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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL MAP3K10 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BMX 422
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CLK2 163
CMGC CLK4 159
Other EIF2AK2 267
TK FER 563
TK JAK2 849
TK JAK3 822
TK LCK 245
TKL MAP3K11 117
TKL MAP3K9 144
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
TK PTK6 191
AGC ROCK2 92
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
TK TNK2 150
CAMK TSSK1B 12
Other TTK 525
TK YES1 277
-----LQLEEIIGVGGFGKVYRALWR--------GE---EVAVKAARLDP-E--K-DP----AVT---AEQVC-Q-EARLFGAL-Q-----HPN----IIALRGACL--N-----------------------------PPHLCLVMEYARGGALSRVLA----GR-----------------RV--PPHVLVNWAVQVARGMNYLHND---APVPIIHRDLKSINILILEAIENHNLADTVL-------------------KITDFGLAREW-----------HK--------------TTKMSAAGTYAWMAPEVIR-----------LSLFSKSSDVWSFGVLLWELLT-GE-VP---------------YREI-DALAVAYGVAMNKLTLPIPSTCP-------------------------------------------EPFARLLEECWDPDPHG--RPD-----FGSILKRL-----
-----FEIGRPLGKGKFGNVYLAREK-----Q-SKF---ILALKVL---FKA--QLEKA---GV-----EHQLRR-EVEIQSHL-R-----HPN----ILRLYGYFH--D-----------------------------ATRVYLILEYAPLGTVYRELQ---KLS-----------------KF--DEQRTATYITELANALSYCHSK---R---VIHRDIKPENLLLGS--------AGEL-------------------KIADFGWSV--------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN----TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI---
-----FEIGRPLGKGKFGNVYLAREK-----K-SHF---IVALKVL---FKS--Q-IEK---EG-----VEHQLRREIEIQAHL-H-----HPN----ILRLYNYFY--D-----------------------------RRRIYLILEYAPRGELYKELQ---KSC-----------------TF--DEQRTATIMEELADALMYCHGK---K---VIHRDIKPENLLLGL--------KGEL-------------------KIADFGWSV--------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FESA----SHNETY-RRIVKVDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV---
-----FEIGRPLGKGKFGNVYLARLK-----E-SHF---IVALKVL---FKS--Q-IEK---EG-----LEHQLRREIEIQAHL-Q-----HPN----ILRLYNYFH--D-----------------------------ARRVYLILEYAPRGELYKELQ---KSE-----------------KL--DEQRTATIIEELADALTYCHDK---K---VIHRDIKPENLLLGF--------RGEV-------------------KIADFGWSV--------HTPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRTYDEKVDLWCIGVLCYELLV-GY-PP---------------FESA----SHSETY-RRILKVDVRFPLSMP-----------------------------------------LGARDLISRLLRYQPLE--RLP-----LAQILKHPWV---
-----ITLLKELGSGQFGVVQLGKWK-------GQY---DVAVKMI---K-E--G-SM----SE-----DEFF-Q-EAQTMMKL-S-----HPK----LVKFYGVCS--K-----------------------------EYPIYIVTEYISNGCLLNYLR----SH---------------GKGL--EPSQLLEMCYDVCEGMAFLESH---Q---FIHRDLAARNCLVDR--------DLCV-------------------KVSDFGMTRYV------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----------YFKYSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY-DNSQVVLKV-SQGHRLYRPHLAS-------------------------------------------DTIYQIMYSCWHELPEK--RPT-----FQQLLSS--I---
