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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK INSRR 203
TK DDR1 572
TK DDR2 563
TK FLT1 827
TK FLT4 845
TK IGF1R 999
TK INSR 1023
TK KDR 834
TK LCK 245
TK MET 1078
TK MUSK 575
STE MYO3A 21
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PTK2B 425
TKL RIPK1 17
TK TEK 824
TK TIE1 839
--I-SIIRELGQGSFGMVYEGLARG-----------LEAGEESTPVALKTV-N-ELAS-PRECIEFLKEASVMKAF--KCHHVVRLLGVVS-Q-----GQPTLVIMELMTRGDLKSHLR-----SLRPEA---------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV-------YE--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGI--FTTHSDVWSFGVVLWEIVTLAE-QPYQGL-SNEQVLKFV----MD----GGV---LE---ELEGCP--LQLQELMSRCWQPNPRLRPSFTHILD---SI
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-R-PDAT-KNARNDFLKEVKIMSRL--KDPNIIRLLGVCV-Q-----DDPLCMITDYMENGDLNQFLS-----AHQLEDKAAE------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL-------YA--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK--FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRD----QGRQVYLS---RPPACP--QGLYELMLRCWSRESEQRPPFSQLHRFL---
---LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML-R-ADAN-KNARNDFLKEIKIMSRL--KDPNIIHLLAVCI-T-----DDPLCMITEYMENGDLNQFLS-----RHEPPN---------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNL-------YS--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK--FTTASDVWAFGVTLWETFTFCQEQPYSQL-SDEQVIENT----GEFFRDQGRQTYLP---QPAICP--DSVYKLMLSCWRRDTKNRPSFQEIHL---LL
---LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAVKML-K-EGAT-ASEYKALMTELKILTHIG-HHLNVVNLLGACTKQ-----GGPLMVIVEYCKYGNLSNYLK-----SKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI-------YK--NPDY--------------VRKGDTRLPLKWMAPESIF-----DKI--YSTKSDVWSYGVLLWEIFSLGG-SPYPGVQMDEDFCSRL----RE----GMR---MR---APEYST--PEIYQIMLDCWHRDPKERPRFAELVEKL---
---LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKML-K-EGAT-ASEHRALMSELKILIHIG-NHLNVVNLLGACTKP-----QGPLMVIVEFCKYGNLSNFLR-----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR---PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-------YK--DPDY--------------VRKGSARLPLKWMAPESIF-----DKV--YTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRL----RD----GTR---MR---APELAT--PAIRRIMLNCWSGDPKARPAFSELVEIL---
---ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTV-N-EAAS-MRERIEFLNEASVMKEF--NCHHVVRLLGVVS-Q-----GQPTLVIMELMTRGDLKSYLR-----SLRPEM---------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-------YE--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV--FTTYSDVWSFGVVLWEIATLAE-QPYQGL-SNEQVLRFV----ME----GGL---LD---KPDNCP--DMLFELMRMCWQYNPKMRPSFLEIISS--I-
---ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV-N-ESAS-LRERIEFLNEASVMKGF--TCHHVVRLLGVVS-K-----GQPTLVVMELMAHGDLKSYLR-----SLRPEA---------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-------YE--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV--FTTSSDMWSFGVVLWEITSLAE-QPYQGL-SNEQVLKFV----MD----GGY---LD---QPDNCP--ERVTDLMRMCWQFNPKMRPTFLEIVNLL---
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKML-K-EGAT-HSEHRALMSELKILIHIG-HHLNVVNLLGACTKP-----GGPLMVIVEFCKFGNLSTYLR-----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL-DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-------YK--DPDY--------------VRKGDARLPLKWMAPETIF-----DRV--YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KE----GTR---MR---APDYTT--PEMYQTMLDCWHGEPSQRPTFSELVEHL---
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL-K-QGSM-SP--DAFLAEANLMKQL--QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK-----TP-----------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGT--FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ER----GYR---MV---RPDNCP--EELYQLMRLCWKERPEDRPTFDYLRSV--L-
---VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSL-N-RITD-IGEVSQFLTEGIIMKDF--SHPNVLSLLGICLRS-----EGSPLVVLPYMKHGDLRNFIR-----NE------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-------YD--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQK--FTTKSDVWSFGVLLWELMTRGA-PPYPDV-NTFDITVYL----LQ----GRR---LL---QPEYCP--DPLYEVMLKCWHPKAEMRPSFSELVSR--I-
--I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML-K-EEAS-ADMQADFQREAALMAEF--DNPNIVKLLGVCA-V-----GKPMCLLFEYMAYGDLNEFLR-----SMSPHTVCSLSHS-------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI-------YS--ADYY--------------KANENDAIPIRWMPPESIF-----YNR--YTTESDVWAYGVVLWEIFSYGL-QPYYGM-AHEEVIYYV----RD----GNI---LS---CPENCP--VELYNLMRLCWSKLPADRPSFTSIHRIL---
---WEITETIGKGTYGKVFKVLNK----------------KNGQKAAVKIL-DPIHDIDEE--IEA--EYNILKAL-SDHPNVVRFYGIYF-KKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGE--------------------------------------------------------------------RMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQL--------TSTRHRR--------------NT---SVGTPFWMAPEVIACEQQLDTT--YDARCDTWSLGITAIELGD-GD-PPLADL-HPMRALFKI----PR----NPP---PK---LRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI-
-IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKAL-K-EASE-SA-RQDFQREAELLTML--QHQHIVRFFGVCT-E-----GRPLLMVFEYMRHGDLNRFLR-----SHGPDAKL----------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI-------YS--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK--FTTESDVWSFGVVLWEIFTYGK-QPWYQL-SNTEAIDCI----TQ----GRE---LE---RPRACP--PEVYAIMRGCWQREPQQRHSIKDVHARL---
--I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL-K-DASD-NA-RKDFHREAELLTNL--QHEHIVKFYGVCV-E-----GDPLIMVFEYMKHGDLNKFLR-----AHGPDAV------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDV-------YS--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK--FTTESDVWSLGVVLWEIFTYGK-QPWYQL-SNNEVIECI----TQ----GRV---LQ---RPRTCP--QEVYELMLGCWQREPHMRKNIKGIHTL--L-
--I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL-K-DPTL-AA-RKDFQREAELLTNL--QHEHIVKFYGVCG-D-----GDPLIMVFEYMKHGDLNKFLR-----AHGPDAMIL---------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV-------YS--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK--FTTESDVWSFGVILWEIFTYGK-QPWFQL-SNTEVIECI----TQ----GRV---LE---RPRVCP--KEVYDVMLGCWQREPQQRLNIKEIYKIL---
--V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAVKTC-K-KDCT-LDNKEKFMSEAVIMKNL--DHPHIVKLIGIIE-------EEPTWIIMELYPYGELGHYLE-----RN------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI--------E--DEDY--------------YKASVTRLPIKWMSPESIN-----FRR--FTTASDVWMFAVCMWEILSFGK-QPFFWL-ENKDVIGVL----EK----GDR---LP---KPDLCP--PVLYTLMTRCWDYDPSDRPRFTELVCS--L-
LES----AELDSGGFGKVSLCFHR-----------------TQGLMIMKTVYK-GPNC-IEHNEALLEEAKMMNRL--RHSRVVKLLGVII-E-----EGKYSLVMEYMEKGNLMHVLK-----AE-------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNE----EHNELR--------EVDGTAKKNGGTLYYMAPEHLN-----DVNAKPTEKSDVYSFAVVLWAIFA-NK-EPYENAICEQQLIMCI----KS----GNR---PDVDDITEYCP--REIISLMKLCWEANPEARPTFPGIEEK--F-
---IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRM-K-EYAS-KDDHRDFAGELEVLCKLG-HHPNIINLLGACE-H-----RGYLYLAIEYAPHGNLLDFLR-----KSRVLETDP---------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ------------EVY--------------VKKTMGRLPVRWMAIESLN-----YSV--YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQ----GYR---LE---KPLNCD--DEVYDLMRQCWREKPYERPSFAQILV---SL
---ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAIKML-K-EYAS-ENDHRDFAGELEVLCKLG-HHPNIINLLGACK-N-----RGYLYIAIEYAPYGNLLDFLR-----KSRVLETDP---------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE------------EVY--------------VKKTMGRLPVRWMAIESLN-----YSV--YTTKSDVWSFGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQ----GYR---ME---QPRNCD--DEVYELMRQCWRDRPYERPPFAQIALQ--L-
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