Protein Surface  Ribbon
Inhibitor STU
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 176 kinases in KIF 3CKXA_STU (STK24, PDB code: 3CKX, chain A)

Multiple sequence alignment of family kinases

Conserved residues:  
                            
Group      Kinase           
STE        MAP4K4       203 
TK         ABL1         261 
TK         ABL2         288 
TKL        ACVR1        208 
TK         ALK         1116 
Other      AURKA        133 
Other      AURKB         77 
Other      AURKC         43 
TK         AXL          527 
TK         BLK          241 
TKL        BMPR1A       234 
TK         BMX          422 
TK         BTK          402 
CAMK       CAMK1G        23 
CAMK       CAMK2A        13 
CAMK       CAMK2B        14 
CAMK       CAMK4         46 
Other      CAMKK1       128 
Other      CAMKK2       165 
CAMK       CASK          12 
CMGC       CDC2           4 
CMGC       CDC2L5       705 
CMGC       CDC2L6        20 
CMGC       CDK15        103 
CMGC       CDK2           4 
CMGC       CDK3           4 
CMGC       CDK4           6 
CMGC       CDK5           4 
CMGC       CDK6          13 
CMGC       CDK8       2.7.11.23 
CMGC       CDK9       2.7.11.23 
CMGC       CDKL1          5 
CMGC       CDKL2          4 
CMGC       CDKL3          4 
CMGC       CDKL5         13 
CAMK       CHEK1          9 
CAMK       CHEK2        220 
TK         CSK          195 
CAMK       DAPK1         13 
CAMK       DAPK2         23 
CAMK       DAPK3         13 
CAMK       DCLK3        356 
CMGC       DYRK1B       111 
CMGC       DYRK3        209 
TK         EGFR         712 
Other      EIF2AK2      267 
Other      EIF2AK4      590 
TK         EPHB1        619 
TK         EPHB2        621 
TK         EPHB4        615 
TK         EPHB6        670 
TK         ERBB4        718 
TK         FER          563 
TK         FES          561 
TK         FGFR1        478 
TK         FGFR2        481 
TK         FGFR3        472 
TK         FGFR4        467 
TK         FGR          263 
TK         FYN          271 
AGC        GRK1         190 
AGC        GRK4         187 
AGC        GRK5         186 
AGC        GRK6         186 
AGC        GRK7         191 
TK         HCK          241 
CMGC       HIPK4         -1 
CMGC       ICK            4 
TK         IGF1R        999 
TK         INSR        1023 
TK         INSRR        979 
TKL        IRAK4        186 
TK         ITK          363 
TK         JAK1         875 
TK         JAK2         849 
TK         JAK3         822 
TK         LCK          245 
TKL        LRRK2       1886 
TK         LTK          510 
CMGC       MAK            4 
STE        MAP2K1        68 
STE        MAP2K3        64 
STE        MAP2K5       166 
STE        MAP2K6        53 
TKL        MAP3K10       98 
TKL        MAP3K11      117 
TKL        MAP3K12      125 
TKL        MAP3K13      168 
STE        MAP3K14      400 
STE        MAP3K8       136 
TKL        MAP3K9       144 
STE        MAP4K1        17 
STE        MAP4K2        16 
STE        MAP4K3        16 
STE        MAP4K5        20 
CMGC       MAPK1         13 
CMGC       MAPK12        27 
CMGC       MAPK13        25 
CMGC       MAPK14        24 
CMGC       MAPK6         20 
CAMK       MAPKAPK2      64 
TK         MATK         235 
TK         MET         1078 
STE        MINK1         25 
STE        MST4          24 
TK         MUSK         575 
STE        MYO3A         21 
STE        MYO3B         27 
CMGC       NLK          126 
TK         NTRK1        510 
TK         NTRK2        538 
TK         NTRK3        538 
STE        PAK1         270 
STE        PAK2         249 
STE        PAK3         268 
STE        PAK7         449 
CMGC       PCTK1        165 
CMGC       PCTK2        192 
CMGC       PCTK3        172 
AGC        PDPK1         82 
CMGC       PFTK1        117 
CAMK       PHKG1         20 
CAMK       PHKG2         24 
CAMK       PIM1          38 
AGC        PKN1         615 
AGC        PKN2         657 
Other      PLK1          53 
Other      PLK2          82 
Other      PLK3          62 
AGC        PRKCA        339 
AGC        PRKCD        349 
AGC        PRKCE        408 
AGC        PRKCI        245 
AGC        PRKCQ        380 
AGC        PRKCZ        252 
CAMK       PRKD1        583 
CAMK       PRKD2        551 
CAMK       PRKD3        576 
TK         PTK2         422 
TK         PTK6         191 
TKL        RAF1         349 
TK         RET          724 
TK         ROS1        1945 
AGC        RPS6KB1       91 
AGC        RPS6KB2       67 
Other      SBK1          53 
STE        SLK           34 
TK         SRC          270 