-----YTKIEKIGEGTYGVVYKGRHK-----T-TGQ---VVAMKKI---RLE--S-EEE---GV-----PSTAIR-EISLLKEL-R-----HPN----IVSLQDVLM--Q-----------------------------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YM--DSSLVKSYLYQILQGIVFCHSR---R---VLHRDLKPQNLLIDD--------KGTI-------------------KLADFGLARAF------GIPIRVY--------------TH---EVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FHGD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF---
-----FQKVEKIGEGTYGVVYKARNK-----L-TGE---VVALKKI---RLD--T-ETE---GV-----PSTAIR-EISLLKEL-N-----HPN----IVKLLDVIH--T-----------------------------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GI--PLPLIKSYLFQLLQGLAFCHSH---R---VLHRDLKPQNLLINT--------EGAI-------------------KLADFGLARAF------GVPVRTY--------------TH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF---
----Y-EPVAEIGVGAYGTVYKARDP-----H-SGH---FVALKSV---RVP--N-GGGGGGGL-----PISTVR-EVALLRRL-EA--FEHPN----VVRLMDVCA--TSR------------------------TDREIKVTLVFEHVDQ-DLRTYLDK-APPP-----------------GL--PAETIKDLMRQFLRGLDFLHAN---C---IVHRDLKPENILVTS--------GGTV-------------------KLADFGLARI-------YSYQMAL--------------TP---VVVTLWYRAPEVLL-----------QSTYATPVDMWSVGCIFAEMFR-RK-PL---------------FCGN-SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AFRALQHSYL---
-----YECVAEIGEGAYGKVFKARDL-----K-NGG--RFVALKRV---RVQ--T-GEE---GM-----PLSTIR-EVAVLRHL-ET--FEHPN----VVRLFDVCT--VSR------------------------TDRETKLTLVFEHVDQ-DLTTYLDK-VPEP-----------------GV--PTETIKDMMFQLLRGLDFLHSH---R---VVHRDLKPQNILVTS--------SGQI-------------------KLADFGLARI-------YSFQMAL--------------TS---VVVTLWYRAPEVLL-----------QSSYATPVDLWSVGCIFAEMFR-RK-PL---------------FRGS-SDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----------------PIEKFVTDIDELGKDLLLKCLTFNPAK--RIS-----AYSALSHPYF---
-----YEIVSTLGEGTFGRVVQCVDH-----R-RGG--ARVALKII---KNV--E-KYK---EA-----AR---L-EINVLEKI-NEKDPDNKN---LCVQMFDWFD--Y-----------------------------HGHMCISFELLGL-STFDFLK---DNN-----------------YLPYPIHQVRHMAFQLCQAVKFLHDN---K---LTHTDLKPENILFVN--------SDYELTYNLEKKRDERSVKSTAVRVVDFGSAT---------FDHEHH--------------ST---IVSTRHYRAPEVIL-----------ELGWSQPCDVWSIGCIIFEYYV-GF-TL---------------FQTH-DNREHLAMM-ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAK--RLT-----LGEALQHPFF---
-----YEIVDTLGEGAFGKVVECIDH-----GMDGM---HVAVKIV---KNV--G-RYR---EA-----ARS----EIQVLEHL-NS---TDPNSVFRCVQMLEWFD--H-----------------------------HGHVCIVFELLGL-STYDFIK---ENS-----------------FLPFQIDHIRQMAYQICQSINFLHHN---K---LTHTDLKPENILFVK--------SDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALGWSQPCDVWSIGCILIEYYL-GF-TV---------------FQTH-DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RIT-----LDEALQHPFF---
----F-KEIELIGSGGFGQVFKAKHR-----I-DGK---TYVIKRV---KYN--N-EKA---ER------------EVKALAKL-D-----HVN----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGE-----------------KL--DKVLALELFEQITKGVDYIHSK---K---LIHRDLKPSNIFLVD--------TKQV-------------------KIGDFGLVTS-------LKNDGKR--------------TR---SKGTLRYMSPEQIS-----------SQDYGKEVDLYALGLILAELLH-VCDTA---------------FET--------SKF-FTDLRDGIISDIFDK------------------------------------------KEKTLLQKLLSKKPED--RPN-----TSEILR----TLT
