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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
TK CSF1R 582
TK EGFR 712
CAMK NUAK1 55
TK PDGFRB 600
TK PTK6 191
TK ROS1 1945
TK SYK 371
TK YES1 277
---LKLVERLGAGQFGEVWMGYYN-------GHTKVAVKSLK-QG-SM-SP---DAFL-A-EANLMKQL-QHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD-----TLSCKIADFGLARLI-E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
---FEIGRPLGKGKFGNVYLAREK------QSKFILALKVLFKAQLEKAGV---EHQLRR-EVEIQSHL-RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS-----AGELKIADFGWSV---HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---YTKIEKIGEGTYGVVYKGRHK------TTGQVVAMKKIRLES-EEEGV---PSTAIR-EISLLKEL-RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD-----KGTIKLADFGLARAF-GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
---FQKVEKIGEGTYGVVYKARNK------LTGEVVALKKIRLDT-ETEGV---PSTAIR-EISLLKEL-NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT-----EGAIKLADFGLARAF-GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
---YEKLEKIGEGTYGTVFKAKNR------ETHEIVALKRVRLDD-DDEGV---PSSALR-EICLLKEL-KHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFD--SCNG----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINR-----NGELKLADFGLARAF-GIPVRCY-SA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--
---LQFGKTLGAGAFGKVVEATAFG-LGKEDAVLKVAVKMLK-ST-AH-ADE-KEALM-S-ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-----GHVAKIGDFGLARDIMN--DSNY-IVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAP----------------------------KNIYSIMQACWALEPTHRPTFQQICSFL----
--F-KKIKVLGSGAFGTVYKGLWIP--EGEKVKIPVAIKELR-EA-TS-PKA-NKEIL-D-EAYVMASV-DNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT-----PQHVKITDFGLAKLLGA--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
---YELQETLGKGTYGKVKRATER------FSGRVVAIKSIRKDK-IKDEQ---DMVHIRREIEIMSSL-NHPHIISIYEVFENKDKIVIIMEYASKGELYDYIS---ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDD-----NCNIKIADFGLSNL--YQKDKFL-QT---FCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVY-GTMPFDGF----DHKNLIRQISSGEYREPTQP---------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V-
--L-VLGRTLGSGAFGQVVEATAHG-LSHSQATMKVAVKMLK-ST-AR-SSE-KQALM-S-ELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE-----GKLVKICDFGLARDIMR--DSNY-ISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHAS----------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL-
--F-TLCRKLGSGYFGEVFEGLWK-------DRVQVAIKVIS-RD-NL-LH--QQMLQ-S-EIQAMKKL-RHKHILALYAVVSVGDPVYIITELMAKGSLLELLR----DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGE-----NTLCKVGDFGLARLI----KEDV-YLSHDHNIPYKWTAPEALS-RGHYSTKSDVWSFGILLHEMFSRGQVPYPGM-SNHEAFLRVDAGYRMPCPLECP----------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL----
-LT--LRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLK-KG-ST-DQE-KIEFL-K-EAHLMSKF-NHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLR----KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYK--NDYY-RKRGEGLLPVRWMAPESLM-DGIFTTQSDVWSFGILIWEILTLGHQPYPAH-SNLDVLNYVQTGGRLEPPRNCP----------------------------DDLWNLMTQCWAQEPDQRPTFHRIQDQL----
TLE---DKELGSGNFGTVKKGYYQ----MKKVVKTVAVKILK-NE-AN-DPALKDELL-A-EANVMQQL-DNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT-----QHYAKISDFGLSKALRA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAMLEKGERMGCPAGCP----------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL
--L-RLEVKLGQGCFGEVWMGTWN-------GTTKVAIKTLK-PG-TM-MP---EAFL-Q-EAQIMKKL-RHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE-----NLVCKIADFGLARLI-E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYRMPCPQGCP----------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL----
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