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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK INSRR 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TKL ACVR1B 207
TK ALK 1116
Other AURKC 43
TK BLK 241
TK BMX 422
TK BTK 402
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA2 613
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK EPHB6 670
TK ERBB3 709
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FRK 234
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK1 212
TKL IRAK3 165
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK KDR 834
TK LCK 245
TK LTK 510
TK LYN 247
TK MATK 235
Other NEK4 6
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK2B 425
TK PTK6 191
TK RET 724
TK SRC 270
TK SRMS 230
STE STK24 24
STE STK39 63
TK SYK 371
TK TEC 370
TK TEK 824
TKL TGFBR1 205
TK TIE1 839
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
STE YSK4 1162
TK ZAP70 338
------I-SIIRELGQGSFGMVYEGLARG-----------LEAGEESTPVALKTVN-E--LAS-PRE-CI-EFL-K----EASVMKAF-KCHHVVRLLGVVS--Q----GQPTLVIMELMTRGDLKSHLR---------SLRPEA-----------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAAN--------KFVHRDLAARNCMVSQ---DFTV---KIGDFGMTRDV------Y-----E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGIFTTHSDVWSFGVVLWEIVTLAE----------QP---------------YQGL-----SNEQVLKFV----MD----GGV---LEELEGCP-------------------------------------------LQLQE-LMSRCWQPNPRLRPSFTHILD---SI--
-------ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLK-E--DTM-EV---E-EFL-K----EAAVMKEI-KHPNLVQLLGVCT--R----EPPFYIITEFMTYGNLLDYLR---------EC-------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE---NHLV---KVADFGLSRLM------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYELL----EK----DYR---MERPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F---
-------ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLK-E--DTM-EV---E-EFL-K----EAAVMKEI-KHPNLVQLLGVCT--L----EPPFYIVTEYMPYGNLLDYLR---------EC-------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE---NHVV---KVADFGLSRLM------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNTFSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYDLL----EK----GYR---MEQPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F---
------I-TLLECVGKGRYGEVWRGSWQ----------------GEN--VAVKIFSSR--DEKSWF---R-ET-------ELYNTVML-RHENILGFIASDM--TSRHSSTQLWLITHYHEMGSLYDYLQ---------LT----------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKK---NGQC---CIADLGLAVMHSQ--------STNQLDVGN--------------NP---RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAR-RMVSNGIVEDYKPP---------------FYDVVPNDPSFEDMRKVV----CV----DQQ---RPNIPNRWFSDPTL-------------------------------------TSLAK-LMKECWYQNPSARLTALRIKK----TL-
-----IV--LQEIIGKGRFGEVWRGRWR----------------GGD--VAVKIFSSR--EERSWF---R-EA-------EIYQTVML-RHENILGFIAADN--KDNGTWTQLWLVSDYHEHGSLFDYLN---------RY----------------------------------------------------------------------TVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKK---NGMC---AIADLGLAVRHDA--------VTDTIDIAP--------------NQ---RVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIAR-RCNSGGVHEEYQLP---------------YYDLVPSDPSIEEMRKVV----CD----QKL---RPNIPNWWQSYEAL-------------------------------------RVMGK-MMRECWYANGAARLTALRIKK----TL-
------I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTLP-E--VCS-EQD-EL-DFL-M----EALIISKF-NHQNIVRCIGVSL--Q----SLPRFILLELMAGGDLKSFLR---------ETRP--------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLTCPGPGRVA---KIGDFGMARDI------Y-----R--ASYY--------------RKGGCAMLPVKWMPPEAFM------EGIFTSKTDTWSFGVLLWEIFSLGY----------MP---------------YPSK-----SNQEVLEFV----TS----GGR---MDPPKNCP-------------------------------------------GPVYR-IMTQCWQHQPEDRPNFAIILER--I---
-------FEIGRPLGKGKFGNVYLARLK----------------ESHFIVALKVLFKS--QIEKEG---L-EHQLR---REIEIQAHL-QHPNILRLYNYFH--D----ARRVYLILEYAPRGELYKELQ--------KSE----------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK--------KVIHRDIKPENLLLGF---RGEV---KIADFGWSV--------------HTPSLRR--------------KT---MCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GY----------PP---------------FESA--------SHSETY----RR----ILK---VDVRFPLSMP-----------------------------------------LGARD-LISRLLRYQPLERLPLAQILKHPWV---
------L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTLK-E--GTM-SP---E-AFL-G----EANVMKAL-QHERLVRLYAVVT-------KEPIYIVTEYMARGCLLDFLK---------TD-------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVSE---ALCC---KIADFGLARII---------------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGVFTIKADVWSFGVLLMEVVTYGR----------VP---------------YPGM-----SNPEVIRNL----ER----GYR---MPRPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L---