---VI--LGELLGKGNFGEVYKGTLK-------DKT---SVAVKTC---K-E--D-LP----QEL---KIKFL-Q-EAKILKQY-D-----HPN----IVKLIGVCT--Q-----------------------------RQPVYIIMELVSGGDFLTFLR----RK---------------KDEL--KLKQLVKFSLDAAAGMLYLESK---N---CIHRDLAARNCLVGE--------NNVL-------------------KISDFGMSRQE------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----------YGRYSSESDVWSFGILLWETFSLGV-CP---------------YPGM-TNQQAREQV-ERGYRMSAPQHCP-------------------------------------------EDISKIMMKCWDYKPEN--RPK-----FSELQKEL-----
-----LKFLQQLGKGNFGSVEMCRYDP-LQDN-TGE---VVAVKKL---Q-H--S-TE-----EH---LRDFE-R-EIEILKSL-Q-----HDN----IVKYKGVCYSAG-----------------------------RRNLKLIMEYLPYGSLRDYLQ----KH---------------KERI--DHIKLLQYTSQICKGMEYLGTK---R---YIHRDLATRNILVEN--------ENRV-------------------KIGDFGLTKVL--PQ--D--KEYY--------------KVKEPGESPIFWYAPESLT-----------ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FRDLA----LRV-
----L-KYISQLGKGNFGSVELCRYDP-LGDN-TGA---LVAVKQL---Q-H--S-GP----DQ----QRDFQ-R-EIQILKAL-H-----SDF----IVKYRGVSYGPG-----------------------------RQSLRLVMEYLPSGCLRDFLQ----RH---------------RARL--DASRLLLYSSQICKGMEYLGSR---R---CVHRDLAARNILVES--------EAHV-------------------KIADFGLAKLL--PL--D--KDYY--------------VVREPGQSPIFWYAPESLS-----------DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP-------------------------------------------AEVHELMKLCWAPSPQD--RPS-----FSALGP---QL--
-----LKLVERLGAGQFGEVWMGYYN-------GHT---KVAVKSL---K-Q--G-SM----SP-----DAFL-A-EANLMKQL-Q-----HQR----LVRLYAVVT--------------------------------QEPIYIITEYMENGSLVDFLK----TP--------------SGIKL--TINKLLDMAAQIAEGMAFIEER---N---YIHRDLRAANILVSD--------TLSC-------------------KIADFGLARLI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPED--RPT-----FDYLRSV--L---
-----LRLEEVIGIGGFGKVYRGSWR--------GE---LVAVKAA---R-Q--D-PD----EDISVTAESVR-Q-EARLFAML-A-----HPN----IIALKAVCL--E-----------------------------EPNLCLVMEYAAGGPLSRALA----GR-----------------RV--PPHVLVNWAVQIARGMHYLHCE---ALVPVIHRDLKSNNILLLQPIESDDMEHKTL-------------------KITDFGLAREW-----------HK--------------TTQMSAAGTYAWMAPEVIK-----------ASTFSKGSDVWSFGVLLWELLT-GE-VP---------------YRGI-DCLAVAYGVAVNKLTLPIPSTCP-------------------------------------------EPFAQLMADCWAQDPHR--RPD-----FASILQQL-----
----L-TLEEIIGIGGFGKVYRAFWI-----G-DE-----VAVKAA---RHDP-D-EDI---SQ-----TIENVRQEAKLFAML-K-----HPN----IIALRGVCL--K-----------------------------EPNLCLVMEFARGGPLNRVLS----GK-----------------RI--PPDILVNWAVQIARGMNYLHDEAIVP---IIHRDLKSSNILILQ--------KVENGDLS-----------NKILKITDFGLAR--------EWHRTTK--------------MS---AAGTYAWMAPEVIR-----------ASMFSKGSDVWSYGVLLWELLT-GE-VP---------------FRGI----DGLAVA-YGVAMNKLALPIPSTCP---------------------------------------EPFAKLMEDCWNPDPHS--RPS-----FTNILDQ---LT-
