|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE MAP4K4 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TKL BMPR1B 204
TK BMX 422
CAMK BRSK1 50
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
TK CSF1R 582
TK CSK 195
CAMK DAPK3 13
TK DDR1 572
TK DDR2 563
TK EPHA1 624
TK EPHA3 621
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FRK 234
TK FYN 271
TK HCK 241
CAMK HUNK 61
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LTK 510
TK LYN 247
STE MAP2K1 68
STE MAP2K5 166
TKL MAP3K7 36
STE MAP4K3 16
CMGC MAPK14 24
CAMK MARK2 53
CAMK MARK4 59
CAMK MELK 11
TK MET 1078
STE MINK1 25
TK MUSK 575
Other NEK5 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
TK PDGFRA 593
TK PDGFRB 600
AGC PKN1 615
AGC PKN2 657
Other PLK3 62
Other PLK4 12
CAMK PRKAA1 18
CAMK PRKAA2 16
AGC PRKACA 44
AGC PRKCD 349
AGC PRKCQ 380
TK PTK2B 425
TK RET 724
TKL RIPK1 17
TKL RIPK4 22
TK ROS1 1945
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
TK SRC 270
STE STK10 36
STE STK24 24
TK SYK 371
TK TEC 370
TK TEK 824
TKL TGFBR1 205
TK TIE1 839
STE TNIK 25
TK TNK1 116
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
----FELVEVVGNGTYGQV---YKGRHV----------------KTGQ---LAAI-KVM---DVT--E-DEEEE---I-KL-------EINMLKKY-SH---HRNIATYYGAFI--KKSPPGHDDQ--LWLVMEFCGAGSITDLVKN-TKGN-----------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHI-H--------H---VIHRDIKGQNVLLTE-----NA-EV----KLVDFGVSAQL----------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD-ENPDAT--YDYRSDLWSCGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPP---PR---LKSKKWS------------------------------------------KKFFS-FIEGCLVKNYMQRPS-----TE-QLLKHPFI-----
----ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---E-EFL-K----EAAVMKEI--K---HPNLVQLLGVCT--R------EPP--FYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NR-QEVNAVVLLYMATQISSAMEYLEK-K--------N---FIHRDLAARNCLVGE-----NH-LV----KVADFGLSRLM----------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA------YNK--FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL----EK----DYR---ME---RPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F-----
----ITMKHKLGGGQYGEV---YVGVWK----------------KYSL---TVAV-KTL---K-E--D-TM-EV---E-EFL-K----EAAVMKEI--K---HPNLVQLLGVCT--L------EPP--FYIVTEYMPYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NR-EEVTAVVLLYMATQISSAMEYLEK-K--------N---FIHRDLAARNCLVGE-----NH-VV----KVADFGLSRLM----------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA------YNT--FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL----EK----GYR---ME---QPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPS-----FA-ETHQA--F-----
---I-TLLECVGKGRYGEV---WRGSWQ----------------GEN-----VAV-KIF---SSR--D-EKSWF---R-ET-------ELYNTVML--R---HENILGFIASDM--TSR--HSSTQ--LWLITHYHEMGSLYDYLQ----LT-----------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHI-EIFGTQGKPA---IAHRDLKSKNILVKK-----NG-QC----CIADLGLAVMHSQ------------STNQLDVGN--------------NP---RVGTKRYMAPEV--LDETIQVDCFD--SYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVPNDPSFEDMRKVV----CV----DQQ---RP---NIPNRWFSDPTL-------------------------------------TSLAK-LMKECWYQNPSARLT-----AL-RIKK----TL---
---I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAV-KTL---P-E--V-CS-EQD-EL-DFL-M----EALIISKF--N---HQNIVRCIGVSL--Q------SLP--RFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQP-SSLAMLDLLHVARDIACGCQYLEE-N--------H---FIHRDIAARNCLLTCP--GPGR-VA----KIGDFGMARDI-------------Y--R--ASYY--------------RKGGCAMLPVKWMPPEA--FM------EGI--FTSKTDTWSFGVLLWEIFSLGY--------------MP---------------YPSK-----SNQEVLEFV----TS----GGR---MD---PPKNCP-------------------------------------------GPVYR-IMTQCWQHQPEDRPN-----FA-IILER--I-----
----FEIGRPLGKGKFGNV---YLAREK----------------QSKF---ILAL-KVL---FKA--QLEKAGV---E-HQLRR----EVEIQSHL--R---HPNILRLYGYFH--D------ATR--VYLILEYAPLGTVYRELQ---KLS-----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHS-K--------R---VIHRDIKPENLLLGS-----AG-EL----KIADFGWSV------------------HAPSSRR--------------TT---LCGTLDYLPPEM--IE------GRM--HDEKVDLWSLGVLCYEFLV-GK--------------PP---------------FEAN--------TYQETY----KR----ISR---VE---FTFPDFVT-----------------------------------------EGARD-LISRLLKHNPSQRPM-----LR-EVLEHPWI-----
----FEIGRPLGKGKFGNV---YLAREK----------------KSHF---IVAL-KVL---FKS--Q-IEKEG---V-EHQLR---REIEIQAHL--H---HPNILRLYNYFY--D------RRR--IYLILEYAPRGELYKELQ---KSC-----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHG-K--------K---VIHRDIKPENLLLGL-----KG-EL----KIADFGWSV------------------HAPSLRR--------------KT---MCGTLDYLPPEM--IE------GRM--HNEKVDLWCIGVLCYELLV-GN--------------PP---------------FESA--------SHNETY----RR----IVK---VD---LKFPASVP-----------------------------------------MGAQD-LISKLLRHNPSERLP-----LA-QVSAHPWV-----
----FEIGRPLGKGKFGNV---YLARLK----------------ESHF---IVAL-KVL---FKS--Q-IEKEG---L-EHQLR---REIEIQAHL--Q---HPNILRLYNYFH--D------ARR--VYLILEYAPRGELYKELQ---KSE-----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHD-K--------K---VIHRDIKPENLLLGF-----RG-EV----KIADFGWSV------------------HTPSLRR--------------KT---MCGTLDYLPPEM--IE------GRT--YDEKVDLWCIGVLCYELLV-GY--------------PP---------------FESA--------SHSETY----RR----ILK---VD---VRFPLSMP-----------------------------------------LGARD-LISRLLRYQPLERLP-----LA-QILKHPWV-----
---L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAI-KTL---K-E--G-TM-SP---E-AFL-G----EANVMKAL--Q---HERLVRLYAVVT---------KEP--IYIVTEYMARGCLLDFLK----TD-------------------------------------------------------------------------------------------------EG-SRLSLPRLIDMSAQIAEGMAYIER-M--------N---SIHRDLRAANILVSE-----AL-CC----KIADFGLARII-------------------DSEY--------------TAQEGAKFPIKWTAPEA--IH------FGV--FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL----ER----GYR---MP---RPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L-----
---I-QMVKQIGKGRYGEV---WMGKWR----------------GEK-----VAV-KVF---FTT--E-EASWF---R-ET-------EIYQTVLM--R---HENILGFIAADI--KGT--GSWTQ--LYLITDYHENGSLYDYLK----ST-----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHT-EIFSTQGKPA---IAHRDLKSKNILVKK-----NG-TC----CIADLGLAVKFIS------------DTNEVDIPP--------------NT---RVGTKRYMPPEV--LDESLNRNHFQ--SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV----CI----KKL---RP---SFPNRWSSDECL-------------------------------------RQMGK-LMTECWAHNPASRLT-----AL-RVKK----TL---
----ITLLKELGSGQFGVV---QLGKWK-----------------GQY---DVAV-KMI---K-E--G-SM-SE---D-EFF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K------EYP--IYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------------------------------------G-KGLEPSQLLEMCYDVCEGMAFLES-H--------Q---FIHRDLAARNCLVDR-----DL-CV----KVSDFGMTRYV----------------L--DDQY--------------VSSVGTKFPVKWSAPEV--FH------YFK--YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV----SQ----GHR---LY---RPHLAS-------------------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQ-QLLSS--I-----
----YRLEKTLGKGQTGLV---KLGVHC----------------ITGQ---KVAI-KIV---NRE--K-LSESV---L-MKVER----EIAILKLI--E---HPHVLKLHDVYE--N------KKY--LYLVLEHVSGGELFDYLV---KKG-----------------------------------------------------------------------------------------------------RLTPKEARKFFRQIVSALDFCHS-Y--------S---ICHRDLKPENLLLDE-----KN-NI----RIADFGMASL-----------------QVGDSLL--------------ET---SCGSPHYACPEV--IK-----GEKY--DGRRADMWSCGVILFALLV-GA--------------LP---------------FDDD--------NLRQLL----EK----VKR---GV---FHMPHFIP-----------------------------------------PDCQS-LLRGMIEVEPEKRLS-----LE-QIQKHPW-Y----
