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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK INSR 203
TKL BRAF 456
TK CSF1R 582
TK EGFR 712
TK ERBB2 720
TK FGFR1 478
TK FGFR3 472
TK ITK 363
TK JAK2 849
TK KDR 834
TK LCK 245
TK PDGFRB 600
Other PLK1 53
TK PTK2 422
TK PTK2B 425
TK SRC 270
TK SYK 371
TK ZAP70 338
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E-SAS-LRE-RIEFL-N-EASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR-SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-YE--TDYY-RKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFVMDGGY----LDQPDNCP--ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
----ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-VTAPT-PQQ-LQAFK-N-EVGVLRKT-RHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLH-II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-SR--WSGS-HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCP--KAMKRLMAECLKKKRDERPLFPQILA---SI-
----LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLK-S-TAH-ADE-KEALM-S-ELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLR-RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-MN--DSNY-IVKGNARLPVKWMAPESIFDCV---YTVQSDVWSYGILLWEIFSLGLNP---------------YPGILVNSKFYKLVKDGYQ----MAQPAFAP--KNIYSIMQACWALEPTHRPTFQQICSFL----
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E-ATS-PKA-NKEIL-D-EAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR-EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GA--EEKE-YHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGER----LPQPPICT--IDVYMIMVKCWMIDADSRPKFRELI----IEF
---L-RKVKVLGSGAFGTVYKGIWIP---DGENVKIPVAIKVLR-E-NTS-PKA-NKEIL-D-EAYVMAGV-GSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHVR-EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL-DI--DETE-YHADGGKVPIKWMALESILRRR---FTHQSDVWSYGVTVWELMTFGAKP---------------YDGI-PAREIPDLLEKGER----LPQPPICT--IDVYMIMVKCWMIDSECRPRFRELVSE--F--
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S-DAT-EKD-LSDLI-S-EMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ-ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HH--IDYY-KKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHR----MDKPSNCT--NELYMMMRDCWHAVPSQRPTFKQLVEDL----
----LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK-D-DAT-DKD-LSDLV-S-EMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLR-ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV-HN--LDYY-KKTTNGRLPVKWMAPEALFDRV---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGI-PVEELFKLLKEGHR----MDKPANCT--HDLYMIMRECWHAAPSQRPTFKQLVEDL----
----LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-E-GAM-SE---EDFI-E-EAEVMMKL-SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR-TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV--L--DDQY-TSSTGTKFPVKWASPEVFSFSR---YSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFR----LYKPRLAS--THVYQIMNHCWKERPEDRPAFSRLLRQL----
----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H-STE--EH-LRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYY-KVKEPGESPIFWYAPESLTESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCP--DEIYMIMTECWNNNVNQRPSFRDLA----LRV
----LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-E-GAT-HSE-HRALM-S-ELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLR-SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-YK--DPDY-VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTR----MRAPDYTT--PEMYQTMLDCWHGEPSQRPTFSELVEHL----
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q-GSM-SP---DAFL-A-EANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK-TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYR----MVRPDNCP--EELYQLMRLCWKERPEDRPTFDYLRSV--L--
---L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-S-TAR-SSE-KQALM-S-ELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLH-RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-MR--DSNY-ISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAIKRGYR----MAQPAHAS--DEIYEIMQKCWEEKFEIRPPFSQLVL---LL-
--YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKS-LLLKPH---QREKMSMEISIHRSL-AHQHVVGFHGFFE--DNDFVFVVLELCRRRSLLELHKRRK----------------------------------------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV--EYDGERK-KT---LCGTPNYIAPEVLSKKG---HSFEVDVWSIGCIMYTLLV-GKPP---------------FETS----CLKETYLRIKK----NEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF--
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N-CTS-DSV-REKFL-Q-EALTMRQF-DHPHIVKLIGVIT---ENPVWIIMELCTLGELRSFLQ-VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM--E--DSTY-YKASKGKLPIKWMAPESINFRR---FTSASDVWMFGVCMWEILMHGVKP---------------FQGV-KNNDVIGRIENGER----LPMPPNCP--PTLYSLMTKCWAYDPSRRPRFTELKAQL----
---V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-K-DCT-LDN-KEKFM-S-EAVIMKNL-DHPHIVKLIGIIE---EEPTWIIMELYPYGELGHYLE-RN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI--E--DEDY-YKASVTRLPIKWMSPESINFRR---FTTASDVWMFAVCMWEILSFGKQP---------------FFWL-ENKDVIGVLEKGDR----LPKPDLCP--PVLYTLMTRCWDYDPSDRPRFTELVCS--L--
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P-GTM-SP---EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK-GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYR----MPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
-TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-N-EAN-DPALKDELL-A-EANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ-QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECINYYK---FSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAMLEKGER----MGCPAGCP--REMYDLMNLCWTYDVENRPGFAAVE----LRL
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q-GTE-KAD-TEEMM-R-EAQIMHQL-DNPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLV-GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY-TARSAGKWPLKWYAPECINFRK---FSSRSDVWSYGVTMWEALSYGQKP---------------YKKM-KGPEVMAFIEQGKR----MECPPECP--PELYALMSDCWIYKWEDRPDFLTVEQR--M--
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