Protein Surface  Ribbon
Inhibitor P16
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 89 kinases in KIF 2FO0A_P16 (ABL1, PDB code: 2FO0, chain A)

Multiple sequence alignment of family kinases

Conserved residues:  
                            
Group      Kinase           
STE        MAP4K4       203 
TK         ABL1         261 
TK         ABL2         288 
TKL        ACVR1        208 
TKL        ACVR1B       207 
Other      AURKC         43 
TK         BLK          241 
TKL        BMPR1A       234 
TKL        BMPR1B       204 
TK         BMX          422 
TKL        BRAF         456 
CAMK       BRSK1         50 
CAMK       BRSK2         19 
TK         BTK          402 
TK         CSF1R        582 
TK         CSK          195 
TK         DDR1         572 
TK         DDR2         563 
TK         EGFR         712 
TK         EPHA1        624 
TK         EPHA3        621 
TK         EPHA8        635 
TK         EPHB1        619 
TK         EPHB2        621 
TK         EPHB3        633 
TK         EPHB4        615 
TK         EPHB6        670 
TK         ERBB3        709 
TK         ERBB4        718 
TK         FGFR1        478 
TK         FGFR2        481 
TK         FGFR3        472 
TK         FGFR4        467 
TK         FGR          263 
TK         FLT4         845 
TK         FRK          234 
TK         FYN          271 
TK         HCK          241 
TK         IGF1R        999 
TK         JAK1         875 
TK         JAK2         849 
TK         JAK3         822 
TK         KDR          834 
CAMK       KIAA0999      66 
TK         KIT          589 
TK         LCK          245 
TKL        LIMK1        339 
TKL        LIMK2        331 
TK         LYN          247 
STE        MAP2K1        68 
STE        MAP2K5       166 
STE        MAP4K3        16 
CMGC       MAPK14        24 
CAMK       MARK2         53 
TK         MET         1078 
CAMK       MGC42105      74 
STE        MINK1         25 
Other      NEK1           4 
Other      NEK2           8 
Other      NEK5           4 
TK         NTRK3        538 
TK         PDGFRA       593 
TK         PDGFRB       600 
Other      PLK3          62 
TK         PTK2B        425 
TK         PTK6         191 
TK         RET          724 
TKL        RIPK1         17 
TKL        RIPK2         18 
CAMK       SIK1          27 
CAMK       SIK2          20 
STE        SLK           34 
TK         SRC          270 
TK         SRMS         230 
STE        STK10         36 
STE        STK24         24 
Other      STK36          4 
TK         SYK          371 
TK         TEC          370 
TK         TEK          824 
TKL        TGFBR1       205 
TK         TIE1         839 
STE        TNIK          25 
TK         TNK1         116 
TK         TNK2         150 
TKL        TNNI3K       463 
TK         TXK          271 
TK         TYK2         589 
TK         YES1         277 


---FELVEVVGNGTYGQVYKGRHV----------------KTGQLAAI-KVM---DVT--EDEEEE---IKL----EINMLKKY-SHHRNIATYYGAFI--KKSPPGHDDQ--LWLVMEFCGAGSITDLVKN--TKGN----------------------------------------------------------------------------------------------------TL---KEDWIAYISREILRGLAHLHI--H--------HVIHRDIKGQNVLLTENAEV-KLVDFGVSAQL-----------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD-ENPDAT---YDYRSDLWSCGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPP----PR---LKSKKWS------------------------------------------KKFFS-FIEGCLVKNYMQRPSTEQLLKHPFI---
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAV-KTL---K-E--DTM-EV---EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--R------EPP--FYIITEFMTYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NRQEV---NAVVLLYMATQISSAMEYLEK--K--------NFIHRDLAARNCLVGENHLV-KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA------YNK---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL----EK----DYR----ME---RPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F---
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAV-KTL---K-E--DTM-EV---EEFL-K-EAAVMKEI--KHPNLVQLLGVCT--L------EPP--FYIVTEYMPYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NREEV---TAVVLLYMATQISSAMEYLEK--K--------NFIHRDLAARNCLVGENHVV-KVADFGLSRLM-----------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA------YNT---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL----EK----GYR----ME---QPEGCP-------------------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F---
--I-TLLECVGKGRYGEVWRGSWQ----------------GEN--VAV-KIF---SSR--DEKSWF---RET----ELYNTVML--RHENILGFIASDM--TSR--HSSTQ--LWLITHYHEMGSLYDYLQ-----LT----------------------------------------------------------------------------------------------------TL---DTVSCLRIVLSIASGLAHLHI--EIFGTQGKPAIAHRDLKSKNILVKKNGQC-CIADLGLAVMHSQ-------------STNQLDVGN--------------NP---RVGTKRYMAPEV--LDETIQVDCFD---SYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVPNDPSFEDMRKVV----CV----DQQ----RP---NIPNRWFSDPTL-------------------------------------TSLAK-LMKECWYQNPSARLTALRIKK----TL-
-IV--LQEIIGKGRFGEVWRGRWR----------------GGD--VAV-KIF---SSR--EERSWF---REA----EIYQTVML--RHENILGFIAADN--KDN--GTWTQ--LWLVSDYHEHGSLFDYLN-----RY----------------------------------------------------------------------------------------------------TV---TIEGMIKLALSAASGLAHLHM--EIVGTQGKPGIAHRDLKSKNILVKKNGMC-AIADLGLAVRHDA-------------VTDTIDIAP--------------NQ---RVGTKRYMAPEV--LDETINMKHFD---SFKCADIYALGLVYWEIAR-RCNSGGV----HEEYQLP---------------YYDLVPSDPSIEEMRKVV----CD----QKL----RP---NIPNWWQSYEAL-------------------------------------RVMGK-MMRECWYANGAARLTALRIKK----TL-
---FEIGRPLGKGKFGNVYLARLK----------------ESHFIVAL-KVL---FKS--QIEKEG---LEHQLRREIEIQAHL--QHPNILRLYNYFH--D------ARR--VYLILEYAPRGELYKELQ----KSE----------------------------------------------------------------------------------------------------KL---DEQRTATIIEELADALTYCHD--K--------KVIHRDIKPENLLLGFRGEV-KIADFGWSV-------------------HTPSLRR--------------KT---MCGTLDYLPPEM--IE------GRT---YDEKVDLWCIGVLCYELLV-GY--------------PP---------------FESA--------SHSETY----RR----ILK----VD---VRFPLSMP-----------------------------------------LGARD-LISRLLRYQPLERLPLAQILKHPWV---
--L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAI-KTL---K-E--GTM-SP---EAFL-G-EANVMKAL--QHERLVRLYAVVT---------KEP--IYIVTEYMARGCLLDFLK-----TD-------------------------------------------------------------------------------------------------EGSRL---SLPRLIDMSAQIAEGMAYIER--M--------NSIHRDLRAANILVSEALCC-KIADFGLARII--------------------DSEY--------------TAQEGAKFPIKWTAPEA--IH------FGV---FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL----ER----GYR----MP---RPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L---