----LTFLKELGTGQFGVV---KYGKWR-----------------GQY---DVAI-KMI---K-E--G-SM-SE---D-EFI-E----EAKVMMNL--S---HEKLVQLYGVCT--K------QRP--IFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------R-HRFQTQQLLEMCKDVCEAMEYLES-K--------Q---FLHRDLAARNCLVND-----QG-VV----KVSDFGLSRYV----------------L--DDEY--------------TSSVGSKFPVRWSPPEV--LM------YSK--FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI----AQ----GLR---LY---RPHLAS-------------------------------------------EKVYT-IMYSCWHEKADERPT-----FK-ILLSN--I-----
----YTKIEKIGEGTYGVV---YKGRHK----------------TTGQ---VVAM-KKI---RLE--S-EEEGV---P-STAIR----EISLLKEL--R---HPNIVSLQDVLM--Q------DSR--LYLIFEFLSM-DLKKYLDSIPPGQ-----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHS-R--------R---VLHRDLKPQNLLIDD-----KG-TI----KLADFGLARAF----------------GIPIRVY--------------TH---EVVTLWYRSPEV--LL-----GSAR--YSTPVDIWSIGTIFAELAT-KK--------------PL---------------FHGD-----SEIDQLFRI----FR----ALG---TP---NNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GK-MALNHPYF-----
----FQKVEKIGEGTYGVV---YKARNK----------------LTGE---VVAL-KKI---RLD--T-ETEGV---P-STAIR----EISLLKEL--N---HPNIVKLLDVIH--T------ENK--LYLVFEFLHQ-DLKKFMDA-SALT-----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHS-H--------R---VLHRDLKPQNLLINT-----EG-AI----KLADFGLARAF----------------GVPVRTY--------------TH---EVVTLWYRAPEI--LL-----GCKY--YSTAVDIWSLGCIFAEMVT-RR--------------AL---------------FPGD-----SEIDQLFRI----FR----TLG---TP---DEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AK-AALAHPFF-----
----YEKLEKIGEGTYGTV---FKAKNR----------------ETHE---IVAL-KRV---RLD--D-DDEGV---P-SSALR----EICLLKEL--K---HKNIVRLHDVLH--S------DKK--LTLVFEFCDQ-DLKKYFD--SCNG-----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHS-R--------N---VLHRDLKPQNLLINR-----NG-EL----KLADFGLARAF----------------GIPVRCY--------------SA---EVVTLWYRPPDV--LF-----GAKL--YSTSIDMWSAGCIFAELANAGR--------------PL---------------FPGN-----DVDDQLKRI----FR----LLG---TP---TEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AE-EALQHPYF-----
----YENLGLVGEGSYGMV---MKCRNK----------------DTGR---IVAI-KKF---LES--D-DDKMV---K-KIAMR----EIKLLKQL--R---HENLVNLLEVCK--K------KKR--WYLVFEFVDHTILDDLEL---FPN-----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHS-H--------N---IIHRDIKPENILVSQ-----SG-VV----KLCDFGFARTL----------------AAPGEVY--------------TD---YVATRWYRAPEL--LV-----GDVK--YGKAVDVWAIGCLVTEMFM-GE--------------PL---------------FPGD-----SDIDQLYHI----MM----CLG---NL---IPRHQELFNKNPVFAGVRLPEIKE-------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CA-ELLHHDFF-----
----YETLGKVGEGSYGTV---MKCKHK----------------NTGQ---IVAI-KIF---YER--P-EQSVN---K--IAMR----EIKFLKQF--H---HENLVNLIEVFR--Q------KKK--IHLVFEFIDHTVLDELQH---YCH-----------------------------------------------------------------------------------------------------GLESKRLRKYLFQILRAIDYLHS-N--------N---IIHRDIKPENILVSQ-----SG-IT----KLCDFGFARTL----------------AAPGDIY--------------TD---YVATRWYRAPEL--VL-----KDTS--YGKPVDIWALGCMIIEMAT-GN--------------PY---------------LPSS-----SDLDLLHKI----VL----KVG---N----LSPHLQNIFSKSPIFAGVVLPQVQ------------HPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-----SS-DLLHHEYF-----
----FEILGVVGEGAYGVV---LKCRHK----------------ETHE---IVAI-KKF---KDS--E-ENEEV---K-ETTLR----ELKMLRTL--K---QENIVELKEAFR--R------RGK--LYLVFEYVEK-NMLELLE--EMPN-----------------------------------------------------------------------------------------------------GVPPEKVKSYIYQLIKAIHWCHK-N--------D---IVHRDIKPENLLISH-----ND-VL----KLCDFGFARNL---------------SEGNNANY--------------TE---YVATRWYRSPEL--LL------GAP--YGKSVDMWSVGCILGELSD-GQ--------------PL---------------FPGE-----SEIDQLFTI----QK----VLG---PL---PSEQMKLFYSNPRFHGLRFPAVNH------------PQSLERRYLGILNSVLLD-LMKNLLKLDPADRYL-----TE-QCLNHPTF-----
----LQFGKTLGAGAFGKV---VEATAFG-----------LGKEDAVL---KVAV-KML---K-S--T-AH-ADE-KE-ALM-S----ELKIMSHLG-Q---HENIVNLLGACT--H------GGP--VLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPLELRDLLHFSSQVAQGMAFLAS-K--------N---CIHRDVAARNVLLTN-----GH-VA----KIGDFGLARDI-------------M--N--DSNY--------------IVKGNARLPVKWMAPES--IF------DCV--YTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ---MA---QPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPT-----FQ-QICSFL-------
----LKLLQTIGKGEFGDV---MLGDYR------------------GN---KVAV-KCI---K-N--D-AT-AQ-----AFL-A----EASVMTQL--R---HSNLVQLLGVIV-EE------KGG--LYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------------------------------------GR-SVLGGDCLLKFSLDVCEAMEYLEG-N--------N---FVHRDLAARNVLVSE-----DN-VA----KVSDFGLTKEA----------------------S--------------STQDTGKLPVKWTAPEA--LR------EKK--FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV----EK----GYK---MD---APDGCP-------------------------------------------PAVYE-VMKNCWHLDAAMRPS-----FL-QLREQL-------
----YEMGEELGSGQFAIV---RKCRQK----------------GTGK---EYAA-KFI---KKR--R-LSSSR---R-GVSREEIEREVNILREI--R---HPNIITLHDIFE--N------KTD--VVLILELVSGGELFDFLA---EKE-----------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHS-K--------R---IAHFDLKPENIMLLD-----KN-VPNPRIKLIDFGIAHK-----------------IEAGNEF--------------KN---IFGTPEFVAPEI--VN------YEP--LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGE--------TKQETL----TN----ISA---VN---YDFDEEYFSNTS-------------------------------------ELAKD-FIRRLLVKDPKRRMT-----IA-QSLEHSWI-----
----LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAV-KIL---R-P--D-AT-KNA-RN-DFL-K----EVKIMSRL--K---DPNIIRLLGVCV--Q------DDP--LCMITDYMENGDLNQFLS----AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQG-PTISYPMLLHVAAQIASGMRYLAT-L--------N---FVHRDLATRNCLVGE-----NF-TI----KIADFGMSRNL-------------Y--A--GDYY--------------RVQGRAVLPIRWMAWEC--IL------MGK--FTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQVYLS---RPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPP-----FS-QLHRFL-------
----LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAV-KML---R-A--D-AN-KNA-RN-DFL-K----EIKIMSRL--K---DPNIIHLLAVCI--T------DDP--LCMITEYMENGDLNQFLS----RHEPPN-----------------------------------------------------------------------------------------SSSSDV-RTVSYTNLKFMATQIASGMKYLSS-L--------N---FVHRDLATRNCLVGK-----NY-TI----KIADFGMSRNL-------------Y--S--GDYY--------------RIQGRAVLPIRWMSWES--IL------LGK--FTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQTYLP---QPAICP-------------------------------------------DSVYK-LMLSCWRRDTKNRPS-----FQ-EIHL---LL----
--LM--VDTVIGEGEFGEV---YRGTLR-------------LPSQDCK---TVAI-KTL---K-D--T-SP-GGQ-WW-NFL-R----EATIMGQF--S---HPHILHLEGVVT--K------RKP--IMIITEFMENGALDAFLR----ER--------------------------------------------------------------------------------------------------E-DQLVPGQLVAMLQGIASGMNYLSN-H--------N---YVHRDLAARNILVNQ-----NL-CC----KVSDFGLTRLL-------------D--D--FDGT--------------YETQGGKIPIRWTAPEA--IA------HRI--FTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----SNQEVMKSI----ED----GYR---LP---PPVDCP-------------------------------------------APLYE-LMKNCWAYDRARRPH-----FQ-KLQAHL-------
---I-SIDKVVGAGEFGEV---CSGRLK-------------LPSKKEI---SVAI-KTL---K-V--G-YT-EKQ-RR-DFL-G----EASIMGQF--D---HPNIIRLEGVVT--K------SKP--VMIVTEYMENGSLDSFLR----KH--------------------------------------------------------------------------------------------------D-AQFTVIQLVGMLRGIASGMKYLSD-M--------G---YVHRDLAARNILINS-----NL-VC----KVSDFGLSRVL-------------E--D--DPEA-------------AYTTRGGKIPIRWTSPEA--IA------YRK--FTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----SNQDVIKAV----DE----GYR---LP---PPMDCP-------------------------------------------AALYQ-LMLDCWQKDRNNRPK-----FE-QIVSIL-------