-------ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAVKMIK-E--GSM-SE---D-EFF-Q----EAQTMMKL-SHPKLVKFYGVCS--K----EYPIYIVTEYISNGCLLNYLR---------SH--------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVDR---DLCV---KVSDFGMTRYV------------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFKYSSKSDVWAFGILMWEVFSLGK----------QP---------------YDLY-----DNSQVVLKV----SQ----GHR---LYRPHLAS-------------------------------------------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I---
-------LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMIK-E--GSM-SE---D-EFI-E----EAKVMMNL-SHEKLVQLYGVCT--K----QRPIFIITEYMANGCLLNYLR---------EM--------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVND---QGVV---KVSDFGLSRYV------------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSKFSSKSDIWAFGVLMWEIYSLGK----------MP---------------YERF-----TNSETAEHI----AQ----GLR---LYRPHLAS-------------------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I---
-------LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKMLK-S--TAH-ADE-KE-ALM-S----ELKIMSHLGQHENIVNLLGACT--H----GGPVLVITEYCCYGDLLNFLR---------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLTN---GHVA---KIGDFGLARDI------M-----N--DSNY--------------IVKGNARLPVKWMAPESIF------DCVYTVQSDVWSYGILLWEIFSLGL----------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ---MAQPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPTFQQICSFL-----
-------LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCIK-N--DAT-AQ-----AFL-A----EASVMTQL-RHSNLVQLLGVIV-EE----KGGLYIVTEYMAKGSLVDYLR---------SR-------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSE---DNVA---KVSDFGLTKEA------------------S--------------STQDTGKLPVKWTAPEALR------EKKFSTKSDVWSFGILLWEIYSFGR----------VP---------------YPRI-----PLKDVVPRV----EK----GYK---MDAPDGCP-------------------------------------------PAVYE-VMKNCWHLDAAMRPSFLQLREQL-----
-------LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-P--DAT-KNA-RN-DFL-K----EVKIMSRL-KDPNIIRLLGVCV--Q----DDPLCMITDYMENGDLNQFLS---------AHQLEDKAAE--------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVGE---NFTI---KIADFGMSRNL------Y-----A--GDYY--------------RVQGRAVLPIRWMAWECIL------MGKFTTASDVWAFGVTLWEVLMLCRA---------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQVYLSRPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPPFSQLHRFL-----
-------LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR-A--DAN-KNA-RN-DFL-K----EIKIMSRL-KDPNIIHLLAVCI--T----DDPLCMITEYMENGDLNQFLS---------RHEPPN-----------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL--------NFVHRDLATRNCLVGK---NYTI---KIADFGMSRNL------Y-----S--GDYY--------------RIQGRAVLPIRWMSWESIL------LGKFTTASDVWAFGVTLWETFTFCQE---------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQTYLPQPAICP-------------------------------------------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL--
------F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKELR-E--ATS-PKA-NK-EIL-D----EAYVMASV-DNPHVCRLLGICL-------TSTVQLITQLMPFGCLLDYVR---------EH--------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKT---PQHV---KITDFGLAKLL------G-----A--EEKE--------------YHAEGGKVPIKWMALESIL------HRIYTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI-----PASEISSIL----EK----GER---LPQPPICT-------------------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF-
-----LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAIKTLK-D--TSP-GGQ-WW-NFL-R----EATIMGQF-SHPHILHLEGVVT--K----RKPIMIITEFMENGALDAFLR---------ER--------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNH--------NYVHRDLAARNILVNQ---NLCC---KVSDFGLTRLL------D-----D--FDGT--------------YETQGGKIPIRWTAPEAIA------HRIFTTASDVWSFGIVMWEVLSFGD----------KP---------------YGEM-----SNQEVMKSI----ED----GYR---LPPPVDCP-------------------------------------------APLYE-LMKNCWAYDRARRPHFQKLQAHL-----
------V-TRQKVIGAGEFGEVYKGMLKT------------SSGKKEVPVAIKTLK-A--GYT-EKQ-RV-DFL-G----EAGIMGQF-SHHNIIRLEGVIS--K----YKPMMIITEYMENGALDKFLR---------EK--------------------------------------------------------------------DGEFSVLQLVGMLRGIAAGMKYLANM--------NYVHRDLAARNILVNS---NLVC---KVSDFGLSRVL------E-----D--DPEA-------------TYTTSGGKIPIRWTAPEAIS------YRKFTSASDVWSFGIVMWEVMTYGE----------RP---------------YWEL-----SNHEVMKAI----ND----GFR---LPTPMDCP-------------------------------------------SAIYQ-LMMQCWQQERARRPKFADIVSIL-----
------I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAIKTLK-V--GYT-EKQ-RR-DFL-G----EASIMGQF-DHPNIIRLEGVVT--K----SKPVMIVTEYMENGSLDSFLR---------KH--------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILINS---NLVC---KVSDFGLSRVL------E-----D--DPEA-------------AYTTRGGKIPIRWTSPEAIA------YRKFTSASDVWSYGIVLWEVMSYGE----------RP---------------YWEM-----SNQDVIKAV----DE----GYR---LPPPMDCP-------------------------------------------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL-----