STE        STK10         36 
CAMK       STK17A        61 
CAMK       STK17B        33 
STE        STK24         24 
STE        STK25         20 
STE        STK3          27 
CAMK       STK33        116 
Other      STK36          4 
STE        STK4          30 
TK         SYK          371 
STE        TAOK1         28 
STE        TAOK2         28 
STE        TAOK3         24 
Other      TBK1           9 
TK         TEC          370 
TK         TEK          824 
TKL        TESK1         57 
TK         TIE1         839 
STE        TNIK          25 
TK         TNK1         116 
TK         TNK2         150 
Other      TTK          525 
TK         TXK          271 
TK         TYRO3        518 
Other      ULK3          14 
Other      WEE1         299 
TK         YES1         277 
TK         ZAP70        338 


--------------------------------FELVEVVGNGTYGQVYKGRH---V-------KTGQ---LAAIKVM---DVT--E-DEE---EE-----I-K-L----------------------------EINMLKKY-SH------HRN-----IATYYGAFI--KKSP-----------------------PGHDDQ------LWLVMEFCGAG---SIT-DLVKN-------TKGN-------------------------TL----KEDWIAYISREILRGLAHLHI--H--------H---VIHRDIKGQNVL--LT----E--------NAEV-------------------KLVDFGVSAQL---------------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD------ENPDAT----YDYRSDLWSCGITAIEMAE-GA----------PP---------------LCDM---------HPMRA-LFLI-PRNPP----PR-LKSKKWS----------------------------------------------------------------------------KKFFS-FIEGCLVKNYMQRPS-------TE-QLLKHPFI--------------------------------------------------------
--------------------------------ITMKHKLGGGQYGEVYEGVW---K-------KYSL---TVAVKTL---K-E--D-TM----EV-----E-E-FL-K-------------------------EAAVMKEI--K------HPN-----LVQLLGVCT--R-----------------------------EPP------FYIITEFMTYG---NLL-DYLR----------EC----------------------NRQEV----NAVVLLYMATQISSAMEYLEK--K--------N---FIHRDLAARNCL--VG----E--------NHLV-------------------KVADFGLSRLM---------------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----------YNK----FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI---------DLSQV-YELL-EKDYR----ME-RPEGCP-----------------------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-------FA-EIHQA--F--------------------------------------------------------
--------------------------------ITMKHKLGGGQYGEVYVGVW---K-------KYSL---TVAVKTL---K-E--D-TM----EV-----E-E-FL-K-------------------------EAAVMKEI--K------HPN-----LVQLLGVCT--L-----------------------------EPP------FYIVTEYMPYG---NLL-DYLR----------EC----------------------NREEV----TAVVLLYMATQISSAMEYLEK--K--------N---FIHRDLAARNCL--VG----E--------NHVV-------------------KVADFGLSRLM---------------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----------YNT----FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI---------DLSQV-YDLL-EKGYR----ME-QPEGCP-----------------------------------------------------------------------------PKVYE-LMRACWKWSPADRPS-------FA-ETHQA--F--------------------------------------------------------
-------------------------------I-TLLECVGKGRYGEVWRGSW---Q-------GEN-----VAVKIF---SSR--D-EKS---WF-----R-E-T----------------------------ELYNTVML--R------HEN-----ILGFIASDM--TSR-------------------------HSSTQ------LWLITHYHEMG---SLY-DYLQ----------LT-------------------------TL----DTVSCLRIVLSIASGLAHLHI--EIFGTQGKPA---IAHRDLKSKNIL--VK----K--------NGQC-------------------CIADLGLAVMHSQ-----------------STNQLDVGN--------------NP---RVGTKRYMAPEV--LDET-----IQVDCFD----SYKRVDIWAFGLVLWEVAR-RMVSNGIVEDYKPP---------------FYDVVP----NDPSFEDM-RKVV-CVDQQ----RP-NIPNRWFSDPTL-----------------------------------------------------------------------TSLAK-LMKECWYQNPSARLT-------AL-RIKK----TL------------------------------------------------------
-------------------------------I-TLIRGLGHGAFGEVYEGQV---SG--MPNDPSPL---QVAVKTL---P-E--V-CS----EQD---EL-D-FL-M-------------------------EALIISKF--N------HQN-----IVRCIGVSL--Q-----------------------------SLP------RFILLELMAGG---DLK-SFLR----------ETRP-----------------RPSQPSSL----AMLDLLHVARDIACGCQYLEE--N--------H---FIHRDIAARNCL--LT----CP-----GPGRVA-------------------KIGDFGMARDI-----------Y---------R--ASYY--------------RKGGCAMLPVKWMPPEA--FM-----------EGI----FTSKTDTWSFGVLLWEIFSLGY----------MP---------------YPSK---------SNQEV-LEFV-TSGGR----MD-PPKNCP-----------------------------------------------------------------------------GPVYR-IMTQCWQHQPEDRPN-------FA-IILER--I--------------------------------------------------------
