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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE MAP2K1 203
TK ABL1 261
CMGC CDK2 4
CMGC CDK9 2.7.11.23
AGC GRK6 186
CMGC GSK3B 56
TKL IRAK4 186
STE MAP2K2 72
STE MAP2K4 102
TK RET 724
STE STK24 24
TK ZAP70 338
----FEKISELGAGNGGVVFKVSHK-----PSGL-VMARKLIHLEIKPAI--R-NQIIR-ELQVLHEC-NSPYIVGFYGAFYS--------DGEIS--ICMEHMDGG--SLDQVLK----KAG-------------------------RIPEQILGKVSIAVIKGLTYLREKH-KIMHRDVKPSNILVN-SRGEIKLCDFGVSG--------QLIDSMANS---FVGTRSYMSPERLQ----GTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE-----LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD-----LKQLMVHAFI---
----ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-EDTM-EV--E-EFL-K-EAAVMKEI-KHPNLVQLLGVCTR--------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEK-K-NFIHRDLAARNCLVG-ENHLVKVADFGLSRLM------T--GDTYTAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP------------------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F---
----FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGV--P-STAIR-EISLLKEL-NHPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHS-H-RVLHRDLKPQNLLIN-TEGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---
----YEKLAKIGQGTFGEVFKARHR-----KTGQKVALKKVLMENEKEGF--P-ITALR-EIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV-------------------------KFTLSEIKRVMQMLLNGLYYIHR-N-KILHRDMKAANVLIT-RDGVLKLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLL---GERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK-----------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF---
---F-RQYRVLGKGGFGEVCACQVR-----ATGKMYACKKLEKKRIKKRK--G-EAMALNEKQILEKV-NSRFVVSLAYAYET--------KDALC--LVLTLMNGG--DLKFHIYH--MGQA-------------------------GFPEARAVFYAAEICCGLEDLHR-E-RIVYRDLKPENILLD-DHGHIRISDLGLAVH-------VPEGQTIKG---RVGTVGYMAPEVVK----NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVK-EVPEEYSER--FS------------------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF---
----YTDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQDKRFKNR----------ELQIMRKL-DHCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHS-F-GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF---
-VGG----NKMGEGGFGVVYKGYVN-----NTT--VAVKKLAAMVDITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSSD--------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-------------------------PLSWHMRCKIAQGAANGINFLHE-N-HHIHRDIKSANILLD-EAFTAKISDFGLARASE----KFAQTVMTSR---IVGTTAYMAPEALR-----GEITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD----------------------------------STSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ
---F-ERISELGAGNGGVVTKVQHR-----PSGLIMARKLIHLEIKPA-I--R-NQIIR-ELQVLHEC-NSPYIVGFYGAFYS--------DGEIS--ICMEHMDGG--SLDQVLK----EAK-------------------------RIPEEILGKVSIAVLRGLAYLREKH-QIMHRDVKPSNILVN-SRGEIKLCDFGVSG--------QLIDSMANS---FVGTRSYMAPERLQ----GTHYSVQSDIWSMGLSLVELAV-GRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERAD-----LKMLTNHTFI---
--LK--DLGEIGRGAYGSVNKMVHK-----PSGQIMAVKRIRSTVDEKEQ--K-QL-LM-DLDVVMRSSDCPYIVQFYGALFR--------EGDCW--ICMELMSTSFDKFYKYVYS--VLDD-------------------------VIPEEILGKITLATVKALNHLKE-NLKIIHRDIKPSNILLD-RSGNIKLCDFGISGQ-------LVDSIAKTR---DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELAT-GRFPYPKW-NSVFDQLTQVVKGDPPQLSNSEEREFS------------------------------------------PSFINFVNLCLTKDESKRPK-----YKELLKHPFI---
---L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS-PSELR-DLL-S-EFNVLKQV-NHPHVIKLYGACSQ--------DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-M-KLVHRDLAARNILVA-EGRKMKISDFGLSRDV---Y--E--EDSYVKRSQGRIPVKWMAIESLF----DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS------------------------------------------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL-----
----FTKLEKIGKGSFGEVFKGIDN-----RTQKVVAIKIIDLEEAEDEI--E-DIQ-Q-EITVLSQC-DSPYVTKYYGSYLK--------DTKLW--IIMEYLGGG--SALDLLE-----PG-------------------------PLDETQIATILREILKGLDYLHS-E-KKIHRDIKAANVLLS-EHGEVKLADFGVAGQL------TDTQIKRNT---FVGTPFWMAPEVIK----QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLIPKNNPPTLEGNYS------------------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI---
LIAD----IELGCGNFGSVRQGVYR---MRKKQIDVAIKVLK-QGTE-KADTE-EMM-R-EAQIMHQL-DNPYIVRLIGVCQ---------AEALM--LVMEMAGGG--PLHKFLV-----GK-----------------------REEIPVSNVAELLHQVSMGMKYLEE-K-NFVHRDLAARNVLLV-NRHYAKISDFGLSKAL--GA--D--DSYYTARSAGKWPLKWYAPECIN----FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP------------------------------------------------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M---
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