-------IKIEKVIGVGEFGEVCSGRLK-------------VPGKREICVAIKTLK-A--GYT-DKQ-RR-DFL-S----EASIMGQF-DHPNIIHLEGVVT--K----CKPVMIITEYMENGSLDAFLR---------KN--------------------------------------------------------------------DGRFTVIQLVGMLRGIGSGMKYLSDM--------SYVHRDLAARNILVNS---NLVC---KVSDFGMSRVL------E-----D--DPEA-------------AYTTRGGKIPIRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSYGE----------RP---------------YWDM-----SNQDVIKAI----EE----GYR---LPPPMDCP-------------------------------------------IALHQ-LMLDCWQKERSDRPKFGQIVNML-----
-------ITIERVIGAGEFGEVCSGRLK-------------LPGKRELPVAIKTLK-V--GYT-EKQ-RR-DFL-G----EASIMGQF-DHPNIIHLEGVVT--K----SKPVMIVTEYMENGSLDTFLK---------KN--------------------------------------------------------------------DGQFTVIQLVGMLRGISAGMKYLSDM--------GYVHRDLAARNILINS---NLVC---KVSDFGLSRVL------E-----D--DPEA-------------AYTTRGGKIPIRWTAPEAIA------FRKFTSASDVWSYGIVMWEVVSYGE----------RP---------------YWEM-----TNQDVIKAV----EE----GYR---LPSPMDCP-------------------------------------------AALYQ-LMLDCWQKERNSRPKFDEIVNML-----
LPPRIPA------------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR---------KH--------------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILVNS---NLVC---KVSDFGLSRVL------E-----D--DPEA-------------AYTTTGGKIPIRWTAPEAIA------YRKFSSASDAWSYGIVMWEVMSYGE----------RP---------------YWEM-----SNQDVILSI----EE----GYR---LPAPMGCP-------------------------------------------ASLHQ-LMLHCWQKERNHRPKFTDIVSFL-----
-------IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKALK-A--GYT-ERQ-RR-DFL-S----EASIMGQF-DHPNIIRLEGVVT--R----GRLAMIVTEYMENGSLDTFLR---------TH--------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVDS---NLVC---KVSDFGLSRVL------E-----D--DPDA-------------AYTTTGGKIPIRWTAPEAIA------FRTFSSASDVWSFGVVMWEVLAYGE----------RP---------------YWNM-----TNRDVISSV----EE----GYR---LPAPMGCP-------------------------------------------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL-----
------V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTLK-A--GYS-EKQ-RR-DFL-S----EASIMGQF-DHPNIIRLEGVVT--K----SRPVMIITEFMENGALDSFLR---------QN--------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVNS---NLVC---KVSDFGLSRYLQ---DDT-----S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LPPPMDCP-------------------------------------------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL-----
------V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTLK-S--GYT-EKQ-RR-DFL-S----EASIMGQF-DHPNVIHLEGVVT--K----STPVMIITEFMENGSLDSFLR---------QN--------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVNS---NLVC---KVSDFGLSRFLE---DDT-----S--DPTY--------------TSALGGKIPIRWTAPEAIQ------YRKFTSASDVWSYGIVMWEVMSYGE----------RP---------------YWDM-----TNQDVINAI----EQ----DYR---LPPPMDCP-------------------------------------------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL-----
------V-KIEEVIGAGEFGEVCRGRLK-------------QPGRREVFVAIKTLK-V--GYT-ERQ-RR-DFL-S----EASIMGQF-DHPNIIRLEGVVT--K----SRPVMILTEFMENCALDSFLR---------LN--------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLSEM--------NYVHRDLAARNILVNS---NLVC---KVSDFGLSRFLE---DDP-----S--DPTY--------------TSSLGGKIPIRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSYGE----------RP---------------YWDM-----SNQDVINAV----EQ----DYR---LPPPMDCP-------------------------------------------TALHQ-LMLDCWVRDRNLRPKFSQIVNTL-----
------V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAIKTLK-G--GYT-ERQ-RR-EFL-S----EASIMGQF-EHPNIIRLEGVVT--N----SMPVMILTEFMENGALDSFLR---------LN--------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNS---NLVC---KVSDFGLSRFLE---ENS-----S--DPTY--------------TSSLGGKIPIRWTAPEAIA------FRKFTSASDAWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LPPPPDCP-------------------------------------------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL-----
-------IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQALW-A--GGA-ESL-QM-TFL-G----RAAVLGQF-QHPNILRLEGVVT--K----SRPLMVLTEFMELGPLDSFLR---------QR--------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVNS---HLVC---KVARLGHSPQG--------------------------------------PSCLLRWAAPEVIA------HGKHTTSSDVWSFGILMWEVMSYGE----------RP---------------YWDM-----SEQEVLNAI----EQ----EFR---LPPPPGCP-------------------------------------------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF--
------L-RKLKVLGSGVFGTVHKGVWIP------------EGESIKIPVCIKVIE-D--KSG-RQS-FQ-AVT-D----HMLAIGSL-DHAHIVRLLGLCP-------GSSLQLVTQYLPLGSLLDHVR---------QH--------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEH--------GMVHRNLAARNVLLKS---PSQV---QVADFGVADLL------P-----P--DDKQ--------------LLYSEAKTPIKWMALESIH------FGKYTHQSDVWSYGVTVWELMTFGA----------EP---------------YAGL-----RLAEVPDLL----EK----GER---LAQPQICT-------------------------------------------IDVYM-VMVKCWMIDENIRPTFKELANE--F---