--I-QMVRQVGKGRYGEVWMGKWR----------------GEK--VAV-KVF---FTT--EEASWF---RET----EIYQTVLM--RHENILGFIAADI--KGT--GSWTQ--LYLITDYHENGSLYDFLK-----CA----------------------------------------------------------------------------------------------------TL---DTRALLKLAYSAACGLCHLHT--EIYGTQGKPAIAHRDLKSKNILIKKNGSC-CIADLGLAVKFNS-------------DTNEVDVPL--------------NT---RVGTKRYMAPEV--LDESLNKNHFQ---PYIMADIYSFGLIIWEMAR-RCITGGI----VEEYQLP---------------YYNMVPSDPSYEDMREVV----CV----KRL----RP---IVSNRWNSDECL-------------------------------------RAVLK-LMSECWAHNPASRLTALRIKK----TL-
--I-QMVKQIGKGRYGEVWMGKWR----------------GEK--VAV-KVF---FTT--EEASWF---RET----EIYQTVLM--RHENILGFIAADI--KGT--GSWTQ--LYLITDYHENGSLYDYLK-----ST----------------------------------------------------------------------------------------------------TL---DAKSMLKLAYSSVSGLCHLHT--EIFSTQGKPAIAHRDLKSKNILVKKNGTC-CIADLGLAVKFIS-------------DTNEVDIPP--------------NT---RVGTKRYMPPEV--LDESLNRNHFQ---SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV----CI----KKL----RP---SFPNRWSSDECL-------------------------------------RQMGK-LMTECWAHNPASRLTALRVKK----TL-
---ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAV-KMI---K-E--GSM-SE---DEFF-Q-EAQTMMKL--SHPKLVKFYGVCS--K------EYP--IYIVTEYISNGCLLNYLR-----SH--------------------------------------------------------------------------------------------------GKGL---EPSQLLEMCYDVCEGMAFLES--H--------QFIHRDLAARNCLVDRDLCV-KVSDFGMTRYV-----------------L--DDQY--------------VSSVGTKFPVKWSAPEV--FH------YFK---YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV----SQ----GHR----LY---RPHLAS-------------------------------------------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I---
---ITVGQRIGSGSFGTVYKGKWH-------------------GDVAV-KML---N-V-TAPT-PQQ-LQAFK-N-EVGVLRKT--RHVNILLFMGYST---------KPQ--LAIVTQWCEGSSLYHHLH-----II--------------------------------------------------------------------------------------------------ETKF---EMIKLIDIARQTAQGMDYLHA--K--------SIIHRDLKSNNIFLHEDLTV-KIGDFGLATVK-------------S---R--WSGS--------------HQFEQLSGSILWMAPEV--IR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ--------------LP---------------YSNI-N---NRDQIIFMV----GR----GYLSPDLSK---VRSNCP-------------------------------------------KAMKR-LMAECLKKKRDERPLFPQILA---SI--
---YRLEKTLGKGQTGLVKLGVHC----------------ITGQKVAI-KIV---NRE--KLSESV---LMKVER-EIAILKLI--EHPHVLKLHDVYE--N------KKY--LYLVLEHVSGGELFDYLV----KKG----------------------------------------------------------------------------------------------------RL---TPKEARKFFRQIVSALDFCHS--Y--------SICHRDLKPENLLLDEKNNI-RIADFGMASL------------------QVGDSLL--------------ET---SCGSPHYACPEV--IK-----GEKY---DGRRADMWSCGVILFALLV-GA--------------LP---------------FDDD--------NLRQLL----EK----VKR----GV---FHMPHFIP-----------------------------------------PDCQS-LLRGMIEVEPEKRLSLEQIQKHPW-Y--
---YRLEKTLGKGQTGLVKLGVHC----------------VTCQKVAI-KIV---NRE--KLSESV---LMKVER-EIAILKLI--EHPHVLKLHDVYE--N------KKY--LYLVLEHVSGGELFDYLV----KKG----------------------------------------------------------------------------------------------------RL---TPKEARKFFRQIISALDFCHS--H--------SICHRDLKPENLLLDEKNNI-RIADFGMASL------------------QVGDSLL--------------ET---SCGSPHYACPEV--IR-----GEKY---DGRKADVWSCGVILFALLV-GA--------------LP---------------FDDD--------NLRQLL----EK----VKR----GV---FHMPHFIP-----------------------------------------PDCQS-LLRGMIEVDAARRLTLEHIQKHIW-Y--
---LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAI-KMI---K-E--GSM-SE---DEFI-E-EAKVMMNL--SHEKLVQLYGVCT--K------QRP--IFIITEYMANGCLLNYLR-----EM--------------------------------------------------------------------------------------------------RHRF---QTQQLLEMCKDVCEAMEYLES--K--------QFLHRDLAARNCLVNDQGVV-KVSDFGLSRYV-----------------L--DDEY--------------TSSVGSKFPVRWSPPEV--LM------YSK---FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI----AQ----GLR----LY---RPHLAS-------------------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I---
---LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAV-KML---K-S--TAH-ADE-KEALM-S-ELKIMSHLG-QHENIVNLLGACT--H------GGP--VLVITEYCCYGDLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPL---ELRDLLHFSSQVAQGMAFLAS--K--------NCIHRDVAARNVLLTNGHVA-KIGDFGLARDI-------------M---N--DSNY--------------IVKGNARLPVKWMAPES--IF------DCV---YTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ----MA---QPAFAP-------------------------------------------KNIYS-IMQACWALEPTHRPTFQQICSFL-----
---LKLLQTIGKGEFGDVMLGDYR------------------GNKVAV-KCI---K-N--DAT-AQ----AFL-A-EASVMTQL--RHSNLVQLLGVIV-EE------KGG--LYIVTEYMAKGSLVDYLR-----SR-------------------------------------------------------------------------------------------------GRSVL---GGDCLLKFSLDVCEAMEYLEG--N--------NFVHRDLAARNVLVSEDNVA-KVSDFGLTKEA-----------------------S--------------STQDTGKLPVKWTAPEA--LR------EKK---FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV----EK----GYK----MD---APDGCP-------------------------------------------PAVYE-VMKNCWHLDAAMRPSFLQLREQL-----
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV-KIL---R-P--DAT-KNA-RNDFL-K-EVKIMSRL--KDPNIIRLLGVCV--Q------DDP--LCMITDYMENGDLNQFLS-----AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTI---SYPMLLHVAAQIASGMRYLAT--L--------NFVHRDLATRNCLVGENFTI-KIADFGMSRNL-------------Y---A--GDYY--------------RVQGRAVLPIRWMAWEC--IL------MGK---FTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQ-VYLS---RPPACP-------------------------------------------QGLYE-LMLRCWSRESEQRPPFSQLHRFL-----
---LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAV-KML---R-A--DAN-KNA-RNDFL-K-EIKIMSRL--KDPNIIHLLAVCI--T------DDP--LCMITEYMENGDLNQFLS-----RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTV---SYTNLKFMATQIASGMKYLSS--L--------NFVHRDLATRNCLVGKNYTI-KIADFGMSRNL-------------Y---S--GDYY--------------RIQGRAVLPIRWMSWES--IL------LGK---FTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQ-TYLP---QPAICP-------------------------------------------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL--