--------------------------------FEIGRPLGKGKFGNVYLARE---K-------QSKF---ILALKVL---FKA--QLEKA---GV-----E-H-QLRR-------------------------EVEIQSHL--R------HPN-----ILRLYGYFH--D-----------------------------ATR------VYLILEYAPLG---TVY-RELQ---------KLS-------------------------KF----DEQRTATYITELANALSYCHS--K--------R---VIHRDIKPENLL--LG----S--------AGEL-------------------KIADFGWSV-----------------------HAPSSRR--------------TT---LCGTLDYLPPEM--IE-----------GRM----HDEKVDLWSLGVLCYEFLV-GK----------PP---------------FEAN------------TY-QETY-KRISR----VE-FTFPDFVT---------------------------------------------------------------------------EGARD-LISRLLKHNPSQRPM-------LR-EVLEHPWI--------------------------------------------------------
--------------------------------FEIGRPLGKGKFGNVYLARE---K-------KSHF---IVALKVL---FKS--Q-IEK---EG-----V-E-HQLR------------------------REIEIQAHL--H------HPN-----ILRLYNYFY--D-----------------------------RRR------IYLILEYAPRG---ELY-KELQ---------KSC-------------------------TF----DEQRTATIMEELADALMYCHG--K--------K---VIHRDIKPENLL--LG----L--------KGEL-------------------KIADFGWSV-----------------------HAPSLRR--------------KT---MCGTLDYLPPEM--IE-----------GRM----HNEKVDLWCIGVLCYELLV-GN----------PP---------------FESA------------SH-NETY-RRIVK----VD-LKFPASVP---------------------------------------------------------------------------MGAQD-LISKLLRHNPSERLP-------LA-QVSAHPWV--------------------------------------------------------
--------------------------------FEIGRPLGKGKFGNVYLARL---K-------ESHF---IVALKVL---FKS--Q-IEK---EG-----L-E-HQLR------------------------REIEIQAHL--Q------HPN-----ILRLYNYFH--D-----------------------------ARR------VYLILEYAPRG---ELY-KELQ---------KSE-------------------------KL----DEQRTATIIEELADALTYCHD--K--------K---VIHRDIKPENLL--LG----F--------RGEV-------------------KIADFGWSV-----------------------HTPSLRR--------------KT---MCGTLDYLPPEM--IE-----------GRT----YDEKVDLWCIGVLCYELLV-GY----------PP---------------FESA------------SH-SETY-RRILK----VD-VRFPLSMP---------------------------------------------------------------------------LGARD-LISRLLRYQPLERLP-------LA-QILKHPWV--------------------------------------------------------
-------------------------------V-ALGKTLGEGEFGAVMEGQL---N-----QDDSIL---KVAVKTM---K-I-AI-CT----RSE---LE-D-FL-S-------------------------EAVCMKEF--D------HPN-----VMRLIGVCF--Q-----------------------------GSERESFPAPVVILPFMKHG---DLH-SFLL----------YSRL------------------GDQPVYL----PTQMLVKFMADIASGMEYLST--K--------R---FIHRDLAARNCM--LN----E--------NMSV-------------------CVADFGLSKKI-----------Y---------N--GDYY--------------RQGRIAKMPVKWIAIES--LA-----------DRV----YTSKSDVWSFGVTMWEIATRGQ----------TP---------------YPGV---------ENSEI-YDYL-RQGNR----LK-QPADCL-----------------------------------------------------------------------------DGLYA-LMSRCWELNPQDRPS-------FT-ELREDL----------------------------------------------------------
-------------------------------L-RLVRKLGSGQFGEVWMGYY---K--------NNM---KVAIKTL---K-E--G-TM----SP-----E-A-FL-G-------------------------EANVMKAL--Q------HER-----LVRLYAVVT--------------------------------KEP------IYIVTEYMARG---CLL-DFLK----------TD----------------------EGSRL----SLPRLIDMSAQIAEGMAYIER--M--------N---SIHRDLRAANIL--VS----E--------ALCC-------------------KIADFGLARII------------------------DSEY--------------TAQEGAKFPIKWTAPEA--IH-----------FGV----FTIKADVWSFGVLLMEVVTYGR----------VP---------------YPGM---------SNPEV-IRNL-ERGYR----MP-RPDTCP-----------------------------------------------------------------------------PELYRGVIAECWRSRPEERPT-------FE-FLQSV--L--------------------------------------------------------
-------------------------------I-QMVRQVGKGRYGEVWMGKW---R-------GEK-----VAVKVF---FTT--E-EAS---WF-----R-E-T----------------------------EIYQTVLM--R------HEN-----ILGFIAADI--KGT-------------------------GSWTQ------LYLITDYHENG---SLY-DFLK----------CA-------------------------TL----DTRALLKLAYSAACGLCHLHT--EIYGTQGKPA---IAHRDLKSKNIL--IK----K--------NGSC-------------------CIADLGLAVKFNS-----------------DTNEVDVPL--------------NT---RVGTKRYMAPEV--LDES-----LNKNHFQ----PYIMADIYSFGLIIWEMAR-RCITGGIVEEYQLP---------------YYNMVP----SDPSYEDM-REVV-CVKRL----RP-IVSNRWNSDECL-----------------------------------------------------------------------RAVLK-LMSECWAHNPASRLT-------AL-RIKK----TL------------------------------------------------------
--------------------------------ITLLKELGSGQFGVVQLGKW---K--------GQY---DVAVKMI---K-E--G-SM----SE-----D-E-FF-Q-------------------------EAQTMMKL--S------HPK-----LVKFYGVCS--K-----------------------------EYP------IYIVTEYISNG---CLL-NYLR----------SH-----------------------GKGL----EPSQLLEMCYDVCEGMAFLES--H--------Q---FIHRDLAARNCL--VD----R--------DLCV-------------------KVSDFGMTRYV---------------------L--DDQY--------------VSSVGTKFPVKWSAPEV--FH-----------YFK----YSSKSDVWAFGILMWEVFSLGK----------QP---------------YDLY---------DNSQV-VLKV-SQGHR----LY-RPHLAS-----------------------------------------------------------------------------DTIYQ-IMYSCWHELPEKRPT-------FQ-QLLSS--I--------------------------------------------------------