------L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKILN-E--TTG-PKA-NV-EFM-D----EALIMASM-DHPHLVRLLGVCL-------SPTIQLVTQLMPHGCLLEYVH---------EH--------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVKS---PNHV---KITDFGLARLL------E-----G--DEKE--------------YNADGGKMPIKWMALECIH------YRKFTHQSDVWSYGVTIWELMTFGG----------KP---------------YDGI-----PTREIPDLL----EK----GER---LPQPPICT-------------------------------------------IDVYM-VMVKCWMIDADSRPKFKELAAE--F---
-----VI--LGELLGKGNFGEVYKGTLK-----------------DKTSVAVKTCK-E--DLP-QEL-KI-KFL-Q----EAKILKQY-DHPNIVKLIGVCT--Q----RQPVYIIMELVSGGDFLTFLR---------RK--------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESK--------NCIHRDLAARNCLVGE---NNVL---KISDFGMSRQE------------D--GGVY--------------SSSGLKQIPIKWTAPEALN------YGRYSSESDVWSFGILLWETFSLGV----------CP---------------YPGM-----TNQQAREQV----ER----GYR---MSAPQHCP-------------------------------------------EDISK-IMMKCWDYKPENRPKFSELQKEL-----
------L-VLGEQIGRGNFGEVFSGRLR----------------ADNTLVAVKSCR-E--TLP-PDL-KA-KFL-Q----EARILKQY-SHPNIVRLIGVCT--Q----KQPIYIVMELVQGGDFLTFLR---------TE--------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK--------CCIHRDLAARNCLVTE---KNVL---KISDFGMSREE------A-----D--GVYA--------------ASGGLRQVPVKWTAPEALN------YGRYSSESDVWSFGILLWETFSLGA----------SP---------------YPNL-----SNQQTREFV----EK----GGR---LPCPELCP-------------------------------------------DAVFR-LMEQCWAYEPGQRPSFSTIYQEL-----
------L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLK-S--DAT-EKD-LS-DLI-S----EMEMMKMIGKHKNIINLLGACT--Q----DGPLYVIVEYASKGNLREYLQ---------ARRPPGLEY-----------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVTE---DNVM---KIADFGLARDI------H-----H--IDYY--------------KKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGV-----PVEELFKLL----KE----GHR---MDKPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-----
-------LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKMLK-D--DAT-EKD-LS-DLV-S----EMEMMKMIGKHKNIINLLGACT--Q----DGPLYVIVEYASKGNLREYLR---------ARRPPGMEY-----------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVTE---NNVM---KIADFGLARDI------N-----N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLMWEIFTLGG----------SP---------------YPGI-----PVEELFKLL----KE----GHR---MDKPANCT-------------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-----
-------LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKMLK-D--DAT-DKD-LS-DLV-S----EMEMMKMIGKHKNIINLLGACT--Q----GGPLYVLVEYAAKGNLREFLR---------ARRPPGLDY-----------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVTE---DNVM---KIADFGLARDV------H-----N--LDYY--------------KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGI-----PVEELFKLL----KE----GHR---MDKPANCT-------------------------------------------HDLYM-IMRECWHAAPSQRPTFKQLVEDL-----
------L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKMLK-D--NAS-DKD-LA-DLV-S----EMEVMKLIGRHKNIINLLGVCT--Q----EGPLYVIVECAAKGNLREFLR---------ARRPPGPDL-----------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--------KCIHRDLAARNVLVTE---DNVM---KIADFGLARGV------H-----H--IDYY--------------KKTSNGRLPVKWMAPEALF------DRVYTHQSDVWSFGILLWEIFTLGG----------SP---------------YPGI-----PVEELFSLL----RE----GHR---MDRPPHCP-------------------------------------------PELYG-LMRECWHAAPSQRPTFKQLVEAL-----
-------ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTLK-P--GTM-SP---K-AFL-E----EAQVMKLL-RHDKLVQLYAVVS-------EEPIYIVTEFMCHGSLLDFLK---------NP-------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVGE---RLAC---KIADFGLARLI------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGRFTIKSDVWSFGILLTELITKGR----------IP---------------YPGM-----NKREVLEQV----EQ----GYH---MPCPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPTFEYLQSFL-----
-------LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKMLK-E--GAT-ASE-HR-ALM-S----ELKILIHIGNHLNVVNLLGACT-KP----QGPLMVIVEFCKYGNLSNFLR---------AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASR--------KCIHRDLAARNILLSE---SDVV---KICDFGLARDI------Y-----K--DPDY--------------VRKGSARLPLKWMAPESIF------DKVYTTQSDVWSFGVLLWEIFSLGA----------SP---------------YPGV-Q---INEEFCQRL----RD----GTR---MRAPELAT-------------------------------------------PAIRR-IMLNCWSGDPKARPAFSELVEIL-----
-------IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTLK-P--GSM-DP---N-DFL-R----EAQIMKNL-RHPKLIQLYAVCT--L----EDPIYIITELMRHGSLQEYLQ---------ND-------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVGE---HNIY---KVADFGLARVFK----VD-----N--EDIY--------------ESRHEIKLPVKWTAPEAIR------SNKFSIKSDVWSFGILLYEIITYGK----------MP---------------YSGM-----TGAQVIQML----AQ----NYR---LPQPSNCP-------------------------------------------QQFYN-IMLECWNAEPKERPTFETLRWK--L---
