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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK KDR 203
TK ALK 1116
TKL BRAF 456
TK EPHB4 615
TK FGFR1 478
TK FGFR2 481
TK IGF1R 999
TK INSR 1023
TK MET 1078
TK TEK 824
-LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE---KNVVKICDFGLARDI---YKDPDY--VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLPE-VCSEQDELDFLMEALIISKF-NHQNIVRCIGVSL-QSLPRFILLELMAGGDLKSFLRETRP-----------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---YRASYY--RKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFVTSGGR----MDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I-
-ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII-----------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK---SRWSGS--HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTLKG-GYTERQRREFLSEASIMGQF-EHPNIIRLEGVVT-NSMPVMILTEFMENGALDSFLRLN-----------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENSSDPTY--TSSLGGKIPIRWTAPEAIAFRK---FTSASDAWSYGIVMWEVMSFGERPYWDM-SNQDVINAIEQDYR----LPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL--
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS-DATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQARRPPGLEY--------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---HHIDYY--KKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHR----MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL--
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKD-DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLRARRPPGMEY--------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI---NNIDYY--KKTTNGRLPVKWMAPEALFDRV---YTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHR----MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL--
-ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVNE-AASMRERIEFLNEASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLRSLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---YETDYY--RKGGKGLLPVRWMSPESLKDGV---FTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFVMEGGL----LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISS-I-
-ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVNE-SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLRSLRPEA--------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---YETDYY--RKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFVMDGGY----LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL--
-VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE-----------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM---YDKEYYSVHNKTGAKLPVKWMALESLQTQK---FTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYLLQGRR----LLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I-
-IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ------EVY--VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
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