--------------------------------LTFLKELGTGQFGVVKYGKW---R--------GQY---DVAIKMI---K-E--G-SM----SE-----D-E-FI-E-------------------------EAKVMMNL--S------HEK-----LVQLYGVCT--K-----------------------------QRP------IFIITEYMANG---CLL-NYLR----------EM-----------------------RHRF----QTQQLLEMCKDVCEAMEYLES--K--------Q---FLHRDLAARNCL--VN----D--------QGVV-------------------KVSDFGLSRYV---------------------L--DDEY--------------TSSVGSKFPVRWSPPEV--LM-----------YSK----FSSKSDIWAFGVLMWEIYSLGK----------MP---------------YERF---------TNSET-AEHI-AQGLR----LY-RPHLAS-----------------------------------------------------------------------------EKVYT-IMYSCWHEKADERPT-------FK-ILLSN--I--------------------------------------------------------
------------------------------FI--FMEVLGSGAFSEVFLVKQ---R-------LTGK---LFALKCI---KKS--P-AFR---DS-----S-L-E--N-------------------------EIAVLKKI--K------HEN-----IVTLEDIYE--S-----------------------------TTH------YYLVMQLVSGG---ELF-DRIL---------ERG-------------------------VY----TEKDASLVIQQVLSAVKYLHE--N--------G---IVHRDLKPENLL--YLT-PEE--------NSKI-------------------MITDFGLSK-----------------------MEQNGIM--------------ST---ACGTPGYVAPEV--LA-----------QKP----YSKAVDCWSIGVITYILLC-GY----------PP---------------FYEE------------TE-SKLF-EKIKE----GY-YEFESPFWDDIS-----------------------------------------------------------------------ESAKD-FICHLLEKDPNERYT-------CE-KALSHPWI--------------------------------------------------------
--------------------------------YQLFEELGKGAFSVVRRCVK---V-------LAGQ---EYAAKII---NTK--K-LSA---RD-----H-Q-KLER-------------------------EARICRLL--K------HPN-----IVRLHDSIS--E-----------------------------EGH------HYLIFDLVTGG---ELF-EDIV---------ARE-------------------------YY----SEADASHCIQQILEAVLHCHQ--M--------G---VVHRDLKPENLL--LA----S--------KLKGA----------------AVKLADFGLAIEV---------------------EGEQQAW--------------FG---FAGTPGYLSPEV--LR-----------KDP----YGKPVDLWACGVILYILLV-GY----------PP---------------FWDE------------DQ-HRLY-QQIKA----GA-YDFPSPEWDTVT-----------------------------------------------------------------------PEAKD-LINKMLTINPSKRIT-------AA-EALKHPWI--------------------------------------------------------
--------------------------------YQLYEDIGKGAFSVVRRCVK---L-------CTGH---EYAAKII---NTK--K-LSA---RD-----H-Q-KLER-------------------------EARICRLL--K------HSN-----IVRLHDSIS--E-----------------------------EGF------HYLVFDLVTGG---ELF-EDIV---------ARE-------------------------YY----SEADASHCIQQILEAVLHCHQ--M--------G---VVHRDLKPENLL--LA----S--------KCKGA----------------AVKLADFGLAIEV---------------------QGDQQAW--------------FG---FAGTPGYLSPEV--LR-----------KEA----YGKPVDIWACGVILYILLV-GY----------PP---------------FWDE------------DQ-HKLY-QQIKA----GA-YDFPSPEWDTVT-----------------------------------------------------------------------PEAKN-LINQMLTINPAKRIT-------AH-EALKHPWV--------------------------------------------------------
--------------------------------FEVESELGRGATSIVYRCKQ---K-------GTQK---PYALKVL---KKT--V-DKK---IV-----R------T-------------------------EIGVLLRL--S------HPN-----IIKLKEIFE--T-----------------------------PTE------ISLVLELVTGG---ELF-DRIV---------EKG-------------------------YY----SERDAADAVKQILEAVAYLHE--N--------G---IVHRDLKPENLL--YA----T---------PAPDA---------------PLKIADFGLSKI----------------------VEHQVLM--------------KT---VCGTPGYCAPEI--LR-----------GCA----YGPEVDMWSVGIITYILLC-GF----------EP---------------FYDE-----------RGD-QFMF-RRILN----CE-YYFISPWWDEVS-----------------------------------------------------------------------LNAKD-LVRKLIVLDPKKRLT-------TF-QALQHPWV--------------------------------------------------------
--------------------------------YKLQSEIGKGAYGVVRLAYN---E-------SEDR---HYAMKVL---SKK--K-LLK---QY-----G-F-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D------HVN-----VVKLIEVLD--DP---------------------------AEDN------LYLVFDLLRKG---PVM-EVPC----------DK-------------------------PF----SEEQARLYLRDVILGLEYLHC--Q--------K---IVHRDIKPSNLL--LG----D--------DGHV-------------------KIADFGVSNQF---------------------EGNDAQL--------------SS---TAGTPAFMAPEA--ISD--------SGQSF----SGKALDVWATGVTLYCFVY-GK----------CP---------------FIDD------------FI-LALH-RKIKN----EP-VVFPEEPEIS-------------------------------------------------------------------------EELKD-LILKMLDKNPETRIG-------VP-DIKLHPWV--------------------------------------------------------