-------LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTLK-P--GTM-SP---E-SFL-E----EAQIMKKL-KHDKLVQLYAVVS-------EEPIYIVTEYMNKGSLLDFLK---------DG-------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGN---GLIC---KIADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGR----------VP---------------YPGM-----NNREVLEQV----ER----GYR---MPCPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPTFEYLQSFL-----
-------LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTMK-P--GSM-SV---E-AFL-A----EANVMKTL-QHDKLVKLHAVVT-------KEPIYIITEFMAKGSLLDFLK---------SD-------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSA---SLVC---KIADFGLARVI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGR----------IP---------------YPGM-----SNPEVIRAL----ER----GYR---MPRPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPTFEYIQSV--L---
-------ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTVN-E--AAS-MRE-RI-EFL-N----EASVMKEF-NCHHVVRLLGVVS--Q----GQPTLVIMELMTRGDLKSYLR---------SLRPEM-----------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN--------KFVHRDLAARNCMVAE---DFTV---KIGDFGMTRDI------Y-----E--TDYY--------------RKGGKGLLPVRWMSPESLK------DGVFTTYSDVWSFGVVLWEIATLAE----------QP---------------YQGL-----SNEQVLRFV----ME----GGL---LDKPDNCP-------------------------------------------DMLFE-LMRMCWQYNPKMRPSFLEIISS--I---
-------ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTVN-E--SAS-LRE-RI-EFL-N----EASVMKGF-TCHHVVRLLGVVS--K----GQPTLVVMELMAHGDLKSYLR---------SLRPEA-----------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVAH---DFTV---KIGDFGMTRDI------Y-----E--TDYY--------------RKGGKGLLPVRWMAPESLK------DGVFTTSSDMWSFGVVLWEITSLAE----------QP---------------YQGL-----SNEQVLKFV----MD----GGY---LDQPDNCP-------------------------------------------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL-----
---FSEE----LKIGEGGFGCVYRAVMR----------------NTV--YAVKRLKEN--ADLEWT---A-VKQSFL--TEVEQLSRF-RHPNIVDFAGYCA--Q----NGFYCLVYGFLPNGSLEDRLHCQ----TQACP----------------------------------------------------------------------PLSWPQRLDILLGTARAIQFLHQDS------PSLIHGDIKSSNVLLDE---RLTP---KLGDFGLARFSRFAG---SSPSQSSMVART--------------QT---VRGTLAYLPEEYIK------TGRLAVDTDTFSFGVVVLETLA-GQ----------RA---------------VKTHG---AR-TKYLKDL----VE----EEA---EEAGVALRST---QSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQ-LACCCLHRRAKRRPPMTQVYE----RL-
--FHKDF-----LIGEGEIFEVYRVEIQ----------------NLT--YAVKLFKQE--KKMQCK---K-HWKRFL--SELEVLLLF-HHPNILELAAYFT--E----TEKFCLIYPYMRNGTLFDRLQC-----VGDTA----------------------------------------------------------------------PLPWHIRIGILIGISKAIHYLHNVQ-----PCSVICGSISSANILLDD---QFQP---KLTDFAMAHFRSHL------EHQSCTINMT--------------SS---SSKHLWYMPEEYIR------QGKLSIKTDVYSFGIVIMEVLT-GC----------RV---------------VLDD-----PKHIQLRDL----LR----ELM---EKRGLDSCLSFLDKKVPPC---------------------------PRNFSAKLFC-LAGRCAATRAKLRPSMDEVLNT---L--
----VGG----NKMGEGGFGVVYKGYVN----------------NTT--VAVKKLAAM--VDITTE---ELKQQFD---QEIKVMAKC-QHENLVELLGFSS--D----GDDLCLVYVYMPNGSLLDRLSC-----LDGTP----------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLDE---AFTA---KISDFGLARASE----------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GEITPKSDIYSFGVVLLEIIT-GL----------PA---------------VDEH-----REPQLLLDI----KE----EIE---DEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYS-VASQCLHEKKNKRPDIKKVQQ----LLQ
-------LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTIR-E--GAM-SE---E-DFI-E----EAEVMMKL-SHPKLVQLYGVCL--E----QAPICLVFEFMEHGCLSDYLR---------TQ--------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--------CVIHRDLAARNCLVGE---NQVI---KVSDFGMTRFV------------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSRYSSKSDVWSFGVLMWEVFSEGK----------IP---------------YENR-----SNSEVVEDI----ST----GFR---LYKPRLAS-------------------------------------------THVYQ-IMNHCWKERPEDRPAFSRLLRQL-----
-------LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKLQ-H--STE--EH-LR-DFE-R----EIEILKSL-QHDNIVKYKGVCYSAG----RRNLKLIMEYLPYGSLRDYLQ---------KH--------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVEN---ENRV---KIGDFGLTKVL-----PQ-----D--KEYY--------------KVKEPGESPIFWYAPESLT------ESKFSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR---LPRPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV-
-------LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKMLK-E--GAT-HSE-HR-ALM-S----ELKILIHIGHHLNVVNLLGACT-KP----GGPLMVIVEFCKFGNLSTYLR---------SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASR--------KCIHRDLAARNILLSE---KNVV---KICDFGLARDI------Y-----K--DPDY--------------VRKGDARLPLKWMAPETIF------DRVYTIQSDVWSFGVLLWEIFSLGA----------SP---------------YPGV-K---IDEEFCRRL----KE----GTR---MRAPDYTT-------------------------------------------PEMYQ-TMLDCWHGEPSQRPTFSELVEHL-----
