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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE MAP2K1 203
TK ABL1 261
CMGC CDK2 4
CMGC CDK9 2.7.11.23
AGC GRK6 186
CMGC GSK3B 56
TKL IRAK4 186
STE MAP2K2 72
STE MAP2K4 102
STE STK24 24
TK ZAP70 338
----FEKISELGAGNGGVVFKVSHK--PSGL-VMARKLIHLEIKPAI--R-NQIIR-ELQVLHEC-NSPYIVGFYGAFYS--------DGEIS--ICMEHMDGG--SLDQVLK----KAG---RIPEQILGKVSIAVIKGLTYLREKH-KIMHRDVKPSNILVN-SRGEIKLCDFGVSG--------QLIDSMANS---FVGTRSYMSPERLQ----GTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE-----LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD-----LKQLMVHAFI---
----ITMKHKLGGGQYGEVYEGVWK--KYSLTVAVKTLK-EDTM-EV--E-EFL-K-EAAVMKEI-KHPNLVQLLGVCTR--------EPPFY--IITEFMTYG--NLLDYLR-----ECNRQEVNAVVLLYMATQISSAMEYLEK-K-NFIHRDLAARNCLVG-ENHLVKVADFGLSRLM------T--GDTYTAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP------------------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F---
----FQKVEKIGEGTYGVVYKARNK--LTGEVVALKKIRLDTETEGV--P-STAIR-EISLLKEL-NHPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHS-H-RVLHRDLKPQNLLIN-TEGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---
----YEKLAKIGQGTFGEVFKARHR--KTGQKVALKKVLMENEKEGF--P-ITALR-EIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV---KFTLSEIKRVMQMLLNGLYYIHR-N-KILHRDMKAANVLIT-RDGVLKLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLL---GERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK-----------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF---
---F-RQYRVLGKGGFGEVCACQVR--ATGKMYACKKLEKKRIKKRK--G-EAMALNEKQILEKV-NSRFVVSLAYAYET--------KDALC--LVLTLMNGG--DLKFHIYH--MGQA---GFPEARAVFYAAEICCGLEDLHR-E-RIVYRDLKPENILLD-DHGHIRISDLGLAVH-------VPEGQTIKG---RVGTVGYMAPEVVK----NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVK-EVPEEYSER--FS------------------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF---
----YTDTKVIGNGSFGVVYQAKLC--DSGELVAIKKVLQDKRFKNR----------ELQIMRKL-DHCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHS-F-GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF---
-VGG----NKMGEGGFGVVYKGYVN--NTT--VAVKKLAAMVDITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSSD--------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP---PLSWHMRCKIAQGAANGINFLHE-N-HHIHRDIKSANILLD-EAFTAKISDFGLARASE----KFAQTVMTSR---IVGTTAYMAPEALR-----GEITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD----------------------------------STSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ
---F-ERISELGAGNGGVVTKVQHR--PSGLIMARKLIHLEIKPA-I--R-NQIIR-ELQVLHEC-NSPYIVGFYGAFYS--------DGEIS--ICMEHMDGG--SLDQVLK----EAK---RIPEEILGKVSIAVLRGLAYLREKH-QIMHRDVKPSNILVN-SRGEIKLCDFGVSG--------QLIDSMANS---FVGTRSYMAPERLQ----GTHYSVQSDIWSMGLSLVELAV-GRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERAD-----LKMLTNHTFI---
--LK--DLGEIGRGAYGSVNKMVHK--PSGQIMAVKRIRSTVDEKEQ--K-QL-LM-DLDVVMRSSDCPYIVQFYGALFR--------EGDCW--ICMELMSTSFDKFYKYVYS--VLDD---VIPEEILGKITLATVKALNHLKE-NLKIIHRDIKPSNILLD-RSGNIKLCDFGISGQ-------LVDSIAKTR---DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELAT-GRFPYPKW-NSVFDQLTQVVKGDPPQLSNSEEREFS------------------------------------------PSFINFVNLCLTKDESKRPK-----YKELLKHPFI---
----FTKLEKIGKGSFGEVFKGIDN--RTQKVVAIKIIDLEEAEDEI--E-DIQ-Q-EITVLSQC-DSPYVTKYYGSYLK--------DTKLW--IIMEYLGGG--SALDLLE-----PG---PLDETQIATILREILKGLDYLHS-E-KKIHRDIKAANVLLS-EHGEVKLADFGVAGQL------TDTQIKRNT---FVGTPFWMAPEVIK----QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLIPKNNPPTLEGNYS------------------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI---
LIAD----IELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTE-KADTE-EMM-R-EAQIMHQL-DNPYIVRLIGVCQ---------AEALM--LVMEMAGGG--PLHKFLV-----GK-REEIPVSNVAELLHQVSMGMKYLEE-K-NFVHRDLAARNVLLV-NRHYAKISDFGLSKAL--GA--D--DSYYTARSAGKWPLKWYAPECIN----FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP------------------------------------------------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M---
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