|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK2 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
TK JAK3 822
-LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-R-EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ----KH-KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
-ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLK-ED-TM-EV--EEFL-K-EAAVMKEIKHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR----ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
-FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHLRHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
-FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFY--DRRRIYLILEYAPRGELYKELQ---KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
-YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLES-EEEGV--PSTAIR-EISLLKELRHPNIVSLQDVLM--QDSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
-FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDT-ETEGV--PSTAIR-EISLLKELNHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HS-GP-DQ-QRDFQ-R-EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ----RH-RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
|