----IHIEKIIGSGDSGEV---CYGRLR-------------VPGQRDV---PVAI-KAL---K-A--G-YT-ERQ-RR-DFL-S----EASIMGQF--D---HPNIIRLEGVVT--R------GRL--AMIVTEYMENGSLDTFLR----TH--------------------------------------------------------------------------------------------------D-GQFTIMQLVGMLRGVGAGMRYLSD-L--------G---YVHRDLAARNVLVDS-----NL-VC----KVSDFGLSRVL-------------E--D--DPDA-------------AYTTTGGKIPIRWTAPEA--IA------FRT--FSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDVISSV----EE----GYR---LP---APMGCP-------------------------------------------HALHQ-LMLDCWHKDRAQRPR-----FS-QIVSVL-------
---V-KIEEVIGAGEFGEV---YKGRLK-------------LPGKREI---YVAI-KTL---K-A--G-YS-EKQ-RR-DFL-S----EASIMGQF--D---HPNIIRLEGVVT--K------SRP--VMIITEFMENGALDSFLR----QN--------------------------------------------------------------------------------------------------D-GQFTVIQLVGMLRGIAAGMKYLAE-M--------N---YVHRDLAARNILVNS-----NL-VC----KVSDFGLSRYLQ----------DDT--S--DPTY--------------TSSLGGKIPVRWTAPEA--IA------YRK--FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LP---PPMDCP-------------------------------------------AALHQ-LMLDCWQKDRNSRPR-----FA-EIVNTL-------
---V-KIEQVIGAGEFGEV---CSGHLK-------------LPGKREI---FVAI-KTL---K-S--G-YT-EKQ-RR-DFL-S----EASIMGQF--D---HPNVIHLEGVVT--K------STP--VMIITEFMENGSLDSFLR----QN--------------------------------------------------------------------------------------------------D-GQFTVIQLVGMLRGIAAGMKYLAD-M--------N---YVHRDLAARNILVNS-----NL-VC----KVSDFGLSRFLE----------DDT--S--DPTY--------------TSALGGKIPIRWTAPEA--IQ------YRK--FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDVINAI----EQ----DYR---LP---PPMDCP-------------------------------------------SALHQ-LMLDCWQKDRNHRPK-----FG-QIVNTL-------
---V-KIEEVIGAGEFGEV---CRGRLK-------------APGKKES---CVAI-KTL---K-G--G-YT-ERQ-RR-EFL-S----EASIMGQF--E---HPNIIRLEGVVT--N------SMP--VMILTEFMENGALDSFLR----LN--------------------------------------------------------------------------------------------------D-GQFTVIQLVGMLRGIASGMRYLAE-M--------S---YVHRDLAARNILVNS-----NL-VC----KVSDFGLSRFLE----------ENS--S--DPTY--------------TSSLGGKIPIRWTAPEA--IA------FRK--FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR---LP---PPPDCP-------------------------------------------TSLHQ-LMLDCWQKDRNARPR-----FP-QVVSAL-------
----IKIEEVIGTGSFGEV---RQGRLQ-------------PRGRREQ---TVAI-QAL---W-A--G-GA-ESL-QM-TFL-G----RAAVLGQF--Q---HPNILRLEGVVT--K------SRP--LMVLTEFMELGPLDSFLR----QR--------------------------------------------------------------------------------------------------E-GQFSSLQLVAMQRGVAAAMQYLSS-F--------A---FVHRSLSAHSVLVNS-----HL-VC----KVARLGHSPQG------------------------------------------PSCLLRWAAPEV--IA------HGK--HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI----EQ----EFR---LP---PPPGCP-------------------------------------------PGLHL-LMLDTWQKDRARRPH-----FD-QLVA---AF----
---L-RKLKVLGSGVFGTV---HKGVWIP------------EGESIKI---PVCI-KVI---E-D--K-SG-RQS-FQ-AVT-D----HMLAIGSL--D---HAHIVRLLGLCP---------GSS--LQLVTQYLPLGSLLDHVR----QH--------------------------------------------------------------------------------------------------R-GALGPQLLLNWGVQIAKGMYYLEE-H--------G---MVHRNLAARNVLLKS-----PS-QV----QVADFGVADLL-------------P--P--DDKQ--------------LLYSEAKTPIKWMALES--IH------FGK--YTHQSDVWSYGVTVWELMTFGA--------------EP---------------YAGL-----RLAEVPDLL----EK----GER---LA---QPQICT-------------------------------------------IDVYM-VMVKCWMIDENIRPT-----FK-ELANE--F-----
---L-VLGKPLGEGCFGQV---VLAEAIGL---------DKDKPNRVT---KVAV-KML---K-S--D-AT-EKD-LS-DLI-S----EMEMMKMIG-K---HKNIINLLGACT--Q------DGP--LYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPE-EQLSSKDLVSCAYQVARGMEYLAS-K--------K---CIHRDLAARNVLVTE-----DN-VM----KIADFGLARDI-------------H--H--IDYY--------------KKTTNGRLPVKWMAPEA--LF------DRI--YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGV-----PVEELFKLL----KE----GHR---MD---KPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-------
----LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPKEAV---TVAV-KML---K-D--D-AT-EKD-LS-DLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q------DGP--LYVIVEYASKGNLREYLR----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPE-EQMTFKDLVSCTYQLARGMEYLAS-Q--------K---CIHRDLAARNVLVTE-----NN-VM----KIADFGLARDI-------------N--N--IDYY--------------KKTTNGRLPVKWMAPEA--LF------DRV--YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR---MD---KPANCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-------
----LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAAKPV---TVAV-KML---K-D--D-AT-DKD-LS-DLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q------GGP--LYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPE-EQLTFKDLVSCAYQVARGMEYLAS-Q--------K---CIHRDLAARNVLVTE-----DN-VM----KIADFGLARDV-------------H--N--LDYY--------------KKTTNGRLPVKWMAPEA--LF------DRV--YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR---MD---KPANCT-------------------------------------------HDLYM-IMRECWHAAPSQRPT-----FK-QLVEDL-------
---L-VLGKPLGEGCFGQV---VRAEAFGM---------DPARPDQAS---TVAV-KML---K-D--N-AS-DKD-LA-DLV-S----EMEVMKLIG-R---HKNIINLLGVCT--Q------EGP--LYVIVECAAKGNLREFLR----ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSE-GPLSFPVLVSCAYQVARGMQYLES-R--------K---CIHRDLAARNVLVTE-----DN-VM----KIADFGLARGV-------------H--H--IDYY--------------KKTSNGRLPVKWMAPEA--LF------DRV--YTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----PVEELFSLL----RE----GHR---MD---RPPHCP-------------------------------------------PELYG-LMRECWHAAPSQRPT-----FK-QLVEAL-------
----ITLERRLGTGCFGDV---WLGTWN-----------------GST---KVAV-KTL---K-P--G-TM-SP---K-AFL-E----EAQVMKLL--R---HDKLVQLYAVVS---------EEP--IYIVTEFMCHGSLLDFLK----NP-------------------------------------------------------------------------------------------------EG-QDLRLPQLVDMAAQVAEGMAYMER-M--------N---YIHRDLRAANILVGE-----RL-AC----KIADFGLARLI----------------K--DDEY--------------NPCQGSKFPIKWTAPEA--AL------FGR--FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV----EQ----GYH---MP---CPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FE-YLQSFL-------
----LHLGRVLGYGAFGKV---VEASAFG-----------IHKGSSCD---TVAV-KML---K-E--G-AT-ASE-HR-ALM-S----ELKILIHIG-N---HLNVVNLLGACT-KP------QGP--LMVIVEFCKYGNLSNFLR----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWL-SPLTMEDLVCYSFQVARGMEFLAS-R--------K---CIHRDLAARNILLSE-----SD-VV----KICDFGLARDI-------------Y--K--DPDY--------------VRKGSARLPLKWMAPES--IF------DKV--YTTQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-Q---INEEFCQRL----RD----GTR---MR---APELAT-------------------------------------------PAIRR-IMLNCWSGDPKARPA-----FS-ELVEIL-------
----IQLLKRLGSGQFGEV---WEGLWN-----------------NTT---PVAV-KTL---K-P--G-SM-DP---N-DFL-R----EAQIMKNL--R---HPKLIQLYAVCT--L------EDP--IYIITELMRHGSLQEYLQ----ND-------------------------------------------------------------------------------------------------TG-SKIHLTQQVDMAAQVASGMAYLES-R--------N---YIHRDLAARNVLVGE-----HN-IY----KVADFGLARVFK-----------VD--N--EDIY--------------ESRHEIKLPVKWTAPEA--IR------SNK--FSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML----AQ----NYR---LP---QPSNCP-------------------------------------------QQFYN-IMLECWNAEPKERPT-----FE-TLRWK--L-----
----LQLIKRLGNGQFGEV---WMGTWN-----------------GNT---KVAI-KTL---K-P--G-TM-SP---E-SFL-E----EAQIMKKL--K---HDKLVQLYAVVS---------EEP--IYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------------------------------------EG-RALKLPNLVDMAAQVAAGMAYIER-M--------N---YIHRDLRSANILVGN-----GL-IC----KIADFGLARLI----------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL------YGR--FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV----ER----GYR---MP---CPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FE-YLQSFL-------
----LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAV-KTM---K-P--G-SM-SV---E-AFL-A----EANVMKTL--Q---HDKLVKLHAVVT---------KEP--IYIITEFMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EG-SKQPLPKLIDFSAQIAEGMAFIEQ-R--------N---YIHRDLRAANILVSA-----SL-VC----KIADFGLARVI----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN------FGS--FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL----ER----GYR---MP---RPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPT-----FE-YIQSV--L-----
-IGS----RKLGEGSFAKV---REGLHV----------------LTGE---KVAI-KVI---DKK--R-AKKDT---Y-VTKNLR--REGQIQQMI--R---HPNITQLLDILE--T------ENS--YYLVMELCPGGNLMHKIY---EKK-----------------------------------------------------------------------------------------------------RLEESEARRYIRQLISAVEHLHR-A--------G---VVHRDLKIENLLLDE-----DN-NI----KLIDFGLSNCAG--------------ILGYSDPF--------------ST---QCGSPAYAAPEL--LA------RKK--YGPKIDVWSIGVNMYAMLT-GT--------------LP---------------FTVE------PFSLRALY----QK----MVD----K---EMNPLPTQ--LS-------------------------------------TGAIS-FLRSLLEPDPVKRPN-----IQ-QALANRWL-----
----ITMSRELGQGSFGMV---YEGVAKG-----------VVKDEPET---RVAI-KTV---N-E--A-AS-MRE-RI-EFL-N----EASVMKEF--N---CHHVVRLLGVVS--Q------GQP--TLVIMELMTRGDLKSYLR----SLRPEM-----------------------------------------------------------------------------------------ENNPVL-APPSLSKMIQMAGEIADGMAYLNA-N--------K---FVHRDLAARNCMVAE-----DF-TV----KIGDFGMTRDI-------------Y--E--TDYY--------------RKGGKGLLPVRWMSPES--LK------DGV--FTTYSDVWSFGVVLWEIATLAE--------------QP---------------YQGL-----SNEQVLRFV----ME----GGL---LD---KPDNCP-------------------------------------------DMLFE-LMRMCWQYNPKMRPS-----FL-EIISS--I-----
----ITLLRELGQGSFGMV---YEGNARD-----------IIKGEAET---RVAV-KTV---N-E--S-AS-LRE-RI-EFL-N----EASVMKGF--T---CHHVVRLLGVVS--K------GQP--TLVVMELMAHGDLKSYLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGR-PPPTLQEMIQMAAEIADGMAYLNA-K--------K---FVHRDLAARNCMVAH-----DF-TV----KIGDFGMTRDI-------------Y--E--TDYY--------------RKGGKGLLPVRWMAPES--LK------DGV--FTTSSDMWSFGVVLWEITSLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGY---LD---QPDNCP-------------------------------------------ERVTD-LMRMCWQFNPKMRPT-----FL-EIVNLL-------
---I-SIIRELGQGSFGMV---YEGLARG-----------LEAGEEST---PVAL-KTV---N-E--L-AS-PRE-CI-EFL-K----EASVMKAF--K---CHHVVRLLGVVS--Q------GQP--TLVIMELMTRGDLKSHLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGL-PQPALGEMIQMAGEIADGMAYLAA-N--------K---FVHRDLAARNCMVSQ-----DF-TV----KIGDFGMTRDV-------------Y--E--TDYY--------------RKGGKGLLPVRWMAPES--LK------DGI--FTTHSDVWSFGVVLWEIVTLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGV---LE---ELEGCP-------------------------------------------LQLQE-LMSRCWQPNPRLRPS-----FT-HILD---SI----
-VGG----NKMGEGGFGVV---YKGYVN----------------NTT-----VAV-KKL---AAM--V-DITTE---ELKQQFD---QEIKVMAKC--Q---HENLVELLGFSS--D------GDD--LCLVYVYMPNGSLLDRLSCLDGTP-----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHE-N--------H---HIHRDIKSANILLDE-----AF-TA----KISDFGLARASE--------------KFAQTVMT--------------SR---IVGTTAYMAPEA--LR-------GE--ITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH-----REPQLLLDI----KE----EIE---DE---EKTIEDYIDKKMNDAD-----------------------------STSVEAMYS-VASQCLHEKKNKRPD-----IK-KVQQ----LLQ--
----LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAI-KTI---R-E--G-AM-SE---E-DFI-E----EAEVMMKL--S---HPKLVQLYGVCL--E------QAP--ICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------------------------------------R-GLFAAETLLGMCLDVCEGMAYLEE-A--------C---VIHRDLAARNCLVGE-----NQ-VI----KVSDFGMTRFV----------------L--DDQY--------------TSSTGTKFPVKWASPEV--FS------FSR--YSSKSDVWSFGVLMWEVFSEGK--------------IP---------------YENR-----SNSEVVEDI----ST----GFR---LY---KPRLAS-------------------------------------------THVYQ-IMNHCWKERPEDRPA-----FS-RLLRQL-------
---L-KRIRDLGEGHFGKV---ELCRYDP------------EGDNTGE---QVAV-KSL---K-P--E-SG-GNH-IA-DLK-K----EIEILRNL--Y---HENIVKYKGICT-ED-------GGNGIKLIMEFLPSGSLKEYLP----KN--------------------------------------------------------------------------------------------------K-NKINLKQQLKYAVQICKGMDYLGS-R--------Q---YVHRDLAARNVLVES-----EH-QV----KIGDFGLTKAI------------ET--D--KEYY--------------TVKDDRDSPVFWYAPEC--LM------QSK--FYIASDVWSFGVTLHELLTYCD--------------SDSSPMALF-LKMIGPTHGQM-----TVTRLVNTL----KE----GKR---LP---CPPNCP-------------------------------------------DEVYQ-LMRKCWEFQPSNRTS-----FQ-NLIE---GF----
----LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAV-KKL---Q-H--S-TE--EH-LR-DFE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG------RRN--LKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------K-ERIDHIKLLQYTSQICKGMEYLGT-K--------R---YIHRDLATRNILVEN-----EN-RV----KIGDFGLTKVL------------PQ--D--KEYY--------------KVKEPGESPIFWYAPES--LT------ESK--FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR---LP---RPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV---
---L-KYISQLGKGNFGSV---ELCRYDP------------LGDNTGA---LVAV-KQL---Q-H--S-GP-DQ--QR-DFQ-R----EIQILKAL--H---SDFIVKYRGVSYGPG------RQS--LRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------------------------------------R-ARLDASRLLLYSSQICKGMEYLGS-R--------R---CVHRDLAARNILVES-----EA-HV----KIADFGLAKLL------------PL--D--KDYY--------------VVREPGQSPIFWYAPES--LS------DNI--FSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EE----GQR---LP---APPACP-------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL----
----LKLGKPLGRGAFGQV---IEADAFG-----------IDKTATCR---TVAV-KML---K-E--G-AT-HSE-HR-ALM-S----ELKILIHIG-H---HLNVVNLLGACT-KP------GGP--LMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK-DFLTLEHLICYSFQVAKGMEFLAS-R--------K---CIHRDLAARNILLSE-----KN-VV----KICDFGLARDI-------------Y--K--DPDY--------------VRKGDARLPLKWMAPET--IF------DRV--YTIQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-K---IDEEFCRRL----KE----GTR---MR---APDYTT-------------------------------------------PEMYQ-TMLDCWHGEPSQRPT-----FS-ELVEHL-------
----LSFGKTLGAGAFGKV---VEATAYG-----------LIKSDAAM---TVAV-KML---K-P--S-AH-LTE-RE-ALM-S----ELKVLSYLG-N---HMNIVNLLGACT--I------GGP--TLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LALDLEDLLSFSYQVAKGMAFLAS-K--------N---CIHRDLAARNILLTH-----GR-IT----KICDFGLARDI-------------K--N--DSNY--------------VVKGNARLPVKWMAPES--IF------NCV--YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI----KE----GFR---ML---SPEHAP-------------------------------------------AEMYD-IMKTCWDADPLKRPT-----FK-QIVQL--I-----
----LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAV-KSL---K-Q--G-SM-SP---D-AFL-A----EANLMKQL--Q---HQRLVRLYAVVT---------QEP--IYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SG-IKLTINKLLDMAAQIAEGMAFIEE-R--------N---YIHRDLRAANILVSD-----TL-SC----KIADFGLARLI----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN------YGT--FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL----ER----GYR---MV---RPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L-----
--LI--HGEVLGKGCFGQA---IKVTHR----------------ETGE---VMVM-KEL---I----R-FD-EET-QR-TFL-K----EVKVMRCL--E---HPNVLKFIGVLY--K------DKR--LNFITEYIKGGTLRGIIK----SM--------------------------------------------------------------------------------------------------D-SQYPWSQRVSFAKDIASGMAYLHS-M--------N---IIHRDLNSHNCLVRE-----NK-NV----VVADFGLARLM-------------V--D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEM--IN------GRS--YDEKVDVFSFGIVLCEIIGRVN--------------AD---------------PDYL-P---RTMDFGLNV----RG----FLD---RY---CPPNCP-------------------------------------------PSFFP-ITVRCCDLDPEKRPS-----FV-KLEH---WL----