--------------------------------YTLKDEIGKGSYGVVKLAYN---E-------NDNT---YYAMKVL---SKK--K-LIR---QA-----G-F-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D------HPN-----VVKLVEVLD--DP---------------------------NEDH------LYMVFELVNQG---PVM-EVPT----------LK-------------------------PL----SEDQARFYFQDLIKGIEYLHY--Q--------K---IIHRDIKPSNLL--VG----E--------DGHI-------------------KIADFGVSNEF---------------------KGSDALL--------------SN---TVGTPAFMAPES--LS----------ETRKIF--SGKALDVWAMGVTLYCFVF-GQ----------CP---------------FMDE------------RI-MCLH-SKIKS----QA-LEFPDQPDIA-------------------------------------------------------------------------EDLKD-LITRMLDKNPESRIV-------VP-EIKLHPWV--------------------------------------------------------
--------------------------------YELCEVIGKGPFSVVRRCIN---R-------ETGQ---QFAVKIV---DVA--K-FTS---SP-----G-L-STEDL----------------------KREASICHML--K------HPH-----IVELLETYS--S-----------------------------DGM------LYMVFEFMDGA---DLCFEIVKR------ADAGF-------------------------VY----SEAVASHYMRQILEALRYCHD--N--------N---IIHRDVKPHCVL--LA----S--------KENSA----------------PVKLGGFGVAIQL---------------------GESGLVA--------------GG---RVGTPHFMAPEV--VK-----------REP----YGKPVDVWGCGVILFILLS-GC----------LP---------------FYGT-------------K-ERLF-EGIIK----GK-YKMNPRQWSHIS-----------------------------------------------------------------------ESAKD-LVRRMLMLDPAERIT-------VY-EALNHPWL--------------------------------------------------------
--------------------------------YTKIEKIGEGTYGVVYKGRH---K-------TTGQ---VVAMKKI---RLE--S-EEE---GV-----P-S-TAIR-------------------------EISLLKEL--R------HPN-----IVSLQDVLM--Q-----------------------------DSR------LYLIFEFLSM----DLK-KYLDS------IPPGQ-------------------------YM----DSSLVKSYLYQILQGIVFCHS--R--------R---VLHRDLKPQNLL--ID----D--------KGTI-------------------KLADFGLARAF---------------------GIPIRVY--------------TH---EVVTLWYRSPEV--LL----------GSAR----YSTPVDIWSIGTIFAELAT-KK----------PL---------------FHGD---------SEIDQ-LFRI-FRALG----TP-NNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-------GK-MALNHPYF--------------------------------------------------------
-------------------------------F-DIIGIIGEGTYGQVYKARD---K-------DTGE---MVALKKV---RLD--N-EKE---GF-----P-I-TAIR-------------------------EIKILRQL--T------HQS-----IINMKEIVT--DKEDAL-------------------DFKKDKGA------FYLVFEYMDH----DLM-GLLE--------SGLV-------------------------HF----NENHIKSFMRQLMEGLDYCHK--K--------N---FLHRDIKCSNIL--LN----N--------RGQI-------------------KLADFGLARLY--------------------SSEESRPY--------------TN---KVITLWYRPPEL--LL----------GEER----YTPAIDVWSCGCILGELFT-KK----------PI---------------FQAN---------QELAQ-LELI-SRICG----SP-CPAVWPDVIKLPYFNTMKPKKQY------------------------------------------------RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-------AE-QALQCEF-L-------------------------------------------------------
-----------------------------EGC-----KVGRGTYGHVYKARR---K-------DGKDE-KEYALKQI---EGT--G-ISM---SA-----C------R-------------------------EIALLREL--K------HPN-----VIALQKVFL--SH---------------------------SDRK------VWLLFDYAEH----DLW-HIIKFHR--ASKANKK-------------------------PMQ--LPRSMVKSLLYQILDGIHYLHA--N--------W---VLHRDLKPANIL--VMGEGPE--------RGRV-------------------KIADMGFARLFN------------------SPLKPLADL--------------DP---VVVTFWYRAPEL--LL----------GARH----YTKAIDIWAIGCIFAELLT-SE----------PI---------------FHCRQEDIKTSNPFHHDQ-LDRI-FSVMG----FP-ADKDWEDIRKMPEYPTLQKDFRRTTYA----------------------------------------NSSLIKYMEKHKVKPDSKVFL-LLQKLLTMDPTKRIT-------SE-QALQDPYF--------------------------------------------------------
------------------------------YL--NLEKLGEGSYATVYKGIS---R-------INGQ---LVALKVI---SMN--A-EEG---VP-------F-TAIR-------------------------EASLLKGL--K------HAN-----IVLLHDIIH--T-----------------------------KET------LTFVFEYMHT----DLA-QYMS--------QHPG-------------------------GL----HPHNVRLFMFQLLRGLAYIHH--Q--------H---VLHRDLKPQNLL--IS----H--------LGEL-------------------KLADFGLARAK---------------------SIPSQTY--------------SS---EVVTLWYRPPDA--LL----------GATE----YSSELDIWGAGCIFIEMFQ-GQ----------PL---------------FPGV--------SNILEQ-LEKI-WEVLG----VP-TEDTWPGVSKLPNYNPEWFPLPTP----------------------------------------------RSLHVVWNRLGRVPEAED-LASQMLKGFPRDRVS-------AQ-EALVHDYF--------------------------------------------------------
