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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
Other AURKA 133
CMGC CDK2 4
Other CHUK 15
TK EGFR 712
TK FGFR1 478
TKL IRAK4 186
TK JAK2 849
CMGC MAPK14 24
TK PDGFRB 600
TK SRC 270
TK SYK 371
TK TNK2 150
TK ZAP70 338
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP---D-AFL-A-EANLMKQL-QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC---KIADFGLARLI----E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-----------TNPEVIQNL-ERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---------
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV---E-HQLRR-EVEIQSHL-RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL---KIADFGWSV------HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN--------------TYQETY-KRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV---P-STAIR-EISLLKEL-NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAF----GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-----------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---------
---W-EMRERLGTGGFGNVCLYQHR-------ELDLKIAIKSCRLE--L-STKNR---E-R-WCH-EIQIMKKL-NHANVVKACDVPE--ELN-ILIHDVPLLAMEYCSGGDLRKLLNKPENCC----------------------------------------------------------------------------------------------------GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKD-----VDQGSLC-TS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GYRP---------------FLHHLQPFTWHEKIKKKDPKCIFA-CEEMSGEVRFSSHLPQPNSLCS------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKA-NK-EIL-D-EAYVMASV-DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV---KITDFGLAKLL--G-A--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-----------PASEISSIL-EKGERLPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKD-LS-DLI-S-EMEMMKMIGKHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM---KIADFGLARDI--H-H--IDYY-KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-----------PVEELFKLL-KEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----------
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE---ELKQQFDQEIKVMAKC-QHENLVELLGFSS--D------GDDLCLVYVYMPNGSLLDRLSCLDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTA---KISDFGLARASE--KFAQTVMT-SR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH-----------REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD----------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ------
----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H--S-TE--EH-LR-DFE-R-EIEILKSL-QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV---KIGDFGLTKVL-PQ-D--KEYY-KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL-KNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-------
----YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRP--F-QSIIH---A-KRTYR-ELRLLKHM-KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR-------HTDDEM-TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-----------DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---------
---L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-S--T-AR-SSE-KQ-ALM-S-ELKIMSHLGPHLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV---KICDFGLARDI--M-R--DSNY-ISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTP---------------YPEL-P---------MNEQFYNAI-KRGYRMAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL--------
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP---E-AFL-Q-EAQVMKKL-RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC---KVADFGLARLI----E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-----------VNREVLDQV-ERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---------
-TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-N--E-AN-DPALKD-ELL-A-EANVMQQL-DNPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA---KISDFGLSKAL--R-A--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-----------KGSEVTAML-EKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL-------
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEA-MD-DFI-R-EVNAMHSL-DHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLV---KIGDFGLMRAL-PQ-N--DDHY-VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-----------NGSQILHKIDKEGERLPRPEDCP------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KAD-TE-EMM-R-EAQIMHQL-DNPYIVRLIGVCQ---------AEALMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA---KISDFGLSKAL-GA-D--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKP---------------YKKM-----------KGPEVMAFI-EQGKRMECPPECP------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M---------
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