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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK KIT 203
TK ABL1 261
TK EGFR 712
TK ERBB3 709
TK HCK 241
TK INSR 1023
TK LCK 245
TK RET 724
TK SRC 270
TK TNK2 150
-LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKP--SAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-KNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I--
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKE--DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F--
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELRE--ATSPKANKEILDEAYVMASV-DNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVREH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELI---IEF
L-RKLKVLGSGVFGTVHKGVWIP-EGESIKIPVCIKVIED--KSGRQSFQAVTDHMLAIGSL-DHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQH---------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLL-PPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGL-RLAEVPDLL-EKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANE-F--
-LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTMKP--GSMSV--EAFLAEANVMKTL-QHDKLVKLHAVVT-KEPIYIITEFMAKGSLLDFLKSD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRAL-ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSV-L--
-ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNE--SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL---
-LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQ--GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKE--NASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL---
L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLKP--GTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L--
L-RLLEKLGDGSFGVVRRGEWD--APSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL-DHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLRKH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDF-L--
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