-------LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLK-Q--GSM-SP---D-AFL-A----EANLMKQL-QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK---------TP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSD---TLSC---KIADFGLARLI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM-----TNPEVIQNL----ER----GYR---MVRPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L---
------V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTLP-E--LCS-PQD-EL-DFL-M----EALIISKF-RHQNIVRCVGLSL--R----ATPRLILLELMSGGDMKSFLR---------HSRP--------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--------HFIHRDIAARNCLLSCAGPSRVA---KIGDFGMARDI------Y-----R--ASYY--------------RRGDRALLPVKWMPPEAFL------EGIFTSKTDSWSFGVLLWEIFSLGY----------MP---------------YPGR-----TNQEVLDFV----VG----GGR---MDPPRGCP-------------------------------------------GPVYR-IMTQCWQHEPELRPSFASILERL-----
-------IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTLK-P--GTM-SV---Q-AFL-E----EANLMKTL-QHDKLVRLYAVVT--R----EEPIYIITEYMAKGSLLDFLK---------SD-------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVSE---SLMC---KIADFGLARVI------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGCFTIKSDVWSFGILLYEIVTYGK----------IP---------------YPGR-----TNADVMTAL----SQ----GYR---MPRVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPTFDYLQSV--L---
-------LTLGAQIGEGEFGAVLQGEYL------------------GQKVAVKNIK-C--DVT-AQ-----AFL-D----ETAVMTKM-QHENLVRLLGVIL-------HQGLYIVMEHVSKGNLVNFLR---------TR-------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESK--------KLVHRDLAARNILVSE---DLVA---KVSDFGLAKAE------------------R--------------KGLDSSRLPVKWTAPEALK------HGKFTSKSDVWSFGVLLWEVFSYGR----------AP---------------YPKM-----SLKEVSEAV----EK----GYR---MEPPEGCP-------------------------------------------GPVHV-LMSSCWEAEPARRPPFRKLAEKL-----
------Y-CYLRVVGKGSYGEVTLVKHR----------------RDGKQYVIKKLNLR--NASSRE---R-RAAEQ----EAQLLSQL-KHPNIVTYKESWE--G---GDGLLYIVMGFCEGGDLYRKLKE------QKGQ----------------------------------------------------------------------LLPENQVVEWFVQIAMALQYLHEK--------HILHRDLKTQNVFLTR---TNII---KVGDLGIARVL------------ENHCDMA--------------ST---LIGTPYYMSPELFS------NKPYNYKSDVWALGCCVYEMAT-LK----------HA---------------FNAK--------DMNSLV----YR----IIE---GKLPPMPRDY---S-------------------------------------PELAE-LIRTMLSKRPEERPSVRSILRQPYI---
-----IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKALK-E--ASE-SA--RQ-DFQ-R----EAELLTML-QHQHIVRFFGVCT--E----GRPLLMVFEYMRHGDLNRFLR---------SHGPDAKL------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--------HFVHRDLATRNCLVGQ---GLVV---KIGDFGMSRDI------Y-----S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRKFTTESDVWSFGVVLWEIFTYGK----------QP---------------WYQL-----SNTEAIDCI----TQ----GRE---LERPRACP-------------------------------------------PEVYA-IMRGCWQREPQQRHSIKDVHARL-----
------I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTLK-D--ASD-NA--RK-DFH-R----EAELLTNL-QHEHIVKFYGVCV--E----GDPLIMVFEYMKHGDLNKFLR---------AHGPDAV--------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--------HFVHRDLATRNCLVGE---NLLV---KIGDFGMSRDV------Y-----S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRKFTTESDVWSLGVVLWEIFTYGK----------QP---------------WYQL-----SNNEVIECI----TQ----GRV---LQRPRTCP-------------------------------------------QEVYE-LMLGCWQREPHMRKNIKGIHTL--L---
------I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKALK-D--PTL-AA--RK-DFQ-R----EAELLTNL-QHEHIVKFYGVCG--D----GDPLIMVFEYMKHGDLNKFLR---------AHGPDAMIL-----------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--------HFVHRDLATRNCLVGA---NLLV---KIGDFGMSRDV------Y-----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRKFTTESDVWSFGVILWEIFTYGK----------QP---------------WFQL-----SNTEVIECI----TQ----GRV---LERPRVCP-------------------------------------------KEVYD-VMLGCWQREPQQRLNIKEIYKIL-----
-----PD----EVLGSGQFGIVYGGKHR----------------KTGRDVAIKIIDKL--RFPTKQ---E-SQLRN----EVAILQNL-HHPGVVNLECMFE--T----PERVFVVMEKLHGDMLEMILS-------SEKG----------------------------------------------------------------------RLPEHITKFLITQILVALRHLHFK--------NIVHCDLKPENVLLAS---ADPFPQVKLCDFGFARI-------------IGEKSFR--------------RS---VVGTPAYLAPEVLR------NKGYNRSLDMWSVGVIIYVSLS-GT----------FP---------------FNED----------EDIH----DQ----IQN---AAFMYPPNPWKEIS-------------------------------------HEAID-LINNLLQVKMRKRYSVDKTLSHPWL---