--LI--HGEVLGKGFFGQA---IKVTHK-----------------ATG---KVMVMKEL-----I--R-CD-EET-QK-TFL-T----EVKVMRSL--D---HPNVLKFIGVLY--K------DKK--LNLLTEYIEGGTLKDFLR----SM----------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHS-M--------C---IIHRDLNSHNCLIKL-----DK-TV----VVADFGLSRLIVEERKRAPMEKATT--------KKRTL-----RKNDRKKRYTVVGNPYWMAPEM--LN------GKS--YDETVDIFSFGIVLCEIIGQVY--------------AD---------------PDCL-P---RTLDFGLNV----KL----FWE---KF---VPTDCP-------------------------------------------PAFFP-LAAICCRLEPESRPA-----FS-KLED---SF----
---V-TLLRALGHGAFGEV---YEGLVIG-----------LPGDSSPL---QVAI-KTL---P-E--L-CS-PQD-EL-DFL-M----EALIISKF--R---HQNIVRCVGLSL--R------ATP--RLILLELMSGGDMKSFLR----HSRP--------------------------------------------------------------------------------------------HLGQP-SPLVMRDLLQLAQDIAQGCHYLEE-N--------H---FIHRDIAARNCLLSCA--GPSR-VA----KIGDFGMARDI-------------Y--R--ASYY--------------RRGDRALLPVKWMPPEA--FL------EGI--FTSKTDSWSFGVLLWEIFSLGY--------------MP---------------YPGR-----TNQEVLDFV----VG----GGR---MD---PPRGCP-------------------------------------------GPVYR-IMTQCWQHEPELRPS-----FA-SILERL-------
----IKLVKRLGAGQFGEV---WMGYYN-----------------NST---KVAV-KTL---K-P--G-TM-SV---Q-AFL-E----EANLMKTL--Q---HDKLVRLYAVVT--R------EEP--IYIITEYMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EG-GKVLLPKLIDFSAQIAEGMAYIER-K--------N---YIHRDLRAANVLVSE-----SL-MC----KIADFGLARVI----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN------FGC--FTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL----SQ----GYR---MP---RVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPT-----FD-YLQSV--L-----
----FEKISELGAGNGGVV---FKVSHK----------------PSGL----VMA-RKL---IHL--E-IKPAI---R-NQIIR----ELQVLHEC--N---SPYIVGFYGAFY--S------DGE--ISICMEHMDGGSLDQVLK---KAG-----------------------------------------------------------------------------------------------------RIPEQILGKVSIAVIKGLTYLREKH--------K---IMHRDVKPSNILVNS-----RG-EI----KLCDFGVSG------------------QLIDSMA--------------NS---FVGTRSYMSPER--LQ------GTH--YSVQSDIWSMGLSLVEMAV-GR--------------YP---------------IPPP-----DAKELELMF----GC----QVE---GD---AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERAD-----LK-QLMVHAFI-----
-IRY---RDTLGHGNGGTV---YKAYHV----------------PSGK---ILAV-KVI---LLD--I-TLELQ---K-QI-MS----ELEILYKC--D---SSYIIGFYGAFF--V------ENR--ISICTEFMDGGSLD-------VYR-----------------------------------------------------------------------------------------------------KMPEHVLGRIAVAVVKGLTYLWS-L--------K---ILHRDVKPSNMLVNT-----RG-QV----KLCDFGVST------------------QLVNSIA--------------KT---YVGTNAYMAPER--IS------GEQ--YGIHSDVWSLGISFMELAL-GR--------------FP---------------YPQI-----QKNQGSLMP----LQ----LLQ---CI---VDEDSPVLPVGEF-----------------------------------SEPFVH-FITQCMRKQPKERPA-----PE-ELMGHPFI-----
----IEVEEVVGRGAFGVV---CKAKWR------------------AK---DVAI-KQI---E-------S-ESE-RK-AFI-V----ELRQLSRV--N---HPNIVKLYGACL----------NP--VCLVMEYAEGGSLYNVLH----GA-------------------------------------------------------------------------------------------------EPLPYYTAAHAMSWCLQCSQGVAYLHS-M--------QPKALIHRDLKPPNLLLVA-----GGTVL----KICDFGTACDI----------------------Q--------------THMTNNKGSAAWMAPEV--FE------GSN--YSEKCDVFSWGIILWEVITR-R--------------KP---------------FDEIGG---PAFRIMWAV----HN----GTR---PP---LIKNLP-------------------------------------------KPIES-LMTRCWSKDPSQRPS-----ME-EIVKI--M-----
----FELIQRIGSGTYGDV---YKARNV----------------NTGE---LAAI-KVI---KLE--P-GEDFA---V-VQ--Q----EIIMMKDC--K---HPNIVAYFGSYL--R------RDK--LWICMEFCGGGSLQDIYH---VTG-----------------------------------------------------------------------------------------------------PLSELQIAYVSRETLQGLYYLHS-K--------G---KMHRDIKGANILLTD-----NG-HV----KLADFGVSAQI----------------TATIAKR--------------KS---FIGTPYWMAPEVAAVE-----RKGG--YNQLCDLWAVGITAIELAE-LQ--------------PP---------------MFDL-----HPMRALFLM----TK----SNF---QP---P--KLKDKMKWS-------------------------------------NSFHH-FVKMALTKNPKKRPT-----AE-KLLQHPFV-----
----YQNLSPVGSGAYGSV---CAAFDT----------------KTGL---RVAV-KKL---SRP--F-QSIIH---A-KRTYR----ELRLLKHM--K---HENVIGLLDVFT--PARSLEEFND--VYLVTHLMGA-DLNNIVK----CQ-----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHS-A--------D---IIHRDLKPSNLAVNE-----DC-EL----KILDFGLAR-------------------HTDDEM--------------TG---YVATRWYRAPEI--ML-----NWMH--YNQTVDIWSVGCIMAELLT-GR--------------TL---------------FPGT-----DHIDQLKLI----LR----LVG---TP---GAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AA-QALAHAYF-----
----YRLLKTIGKGNFAKV---KLARHI----------------LTGK---EVAV-KII---DKT--Q-LNSSS---L-QKLFR----EVRIMKVL--N---HPNIVKLFEVIE--T------EKT--LYLVMEYASGGEVFDYLV---AHG-----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQ-K--------F---IVHRDLKAENLLLDA-----DM-NI----KIADFGFSNE-----------------FTFGNKL--------------DT---FCGSPPYAAPEL--FQ-----GKKY--DGPEVDVWSLGVILYTLVS-GS--------------LP---------------FDGQ--------NLKELR----ER----VLR---GK---YRIPFYMS-----------------------------------------TDCEN-LLKKFLILNPSKRGT-----LE-QIMKDRWM-----
----YRLLRTIGKGNFAKV---KLARHI----------------LTGR---EVAI-KII---DKT--Q-LNPSS---L-QKLFR----EVRIMKGL--N---HPNIVKLFEVIE--T------EKT--LYLVMEYASAGEVFDYLV---SHG-----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQ-K--------N---IVHRDLKAENLLLDA-----EA-NI----KIADFGFSNE-----------------FTLGSKL--------------DT---FCGSPPYAAPEL--FQ-----GKKY--DGPEVDIWSLGVILYTLVS-GS--------------LP---------------FDGH--------NLKELR----ER----VLR---GK---YRVPFYMS-----------------------------------------TDCES-ILRRFLVLNPAKRCT-----LE-QIMKDKWI-----
----YELHETIGTGGFAKV---KLACHI----------------LTGE---MVAI-KIM---DKN--T-LGSDL---P-RIKT-----EIEALKNL--R---HQHICQLYHVLE--T------ANK--IFMVLEYCPGGELFDYII---SQD-----------------------------------------------------------------------------------------------------RLSEEETRVVFRQIVSAVAYVHS-Q--------G---YAHRDLKPENLLFDE-----YH-KL----KLIDFGLCAKP---------------KGNKDYHL--------------QT---CCGSLAYAAPEL--IQ-----GKSY--LGSEADVWSMGILLYVLMC-GF--------------LP---------------FDDD--------NVMALY----KK----IMR---GK---YDVPKWLS-----------------------------------------PSSIL-LLQQMLQVDPKKRIS-----MK-NLLNHPWI-----
----VHFNEVIGRGHFGCV---YHGTLL-------------DNDGKKI---HCAV-KSL---N-R--I-TD-IGE-VS-QFL-T----EGIIMKDF--S---HPNVLSLLGICL-RS------EGS--PLVVLPYMKHGDLRNFIR----NE--------------------------------------------------------------------------------------------------T-HNPTVKDLIGFGLQVAKGMKYLAS-K--------K---FVHRDLAARNCMLDE-----KF-TV----KVADFGLARDM-------------Y--D--KEYYS------------VHNKTGAKLPVKWMALES--LQ------TQK--FTTKSDVWSFGVLLWELMTRGA--------------PP---------------YPDV-----NTFDITVYL----LQ----GRR---LL---QPEYCP-------------------------------------------DPLYE-VMLKCWHPKAEMRPS-----FS-ELVSR--I-----
----FELVEVVGNGTYGQV---YKGRHV----------------KTGQ---LAAI-KVM---DVT--E-DEEEE---I-KQ-------EINMLKKY-SH---HRNIATYYGAFI--KKSPPGNDDQ--LWLVMEFCGAGSVTDLVKN-TKGN-----------------------------------------------------------------------------------------------------ALKEDCIAYICREILRGLAHLHA-H--------K---VIHRDIKGQNVLLTE-----NA-EV----KLVDFGVSAQL----------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD-ENPDAT--YDYRSDIWSLGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPP---PR---LKSKKWS------------------------------------------KKFID-FIDTCLIKTYLSRPP-----TE-QLLKFPFI-----
---I-EYVRDIGEGAFGRV---FQARAPG-----------LLPYEPFT---MVAV-KML---K-E--E-AS-ADM-QA-DFQ-R----EAALMAEF--D---NPNIVKLLGVCA--V------GKP--MCLLFEYMAYGDLNEFLR----SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSE-R--------K---FVHRDLATRNCLVGE-----NM-VV----KIADFGLSRNI-------------Y--S--ADYY--------------KANENDAIPIRWMPPES--IF------YNR--YTTESDVWAYGVVLWEIFSYGL--------------QP---------------YYGM-----AHEEVIYYV----RD----GNI---LS---CPENCP-------------------------------------------VELYN-LMRLCWSKLPADRPS-----FT-SIHRIL-------