----I-VLKRELGEGAFGKVFLAECYNLSPTK-DKM---LVAVKAL---K-D--P-TL----AA----RKDFQ-R-EAELLTNL-Q-----HEH----IVKFYGVCG--D-----------------------------GDPLIMVFEYMKHGDLNKFLR----AHGPDAMILVDGQPRQAKGEL--GLSQMLHIASQIASGMVYLASQ---H---FVHRDLATRNCLVGA--------NLLV-------------------KIGDFGMSRDV---Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----------YRKFTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-SNTEVIECI-TQGRVLERPRVCP-------------------------------------------KEVYDVMLGCWQREPQQ--RLN-----IKEIYKIL-----
-----YELQETLGKGTYGKVKRATER-----F-SGR---VVAIKSI---RKD--K-IKD---EQ-----DMVHIRREIEIMSSL-N-----HPH----IISIYEVFE--N-----------------------------KDKIVIIMEYASKGELYDYIS---ERR-----------------RL--SERETRHFFRQIVSAVHYCHKN---G---VVHRDLKLENILLDD--------NCNI-------------------KIADFGLSNL-------YQKDKFL--------------QT---FCGSPLYASPEIVN----------GRPYRGPEVDSWALGVLLYTLVY-GT-MP---------------FDGF----DHKNLI-RQISSGEYREPTQP------------------------------------------SDARGLIRWMLMVNPDR--RAT-----IEDIANHWW-V--
-----YEFLETLGKGTYGKVKKARES-----S-GR----LVAIKSI---RKD--K-IKD---EQ-----DLMHIRREIEIMSSL-N-----HPH----IIAIHEVFE--N-----------------------------SSKIVIVMEYASRGDLYDYIS---ERQ-----------------QL--SEREARHFFRQIVSAVHYCHQN---R---VVHRDLKLENILLDA--------NGNI-------------------KIADFGLSNL-------YHQGKFL--------------QT---FCGSPLYASPEIVN----------GKPYTGPEVDSWSLGVLLYILVH-GT-MP---------------FDGH----DHKILV-KQISNGAYREPPK-----P-------------------------------------SDACGLIRWLLMVNPTR--RAT-----LEDVASHWW-V--
----F-TLCRKLGSGYFGEVFEGLWK-------DRV---QVAIKVI---S-R--D-NL----LH----QQMLQ-S-EIQAMKKL-R-----HKH----ILALYAVVS--V-----------------------------GDPVYIITELMAKGSLLELLR----DS--------------DEKVL--PVSELLDIAWQVAEGMCYLESQ---N---YIHRDLAARNILVGE--------NTLC-------------------KVGDFGLARLI---------KEDV--------------YLSHDHNIPYKWTAPEALS-----------RGHYSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-SNHEAFLRV-DAGYRMPCPLECP-------------------------------------------PSVHKLMLTCWCRDPEQ--RPC-----FKALRERL-----
-----YDVVKVIGRGAFGEVQLVRHK-----A-SQK---VYAMKLL---SKF--E-MIK---RS-----DSAFFWEERDIMAFA-N-----SPW----VVQLFYAFQ--D-----------------------------DRYLYMVMEYMPGGDLVNLMS----NY-----------------DV--PEKWAKFYTAEVVLALDAIHSM---G---LIHRDVKPDNMLLDK--------HGHL-------------------KLADFGTCMKM-----DETGMVHC--------------DT---AVGTPDYISPEVLKS-------QGGDGFYGRECDWWSVGVFLYEMLV-GD-TP---------------FYAD----SLVGTY-SKIMDHKNSLCFPEDAEIS-------------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF---
-----FELLKVLGQGSYGKVFLVRKV-----K-GSDAGQLYAMKVL---KKA--T-LKV---RD-----RVRSKM-ERDILAEV-N-----HPF----IVKLHYAFQ--T-----------------------------EGKLYLILDFLRGGDLFTRLS---KEV-----------------MF--TEEDVKFYLAELALALDHLHSL---G---IIYRDLKPENILLDE--------EGHI-------------------KITDFGLSKEA------IDHDKRA--------------YS---FCGTIEYMAPEVVN-----------RRGHTQSADWWSFGVLMFEMLT-GS-LP---------------FQGK----DRKETM-ALILKAKLGMPQFLS-----------------------------------------GEAQSLLRALFKRNPCN--RLGAGIDGVEEIKRHPFF---