--F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAI-KEL---R-E--ATS-PKA-NKEIL-D-EAYVMASV--DNPHVCRLLGICL---------TST--VQLITQLMPFGCLLDYVR-----EH--------------------------------------------------------------------------------------------------KDNI---GSQYLLNWCVQIAKGMNYLED--R--------RLVHRDLAARNVLVKTPQHV-KITDFGLAKLL-------------G---A--EEKE--------------YHAEGGKVPIKWMALES--IL------HRI---YTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----PASEISSIL----EK----GER----LP---QPPICT-------------------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF-
-LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAI-KTL---K-D--TSP-GGQ-WWNFL-R-EATIMGQF--SHPHILHLEGVVT--K------RKP--IMIITEFMENGALDAFLR-----ER--------------------------------------------------------------------------------------------------EDQL---VPGQLVAMLQGIASGMNYLSN--H--------NYVHRDLAARNILVNQNLCC-KVSDFGLTRLL-------------D---D--FDGT--------------YETQGGKIPIRWTAPEA--IA------HRI---FTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----SNQEVMKSI----ED----GYR----LP---PPVDCP-------------------------------------------APLYE-LMKNCWAYDRARRPHFQKLQAHL-----
--I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAI-KTL---K-V--GYT-EKQ-RRDFL-G-EASIMGQF--DHPNIIRLEGVVT--K------SKP--VMIVTEYMENGSLDSFLR-----KH--------------------------------------------------------------------------------------------------DAQF---TVIQLVGMLRGIASGMKYLSD--M--------GYVHRDLAARNILINSNLVC-KVSDFGLSRVL-------------E---D--DPEA-------------AYTTRGGKIPIRWTSPEA--IA------YRK---FTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----SNQDVIKAV----DE----GYR----LP---PPMDCP-------------------------------------------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL-----
---IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAI-KAL---K-A--GYT-ERQ-RRDFL-S-EASIMGQF--DHPNIIRLEGVVT--R------GRL--AMIVTEYMENGSLDTFLR-----TH--------------------------------------------------------------------------------------------------DGQF---TIMQLVGMLRGVGAGMRYLSD--L--------GYVHRDLAARNVLVDSNLVC-KVSDFGLSRVL-------------E---D--DPDA-------------AYTTTGGKIPIRWTAPEA--IA------FRT---FSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDVISSV----EE----GYR----LP---APMGCP-------------------------------------------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL-----
--V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAI-KTL---K-A--GYS-EKQ-RRDFL-S-EASIMGQF--DHPNIIRLEGVVT--K------SRP--VMIITEFMENGALDSFLR-----QN--------------------------------------------------------------------------------------------------DGQF---TVIQLVGMLRGIAAGMKYLAE--M--------NYVHRDLAARNILVNSNLVC-KVSDFGLSRYLQ----------DDT---S--DPTY--------------TSSLGGKIPVRWTAPEA--IA------YRK---FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LP---PPMDCP-------------------------------------------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL-----
--V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAI-KTL---K-S--GYT-EKQ-RRDFL-S-EASIMGQF--DHPNVIHLEGVVT--K------STP--VMIITEFMENGSLDSFLR-----QN--------------------------------------------------------------------------------------------------DGQF---TVIQLVGMLRGIAAGMKYLAD--M--------NYVHRDLAARNILVNSNLVC-KVSDFGLSRFLE----------DDT---S--DPTY--------------TSALGGKIPIRWTAPEA--IQ------YRK---FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDVINAI----EQ----DYR----LP---PPMDCP-------------------------------------------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL-----
--V-KIEEVIGAGEFGEVCRGRLK-------------QPGRREVFVAI-KTL---K-V--GYT-ERQ-RRDFL-S-EASIMGQF--DHPNIIRLEGVVT--K------SRP--VMILTEFMENCALDSFLR-----LN--------------------------------------------------------------------------------------------------DGQF---TVIQLVGMLRGIAAGMKYLSE--M--------NYVHRDLAARNILVNSNLVC-KVSDFGLSRFLE----------DDP---S--DPTY--------------TSSLGGKIPIRWTAPEA--IA------YRK---FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----SNQDVINAV----EQ----DYR----LP---PPMDCP-------------------------------------------TALHQ-LMLDCWVRDRNLRPKFSQIVNTL-----
--V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAI-KTL---K-G--GYT-ERQ-RREFL-S-EASIMGQF--EHPNIIRLEGVVT--N------SMP--VMILTEFMENGALDSFLR-----LN--------------------------------------------------------------------------------------------------DGQF---TVIQLVGMLRGIASGMRYLAE--M--------SYVHRDLAARNILVNSNLVC-KVSDFGLSRFLE----------ENS---S--DPTY--------------TSSLGGKIPIRWTAPEA--IA------FRK---FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LP---PPPDCP-------------------------------------------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL-----
---IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAI-QAL---W-A--GGA-ESL-QMTFL-G-RAAVLGQF--QHPNILRLEGVVT--K------SRP--LMVLTEFMELGPLDSFLR-----QR--------------------------------------------------------------------------------------------------EGQF---SSLQLVAMQRGVAAAMQYLSS--F--------AFVHRSLSAHSVLVNSHLVC-KVARLGHSPQG-------------------------------------------PSCLLRWAAPEV--IA------HGK---HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI----EQ----EFR----LP---PPPGCP-------------------------------------------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF--
--L-RKLKVLGSGVFGTVHKGVWIP------------EGESIKIPVCI-KVI---E-D--KSG-RQS-FQAVT-D-HMLAIGSL--DHAHIVRLLGLCP---------GSS--LQLVTQYLPLGSLLDHVR-----QH--------------------------------------------------------------------------------------------------RGAL---GPQLLLNWGVQIAKGMYYLEE--H--------GMVHRNLAARNVLLKSPSQV-QVADFGVADLL-------------P---P--DDKQ--------------LLYSEAKTPIKWMALES--IH------FGK---YTHQSDVWSYGVTVWELMTFGA--------------EP---------------YAGL-----RLAEVPDLL----EK----GER----LA---QPQICT-------------------------------------------IDVYM-VMVKCWMIDENIRPTFKELANE--F---
--L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAI-KIL---N-E--TTG-PKA-NVEFM-D-EALIMASM--DHPHLVRLLGVCL---------SPT--IQLVTQLMPHGCLLEYVH-----EH--------------------------------------------------------------------------------------------------KDNI---GSQLLLNWCVQIAKGMMYLEE--R--------RLVHRDLAARNVLVKSPNHV-KITDFGLARLL-------------E---G--DEKE--------------YNADGGKMPIKWMALEC--IH------YRK---FTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----PTREIPDLL----EK----GER----LP---QPPICT-------------------------------------------IDVYM-VMVKCWMIDADSRPKFKELAAE--F---
--L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAV-KML---K-S--DAT-EKD-LSDLI-S-EMEMMKMIG-KHKNIINLLGACT--Q------DGP--LYVIVEYASKGNLREYLQ-----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS--K--------KCIHRDLAARNVLVTEDNVM-KIADFGLARDI-------------H---H--IDYY--------------KKTTNGRLPVKWMAPEA--LF------DRI---YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGV-----PVEELFKLL----KE----GHR----MD---KPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-----
---LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAV-KML---K-D--DAT-EKD-LSDLV-S-EMEMMKMIG-KHKNIINLLGACT--Q------DGP--LYVIVEYASKGNLREYLR-----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--Q--------KCIHRDLAARNVLVTENNVM-KIADFGLARDI-------------N---N--IDYY--------------KKTTNGRLPVKWMAPEA--LF------DRV---YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MD---KPANCT-------------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-----
---LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAV-KML---K-D--DAT-DKD-LSDLV-S-EMEMMKMIG-KHKNIINLLGACT--Q------GGP--LYVLVEYAAKGNLREFLR-----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQL---TFKDLVSCAYQVARGMEYLAS--Q--------KCIHRDLAARNVLVTEDNVM-KIADFGLARDV-------------H---N--LDYY--------------KKTTNGRLPVKWMAPEA--LF------DRV---YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MD---KPANCT-------------------------------------------HDLYM-IMRECWHAAPSQRPTFKQLVEDL-----
--L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAV-KML---K-D--NAS-DKD-LADLV-S-EMEVMKLIG-RHKNIINLLGVCT--Q------EGP--LYVIVECAAKGNLREFLR-----ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPL---SFPVLVSCAYQVARGMQYLES--R--------KCIHRDLAARNVLVTEDNVM-KIADFGLARGV-------------H---H--IDYY--------------KKTSNGRLPVKWMAPEA--LF------DRV---YTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----PVEELFSLL----RE----GHR----MD---RPPHCP-------------------------------------------PELYG-LMRECWHAAPSQRPTFKQLVEAL-----
---ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAV-KTL---K-P--GTM-SP---KAFL-E-EAQVMKLL--RHDKLVQLYAVVS---------EEP--IYIVTEFMCHGSLLDFLK-----NP-------------------------------------------------------------------------------------------------EGQDL---RLPQLVDMAAQVAEGMAYMER--M--------NYIHRDLRAANILVGERLAC-KIADFGLARLI-----------------K--DDEY--------------NPCQGSKFPIKWTAPEA--AL------FGR---FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV----EQ----GYH----MP---CPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPTFEYLQSFL-----
---LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAV-KML---K-E--GAT-ASE-HRALM-S-ELKILIHIG-NHLNVVNLLGACT-KP------QGP--LMVIVEFCKYGNLSNFLR-----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPL---TMEDLVCYSFQVARGMEFLAS--R--------KCIHRDLAARNILLSESDVV-KICDFGLARDI-------------Y---K--DPDY--------------VRKGSARLPLKWMAPES--IF------DKV---YTTQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-Q---INEEFCQRL----RD----GTR----MR---APELAT-------------------------------------------PAIRR-IMLNCWSGDPKARPAFSELVEIL-----
---IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAV-KTL---K-P--GSM-DP---NDFL-R-EAQIMKNL--RHPKLIQLYAVCT--L------EDP--IYIITELMRHGSLQEYLQ-----ND-------------------------------------------------------------------------------------------------TGSKI---HLTQQVDMAAQVASGMAYLES--R--------NYIHRDLAARNVLVGEHNIY-KVADFGLARVFK-----------VD---N--EDIY--------------ESRHEIKLPVKWTAPEA--IR------SNK---FSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML----AQ----NYR----LP---QPSNCP-------------------------------------------QQFYN-IMLECWNAEPKERPTFETLRWK--L---
---LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAI-KTL---K-P--GTM-SP---ESFL-E-EAQIMKKL--KHDKLVQLYAVVS---------EEP--IYIVTEYMNKGSLLDFLK-----DG-------------------------------------------------------------------------------------------------EGRAL---KLPNLVDMAAQVAAGMAYIER--M--------NYIHRDLRSANILVGNGLIC-KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL------YGR---FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV----ER----GYR----MP---CPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPTFEYLQSFL-----
---LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAV-KTM---K-P--GSM-SV---EAFL-A-EANVMKTL--QHDKLVKLHAVVT---------KEP--IYIITEFMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--R--------NYIHRDLRAANILVSASLVC-KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN------FGS---FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL----ER----GYR----MP---RPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPTFEYIQSV--L---
---ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAI-KTV---N-E--AAS-MRE-RIEFL-N-EASVMKEF--NCHHVVRLLGVVS--Q------GQP--TLVIMELMTRGDLKSYLR-----SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPP---SLSKMIQMAGEIADGMAYLNA--N--------KFVHRDLAARNCMVAEDFTV-KIGDFGMTRDI-------------Y---E--TDYY--------------RKGGKGLLPVRWMSPES--LK------DGV---FTTYSDVWSFGVVLWEIATLAE--------------QP---------------YQGL-----SNEQVLRFV----ME----GGL----LD---KPDNCP-------------------------------------------DMLFE-LMRMCWQYNPKMRPSFLEIISS--I---
--L-KRIRDLGEGHFGKVELCRYDP------------EGDNTGEQVAV-KSL---K-P--ESG-GNH-IADLK-K-EIEILRNL--YHENIVKYKGICT-ED-------GGNGIKLIMEFLPSGSLKEYLP-----KN--------------------------------------------------------------------------------------------------KNKI---NLKQQLKYAVQICKGMDYLGS--R--------QYVHRDLAARNVLVESEHQV-KIGDFGLTKAI------------ET---D--KEYY--------------TVKDDRDSPVFWYAPEC--LM------QSK---FYIASDVWSFGVTLHELLTYCD--------------SDSSPMALF-LKMIGPTHGQM-----TVTRLVNTL----KE----GKR----LP---CPPNCP-------------------------------------------DEVYQ-LMRKCWEFQPSNRTSFQNLIE---GF--
---LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAV-KKL---Q-H--STE--EH-LRDFE-R-EIEILKSL--QHDNIVKYKGVCYSAG------RRN--LKLIMEYLPYGSLRDYLQ-----KH--------------------------------------------------------------------------------------------------KERI---DHIKLLQYTSQICKGMEYLGT--K--------RYIHRDLATRNILVENENRV-KIGDFGLTKVL------------PQ---D--KEYY--------------KVKEPGESPIFWYAPES--LT------ESK---FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR----LP---RPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV-
--L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAV-KQL---Q-H--SGP-DQ--QRDFQ-R-EIQILKAL--HSDFIVKYRGVSYGPG------RQS--LRLVMEYLPSGCLRDFLQ-----RH--------------------------------------------------------------------------------------------------RARL---DASRLLLYSSQICKGMEYLGS--R--------RCVHRDLAARNILVESEAHV-KIADFGLAKLL------------PL---D--KDYY--------------VVREPGQSPIFWYAPES--LS------DNI---FSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EE----GQR----LP---APPACP-------------------------------------------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL--