--------------------------------FQKVEKIGEGTYGVVYKARN---K-------LTGE---VVALKKI---RLD--T-ETE---GV-----P-S-TAIR-------------------------EISLLKEL--N------HPN-----IVKLLDVIH--T-----------------------------ENK------LYLVFEFLHQ----DLK-KFMDA-------SALT-------------------------GI----PLPLIKSYLFQLLQGLAFCHS--H--------R---VLHRDLKPQNLL--IN----T--------EGAI-------------------KLADFGLARAF---------------------GVPVRTY--------------TH---EVVTLWYRAPEI--LL----------GCKY----YSTAVDIWSLGCIFAEMVT-RR----------AL---------------FPGD---------SEIDQ-LFRI-FRTLG----TP-DEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-------AK-AALAHPFF--------------------------------------------------------
--------------------------------FQKVEKIGEGTYGVVYKAKN---R-------ETGQ---LVALKKI---RLD--L-EME---GV-----P-S-TAIR-------------------------EISLLKEL--K------HPN-----IVRLLDVVH--N-----------------------------ERK------LYLVFEFLSQ----DLK-KYMDS-------TPGS-------------------------EL----PLHLIKSYLFQLLQGVSFCHS--H--------R---VIHRDLKPQNLL--IN----E--------LGAI-------------------KLADFGLARAF---------------------GVPLRTY--------------TH---EVVTLWYRAPEI--LL----------GSKF----YTTAVDIWSIGCIFAEMVT-RK----------AL---------------FPGD---------SEIDQ-LFRI-FRMLG----TP-SEDTWPGVTQLPDYKGSFPKWTR-------------------------------------------------KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-------AK-TALAHPYF--------------------------------------------------------
-------------------------------Y-EPVAEIGVGAYGTVYKARD---P-------HSGH---FVALKSV---RVP--N-GGGGGGGL-----P-I-STVR-------------------------EVALLRRL--EA---FEHPN-----VVRLMDVCA--TSR------------------------TDREIK------VTLVFEHVDQ----DLR-TYLDK-------APPP-------------------------GL----PAETIKDLMRQFLRGLDFLHA--N--------C---IVHRDLKPENIL--VT----S--------GGTV-------------------KLADFGLARI----------------------YSYQMAL--------------TP---VVVTLWYRAPEV--LL-----------QST----YATPVDMWSVGCIFAEMFR-RK----------PL---------------FCGN---------SEADQ-LGKI-FDLIG----LP-PEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS-------AF-RALQHSYL--------------------------------------------------------
--------------------------------YEKLEKIGEGTYGTVFKAKN---R-------ETHE---IVALKRV---RLD--D-DDE---GV-----P-S-SALR-------------------------EICLLKEL--K------HKN-----IVRLHDVLH--S-----------------------------DKK------LTLVFEFCDQ----DLK-KYFD--------SCNG-------------------------DL----DPEIVKSFLFQLLKGLGFCHS--R--------N---VLHRDLKPQNLL--IN----R--------NGEL-------------------KLADFGLARAF---------------------GIPVRCY--------------SA---EVVTLWYRPPDV--LF----------GAKL----YSTSIDMWSAGCIFAELANAGR----------PL---------------FPGN---------DVDDQ-LKRI-FRLLG----TP-TEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-------AE-EALQHPYF--------------------------------------------------------
--------------------------------YECVAEIGEGAYGKVFKARD---L-------KNGG--RFVALKRV---RVQ--T-GEE---GM-----P-L-STIR-------------------------EVAVLRHL--ET---FEHPN-----VVRLFDVCT--VSR------------------------TDRETK------LTLVFEHVDQ----DLT-TYLDK-------VPEP-------------------------GV----PTETIKDMMFQLLRGLDFLHS--H--------R---VVHRDLKPQNIL--VT----S--------SGQI-------------------KLADFGLARI----------------------YSFQMAL--------------TS---VVVTLWYRAPEV--LL-----------QSS----YATPVDLWSVGCIFAEMFR-RK----------PL---------------FRGS---------SDVDQ-LGKI-LDVIG----LP-GEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKD-LLLKCLTFNPAKRIS-------AY-SALSHPYF--------------------------------------------------------
-----------------------------EGC-----KVGRGTYGHVYKAKR---K-------DGKDD-KDYALKQI---EGT--G-ISM---SA-----C------R-------------------------EIALLREL--K------HPN-----VISLQKVFL--SH---------------------------ADRK------VWLLFDYAEH----DLW-HIIKFHRASKANKKPV-------------------------QL----PRGMVKSLLYQILDGIHYLHA--N--------W---VLHRDLKPANIL--VMGEGPE--------RGRV-------------------KIADMGFARLFN------------------SPLKPLADL--------------DP---VVVTFWYRAPEL--LL----------GARH----YTKAIDIWAIGCIFAELLT-SE----------PI---------------FHCRQEDIKTSNPYHHDQ-LDRI-FNVMG----FP-ADKDWEDIKKMPEHSTLMKDFRRNTYT----------------------------------------NCSLIKYMEKHKVKPDSKAFH-LLQKLLTMDPIKRIT-------SE-QAMQDPYF--------------------------------------------------------
--------------------------------YEKLAKIGQGTFGEVFKARH---R-------KTGQ---KVALKKV---LME--N-EKE---GF-----P-I-TALR-------------------------EIKILQLL--K------HEN-----VVNLIEICR--TKASP---------------------YNRCKGS------IYLVFDFCEH----DLA-GLLS--------NVLV-------------------------KF----TLSEIKRVMQMLLNGLYYIHR--N--------K---ILHRDMKAANVL--IT----R--------DGVL-------------------KLADFGLARAFSL-----------------AKNSQPNRY--------------TN---RVVTLWYRPPEL--LL----------GERD----YGPPIDLWGAGCIMAEMWT-RS----------PI---------------MQGN---------TEQHQ-LALI-SQLCG----SI-TPEVWPNVDNYELYEKLELVKGQK----------------------------------------------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-------SD-DALNHDFF--------------------------------------------------------