-----PD----EVLGSGQFGVVYGGKHR----------------KTGRDVAVKVIDKL--RFPTKQ---E-SQLRN----EVAILQSL-RHPGIVNLECMFE--T----PEKVFVVMEKLHGDMLEMILS-------SEKG----------------------------------------------------------------------RLPERLTKFLITQILVALRHLHFK--------NIVHCDLKPENVLLAS---ADPFPQVKLCDFGFARI-------------IGEKSFR--------------RS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GT----------FP---------------FNED----------EDIN----DQ----IQN---AAFMYPASPWSHIS-------------------------------------AGAID-LINNLLQVKMRKRYSVDKSLSHPWL---
----FAD----EVLGSGQFGIVYGGKHR----------------KTGRDVAIKVIDKM--RFPTKQ---E-SQLRN----EVAILQNL-HHPGIVNLECMFE--T----PERVFVVMEKLHGDMLEMILS-------SEKS----------------------------------------------------------------------RLPERITKFMVTQILVALRNLHFK--------NIVHCDLKPENVLLAS---AEPFPQVKLCDFGFARI-------------IGEKSFR--------------RS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GT----------FP---------------FNED----------EDIN----DQ----IQN---AAFMYPPNPWREIS-------------------------------------GEAID-LINNLLQVKMRKRYSVDKSLSHPWL---
------V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAVKTCK-K--DCT-LDN-KE-KFM-S----EAVIMKNL-DHPHIVKLIGIIE-------EEPTWIIMELYPYGELGHYLE---------RN--------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESI--------NCVHRDIAVRNILVAS---PECV---KLGDFGLSRYI------------E--DEDY--------------YKASVTRLPIKWMSPESIN------FRRFTTASDVWMFAVCMWEILSFGK----------QP---------------FFWL-----ENKDVIGVL----EK----GDR---LPKPDLCP-------------------------------------------PVLYT-LMTRCWDYDPSDRPRFTELVCS--L---
------F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVIS-R--DNL-LH--QQ-MLQ-S----EIQAMKKL-RHKHILALYAVVS--V----GDPVYIITELMAKGSLLELLR---------DS-------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVGE---NTLC---KVGDFGLARLI---------------KEDV--------------YLSHDHNIPYKWTAPEALS------RGHYSTKSDVWSFGILLHEMFSRGQ----------VP---------------YPGM-----SNHEAFLRV----DA----GYR---MPCPLECP-------------------------------------------PSVHK-LMLTCWCRDPEQRPCFKALRERL-----
------L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKMLK-E--NAS-PSE-LR-DLL-S----EFNVLKQV-NHPHVIKLYGACS--Q----DGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAE---GRKM---KISDFGLSRDV------Y-----E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHIYTTQSDVWSFGVLLWEIVTLGG----------NP---------------YPGI-----PPERLFNLL----KT----GHR---MERPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPVFADISKDL-----
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTLK-P--GTM-SP---E-AFL-Q----EAQVMKKL-RHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK---------GE-------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGE---NLVC---KVADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----VNREVLDQV----ER----GYR---MPCPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L---
-----FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAIKVIK-S--ANM-K---LT-DLA-K----EIQTLKGL-RHERLIRLHAVCS--G----GEPVYIVTELMRKGNLQAFLG---------TP-------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVDD---GLAC---KVADFGLARLL------------K--DDIY--------------SPSSSSKIPVKWTAPEAAN------YRVFSQKSDVWSFGVLLHEVFTYGQ----------CP---------------YEGM-----TNHETLQQI----MR----GYR---LPRPAACP-------------------------------------------AEVYV-LMLECWRSSPEERPSFATLREKL-----
-------FTKLEKIGKGSFGEVFKGIDN----------------RTQKVVAIKIIDLE--EAEDEI---E-DIQ-Q----EITVLSQC-DSPYVTKYYGSYL--K----DTKLWIIMEYLGGGSALDLLE---------PG----------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE--------KKIHRDIKAANVLLSE---HGEV---KLADFGVAGQL------------TDTQIKR--------------NT---FVGTPFWMAPEVIK------QSAYDSKADIWSLGITAIELAR-GE----------PP---------------HSEL-----HPMKVLFLI----PK----NNP---PTLEGNYS-------------------------------------------KPLKE-FVEACLNKEPSFRPTAKELLKHKFI---
-------YELQEVIGSGATAVVQAALCK----------------PRQERVAIKRINLE--KCQTSM---D-E-LLK----EIQAMSQC-SHPNVVTYYTSFV--V----KDELWLVMKLLSGGSMLDIIKYIVNRGEHKNG----------------------------------------------------------------------VLEEAIIATILKEVLEGLDYLHRN--------GQIHRDLKAGNILLGE---DGSV---QIADFGVSAFLAT-------GGDVTRNKVR--------------KT---FVGTPCWMAPEVME-----QVRGYDFKADMWSFGITAIELAT-GA----------AP---------------YHKY-----PPMKVLMLT----LQ----NDP---PTLETGVEDKE--MMK--------------------------------KYGKSFRK-LLSLCLQKDPSKRPTAAELLKCKFF---
----TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKILK-N--EAN-DPALKD-ELL-A----EANVMQQL-DNPYIVRMIGICE-------AESWMLVMEMAELGPLNKYLQ---------QN---------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLVT---QHYA---KISDFGLSKAL------R-----A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYKFSSKSDVWSFGVLMWEAFSYGQ----------KP---------------YRGM-----KGSEVTAML----EK----GER---MGCPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPGFAAVE----LRL-