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAV-KML---K-E--GAT-HSE-HRALM-S-ELKILIHIG-HHLNVVNLLGACT-KP------GGP--LMVIVEFCKFGNLSTYLR-----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFL---TLEHLICYSFQVAKGMEFLAS--R--------KCIHRDLAARNILLSEKNVV-KICDFGLARDI-------------Y---K--DPDY--------------VRKGDARLPLKWMAPET--IF------DRV---YTIQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-K---IDEEFCRRL----KE----GTR----MR---APDYTT-------------------------------------------PEMYQ-TMLDCWHGEPSQRPTFSELVEHL-----
---YEIDRTIGKGNFAVVKRATHL----------------VTKAKVAI-KII---DKT--QLDEEN---LKKIFR-EVQIMKML--CHPHIIRLYQVME--T------ERM--IYLVTEYASGGEIFDHLV----AHG----------------------------------------------------------------------------------------------------RM---AEKEARRKFKQIVTAVYFCHC--R--------NIVHRDLKAENLLLDANLNI-KIADFGFSNL------------------FTPGQLL--------------KT---WCGSPPYAAPEL--FE-----GKEY---DGPKVDIWSLGVVLYVLVC-GA--------------LP---------------FDGS--------TLQNLR----AR----VLS----GK---FRIPFFMS-----------------------------------------TECEH-LIRHMLVLDPNKRLSMEQICKHKWM---
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAV-KML---K-P--SAH-LTE-REALM-S-ELKVLSYLG-NHMNIVNLLGACT--I------GGP--TLVITEYCCYGDLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELAL---DLEDLLSFSYQVAKGMAFLAS--K--------NCIHRDLAARNILLTHGRIT-KICDFGLARDI-------------K---N--DSNY--------------VVKGNARLPVKWMAPES--IF------NCV---YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI----KE----GFR----ML---SPEHAP-------------------------------------------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I---
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAV-KSL---K-Q--GSM-SP---DAFL-A-EANLMKQL--QHQRLVRLYAVVT---------QEP--IYIITEYMENGSLVDFLK-----TP-------------------------------------------------------------------------------------------------SGIKL---TINKLLDMAAQIAEGMAFIEE--R--------NYIHRDLRAANILVSDTLSC-KIADFGLARLI-----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN------YGT---FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL----ER----GYR----MV---RPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L---
-LI--HGEVLGKGCFGQAIKVTHR----------------ETGEVMVM-KEL---I----RFD-EET-QRTFL-K-EVKVMRCL--EHPNVLKFIGVLY--K------DKR--LNFITEYIKGGTLRGIIK-----SM--------------------------------------------------------------------------------------------------DSQY---PWSQRVSFAKDIASGMAYLHS--M--------NIIHRDLNSHNCLVRENKNV-VVADFGLARLM-------------V---D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEM--IN------GRS---YDEKVDVFSFGIVLCEIIGRVN--------------AD---------------PDYL-P---RTMDFGLNV----RG----FLD----RY---CPPNCP-------------------------------------------PSFFP-ITVRCCDLDPEKRPSFVKLEH---WL--
-LI--HGEVLGKGFFGQAIKVTHK-----------------ATGKVMVMKEL-----I--RCD-EET-QKTFL-T-EVKVMRSL--DHPNVLKFIGVLY--K------DKK--LNLLTEYIEGGTLKDFLR-----SM---------------------------------------------------------------------------------------------------DPF---PWQQKVRFAKGIASGMAYLHS--M--------CIIHRDLNSHNCLIKLDKTV-VVADFGLSRLIVEERKRAPMEKATT---------KKRTL-----RKNDRKKRYTVVGNPYWMAPEM--LN------GKS---YDETVDIFSFGIVLCEIIGQVY--------------AD---------------PDCL-P---RTLDFGLNV----KL----FWE----KF---VPTDCP-------------------------------------------PAFFP-LAAICCRLEPESRPAFSKLED---SF--
---IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAV-KTL---K-P--GTM-SV---QAFL-E-EANLMKTL--QHDKLVRLYAVVT--R------EEP--IYIITEYMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EGGKV---LLPKLIDFSAQIAEGMAYIER--K--------NYIHRDLRAANVLVSESLMC-KIADFGLARVI-----------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN------FGC---FTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL----SQ----GYR----MP---RVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPTFDYLQSV--L---
---FEKISELGAGNGGVVFKVSHK----------------PSGL-VMA-RKL---IHL--EIKPAI---RNQIIR-ELQVLHEC--NSPYIVGFYGAFY--S------DGE--ISICMEHMDGGSLDQVLK----KAG----------------------------------------------------------------------------------------------------RI---PEQILGKVSIAVIKGLTYLRE-KH--------KIMHRDVKPSNILVNSRGEI-KLCDFGVSG-------------------QLIDSMA--------------NS---FVGTRSYMSPER--LQ------GTH---YSVQSDIWSMGLSLVEMAV-GR--------------YP---------------IPPP-----DAKELELMF----GC----QVE----GD---AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERADLKQLMVHAFI---
IRY---RDTLGHGNGGTVYKAYHV----------------PSGKILAV-KVI---LLD--ITLELQ---KQI-MS-ELEILYKC--DSSYIIGFYGAFF--V------ENR--ISICTEFMDGGSLD--------VYR----------------------------------------------------------------------------------------------------KM---PEHVLGRIAVAVVKGLTYLWS--L--------KILHRDVKPSNMLVNTRGQV-KLCDFGVST-------------------QLVNSIA--------------KT---YVGTNAYMAPER--IS------GEQ---YGIHSDVWSLGISFMELAL-GR--------------FP---------------YPQI-----QKNQGSLMP----LQ----LLQ----CI---VDEDSPVLPVGEF-----------------------------------SEPFVH-FITQCMRKQPKERPAPEELMGHPFI---
---FELIQRIGSGTYGDVYKARNV----------------NTGELAAI-KVI---KLE--PGEDFA---VVQ--Q-EIIMMKDC--KHPNIVAYFGSYL--R------RDK--LWICMEFCGGGSLQDIYH----VTG----------------------------------------------------------------------------------------------------PL---SELQIAYVSRETLQGLYYLHS--K--------GKMHRDIKGANILLTDNGHV-KLADFGVSAQI-----------------TATIAKR--------------KS---FIGTPYWMAPEVAAVE-----RKGG---YNQLCDLWAVGITAIELAE-LQ--------------PP---------------MFDL-----HPMRALFLM----TK----SNF----QP---P--KLKDKMKWS-------------------------------------NSFHH-FVKMALTKNPKKRPTAEKLLQHPFV---
---YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAV-KKL---SRP--FQSIIH---AKRTYR-ELRLLKHM--KHENVIGLLDVFT--PARSLEEFND--VYLVTHLMGA-DLNNIVK-----CQ----------------------------------------------------------------------------------------------------KL---TDDHVQFLIYQILRGLKYIHS--A--------DIIHRDLKPSNLAVNEDCEL-KILDFGLAR--------------------HTDDEM--------------TG---YVATRWYRAPEI--ML-----NWMH---YNQTVDIWSVGCIMAELLT-GR--------------TL---------------FPGT-----DHIDQLKLI----LR----LVG----TP---GAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRITAAQALAHAYF---
---YRLLKTIGKGNFAKVKLARHI----------------LTGKEVAV-KII---DKT--QLNSSS---LQKLFR-EVRIMKVL--NHPNIVKLFEVIE--T------EKT--LYLVMEYASGGEVFDYLV----AHG----------------------------------------------------------------------------------------------------RM---KEKEARAKFRQIVSAVQYCHQ--K--------FIVHRDLKAENLLLDADMNI-KIADFGFSNE------------------FTFGNKL--------------DT---FCGSPPYAAPEL--FQ-----GKKY---DGPEVDVWSLGVILYTLVS-GS--------------LP---------------FDGQ--------NLKELR----ER----VLR----GK---YRIPFYMS-----------------------------------------TDCEN-LLKKFLILNPSKRGTLEQIMKDRWM---
---VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAV-KSL---N-R--ITD-IGE-VSQFL-T-EGIIMKDF--SHPNVLSLLGICL-RS------EGS--PLVVLPYMKHGDLRNFIR-----NE--------------------------------------------------------------------------------------------------THNP---TVKDLIGFGLQVAKGMKYLAS--K--------KFVHRDLAARNCMLDEKFTV-KVADFGLARDM-------------Y---D--KEYYS------------VHNKTGAKLPVKWMALES--LQ------TQK---FTTKSDVWSFGVLLWELMTRGA--------------PP---------------YPDV-----NTFDITVYL----LQ----GRR----LL---QPEYCP-------------------------------------------DPLYE-VMLKCWHPKAEMRPSFSELVSR--I---
---YRIRGEIGSGNFSQVKLGIHS----------------LTKEKVAI-KIL---DKT--KLDQKT---QRLLSR-EISSMEKL--HHPNIIRLYEVVE--T------LSK--LHLVMEYAGGGELFGKIS----TEG----------------------------------------------------------------------------------------------------KL---SEPESKLIFSQIVSAVKHMHE--N--------QIIHRDLKAENVFYTSNTCV-KVGDFGFSTV------------------SKKGEML--------------NT---FCGSPPYAAPEL--FR-----DEHY---IGIYVDIWALGVLLYFMVT-GT--------------MP---------------FRAE--------TVAKLK----KS----ILE----GT---YSVPPHV----S-------------------------------------EPCHR-LIRGVLQQIPTERYGIDCIMNDEWM---
---FELVEVVGNGTYGQVYKGRHV----------------KTGQLAAI-KVM---DVT--EDEEEE---IKQ----EINMLKKY-SHHRNIATYYGAFI--KKSPPGNDDQ--LWLVMEFCGAGSVTDLVKN--TKGN----------------------------------------------------------------------------------------------------AL---KEDCIAYICREILRGLAHLHA--H--------KVIHRDIKGQNVLLTENAEV-KLVDFGVSAQL-----------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD-ENPDAT---YDYRSDIWSLGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPP----PR---LKSKKWS------------------------------------------KKFID-FIDTCLIKTYLSRPPTEQLLKFPFI---
--Y-VRLQKIGEGSFGKAILVKST----------------EDGRQYVI-KEI---NIS--RMSSKE---REESRR-EVAVLANM--KHPNIVQYRESFE--E------NGS--LYIVMDYCEGGDLFKRINA--QKGV----------------------------------------------------------------------------------------------------LF---QEDQILDWFVQICLALKHVHD--R--------KILHRDIKSQNIFLTKDGTV-QLGDFGIARVL-----------------NSTVELA--------------RT---CIGTPYYLSPEI--CE------NKP---YNNKSDIWALGCVLYELCT-LK--------------HA---------------FEAG--------SMKNLV----LK----IIS----GS---FPPVSLHYS----------------------------------------YDLRS-LVSQLFKRNPRDRPSVNSILEKGF-I--
---YEVLYTIGTGSYGRCQKIRRK----------------SDGKILVW-KEL---DYG--SMTEAE---KQMLVS-EVNLLREL--KHPNIVRYYDRII--DR----TNTT--LYIVMEYCEGGDLASVITKGTKERQ----------------------------------------------------------------------------------------------------YL---DEEFVLRVMTQLTLALKECHR--RSD---GGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARIL-----------------NHDTSFA--------------KT---FVGTPYYMSPEQ--MN------RMS---YNEKSDIWSLGCLLYELCA-LM--------------PP---------------FTAF--------SQKELA----GK----IRE----GK---FRRIPYRY---S-------------------------------------DELNE-IITRMLNLKDYHRPSVEEILENPL-I--
---YDVIKAIGQGAFGKAYLAKGK----------------SDSKHCVI-KEI---NFE--KMPIQE---KEASKK-EVILLEKM--KHPNIVAFFNSFQ--E------NGR--LFIVMEYCDGGDLMKRINR--QRGV----------------------------------------------------------------------------------------------------LF---SEDQILGWFVQISLGLKHIHD--R--------KILHRDIKAQNIFLSKNGMVAKLGDFGIARVL-----------------NNSMELA--------------RT---CIGTPYYLSPEI--CQ------NKP---YNNKTDIWSLGCVLYELCT-LK--------------HP---------------FEGN--------NLQQLV----LK----ICQ----AH---FAPISPGF---S-------------------------------------RELHS-LISQLFQVSPRDRPSINSILKRPFL---
--I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAV-KAL---K-D--PTL-AA--RKDFQ-R-EAELLTNL--QHEHIVKFYGVCG--D------GDP--LIMVFEYMKHGDLNKFLR-----AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS--Q--------HFVHRDLATRNCLVGANLLV-KIGDFGMSRDV-------------Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM------YRK---FTTESDVWSFGVILWEIFTYGK--------------QP---------------WFQL-----SNTEVIECI----TQ----GRV----LE---RPRVCP-------------------------------------------KEVYD-VMLGCWQREPQQRLNIKEIYKIL-----
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAV-KML---K-P--TAR-SSE-KQALM-S-ELKIMTHLG-PHLNIVNLLGACT--K------SGP--IYIITEYCFYGDLVNYLH-----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGL---TLLDLLSFTYQVARGMEFLAS--K--------NCVHRDLAARNVLLAQGKIV-KICDFGLARDI-------------M---H--DSNY--------------VSKGSTFLPVKWMAPES--IF------DNL---YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI----KS----GYR----MA---KPDHAT-------------------------------------------SEVYE-IMVKCWNSEPEKRPSFYHLSE---IV--
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAV-KML---K-S--TAR-SSE-KQALM-S-ELKIMSHLG-PHLNVVNLLGACT--K------GGP--IYIITEYCRYGDLVDYLH-----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVL---SYMDLVGFSYQVANGMEFLAS--K--------NCVHRDLAARNVLICEGKLV-KICDFGLARDI-------------M---R--DSNY--------------ISKGSTFLPLKWMAPES--IF------NSL---YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI----KR----GYR----MA---QPAHAS-------------------------------------------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL--
-YL--KGRLLGKGGFARCYEATDT----------------ETGSAYAV-KVI---PQS--RVAKPH---QREKILNEIELHRDL--QHRHIVRFSHHFE--D------ADN--IYIFLELCSRKSLAHIWK----ARH----------------------------------------------------------------------------------------------------TL---LEPEVRYYLRQILSGLKYLHQ--R--------GILHRDLKLGNFFITENMEL-KVGDFGLAARL-----------------EPPEQRK--------------KT---ICGTPNYVAPEV--LL------RQG---HGPEADVWSLGCVMYTLLC-GS--------------PP---------------FETA--------DLKETY----RC----IKQ----VH---YTLPASLS-----------------------------------------LPARQ-LLAAILRASPRDRPSIDQILRHDFF---
--V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAV-KTC---K-K--DCT-LDN-KEKFM-S-EAVIMKNL--DHPHIVKLIGIIE---------EEP--TWIIMELYPYGELGHYLE-----RN--------------------------------------------------------------------------------------------------KNSL---KVLTLVLYSLQICKAMAYLES--I--------NCVHRDIAVRNILVASPECV-KLGDFGLSRYI-----------------E--DEDY--------------YKASVTRLPIKWMSPES--IN------FRR---FTTASDVWMFAVCMWEILSFGK--------------QP---------------FFWL-----ENKDVIGVL----EK----GDR----LP---KPDLCP-------------------------------------------PVLYT-LMTRCWDYDPSDRPRFTELVCS--L---
--F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAI-KVI---S-R--DNL-LH--QQMLQ-S-EIQAMKKL--RHKHILALYAVVS--V------GDP--VYIITELMAKGSLLELLR-----DS-------------------------------------------------------------------------------------------------DEKVL---PVSELLDIAWQVAEGMCYLES--Q--------NYIHRDLAARNILVGENTLC-KVGDFGLARLI--------------------KEDV--------------YLSHDHNIPYKWTAPEA--LS------RGH---YSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----SNHEAFLRV----DA----GYR----MP---CPLECP-------------------------------------------PSVHK-LMLTCWCRDPEQRPCFKALRERL-----
