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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
Other AURKA 133
CMGC CDK2 4
TK FGFR1 478
TK ITK 363
TK PDGFRB 600
TK TNK2 150
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK---TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
-FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--EHQLRREVEIQSHL-RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ--KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETY-KRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-
-FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV--PSTAIREISLLKEL-NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQ---ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HH--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLL-KEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
-LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-E--G-AM-SE--EDFI-EEAEVMMKL-SHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR---TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV--L--DDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIPYENR-SNSEVVEDI-STGFRLYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL---
L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-S--T-AR-SSEKQALM-SELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLH---RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-MR--DSNYISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI-KRGYRMAQPAHAS----------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL
L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMDDFI-REVNAMHSL-DHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLR---KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHYVMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-
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