-------LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAIKAIR-E--GAM-CE---E-DFI-E----EAKVMMKL-THPKLVQLYGVCT--Q----QKPIYIVTEFMERGCLLNFLR---------QR--------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--------SFIHRDLAARNCLVSE---AGVV---KVSDFGMARYV------------L--DDQY--------------TSSSGAKFPVKWCPPEVFN------YSRFSSKSDVWSFGVLMWEVFTEGR----------MP---------------FEKY-----TNYEVVTMV----TR----GHR---LYQPKLAS-------------------------------------------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I---
-------IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRMK-E--YAS-KDD-HR-DFA-G----ELEVLCKLGHHPNIINLLGACE--H----RGYLYLAIEYAPHGNLLDFLR---------KSRVLETDP-----------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQK--------QFIHRDLAARNILVGE---NYVA---KIADFGLSRGQ----------------EVY--------------VKKTMGRLPVRWMAIESLN------YSVYTTNSDVWSYGVLLWEIVSLGG----------TP---------------YCGM-----TCAELYEKL----PQ----GYR---LEKPLNCD-------------------------------------------DEVYD-LMRQCWREKPYERPSFAQILV---SL--
-----IV--LQESIGKGRFGEVWRGKWR----------------GEE--VAVKIFSSR--EERSWF---R-EA-------EIYQTVML-RHENILGFIAADN--KDNGTWTQLWLVSDYHEHGSLFDYLN---------RY----------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKK---NGTC---CIADLGLAVRHDS--------ATDTIDIAP--------------NH---RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLP---------------YYDLVPSDPSVEEMRKVV----CE----QKL---RPNIPNRWQSCEAL-------------------------------------RVMAK-IMRECWYANGAARLTALRIKK----TL-
-------ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAIKMLK-E--YAS-END-HR-DFA-G----ELEVLCKLGHHPNIINLLGACK--N----RGYLYIAIEYAPYGNLLDFLR---------KSRVLETDP-----------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEK--------QFIHRDLAARNVLVGE---NLAS---KIADFGLSRGE----------------EVY--------------VKKTMGRLPVRWMAIESLN------YSVYTTKSDVWSFGVLLWEIVSLGG----------TP---------------YCGM-----TCAELYEKL----PQ----GYR---MEQPRNCD-------------------------------------------DEVYE-LMRQCWRDRPYERPPFAQIALQ--L---
------L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCLK-PDVLSQ-PEA-MD-DFI-R----EVNAMHSL-DHRNLIRLYGVVL-------TPPMKMVTELAPLGSLLDRLR---------KH--------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLAT---RDLV---KIGDFGLMRAL-----PQ-----N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRTFSHASDTWMFGVTLWEMFTYGQ----------EP---------------WIGL-----NGSQILHKI---DKE----GER---LPRPEDCP-------------------------------------------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L---
------L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAIKAIN-E--GSM-SE---E-DFI-E----EAKVMMKL-SHSKLVQLYGVCI--Q----RKPLYIVTEFMENGCLLNYLR---------EN--------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVSS---TCIV---KISDFGMTRYV------------L--DDEY--------------VSSFGAKFPIKWSPPEVFL------FNKYSSKSDVWSFGVLMWEVFTEGK----------MP---------------FENK-----SNLQVVEAI----SE----GFR---LYRPHLAP-------------------------------------------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV--
------L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAVKALK-A--DCG-PQH-RS-GWK-Q----EIDILRTL-YHEHIIKYKGCCEDQG----EKSLQLVMEYVPLGSLRDYLP---------RH----------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ--------HYIHRDLAARNVLLDN---DRLV---KIGDFGLAKAV-----PE-----G--HEYY--------------RVREDGDSPVFWYAPECLK------EYKFYYASDVWSFGVTLYELLTHCD----------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER---LPRPDKCP-------------------------------------------CEVYH-LMKNCWETEASFRPTFENLIP---IL--
------L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTLK-P--GTM-MP---E-AFL-Q----EAQIMKKL-RHDKLVPLYAVVS-------EEPIYIVTEFMSKGSLLDFLK---------EG-------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGE---NLVC---KIADFGLARLI------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGR----------VP---------------YPGM-----VNREVLEQV----ER----GYR---MPCPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL-----
-------WTKGEILGKGAYGTVYCGLTS----------------QGQ-LIAVKQVALD--TSNKLA---A-EKEYRKLQEEVDLLKAL-KHVNIVAYLGTCL--Q----ENTVSIFMEFVPGGSISSIIN--------RFG----------------------------------------------------------------------PLPEMVFCKYTKQILQGVAYLHEN--------CVVHRDIKGNNVMLMP---TGII---KLIDFGCARRLAWA------GLNGTHSDML--------------KS---MHGTPYWMAPEVIN------ESGYGRKSDIWSIGCTVFEMAT-GK----------PP---------------LASM-------DRMAAMF----YI----GAH---RGLMPPLPDHFS---------------------------------------ENAAD-FVRMCLTRDQHERPSALQLLKHSFL---
---LIAD----IELGCGNFGSVRQGVYR--------------MRKKQIDVAIKVLK-Q--GTE-KAD-TE-EMM-R----EAQIMHQL-DNPYIVRLIGVCQ-------AEALMLVMEMAGGGPLHKFLV---------GK--------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--------NFVHRDLAARNVLLVN---RHYA---KISDFGLSKAL-----GA-----D--DSYY--------------TARSAGKWPLKWYAPECIN------FRKFSSRSDVWSYGVTMWEALSYGQ----------KP---------------YKKM-----KGPEVMAFI----EQ----GKR---MECPPECP-------------------------------------------PELYA-LMSDCWIYKWEDRPDFLTVEQR--M---
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