----YDVIKAIGQGAFGKA---YLAKGK----------------SDSK---HCVI-KEI---NFE--K-MPIQE---K-EASKK----EVILLEKM--K---HPNIVAFFNSFQ--E------NGR--LFIVMEYCDGGDLMKRINR-QRGV-----------------------------------------------------------------------------------------------------LFSEDQILGWFVQISLGLKHIHD-R--------K---ILHRDIKAQNIFLSK-----NG-MV---AKLGDFGIARVL----------------NNSMELA--------------RT---CIGTPYYLSPEI--CQ------NKP--YNNKTDIWSLGCVLYELCT-LK--------------HP---------------FEGN--------NLQQLV----LK----ICQ---AH---FAPISPGF---S-------------------------------------RELHS-LISQLFQVSPRDRPS-----IN-SILKRPFL-----
--IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAV-KAL---K-E--A-SE-SA--RQ-DFQ-R----EAELLTML--Q---HQHIVRFFGVCT--E------GRP--LLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAP-GPLGLGQLLAVASQVAAGMVYLAG-L--------H---FVHRDLATRNCLVGQ-----GL-VV----KIGDFGMSRDI-------------Y--S--TDYY--------------RVGGRTMLPIRWMPPES--IL------YRK--FTTESDVWSFGVVLWEIFTYGK--------------QP---------------WYQL-----SNTEAIDCI----TQ----GRE---LE---RPRACP-------------------------------------------PEVYA-IMRGCWQREPQQRHS-----IK-DVHARL-------
---I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAV-KTL---K-D--A-SD-NA--RK-DFH-R----EAELLTNL--Q---HEHIVKFYGVCV--E------GDP--LIMVFEYMKHGDLNKFLR----AHGPDAV--------------------------------------------------------------------------------------LMAEGNPP-TELTQSQMLHIAQQIAAGMVYLAS-Q--------H---FVHRDLATRNCLVGE-----NL-LV----KIGDFGMSRDV-------------Y--S--TDYY--------------RVGGHTMLPIRWMPPES--IM------YRK--FTTESDVWSLGVVLWEIFTYGK--------------QP---------------WYQL-----SNNEVIECI----TQ----GRV---LQ---RPRTCP-------------------------------------------QEVYE-LMLGCWQREPHMRKN-----IK-GIHTL--L-----
---I-VLKRELGEGAFGKV---FLAECYN-----------LSPTKDKM---LVAV-KAL---K-D--P-TL-AA--RK-DFQ-R----EAELLTNL--Q---HEHIVKFYGVCG--D------GDP--LIMVFEYMKHGDLNKFLR----AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAK-GELGLSQMLHIASQIASGMVYLAS-Q--------H---FVHRDLATRNCLVGA-----NL-LV----KIGDFGMSRDV-------------Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM------YRK--FTTESDVWSFGVILWEIFTYGK--------------QP---------------WFQL-----SNTEVIECI----TQ----GRV---LE---RPRVCP-------------------------------------------KEVYD-VMLGCWQREPQQRLN-----IK-EIYKIL-------
----YELQETLGKGTYGKV---KRATER----------------FSGR---VVAI-KSI---RKD--K-IKDEQ---D-MVHIR---REIEIMSSL--N---HPHIISIYEVFE--N------KDK--IVIIMEYASKGELYDYIS---ERR-----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHK-N--------G---VVHRDLKLENILLDD-----NC-NI----KIADFGLSNL-----------------YQKDKFL--------------QT---FCGSPLYASPEI--VN-----GRPY--RGPEVDSWALGVLLYTLVY-GT--------------MP---------------FDGF--------DHKNLI----RQ----ISS---GE---YREPTQP------------------------------------------SDARG-LIRWMLMVNPDRRAT-----IE-DIANHWW-V----
----YEFLETLGKGTYGKV---KKARES----------------SGR----LVAI-KSI---RKD--K-IKDEQ---D-LMHIR---REIEIMSSL--N---HPHIIAIHEVFE--N------SSK--IVIVMEYASRGDLYDYIS---ERQ-----------------------------------------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQ-N--------R---VVHRDLKLENILLDA-----NG-NI----KIADFGLSNL-----------------YHQGKFL--------------QT---FCGSPLYASPEI--VN-----GKPY--TGPEVDSWSLGVLLYILVH-GT--------------MP---------------FDGH--------DHKILV----KQ----ISN---GA---YREPPK-----P-------------------------------------SDACG-LIRWLLMVNPTRRAT-----LE-DVASHWW-V----
---L-VLGRVLGSGAFGKV---VEGTAYG-----------LSRSQPVM---KVAV-KML---K-P--T-AR-SSE-KQ-ALM-S----ELKIMTHLG-P---HLNIVNLLGACT--K------SGP--IYIITEYCFYGDLVNYLH----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNS-EGLTLLDLLSFTYQVARGMEFLAS-K--------N---CVHRDLAARNVLLAQ-----GK-IV----KICDFGLARDI-------------M--H--DSNY--------------VSKGSTFLPVKWMAPES--IF------DNL--YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI----KS----GYR---MA---KPDHAT-------------------------------------------SEVYE-IMVKCWNSEPEKRPS-----FY-HLSE---IV----
---L-VLGRTLGSGAFGQV---VEATAHG-----------LSHSQATM---KVAV-KML---K-S--T-AR-SSE-KQ-ALM-S----ELKIMSHLG-P---HLNVVNLLGACT--K------GGP--IYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES-PVLSYMDLVGFSYQVANGMEFLAS-K--------N---CVHRDLAARNVLICE-----GK-LV----KICDFGLARDI-------------M--R--DSNY--------------ISKGSTFLPLKWMAPES--IF------NSL--YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI----KR----GYR---MA---QPAHAS-------------------------------------------DEIYE-IMQKCWEEKFEIRPP-----FS-QLVL---LL----
---F-KFLAVLGRGHFGKV---LLSEFR----------------PSGE---LFAI-KAL---KKG--D-IVARD---E-VESLM---CEKRILAAV--TSAGHPFLVNLFGCFQ--T------PEH--VCFVMEYSAGGDLMLHIH----SD-----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHE-H--------K---IVYRDLKLDNLLLDT-----EG-YV----KIADFGLCKEG----------------MGYGDRT--------------ST---FCGTPEFLAPEV--LT------DTS--YTRAVDWWGLGVLLYEMLV-GE--------------SP---------------FPGD--------DEEEVF----DS----IVN---DE---VRYPRFLS-----------------------------------------AEAIG-IMRRLLRRNPERRLGSSERDAE-DVKKQPFF-----
--FR--CCAVLGRGHFGKV---LLAEYK----------------NTNE---MFAI-KAL---KKG--D-IVARD---E-VDSLM---CEKRIFETV--NSVRHPFLVNLFACFQ--T------KEH--VCFVMEYAAGGDLMMHIH----TD-----------------------------------------------------------------------------------------------------VFSEPRAVFYAACVVLGLQYLHE-H--------K---IVYRDLKLDNLLLDT-----EG-FV----KIADFGLCKEG----------------MGYGDRT--------------ST---FCGTPEFLAPEV--LT------ETS--YTRAVDWWGLGVLIYEMLV-GE--------------SP---------------FPGD--------DEEEVF----DS----IVN---DE---VRYPRFLS-----------------------------------------TEAIS-IMRRLLRRNPERRLGASEKDAE-DVKKHPFF-----
--YL--KGRLLGKGGFARC---YEATDT----------------ETGS---AYAV-KVI---PQS--R-VAKPH---Q-REKIL---NEIELHRDL--Q---HRHIVRFSHHFE--D------ADN--IYIFLELCSRKSLAHIWK---ARH-----------------------------------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQ-R--------G---ILHRDLKLGNFFITE-----NM-EL----KVGDFGLAARL----------------EPPEQRK--------------KT---ICGTPNYVAPEV--LL------RQG--HGPEADVWSLGCVMYTLLC-GS--------------PP---------------FETA--------DLKETY----RC----IKQ---VH---YTLPASLS-----------------------------------------LPARQ-LLAAILRASPRDRPS-----ID-QILRHDFF-----
---F-KVGNLLGKGSFAGV---YRAESI----------------HTGL---EVAI-KMI---DKK--A-MYKAG---M-VQRVQ---NEVKIHCQL--K---HPSILELYNYFE--D------SNY--VYLVLEMCHNGEMNRYLK--NRVK-----------------------------------------------------------------------------------------------------PFSENEARHFMHQIITGMLYLHS-H--------G---ILHRDLTLSNLLLTR-----NM-NI----KIADFGLATQL----------------KMPHEKH--------------YT---LCGTPNYISPEI--AT------RSA--HGLESDVWSLGCMFYTLLI-GR--------------PP---------------FDTD--------TVKNTL----NK----VVL---AD---YEMPSFLS-----------------------------------------IEAKD-LIHQLLRRNPADRLS-----LS-SVLDHPFM-----
---Y-ILGDTLGVGTFGKV---KVGKHE----------------LTGH---KVAV-KIL---NRQ--K-IRSLD---V-VGKIR---REIQNLKLF--R---HPHIIKLYQVIS--T------PSD--IFMVMEYVSGGELFDYIC---KNG-----------------------------------------------------------------------------------------------------RLDEKESRRLFQQILSGVDYCHR-H--------M---VVHRDLKPENVLLDA-----HM-NA----KIADFGLSNM-----------------MSDGEFL--------------RT---SCGSPNYAAPEV--IS-----GRLY--AGPEVDIWSSGVILYALLC-GT--------------LP---------------FDDD--------HVPTLF----KK----ICD---GI---FYTPQYLN-----------------------------------------PSVIS-LLKHMLQVDPMKRAT-----IK-DIREHEWF-----
----YVLGDTLGVGTFGKV---KIGEHQ----------------LTGH---KVAV-KIL---NRQ--K-IRSLD---V-VGKIK---REIQNLKLF--R---HPHIIKLYQVIS--T------PTD--FFMVMEYVSGGELFDYIC---KHG-----------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHR-H--------M---VVHRDLKPENVLLDA-----HM-NA----KIADFGLSNM-----------------MSDGEFL--------------RT---SCGSPNYAAPEV--IS-----GRLY--AGPEVDIWSCGVILYALLC-GT--------------LP---------------FDDE--------HVPTLF----KK----IRG---GV---FYIPEYLN-----------------------------------------RSVAT-LLMHMLQVDPLKRAT-----IK-DIREHEWF-----