--------------------------------YEKIGKIGEGSYGVVFKCRN---R-------DTGQ---IVAIKKF---LES--E-DDP---VI-----K-K-IALR-------------------------EIRMLKQL--K------HPN-----LVNLLEVFR--R-----------------------------KRR------LHLVFEYCDHT---VLH-ELDR---------YQR-------------------------GV----PEHLVKSITWQTLQAVNFCHK--H--------N---CIHRDVKPENIL--IT----K--------HSVI-------------------KLCDFGFARLL---------------------AGPSDYY--------------TD---YVATRWYRSPEL--LV----------GDTQ----YGPPVDVWAIGCVFAELLS-GV----------PL---------------WPGK---------SDVDQ-LYLI-RKTLG----DL-IPRHQQVFSTNQYFSGVKIPDPED-----------------------------------------------MEPLELKFPNISYPALG-LLKGCLHMDPTQRLT-------CE-QLLHHPYF--------------------------------------------------------
--------------------------------YENLGLVGEGSYGMVMKCRN---K-------DTGR---IVAIKKF---LES--D-DDK---MV-----K-K-IAMR-------------------------EIKLLKQL--R------HEN-----LVNLLEVCK--K-----------------------------KKR------WYLVFEFVDHT---ILD-DLEL---------FPN-------------------------GL----DYQVVQKYLFQIINGIGFCHS--H--------N---IIHRDIKPENIL--VS----Q--------SGVV-------------------KLCDFGFARTL---------------------AAPGEVY--------------TD---YVATRWYRAPEL--LV----------GDVK----YGKAVDVWAIGCLVTEMFM-GE----------PL---------------FPGD---------SDIDQ-LYHI-MMCLG----NL-IPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-------CA-ELLHHDFF--------------------------------------------------------
--------------------------------YETLGKVGEGSYGTVMKCKH---K-------NTGQ---IVAIKIF---YER--P-EQS---VN-----K---IAMR-------------------------EIKFLKQF--H------HEN-----LVNLIEVFR--Q-----------------------------KKK------IHLVFEFIDHT---VLD-ELQH---------YCH-------------------------GL----ESKRLRKYLFQILRAIDYLHS--N--------N---IIHRDIKPENIL--VS----Q--------SGIT-------------------KLCDFGFARTL---------------------AAPGDIY--------------TD---YVATRWYRAPEL--VL----------KDTS----YGKPVDIWALGCMIIEMAT-GN----------PY---------------LPSS---------SDLDL-LHKI-VLKVG----N--LSPHLQNIFSKSPIFAGVVLPQVQ----------------------------------------------HPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-------SS-DLLHHEYF--------------------------------------------------------
--------------------------------FEILGVVGEGAYGVVLKCRH---K-------ETHE---IVAIKKF---KDS--E-ENE---EV-----K-E-TTLR-------------------------ELKMLRTL--K------QEN-----IVELKEAFR--R-----------------------------RGK------LYLVFEYVEK----NML-ELLE--------EMPN-------------------------GV----PPEKVKSYIYQLIKAIHWCHK--N--------D---IVHRDIKPENLL--IS----H--------NDVL-------------------KLCDFGFARNL--------------------SEGNNANY--------------TE---YVATRWYRSPEL--LL-----------GAP----YGKSVDMWSVGCILGELSD-GQ----------PL---------------FPGE---------SEIDQ-LFTI-QKVLG----PL-PSEQMKLFYSNPRFHGLRFPAVNH----------------------------------------------PQSLERRYLGILNSVLLD-LMKNLLKLDPADRYL-------TE-QCLNHPTF--------------------------------------------------------
-------------------------------W-DLVQTLGEGAYGEVQLAVN---R-------VTEE---AVAVKIV---DMK--R-AVD---CP-----E-N-I-KK-------------------------EICINKML--N------HEN-----VVKFYGHRR--E-----------------------------GNI------QYLFLEYCSGG---ELF-DRIE---------PDI-------------------------GM----PEPDAQRFFHQLMAGVVYLHG--I--------G---ITHRDIKPENLL--LD----E--------RDNL-------------------KISDFGLATVFR-------------------YNNRERLL--------------NK---MCGTLPYVAPEL--LK----------RREF----HAEPVDVWSCGIVLTAMLA-GE----------LP---------------WDQP-----------SDS-CQEY-SDWKE----KK-TYLNPWKKI--D-----------------------------------------------------------------------SAPLA-LLHKILVENPSARIT-------IP-DIKKDRW-Y-------------------------------------------------------
------------------------------YI--MSKTLGSGACGEVKLAFE---R-------KTCK---KVAIKII---SKR--K-FAI---GS-----A-R-EADPALN-------------------VETEIEILKKL--N------HPC-----IIKIKNFF---D-----------------------------AED------YYIVLELMEGG---ELF-DKVV---------GNK-------------------------RL----KEATCKLYFYQMLLAVQYLHE--N--------G---IIHRDLKPENVL--LS----S--------QEEDC----------------LIKITDFGHSKI----------------------LGETSLM--------------RT---LCGTPTYLAPEV--LVS--------VGTAG----YNRAVDCWSLGVILFICLS-GY----------PP---------------FSEH-----------RTQ-VSLK-DQITS----GK-YNFIPEVWAEVS-----------------------------------------------------------------------EKALD-LVKKLLVVDPKARFT-------TE-EALRHPWL--------------------------------------------------------
