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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ITK 203
TK BTK 402
CMGC CDK2 4
TK FLT4 845
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LCK 245
Other PLK2 82
TK SYK 371
TK TEK 824
TK TNK2 150
---LTFVQEIGSGQFGLVHLGYWL------NKDKVAIKTIR-E--GAM-SE---EDFI-E-EAEVMMKL-SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR---TQ---------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV--L--DDQY-TSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDI-STGFRLYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----
---LTFLKELGTGQFGVVKYGKWR------GQYDVAIKMIK-E--GSM-SE---DEFI-E-EAKVMMNL-SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLR---EM---------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV--L--DDEY-TSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMP---------------YERF-TNSETAEHI-AQGLRLYRPHLAS----------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I--
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLD--TETEGV---PSTAIR-EISLLKEL-NHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALT-----------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
---LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLK-E--GAT-ASE-HRALM-S-ELKILIHIGNHLNVVNLLGACT-KPQGPLMVIVEFCKYGNLSNFLR---AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-YK--DPDY-VRKGSARLPLKWMAPESIF-DKVYTTQSDVWSFGVLLWEIFSLGASP---------------YPGVQINEEFCQRL-RDGTRMRAPELAT----------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL----
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-H--STE--EH-LRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ---KH---------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYY-KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-H--SGP-DQ--QRDFQ-R-EIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ---RH---------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYY-VVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
---LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-E--GAT-HSE-HRALM-S-ELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLR---SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL----------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-YK--DPDY-VRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRL-KEGTRMRAPDYTT----------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
---LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-P--SAH-LTE-REALM-S-ELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLR---RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-KN--DSNY-VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMI-KEGFRMLSPEHAP----------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I--
---LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-Q--GSM-SP---DAFL-A-EANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK---TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
--Y-CRGKVLGKGGFAKCYEMTDL-----TNNKVYAAKIIPHS--RVAKPH---QREKIDKEIELHRIL-HHKHVVQFYHYFE--DKENIYILLEYCSRRSMAHILK--ARK-----------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARL--EPLEHRR-RT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPP---------------FETT----NLKETY-RCIREARYTMPSSLL--------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF--
TLE---DKELGSGNFGTVKKGYYQ---MKKVVKTVAVKILK-N--EAN-DPALKDELL-A-EANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ---QN----------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAML-EKGERMGCPAGCP----------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL
---IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMK-E--YAS-KDD-HRDFA-G-ELEVLCKLGHHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLR---KSRVLETDP------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ------EVY-VKKTMGRLPVRWMAIESLN-YSVYTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM-TCAELYEKL-PQGYRLEKPLNCD----------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL-
--L-RLLEKLGDGSFGVVRRGEWD--APSGKTVSVAVKCLK-PDVLSQ-PEA-MDDFI-R-EVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR---KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHY-VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
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