---F-ERIKTLGTGSFGRV---MLVKHK----------------ETGN---HYAM-KIL---DKQ--K-VVKLK---Q-IEHTL---NEKRILQAV--N---FPFLVKLEFSFK--D------NSN--LYMVMEYVPGGEMFSHLR---RIG-----------------------------------------------------------------------------------------------------RFSEPHARFYAAQIVLTFEYLHS-L--------D---LIYRDLKPENLLIDQ-----QG-YI----QVTDFGFAK-------------------RVKGRT--------------WT---LCGTPEYLAPEI--IL------SKG--YNKAVDWWALGVLIYEMAA-GY--------------PP---------------FFAD--------QPIQIY----EK----IVS---GK---VRFPSHFS-----------------------------------------SDLKD-LLRNLLQVDLTKRFGNLKNGVN-DIKNHKWF-----
--FI--FHKVLGKGSFGKV---LLGELK----------------GRGE---YFAI-KAL---KKD--V-VLIDD---D-VECTM---VEKRVLTLA-AE---NPFLTHLICTFQ--T------KDH--LFFVMEFLNGGDLMYHIQ---DKG-----------------------------------------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHS-K--------G---IIYRDLKLDNVLLDR-----DG-HI----KIADFGMCKEN----------------IFGESRA--------------ST---FCGTPDYIAPEI--LQ------GLK--YTFSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGD--------DEDELF----ES----IRV---DT---PHYPRWIT-----------------------------------------KESKD-ILEKLFEREPTKRLG----VTG-NIKIHPFF-----
--FI--LHKMLGKGSFGKV---FLAEFK----------------KTNQ---FFAI-KAL---KKD--V-VLMDD---D-VECTM---VEKRVLSLA-WE---HPFLTHMFCTFQ--T------KEN--LFFVMEYLNGGDLMYHIQ---SCH-----------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHS-K--------G---IVYRDLKLDNILLDK-----DG-HI----KIADFGMCKEN----------------MLGDAKT--------------NT---FCGTPDYIAPEI--LL------GQK--YNHSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGQ--------DEEELF----HS----IRM---DN---PFYPRWLE-----------------------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF-----
---V-VLNRILGEGFFGEV---YEGVYT-------------NHKGEKI---NVAV-KTC---K-K--D-CT-LDN-KE-KFM-S----EAVIMKNL--D---HPHIVKLIGIIE---------EEP--TWIIMELYPYGELGHYLE----RN--------------------------------------------------------------------------------------------------K-NSLKVLTLVLYSLQICKAMAYLES-I--------N---CVHRDIAVRNILVAS-----PE-CV----KLGDFGLSRYI----------------E--DEDY--------------YKASVTRLPIKWMSPES--IN------FRR--FTTASDVWMFAVCMWEILSFGK--------------QP---------------FFWL-----ENKDVIGVL----EK----GDR---LP---KPDLCP-------------------------------------------PVLYT-LMTRCWDYDPSDRPR-----FT-ELVCS--L-----
---L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAV-KML---K-E--N-AS-PSE-LR-DLL-S----EFNVLKQV--N---HPHVIKLYGACS--Q------DGP--LLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAE-M--------K---LVHRDLAARNILVAE-----GR-KM----KISDFGLSRDV-------------Y--E--EDSY--------------VKRSQGRIPVKWMAIES--LF------DHI--YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL----KT----GHR---ME---RPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPV-----FA-DISKDL-------
-LES----AELDSGGFGKV---SLCFHR-----------------TQG---LMIM-KTV--YK-G--P-NC-IEH-NE-ALL-E----EAKMMNRL--R---HSRVVKLLGVII--E------EGK--YSLVMEYMEKGNLMHVLK----AE----------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHG-K--------G---VIHKDLKPENILVDN-----DF-HI----KIADLGLASFKMWS------KLNNE------EHNELR--------EVDGTAKKNGGTLYYMAPEH--LN------DVNAKPTEKSDVYSFAVVLWAIFA-NK--------------EP---------------YENA-I---CEQQLIMCI----KS----GNR---PDVDDITEYCP-------------------------------------------REIIS-LMKLCWEANPEARPT-----FP-GIEEK--F-----
FTGW----EKVGSGGFGQV---YKVRHV----------------HWKT---WLAI-KCS---PSL--H-VDDRE---R-MELLE----EAKKMEMA--K---FRYILPVYGIC----------REP--VGLVMEYMETGSLEKLLA----SE-----------------------------------------------------------------------------------------------------PLPWDLRFRIIHETAVGMNFLHC-MA------PP---LLHLDLKPANILLDA-----HY-HV----KISDFGLAKCNG-------------LSHSHDLSM--------------DG---LFGTIAYLPPER--IR----EKSRL--FDTKHDVYSFAIVIWGVLT-QK--------------KP---------------FADE----KNILHIMVKV----VK----GHR---PE---LPPVCRARPRAC-------------------------------------SHLIR-LMQRCWQGDPRVRPT-----FQ---------GNGLN
--LT--LRLLLGSGAFGEV---YEGTAVDI----------LGVGSGEI---KVAV-KTL---K-K--G-ST-DQE-KI-EFL-K----EAHLMSKF--N---HPNILKQLGVCL--L------NEP--QYIILELMEGGDLLTYLR----KARM--------------------------------------------------------------------------------------------ATFYG-PLLTLVDLVDLCVDISKGCVYLER-M--------H---FIHRDLAARNCLVSVKDYTSPR-IV----KIGDFGLARDI-------------Y--K--NDYY--------------RKRGEGLLPVRWMAPES--LM------DGI--FTTQSDVWSFGILIWEILTLGH--------------QP---------------YPAH-----SNLDVLNYV----QT----GGR---LE---PPRNCP-------------------------------------------DDLWN-LMTQCWAQEPDQRPT-----FH-RIQDQL-------
----FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAM-KVL---KKA--T-LKVRD---R-VRTKM----ERDILADV--N---HPFVVKLHYAFQ--T------EGK--LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHS-L--------G---IIYRDLKPENILLDE-----EG-HI----KLTDFGLSKEA----------------IDHEKKA--------------YS---FCGTVEYMAPEV--VN------RQG--HSHSADWWSYGVLMFEMLT-GS--------------LP---------------FQGK--------DRKETM----TL----ILK---AK---LGMPQFLS-----------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAE-EIKRHV--FY---
----FELLKVLGQGSYGKV---FLVRKV----------------KGSDAGQLYAM-KVL---KKA--T-LKVRD---R-VRSKM----ERDILAEV--N---HPFIVKLHYAFQ--T------EGK--LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHS-L--------G---IIYRDLKPENILLDE-----EG-HI----KITDFGLSKEA----------------IDHDKRA--------------YS---FCGTIEYMAPEV--VN------RRG--HTQSADWWSFGVLMFEMLT-GS--------------LP---------------FQGK--------DRKETM----AL----ILK---AK---LGMPQFLS-----------------------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVE-EIKRHPFF-----
----FELLKVLGQGSFGKV---FLVKKI----------------SGSDARQLYAM-KVL---KKA--T-LKVRD---R-VRTKM----ERDILVEV--N---HPFIVKLHYAFQ--T------EGK--LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHS-L--------G---IIYRDLKPENILLDE-----EG-HI----KLTDFGLSKES----------------IDHEKKA--------------YS---FCGTVEYMAPEV--VN------RRG--HTQSADWWSFGVLMFEMLT-GT--------------LP---------------FQGK--------DRKETM----TM----ILK---AK---LGMPQFLS-----------------------------------------PEAQS-LLRMLFKRNPANRLGAGPDGVE-EIKRHSFF-----
----YDIERTLGKGNFAVV---KLARHR----------------VTKT---QVAI-KII---DKT--R-LDSSN---L-EKIYR----EVQLMKLL--N---HPHIIKLYQVME--T------KDM--LYIVTEFAKNGEMFDYLT---SNG-----------------------------------------------------------------------------------------------------HLSENEARKKFWQILSAVEYCHD-H--------H---IVHRDLKTENLLLDG-----NM-DI----KLADFGFGNF-----------------YKSGEPL--------------ST---WCGSPPYAAPEV--FE-----GKEY--EGPQLDIWSLGVVLYVLVC-GS--------------LP---------------FDGP--------NLPTLR----QR----VLE---GR---FRIPFFMS-----------------------------------------QDCES-LIRRMLVVDPARRIT-----IA-QIRQHRWM-----
----YDIEGTLGKGNFAVV---KLGRHR----------------ITKT---EVAI-KII---DKS--Q-LDAVN---L-EKIYR----EVQIMKML--D---HPHIIKLYQVME--T------KSM--LYLVTEYAKNGEIFDYLA---NHG-----------------------------------------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHG-R--------K---IVHRDLKAENLLLDN-----NM-NI----KIADFGFGNF-----------------FKSGELL--------------AT---WCGSPPYAAPEV--FE-----GQQY--EGPQLDIWSMGVVLYVLVC-GA--------------LP---------------FDGP--------TLPILR----QR----VLE---GR---FRIPYFMS-----------------------------------------EDCEH-LIRRMLVLDPSKRLT-----IA-QIKEHKWM-----
----WEIIGELGDGAFGKV---YKAQNK----------------ETSV---LAAA-KVI---DTK--S-EEELE---D-YM--V----EIDILASC--D---HPNIVKLLDAFY--Y------ENN--LWILIEFCAGGAVDAVML--ELER-----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHD-N--------K---IIHRDLKAGNILFTL-----DG-DI----KLADFGVSAKN----------------TRTIQRR--------------DS---FIGTPYWMAPEV--VMCE-TSKDRP--YDYKADVWSLGITLIEMAE-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SEP---PT---LAQPSRWS-----------------------------------------SNFKD-FLKKCLEKNVDARWT-----TS-QLLQHPFV-----
