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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK2 203
TK ABL1 261
CMGC CDK2 4
CAMK DCLK3 356
TK FYN 271
CMGC GSK3A 119
TK JAK1 875
TK JAK3 822
TK LCK 245
STE MAP4K2 16
AGC PDPK1 82
AGC PKN1 615
TK RET 724
STE STK3 27
STE STK4 30
TK TNK1 116
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKL---Q-HSTE--EHLRD-FE-R-EIEILKSLQ---HDNIVKYKGVCYSAG----RRN--LK--LIMEYLPYG--SLRDYLQ---KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV----KIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPES--LT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV---------
---ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTL---K-EDTM-EV--EE-FL-K-EAAVMKEIK---HPNLVQLLGVCT--R----EPP--FY--IITEFMTYG--NLLDYLR---EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV----KVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPES--LA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F-----------
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKI---RLDTETEGV--PS-TAIR-EISLLKELN---HPNIVKLLDVIH--T----ENK--LY--LVFEFLHQ---DLKKFMDASALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEI--LLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
---YETGRVIGDGNFAVVKECRHR-----ETRQAYAMKII---DKSRLKGKE--DM-V-DS-EILIIQSLS---HPNIVKLHEVYE--T----DME--IY--LILEYVQGG--DLFDAII--ESV-------------------------KFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQ-RNEDKSTTLKLADFGLAK-------HVVRPIFT---VCGTPTYVAPEI--LS-EKGYGLEVDMWAAGVILYILLC-GFPP---------------FRSP--ERDQDELFNIIQLGHFEFLPPYWDNIS----------------------DAAKDLVSRLLVVDPKKRYT-----AHQVLQHPWI-----------
---LQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTL---K-PGTM-SP--ES-FL-E-EAQIMKKLK---HDKLVQLYAVVS-------EEP--IY--IVTEYMNKG--SLLDFLK---DG----------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLIC----KIADFGLARLI----E--DNEYTARQGAKFPIKWTAPEA--AL-YGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQVERGYRMPCPQDCP----------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL-------------
---YTDIKVIGNGSFGVVYQARLA-----ETRELVAIKKV---LQDKRFKNR----------ELQIMRKLD---HCNIVRLRYFFY--SSGEKKDE--LYLNLVLEYVPETVYRVARHFT-KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPEL--IFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF-----------
--L-KRIRDLGEGHFGKVELCRYDP-EGDNTGEQVAVKSL---K-PESG-GNHIAD-LK-K-EIEILRNLY---HENIVKYKGICT-ED-----GGNGIK--LIMEFLPSG--SLKEYLP---KN-----------------------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVE-SEHQV----KIGDFGLTKAI-ET-D--KEYYTVKDDRDSPVFWYAPEC--LM-QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKRLPCPPNCP----------------------------DEVYQLMRKCWEFQPSNRTS-----FQNLIE---GF----------
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQL---Q-HSGP-DQ-QRD-FQ-R-EIQILKALH---SDFIVKYRGVSYGPG----RQS--LR--LVMEYLPSG--CLRDFLQ---RH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHV----KIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPES--LS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPS-----FSALGP---QL----------
---LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSL---K-QGSM-SP--DA-FL-A-EANLMKQLQ---HQRLVRLYAVVT-------QEP--IY--IITEYMENG--SLVDFLK---TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC----KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEA--IN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L-----------
---FELLQRVGAGTYGDVYKARDT-----VTSELAAVKIV---KLDPGDDIS--SL---QQ-EITILRECR---HPNVVAYIGSYL--R----NDR--LW--ICMEFCGGG--SLQEIYH--ATG-------------------------PLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLT-LQGDV----KLADFGVSGEL----TASVAKRRS---FIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGE-LQPP---------------LFHL-HPMRALMLMSKSSFQPPKLRDKTR--WT----------------------QNFHHFLKLALTKNPKKRPT-----AEKLLQHPF-T----------
--F-KFGKILGEGSFSTVVLAREL-----ATSREYAIKIL---EKRHIIKEN--KVPYVTR-ERDVMSRLD---HPFFVKLYFTFQ--D----DEK--LY--FGLSYAKNG--ELLKYIR--KIG-------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPEL--LT-EKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG----NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
--F-KFLAVLGRGHFGKVLLSEFR-----PSGELFAIKAL---KKGDIVARD--EV-ESLMCEKRILAAVTSAGHPFLVNLFGCFQ--T----PEH--VC--FVMEYSAGG--DLMLHIH---SD-------------------------VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLD-TEGYV----KIADFGLCKEG----MGYGDRTST---FCGTPEFLAPEV--LT-DTSYTRAVDWWGLGVLLYEMLV-GESP---------------FPGD----DEEEVFDSIVNDEVRYPRFLS--------------------------AEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF-----------
--L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML---K-ENAS-PSELRD-LL-S-EFNVLKQVN---HPHVIKLYGACS--Q----DGP--LL--LIVEYAKYG--SLRGFLR---ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRKM----KISDFGLSRDV--Y-E--EDSYVKRSQGRIPVKWMAIES--LF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL-------------
--F-DVLEKLGEGSYGSVFKAIHK-----ESGQVVAIKQV---PVESDLQEI-------IK-EISIMQQCD---SPYVVKYYGSYF--K----NTD--LW--IVMEYCGAG--SVSDIIR-LRNK-------------------------TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLN-TEGHA----KLADFGVAGQL----TDTMAKRNT---VIGTPFWMAPEV--IQ-EIGYNCVADIWSLGITSIEMAE-GKPP---------------YADI-HPMRAIFMIPTNPPPTFRKPELWS--------------------------DDFTDFVKKCLVKNPEQRAT-----ATQLLQHPFI-----------
--F-DVLEKLGEGSYGSVYKAIHK-----ETGQIVAIKQV---PVESDLQEI-------IK-EISIMQQCD---SPHVVKYYGSYF--K----NTD--LW--IVMEYCGAG--SVSDIIR-LRNK-------------------------TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLN-TEGHA----KLADFGVAGQL----TDTMAKRNT---VIGTPFWMAPEV--IQ-EIGYNCVADIWSLGITAIEMAE-GKPP---------------YADI-HPMRAIFMIPTNPPPTFRKPELWS--------------------------DNFTDFVKQCLVKSPEQRAT-----ATQLLQHPFV-----------
VCR---GELLGSGCFGVVHRGLWT--LPSGKSVPVAVKSLRVGP-EGPM-GTELGD-FL-R-EVSVMMNLE---HPHVLRLHGLVL-------GQP--LQ--MVMELAPLG--SLHARLT---AP---------------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLA-SPRTI----KVADFGLVRPL-GG-A--RGRYVMGGPRPIPYAWCAPES--LR-HGAFSSASDVWMFGVTLWEMFSGGEEP---------------WAGV-PPYLILQRLEDRARLPRPPLCS----------------------------RALYSLALRCWAPHPADRPS-----FSHLE----GLL---------
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