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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK2 203
CMGC CDC2 4
CMGC CDK2 4
TK JAK1 875
TK JAK3 822
TK PTK2 422
-LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE--EHLRDFE-REIEILKSLQHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQ----KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
-YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKELRHPNIVSLQDVLM--QDSR--LYLIFEFLSM-DLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
-FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETEGV--PSTAIREISLLKELNHPNIVKLLDVIH--TENK--LYLVFEFLHQ-DLKKFMDA-SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
L-KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLK-PESG-GNHIADLK-KEIEILRNLYHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLP----KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETD--KEYYTVKDDRDSPVFWYAPECLM-QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKRLPCPPNCP----------------------------DEVYQLMRKCWEFQPSNRTSFQNLIE---GF-
L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGP-DQ-QRDFQ-REIQILKALHSDFIVKYRGVSYGPGRQS--LRLVMEYLPSGCLRDFLQ----RHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
-IELGRCIGEGQFGDVHQGIYM-SPENPALAVAIKTCK-NCTS-DSVREKFL-QEALTMRQFDHPHIVKLIGVIT---ENP--VWIIMELCTLGELRSFLQ----VRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM--E--DSTYYKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKP---------------FQGV-KNNDVIGRIENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL----
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