--L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAV-KML---K-E--NAS-PSE-LRDLL-S-EFNVLKQV--NHPHVIKLYGACS--Q------DGP--LLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAE--M--------KLVHRDLAARNILVAEGRKM-KISDFGLSRDV-------------Y---E--EDSY--------------VKRSQGRIPVKWMAIES--LF------DHI---YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL----KT----GHR----ME---RPDNCS-------------------------------------------EEMYR-LMLQCWKQEPDKRPVFADISKDL-----
LES----AELDSGGFGKVSLCFHR-----------------TQGLMIM-KTV--YK-G--PNC-IEH-NEALL-E-EAKMMNRL--RHSRVVKLLGVII--E------EGK--YSLVMEYMEKGNLMHVLK-----AE---------------------------------------------------------------------------------------------------MST---PLSVKGRIILEIIEGMCYLHG--K--------GVIHKDLKPENILVDNDFHI-KIADLGLASFKMWS------KLNNE-------EHNELR--------EVDGTAKKNGGTLYYMAPEH--LN------DVNA-KPTEKSDVYSFAVVLWAIFA-NK--------------EP---------------YENA-I---CEQQLIMCI----KS----GNR----PDVDDITEYCP-------------------------------------------REIIS-LMKLCWEANPEARPTFPGIEEK--F---
LAD---LRYLSRGASGTVSSARHA----------------DWRVQVAV-KHL---HIH--TPLLDS---ERKDVLREAEILHKA--RFSYILPILGICN--E------PEF--LGIVTEYMPNGSLNELLH----RKT----------------------------------------------------------------------------------------------------EYPDVAWPLRFRILHEIALGVNYLHN--MT------PPLLHHDLKTQNILLDNEFHV-KIADFGLSKWRMM------------SLSQSRSSKS--------------AP---EGGTIIYMPPEN--YEP---GQKSR---ASIKHDIYSYAVITWEVLS-RK--------------QP---------------FEDVT---NPLQIMYSVS----QG----HRP----VI---NEESLPYDIPHR-------------------------------------ARMIS-LIESGWAQNPDERPSFLKCL-----IEL
---YDIERTLGKGNFAVVKLARHR----------------VTKTQVAI-KII---DKT--RLDSSN---LEKIYR-EVQLMKLL--NHPHIIKLYQVME--T------KDM--LYIVTEFAKNGEMFDYLT----SNG----------------------------------------------------------------------------------------------------HL---SENEARKKFWQILSAVEYCHD--H--------HIVHRDLKTENLLLDGNMDI-KLADFGFGNF------------------YKSGEPL--------------ST---WCGSPPYAAPEV--FE-----GKEY---EGPQLDIWSLGVVLYVLVC-GS--------------LP---------------FDGP--------NLPTLR----QR----VLE----GR---FRIPFFMS-----------------------------------------QDCES-LIRRMLVVDPARRITIAQIRQHRWM---
---YDIEGTLGKGNFAVVKLGRHR----------------ITKTEVAI-KII---DKS--QLDAVN---LEKIYR-EVQIMKML--DHPHIIKLYQVME--T------KSM--LYLVTEYAKNGEIFDYLA----NHG----------------------------------------------------------------------------------------------------RL---NESEARRKFWQILSAVDYCHG--R--------KIVHRDLKAENLLLDNNMNI-KIADFGFGNF------------------FKSGELL--------------AT---WCGSPPYAAPEV--FE-----GQQY---EGPQLDIWSMGVVLYVLVC-GA--------------LP---------------FDGP--------TLPILR----QR----VLE----GR---FRIPYFMS-----------------------------------------EDCEH-LIRRMLVLDPSKRLTIAQIKEHKWM---
---WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAA-KVI---DTK--SEEELE---DYM--V-EIDILASC--DHPNIVKLLDAFY--Y------ENN--LWILIEFCAGGAVDAVML---ELER----------------------------------------------------------------------------------------------------PL---TESQIQVVCKQTLDALNYLHD--N--------KIIHRDLKAGNILFTLDGDI-KLADFGVSAKN-----------------TRTIQRR--------------DS---FIGTPYWMAPEV--VMCE-TSKDRP---YDYKADVWSLGITLIEMAE-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SEP----PT---LAQPSRWS-----------------------------------------SNFKD-FLKKCLEKNVDARWTTSQLLQHPFV---
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAI-KTL---K-P--GTM-SP---EAFL-Q-EAQVMKKL--RHEKLVQLYAVVS---------EEP--IYIVTEYMSKGSLLDFLK-----GE-------------------------------------------------------------------------------------------------TGKYL---RLPQLVDMAAQIASGMAYVER--M--------NYVHRDLRAANILVGENLVC-KVADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL------YGR---FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV----ER----GYR----MP---CPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L---
-FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAI-KVI---K-S--ANM-K---LTDLA-K-EIQTLKGL--RHERLIRLHAVCS--G------GEP--VYIVTELMRKGNLQAFLG-----TP-------------------------------------------------------------------------------------------------EGRAL---RLPPLLGFACQVAEGMSYLEE--Q--------RVVHRDLAARNVLVDDGLAC-KVADFGLARLL-----------------K--DDIY--------------SPSSSSKIPVKWTAPEA--AN------YRV---FSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----TNHETLQQI----MR----GYR----LP---RPAACP-------------------------------------------AEVYV-LMLECWRSSPEERPSFATLREKL-----
---WEIVGELGDGAFGKVYKAKNK----------------ETGALAAA-KVI---ETK--SEEELE---DYI--V-EIEILATC--DHPYIVKLLGAYY--H------DGK--LWIMIEFCPGGAVDAIML---ELDR----------------------------------------------------------------------------------------------------GL---TEPQIQVVCRQMLEALNFLHS--K--------RIIHRDLKAGNVLMTLEGDI-RLADFGVSAKN-----------------LKTLQKR--------------DS---FIGTPYWMAPEV--VMCE-TMKDTP---YDYKADIWSLGITLIEMAQ-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SDP----PT---LLTPSKWS-----------------------------------------VEFRD-FLKIALDKNPETRPSAAQLLEHPFV---
---FTKLEKIGKGSFGEVFKGIDN----------------RTQKVVAI-KII---DLE--EAEDEI---EDIQ-Q-EITVLSQC--DSPYVTKYYGSYL--K------DTK--LWIIMEYLGGGSALDLLE-----PG----------------------------------------------------------------------------------------------------PL---DETQIATILREILKGLDYLHS--E--------KKIHRDIKAANVLLSEHGEV-KLADFGVAGQL-----------------TDTQIKR--------------NT---FVGTPFWMAPEV--IK------QSA---YDSKADIWSLGITAIELAR-GE--------------PP---------------HSEL-----HPMKVLFLI----PK----NNP----PT---LEGNYS-------------------------------------------KPLKE-FVEACLNKEPSFRPTAKELLKHKFI---
---YHVLEMIGEGSFGRVYKGRRK----------------YSAQVVAL-KFI---PKL--GRSEKE---LRNLQR-EIEIMRGL--RHPNIVHMLDSFE--T------DKE--VVVVTDYAEG-ELFQILE----DDG----------------------------------------------------------------------------------------------------KL---PEDQVQAIAAQLVSALYYLHS--H--------RILHRDMKPQNILLAKGGGI-KLCDFGFARAM-----------------STNTMVL--------------TS---IKGTPLYMSPEL--VE------ERP---YDHTADLWSVGCILYELAV-GT--------------PP---------------FYAT--------SIFQLV----SL----ILK----DP---VRWPSTIS-----------------------------------------PCFKN-FLQGLLTKDPRQRLSWPDLLYHPFI---
TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAV-KIL---K-N--EAN-DPALKDELL-A-EANVMQQL--DNPYIVRMIGICE---------AES--WMLVMEMAELGPLNKYLQ-----QN---------------------------------------------------------------------------------------------------RHV---KDKNIIELVHQVSMGMKYLEE--S--------NFVHRDLAARNVLLVTQHYA-KISDFGLSKAL-------------R---A--DENY-------------YKAQTHGKWPVKWYAPEC--IN------YYK---FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML----EK----GER----MG---CPAGCP-------------------------------------------REMYD-LMNLCWTYDVENRPGFAAVE----LRL-
---LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAI-KAI---R-E--GAM-CE---EDFI-E-EAKVMMKL--THPKLVQLYGVCT--Q------QKP--IYIVTEFMERGCLLNFLR-----QR--------------------------------------------------------------------------------------------------QGHF---SRDVLLSMCQDVCEGMEYLER--N--------SFIHRDLAARNCLVSEAGVV-KVSDFGMARYV-----------------L--DDQY--------------TSSSGAKFPVKWCPPEV--FN------YSR---FSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----TNYEVVTMV----TR----GHR----LY---QPKLAS-------------------------------------------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I---
---IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAI-KRM---K-E--YAS-KDD-HRDFA-G-ELEVLCKLG-HHPNIINLLGACE--H------RGY--LYLAIEYAPHGNLLDFLR-----KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTL---SSQQLLHFAADVARGMDYLSQ--K--------QFIHRDLAARNILVGENYVA-KIADFGLSRGQ---------------------EVY--------------VKKTMGRLPVRWMAIES--LN------YSV---YTTNSDVWSYGVLLWEIVSLGG--------------TP---------------YCGM-----TCAELYEKL----PQ----GYR----LE---KPLNCD-------------------------------------------DEVYD-LMRQCWREKPYERPSFAQILV---SL--
-IV--LQESIGKGRFGEVWRGKWR----------------GEE--VAV-KIF---SSR--EERSWF---REA----EIYQTVML--RHENILGFIAADN--KDN--GTWTQ--LWLVSDYHEHGSLFDYLN-----RY----------------------------------------------------------------------------------------------------TV---TVEGMIKLALSTASGLAHLHM--EIVGTQGKPAIAHRDLKSKNILVKKNGTC-CIADLGLAVRHDS-------------ATDTIDIAP--------------NH---RVGTKRYMAPEV--LDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGI----HEDYQLP---------------YYDLVPSDPSVEEMRKVV----CE----QKL----RP---NIPNRWQSCEAL-------------------------------------RVMAK-IMRECWYANGAARLTALRIKK----TL-
---ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAI-KML---K-E--YAS-END-HRDFA-G-ELEVLCKLG-HHPNIINLLGACK--N------RGY--LYIAIEYAPYGNLLDFLR-----KSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTL---SSRQLLRFASDAANGMQYLSE--K--------QFIHRDLAARNVLVGENLAS-KIADFGLSRGE---------------------EVY--------------VKKTMGRLPVRWMAIES--LN------YSV---YTTKSDVWSFGVLLWEIVSLGG--------------TP---------------YCGM-----TCAELYEKL----PQ----GYR----ME---QPRNCD-------------------------------------------DEVYE-LMRQCWRDRPYERPPFAQIALQ--L---
---FELVELVGNGTYGQVYKGRHV----------------KTGQLAAI-KVM---DVT--GDEEEE---IKQ----EINMLKKY-SHHRNIATYYGAFI--KKNPPGMDDQ--LWLVMEFCGAGSVTDLIKN--TKGN----------------------------------------------------------------------------------------------------TL---KEEWIAYICREILRGLSHLHQ--H--------KVIHRDIKGQNVLLTENAEV-KLVDFGVSAQL-----------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD-ENPDAT---YDFKSDLWSLGITAIEMAE-GA--------------PP---------------LCDM-----HPMRALFLI----PR----NPA----PR---LKSKKWS------------------------------------------KKFQS-FIESCLVKNHSQRPATEQLMKHPFI---
VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAV-KSLRVGP-E--GPM-GTE-LGDFL-R-EVSVMMNL--EHPHVLRLHGLVL---------GQP--LQMVMELAPLGSLHARLT-----AP------------------------------------------------------------------------------------------------APTPPL---LVALLCLFLRQLAGAMAYLGA--R--------GLVHRDLATRNLLLASPRTI-KVADFGLVRPL------------GG---A--RGRY--------------VMGGPRPIPYAWCAPES--LR------HGA---FSSASDVWMFGVTLWEMFSGGE--------------EP---------------WAGV-----PPYLILQRL----ED----RAR----LP---RPPLCS-------------------------------------------RALYS-LALRCWAPHPADRPSFSHLE----GLL-
--L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAV-KCL---K-PDVLSQ-PEA-MDDFI-R-EVNAMHSL--DHRNLIRLYGVVL---------TPP--MKMVTELAPLGSLLDRLR-----KH--------------------------------------------------------------------------------------------------QGHF---LLGTLSRYAVQVAEGMGYLES--K--------RFIHRDLAARNLLLATRDLV-KIGDFGLMRAL------------PQ---N--DDHY--------------VMQEHRKVPFAWCAPES--LK------TRT---FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKI---DKE----GER----LP---RPEDCP-------------------------------------------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L---
---IEFHEIIGSGSFGKVYKGRCR------------------NKIVAI-KRY---R-ANTYCS-KSD-VDMFC-R-EVSILCQL--NHPCVIQFVGACL-ND------PSQ--FAIVTQYISGGSLFSLLH-----EQ--------------------------------------------------------------------------------------------------KRIL---DLQSKLIIAVDVAKGMEYLHNLTQ--------PIIHRDLNSHNILLYEDGHA-VVADFGESRFL-------------Q---S--LD-E--------------DNMTKQPGNLRWMAPEV--FT------QCT--RYTIKADVFSYALCLWEILT-GE--------------IP---------------FAHL-----KPAAAAADM---AYH----HIR----PP---IGYSIP-------------------------------------------KPISS-LLIRGWNACPEGRPEFSEVVMKL-----
--L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAI-KAI---N-E--GSM-SE---EDFI-E-EAKVMMKL--SHSKLVQLYGVCI--Q------RKP--LYIVTEFMENGCLLNYLR-----EN--------------------------------------------------------------------------------------------------KGKL---RKEMLLSVCQDICEGMEYLER--N--------GYIHRDLAARNCLVSSTCIV-KISDFGMTRYV-----------------L--DDEY--------------VSSFGAKFPIKWSPPEV--FL------FNK---YSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI----SE----GFR----LY---RPHLAP-------------------------------------------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV--
--L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAV-KAL---K-A--DCG-PQH-RSGWK-Q-EIDILRTL--YHEHIIKYKGCCEDQG------EKS--LQLVMEYVPLGSLRDYLP-----RH----------------------------------------------------------------------------------------------------SI---GLAQLLLFAQQICEGMAYLHA--Q--------HYIHRDLAARNVLLDNDRLV-KIGDFGLAKAV------------PE---G--HEYY--------------RVREDGDSPVFWYAPEC--LK------EYK---FYYASDVWSFGVTLYELLTHCD--------------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER----LP---RPDKCP-------------------------------------------CEVYH-LMKNCWETEASFRPTFENLIP---IL--
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAI-KTL---K-P--GTM-MP---EAFL-Q-EAQIMKKL--RHDKLVPLYAVVS---------EEP--IYIVTEFMSKGSLLDFLK-----EG-------------------------------------------------------------------------------------------------DGKYL---KLPQLVDMAAQIADGMAYIER--M--------NYIHRDLRAANILVGENLVC-KIADFGLARLI-----------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL------YGR---FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV----ER----GYR----MP---CPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL-----