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAI-KTL---K-P--G-TM-SP---E-AFL-Q----EAQVMKKL--R---HEKLVQLYAVVS---------EEP--IYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TG-KYLRLPQLVDMAAQIASGMAYVER-M--------N---YVHRDLRAANILVGE-----NL-VC----KVADFGLARLI----------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL------YGR--FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV----ER----GYR---MP---CPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FE-YLQAF--L-----
----WEIVGELGDGAFGKV---YKAKNK----------------ETGA---LAAA-KVI---ETK--S-EEELE---D-YI--V----EIEILATC--D---HPYIVKLLGAYY--H------DGK--LWIMIEFCPGGAVDAIML--ELDR-----------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHS-K--------R---IIHRDLKAGNVLMTL-----EG-DI----RLADFGVSAKN----------------LKTLQKR--------------DS---FIGTPYWMAPEV--VMCE-TMKDTP--YDYKADIWSLGITLIEMAQ-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SDP---PT---LLTPSKWS-----------------------------------------VEFRD-FLKIALDKNPETRPS-----AA-QLLEHPFV-----
----FTKLEKIGKGSFGEV---FKGIDN----------------RTQK---VVAI-KII---DLE--E-AEDEI---E-DIQ-Q----EITVLSQC--D---SPYVTKYYGSYL--K------DTK--LWIIMEYLGGGSALDLLE----PG-----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHS-E--------K---KIHRDIKAANVLLSE-----HG-EV----KLADFGVAGQL----------------TDTQIKR--------------NT---FVGTPFWMAPEV--IK------QSA--YDSKADIWSLGITAIELAR-GE--------------PP---------------HSEL-----HPMKVLFLI----PK----NNP---PT---LEGNYS-------------------------------------------KPLKE-FVEACLNKEPSFRPT-----AK-ELLKHKFI-----
-TLE---DKELGSGNFGTV---KKGYYQ--------------MKKVVK---TVAV-KIL---K-N--E-AN-DPALKD-ELL-A----EANVMQQL--D---NPYIVRMIGICE---------AES--WMLVMEMAELGPLNKYLQ----QN----------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEE-S--------N---FVHRDLAARNVLLVT-----QH-YA----KISDFGLSKAL-------------R--A--DENY-------------YKAQTHGKWPVKWYAPEC--IN------YYK--FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML----EK----GER---MG---CPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPG-----FA-AVE----LRL---
----LTFMRELGSGLFGVV---RLGKWR-----------------AQY---KVAI-KAI---R-E--G-AM-CE---E-DFI-E----EAKVMMKL--T---HPKLVQLYGVCT--Q------QKP--IYIVTEFMERGCLLNFLR----QR--------------------------------------------------------------------------------------------------Q-GHFSRDVLLSMCQDVCEGMEYLER-N--------S---FIHRDLAARNCLVSE-----AG-VV----KVSDFGMARYV----------------L--DDQY--------------TSSSGAKFPVKWCPPEV--FN------YSR--FSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----TNYEVVTMV----TR----GHR---LY---QPKLAS-------------------------------------------NYVYE-VMLRCWQEKPEGRPS-----FE-DLLRT--I-----
----IKFQDVIGEGNFGQV---LKARIK--------------KDGLRM---DAAI-KRM---K-E--Y-AS-KDD-HR-DFA-G----ELEVLCKLG-H---HPNIINLLGACE--H------RGY--LYLAIEYAPHGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTA-STLSSQQLLHFAADVARGMDYLSQ-K--------Q---FIHRDLAARNILVGE-----NY-VA----KIADFGLSRGQ--------------------EVY--------------VKKTMGRLPVRWMAIES--LN------YSV--YTTNSDVWSYGVLLWEIVSLGG--------------TP---------------YCGM-----TCAELYEKL----PQ----GYR---LE---KPLNCD-------------------------------------------DEVYD-LMRQCWREKPYERPS-----FA-QILV---SL----
--IV--LQESIGKGRFGEV---WRGKWR----------------GEE-----VAV-KIF---SSR--E-ERSWF---R-EA-------EIYQTVML--R---HENILGFIAADN--KDN--GTWTQ--LWLVSDYHEHGSLFDYLN----RY-----------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHM-EIVGTQGKPA---IAHRDLKSKNILVKK-----NG-TC----CIADLGLAVRHDS------------ATDTIDIAP--------------NH---RVGTKRYMAPEV--LDDSINMKHFE--SFKRADIYAMGLVFWEIAR-RCSIGGI----HEDYQLP---------------YYDLVPSDPSVEEMRKVV----CE----QKL---RP---NIPNRWQSCEAL-------------------------------------RVMAK-IMRECWYANGAARLT-----AL-RIKK----TL---
----ITFEDLIGEGNFGQV---IRAMIK--------------KDGLKM---NAAI-KML---K-E--Y-AS-END-HR-DFA-G----ELEVLCKLG-H---HPNIINLLGACK--N------RGY--LYIAIEYAPYGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAREHGTA-STLSSRQLLRFASDAANGMQYLSE-K--------Q---FIHRDLAARNVLVGE-----NL-AS----KIADFGLSRGE--------------------EVY--------------VKKTMGRLPVRWMAIES--LN------YSV--YTTKSDVWSFGVLLWEIVSLGG--------------TP---------------YCGM-----TCAELYEKL----PQ----GYR---ME---QPRNCD-------------------------------------------DEVYE-LMRQCWRDRPYERPP-----FA-QIALQ--L-----
----FELVELVGNGTYGQV---YKGRHV----------------KTGQ---LAAI-KVM---DVT--G-DEEEE---I-KQ-------EINMLKKY-SH---HRNIATYYGAFI--KKNPPGMDDQ--LWLVMEFCGAGSVTDLIKN-TKGN-----------------------------------------------------------------------------------------------------TLKEEWIAYICREILRGLSHLHQ-H--------K---VIHRDIKGQNVLLTE-----NA-EV----KLVDFGVSAQL----------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD-ENPDAT--YDFKSDLWSLGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPA---PR---LKSKKWS------------------------------------------KKFQS-FIESCLVKNHSQRPA-----TE-QLMKHPFI-----
-VCR---GELLGSGCFGVV---HRGLWT-------------LPSGKSV---PVAV-KSLRVGP-E--G-PM-GTE-LG-DFL-R----EVSVMMNL--E---HPHVLRLHGLVL---------GQP--LQMVMELAPLGSLHARLT----AP------------------------------------------------------------------------------------------------APT-PPLLVALLCLFLRQLAGAMAYLGA-R--------G---LVHRDLATRNLLLAS-----PR-TI----KVADFGLVRPL------------GG--A--RGRY--------------VMGGPRPIPYAWCAPES--LR------HGA--FSSASDVWMFGVTLWEMFSGGE--------------EP---------------WAGV-----PPYLILQRL----ED----RAR---LP---RPPLCS-------------------------------------------RALYS-LALRCWAPHPADRPS-----FS-HLE----GLL---
---L-RLLEKLGDGSFGVV---RRGEWD-------------APSGKTV---SVAV-KCL---K-PDVL-SQ-PEA-MD-DFI-R----EVNAMHSL--D---HRNLIRLYGVVL---------TPP--MKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------Q-GHFLLGTLSRYAVQVAEGMGYLES-K--------R---FIHRDLAARNLLLAT-----RD-LV----KIGDFGLMRAL------------PQ--N--DDHY--------------VMQEHRKVPFAWCAPES--LK------TRT--FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKI---DKE----GER---LP---RPEDCP-------------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FV-ALRDF--L-----
---L-AFIKEIGSGQFGVV---HLGEWR-----------------SHI---QVAI-KAI---N-E--G-SM-SE---E-DFI-E----EAKVMMKL--S---HSKLVQLYGVCI--Q------RKP--LYIVTEFMENGCLLNYLR----EN--------------------------------------------------------------------------------------------------K-GKLRKEMLLSVCQDICEGMEYLER-N--------G---YIHRDLAARNCLVSS-----TC-IV----KISDFGMTRYV----------------L--DDEY--------------VSSFGAKFPIKWSPPEV--FL------FNK--YSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI----SE----GFR---LY---RPHLAP-------------------------------------------MSIYE-VMYSCWHEKPEGRPT-----FA-ELLR---AV----
---L-KKIRDLGEGHFGKV---SLYCYDP------------TNDGTGE---MVAV-KAL---K-A--D-CG-PQH-RS-GWK-Q----EIDILRTL--Y---HEHIIKYKGCCEDQG------EKS--LQLVMEYVPLGSLRDYLP----RH-----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHA-Q--------H---YIHRDLAARNVLLDN-----DR-LV----KIGDFGLAKAV------------PE--G--HEYY--------------RVREDGDSPVFWYAPEC--LK------EYK--FYYASDVWSFGVTLYELLTHCD--------------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER---LP---RPDKCP-------------------------------------------CEVYH-LMKNCWETEASFRPT-----FE-NLIP---IL----
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAI-KTL---K-P--G-TM-MP---E-AFL-Q----EAQIMKKL--R---HDKLVPLYAVVS---------EEP--IYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DG-KYLKLPQLVDMAAQIADGMAYIER-M--------N---YIHRDLRAANILVGE-----NL-VC----KIADFGLARLI----------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL------YGR--FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV----ER----GYR---MP---CPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FE-YIQSFL-------
|