-----FELLKVLGQGSFGKVFLVKKI-----S-GSDARQLYAMKVL---KKA--T-LKV---RD-----RVRTKM-ERDILVEV-N-----HPF----IVKLHYAFQ--T-----------------------------EGKLYLILDFLRGGDLFTRLS---KEV-----------------MF--TEEDVKFYLAELALALDHLHSL---G---IIYRDLKPENILLDE--------EGHI-------------------KLTDFGLSKES------IDHEKKA--------------YS---FCGTVEYMAPEVVN-----------RRGHTQSADWWSFGVLMFEMLT-GT-LP---------------FQGK----DRKETM-TMILKAKLGMPQFLS-----------------------------------------PEAQSLLRMLFKRNPAN--RLGAGPDGVEEIKRHSFF---
-----FELLKVLGQGSFGKVFLVRKK-----T-GPDAGQLYAMKVL---KKA--S-LKV---RD-----RVRTKM-ERDILVEV-N-----HPF----IVKLHYAFQ--T-----------------------------EGKLYLILDFLRGGDVFTRLS---KEV-----------------LF--TEEDVKFYLAELALALDHLHQL---G---IVYRDLKPENILLDE--------IGHI-------------------KLTDFGLSKES------VDQEKKA--------------YS---FCGTVEYMAPEVVN-----------RRGHSQSADWWSYGVLMFEMLT-GT-LP---------------FQGK----DRNETM-NMILKAKLGMPQFLS-----------------------------------------AEAQSLLRMLFKRNPAN--RLGS--EGVEEIKRHLFF---
----L-RLLEKLGDGSFGVVRRGEWD--APSG-KTV---SVAVKCL---K-PDVL-SQ----PEA---MDDFI-R-EVNAMHSL-D-----HRN----LIRLYGVVL--------------------------------TPPMKMVTELAPLGSLLDRLR----KH---------------QGHF--LLGTLSRYAVQVAEGMGYLESK---R---FIHRDLAARNLLLAT--------RDLV-------------------KIGDFGLMRAL--PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK-----------TRTFSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPED--RPT-----FVALRDF--L---
YLLGI-----NLGEGSYAKVKSAYSE-----R-LKF---NVAIKII---DRK--K-APA---DF-----LEKFLPREIEILAML-N-----HCS----IIKTYEIFE--T----------------------------SHGKVYIVMELAVQGDLLELIK---TRG-----------------AL--HEDEARKKFHQLSLAIKYCHDL---D---VVHRDLKCDNLLLDK--------DFNI-------------------KLSDFSFSKRCLR--DDSGRMALS--------------KT---FCGSPAYAAPEVLQ----------GIPYQPKVYDIWSLGVILYIMVC-GS-MP---------------YDDS----NIKKML-RIQKEHRVNFPRSKHLT---------------------------------------GECKDLIYHMLQPDVNR--RLH-----IDEILSHCWM---
-----YSILKQIGSGGSSKVFQVLNE-----K-KQ----IYAIKYV---NLE--E-ADN---QT-----LDSYRN-EIAYLNKLQQ----HSDK----IIRLYDYEI--T-----------------------------DQYIYMVMECGNI-DLNSWLK---KKK-----------------SI--DPWERKSYWKNMLEAVHTIHQH---G---IVHSDLKPANFLIV---------DGML-------------------KLIDFGIANQMQ----PDTTSVVK--------------DS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TP---------------FQQI---INQISKL-HAIIDPNHEIEFPDIPE---------------------------------------KDLQDVLKCCLKRDPKQ--RIS-----IPELLAHPYV---
----L-RLEVKLGQGCFGEVWMGTWN-------GTT---KVAIKTL---K-P--G-TM----MP-----EAFL-Q-EAQIMKKL-R-----HDK----LVPLYAVVS--------------------------------EEPIYIVTEFMSKGSLLDFLK----EG--------------DGKYL--KLPQLVDMAAQIADGMAYIERM---N---YIHRDLRAANILVGE--------NLVC-------------------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV-ERGYRMPCPQGCP-------------------------------------------ESLHELMNLCWKKDPDE--RPT-----FEYIQSFL-----
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