMELYPYGELGHYLE----RN---------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESIN-CVHR-DIAVRNILVAS---PECVKLGDFGLSRYI----E--DEDY--YKASVTRLPIKWMSPESINFRR---FTTASDVWMFAVCMWEILSFGKQPFFWL-ENKDVIGVL-EKGDRLPKPDLCP--------------PVLYTLMTRCWDYDPSDRPR-----FTELVCS--L---
---L-VLGKTLGEGEFGKV---VKATAFH--LKGRAGYTTVAVKMLK-E--NAS-PSELR-DLL-S-EFNVLKQV-NHPHVIKLYGACS--QDGP-----LLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMK-LVHR-DLAARNILVAE---GRKMKISDFGLSRDV--Y-E--EDSY--VKRSQGRIPVKWMAIESLFDHI---YTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHRMERPDNCS--------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL-----
----FELLKVLGQGSFGKVFLVRKVTRP-------DSGHLYAMKVLKKA--TLKVRD--R-VRTKM-ERDILADV-NHPFVVKLHYAFQ--TEGK-----LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSLG-IIYR-DLKPENILLDE---EGHIKLTDFGLSKEA----IDHEKKA--YS---FCGTVEYMAPEVVNRQG---HSHSADWWSYGVLMFEMLT-GSLPFQGK----DRKETM-TLILKAKLGMPQFLS------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY-
---L-RLEVKLGQGCFGEV---WMGTWN--------GTTRVAIKTLK-P--GTM-SP--E-AFL-Q-EAQVMKKL-RHEKLVQLYAVVS---EEP-----IYIVTEYMSKGSLLDFLK----GE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMN-YVHR-DLRAANILVGE---NLVCKVADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYRMPCPPECP--------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L---
----FTKLEKIGKGSFGEV---FKGIDN-------RTQKVVAIKIIDLE--EAEDEI--E-DIQ-Q-EITVLSQC-DSPYVTKYYGSYL--KDTK-----LWIIMEYLGGGSALDLLE----PG-----------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEK-KIHR-DIKAANVLLSE---HGEVKLADFGVAGQL----TDTQIKR--NT---FVGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELAR-GEPPHSEL-HPMKVLFLI-PKNNPPTLEGNYS--------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI---
---L-RLLEKLGDGSFGVV---RRGEWD----APSGKTVSVAVKCLK-PDVLSQ-PEAMD-DFI-R-EVNAMHSL-DHRNLIRLYGVVL---TPP-----MKMVTELAPLGSLLDRLR----KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKR-FIHR-DLAARNLLLAT---RDLVKIGDFGLMRAL-PQ-N--DDHY--VMQEHRKVPFAWCAPESLKTRT---FSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP--------------QDIYNVMVQCWAHKPEDRPT-----FVALRDF--L---
LIAD----IELGCGNFGSV---RQGVYR-----MRKKQIDVAIKVLK-Q--GTE-KADTE-EMM-R-EAQIMHQL-DNPYIVRLIGVCQ---AEA-----LMLVMEMAGGGPLHKFLV----GK---------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKN-FVHR-DLAARNVLLVN---RHYAKISDFGLSKAL-GA-D--DSYY--TARSAGKWPLKWYAPECINFRK---FSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFI-EQGKRMECPPECP--------------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M---
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