|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK INSR 203
TK ALK 1116
TK EGFR 712
TK HCK 241
TKL IRAK4 186
TK KIT 589
TK LCK 245
TK MERTK 587
TK MET 1078
TK MST1R 1082
Other PLK1 53
TK RET 724
STE STK24 24
TK TNK2 150
---ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-E--SAS-LRERI-EFL-N-EASVMKGF-TCHHVVRLLGVVS-KGQP-----TLVVMELMAHGDLKSYLR----SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCP--------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
--I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-E--VCS-EQDEL-DFL-M-EALIISKF-NHQNIVRCIGVSL-QSLP-----RFILLELMAGGDLKSFLR----ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYY--RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFV-TSGGRMDPPKNCP--------------GPVYRIMTQCWQHQPEDRPNFAIILER--I---
--F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-E--ATS-PKANK-EIL-D-EAYVMASV-DNPHVCRLLGICL--TST-----VQLITQLMPFGCLLDYVR----EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKE--YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICT--------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTMK-P--GSM-SV--E-AFL-A-EANVMKTL-QHDKLVKLHAVVT--KEP-----IYIITEFMAKGSLLDFLK----SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRAL-ERGYRMPRPENCP--------------EELYNIMMRCWKNRPEERPTFEYIQSV--L---
VGG----NKMGEGGFGVVYKGYVN-----NTT--VAVKKLAAM--VDITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSS-DGDD-----LCLVYVYMPNGSLLDRLSCLDGTP-----------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE--KFAQTVMT--SR---IVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIIT-GLPAVDEH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
---LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-P--SAH-LTERE-ALM-S-ELKVLSYLGNHMNIVNLLGACT-IGGP-----TLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI--K-N--DSNY--VVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAP--------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I---
---LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-Q--GSM-SP--D-AFL-A-EANLMKQL-QHQRLVRLYAVVT--QEP-----IYIITEYMENGSLVDFLK----TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI----E--DNEY--TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP--------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
--L-ILGKILGEGEFGSVMEGNLK--QEDGTSLKVAVKTMKLD--NSS-QREIE-EFL-S-EAACMKDF-SHPNVIRLLGVCI-EMSSQGIPKPMVILPFMKYGDLHTYLL----YSRL----------------------------------------------------------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKI--Y-S--GDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGV-QNHEMYDYL-LHGHRLKQPEDCL--------------DELYEIMYSCWRTDPLDRPTFSVLRLQ--L---
---VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLN-R--ITD-IGEVS-QFL-T-EGIIMKDF-SHPNVLSLLGICLRSEGS-----PLVVLPYMKHGDLRNFIR----NE---------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYL-LQGRRLLQPEYCP--------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I---
THS---DRVIGKGHFGVVYHGEYI--DQAQNRIQCAIKSLS-R--ITE-MQQVE-AFL-R-EGLLMRGL-NHPNVLALIGIMLPPEGL-----PHVLLPYMCHGDLLQFIR----SP---------------------------------------------------------------------------QRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDE---SFTVKVADFGLARDI--L-D--REYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHI-DPFDLTHFL-AQGRRLPQPEYCP--------------DSLYQVMQQCWEADPAVRPTFRVLV----GEV-
-YV--RGRFLGKGGFAKCFEISDA-----DTKEVFAGKIVPKS--LLLKPH--Q-REKMSMEISIHRSL-AHQHVVGFHGFFE-DNDF-----VFVVLELCRRRSLLELHK---RRK-----------------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNE---DLEVKIGDFGLATKV----EYDGERK--KT---LCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLV-GKPPFETS----CLKETY-LRIKKNEYSIPKHIN------------PVAASLIQKMLQTDPTARPTINELLNDEFF---
--L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-E--NAS-PSELR-DLL-S-EFNVLKQV-NHPHVIKLYGACS-QDGP-----LLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV--Y-E--EDSY--VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHRMERPDNCS--------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
---FTKLEKIGKGSFGEVFKGIDN-----RTQKVVAIKIIDLE--EAEDEI--E-DIQ-Q-EITVLSQC-DSPYVTKYYGSYL-KDTK-----LWIIMEYLGGGSALDLLE----PG-----------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL----TDTQIKR--NT---FVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAR-GEPPHSEL-HPMKVLFLI-PKNNPPTLEGNYS--------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI---
--L-RLLEKLGDGSFGVVRRGEWD--APSGKTVSVAVKCLK-PDVLSQ-PEAMD-DFI-R-EVNAMHSL-DHRNLIRLYGVVL--TPP-----MKMVTELAPLGSLLDRLR----KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL-PQ-N--DDHY--VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP--------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---
|