--------------------------------LKLLQTIGKGEFGDVMLGDY---R---------GN---KVAVKCI---K-N--D-AT----AQ-------A-FL-A-------------------------EASVMTQL--R------HSN-----LVQLLGVIV-EE-----------------------------KGG------LYIVTEYMAKG---SLV-DYLR----------SR----------------------GRSVL----GGDCLLKFSLDVCEAMEYLEG--N--------N---FVHRDLAARNVL--VS----E--------DNVA-------------------KVSDFGLTKEA---------------------------S--------------STQDTGKLPVKWTAPEA--LR-----------EKK----FSTKSDVWSFGILLWEIYSFGR----------VP---------------YPRI---------PLKDV-VPRV-EKGYK----MD-APDGCP-----------------------------------------------------------------------------PAVYE-VMKNCWHLDAAMRPS-------FL-QLREQL----------------------------------------------------------
--------------------------------YDTGEELGSGQFAVVKKCRE---K-------STGL---QYAAKFI---KKR--R-TKS---SR-----R-G-VSREDI---------------------EREVSILKEI--Q------HPN-----VITLHEVYE--N-----------------------------KTD------VILILELVAGG---ELF-DFLA---------EKE-------------------------SL----TEEEATEFLKQILNGVYYLHS--L--------Q---IAHFDLKPENIM--LL----D--------RNVPKP---------------RIKIIDFGLAHK----------------------IDFGNEF--------------KN---IFGTPEFVAPEI--VN-----------YEP----LGLEADMWSIGVITYILLS-GA----------SP---------------FLGD------------TK-QETL-ANVSA----VN-YEFEDEYFSNTS-----------------------------------------------------------------------ALAKD-FIRRLLVKDPKKRMT-------IQ-DSLQHPWI--------------------------------------------------------
--------------------------------YDIGEELGSGQFAIVKKCRE---K-------STGL---EYAAKFI---KKR--Q-SRA---SR-----R-G-VSREEI---------------------EREVSILRQV--L------HHN-----VITLHDVYE--N-----------------------------RTD------VVLILELVSGG---ELF-DFLA---------QKE-------------------------SL----SEEEATSFIKQILDGVNYLHT--K--------K---IAHFDLKPENIM--LL----D--------KNIPIP---------------HIKLIDFGLAHE----------------------IEDGVEF--------------KN---IFGTPEFVAPEI--VN-----------YEP----LGLEADMWSIGVITYILLS-GA----------SP---------------FLGD------------TK-QETL-ANITA----VS-YDFDEEFFSQTS-----------------------------------------------------------------------ELAKD-FIRKLLVKETRKRLT-------IQ-EALRHPWI--------------------------------------------------------
--------------------------------YEMGEELGSGQFAIVRKCRQ---K-------GTGK---EYAAKFI---KKR--R-LSS---SR-----R-G-VSREEI---------------------EREVNILREI--R------HPN-----IITLHDIFE--N-----------------------------KTD------VVLILELVSGG---ELF-DFLA---------EKE-------------------------SL----TEDEATQFLKQILDGVHYLHS--K--------R---IAHFDLKPENIM--LL----D--------KNVPNP---------------RIKLIDFGIAHK----------------------IEAGNEF--------------KN---IFGTPEFVAPEI--VN-----------YEP----LGLEADMWSIGVITYILLS-GA----------SP---------------FLGE------------TK-QETL-TNISA----VN-YDFDEEYFSNTS-----------------------------------------------------------------------ELAKD-FIRRLLVKDPKRRMT-------IA-QSLEHSWI--------------------------------------------------------
--------------------------------YETGRVIGDGNFAVVKECRH---R-------ETRQ---AYAMKII---DKS--R-LKG---KE-----D-M-V-DS-------------------------EILIIQSL--S------HPN-----IVKLHEVYE--T-----------------------------DME------IYLILEYVQGG---DLF-DAII---------ESV-------------------------KF----PEPDAALMIMDLCKALVHMHD--K--------S---IVHRDLKPENLL--VQ----R--------NEDKST---------------TLKLADFGLAK------------------------HVVRPI--------------FT---VCGTPTYVAPEI--LS-----------EKG----YGLEVDMWAAGVILYILLC-GF----------PP---------------FRSP----------ERDQ-DELF-NIIQL----GH-FEFLPPYWDNIS-----------------------------------------------------------------------DAAKD-LVSRLLVVDPKKRYT-------AH-QVLQHPWI--------------------------------------------------------
--------------------------------YEIDSLIGKGSFGQVVKAYD---H-------QTQE---LVAIKII---KNK--K-AFL---NQ-----A-Q-I----------------------------ELRLLELM-NQ------HDTEMKYYIVHLKRHFM--F-----------------------------RNH------LCLVFELLSY----NLY-DLLR----------NT-------------------------HFR-GVSLNLTRKLAQQLCTALLFLATPEL--------S---IIHCDLKPENIL--LCN--PK--------RSAI-------------------KIVDFGSSCQ------------------------LGQRI--------------YQ---YIQSRFYRSPEV--LL-----------GTP----YDLAIDMWSLGCILVEMHT-GE----------PL---------------FSGS---------NEVDQ-MNRI-VEVLG----IP-PAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD-LVLRMLEYEPAARIS-------PL-GALQHGFF--------------------------------------------------------
--------------------------------YEVLKIIGKGSFGQVARVYD---H-------KLRQ---YVALKMV---RNE--K-RFH---RQ-----A-A-E----------------------------EIRILEHL--KKQDKTGSMN-----VIHMLESFT--F-----------------------------RNH------VCMAFELLSI----DLY-ELIKK-------NKFQ-------------------------GF----SVQLVRKFAQSILQSLDALHK--N--------K---IIHCDLKPENIL--LK----H--------HGRSS-----------------TKVIDFGSSCF------------------------EYQKL--------------YT---YIQSRFYRAPEI--IL-----------GSR----YSTPIDIWSFGCILAELLT-GQ----------PL---------------FPGE---------DEGDQ-LACM-MELLG----MP-PPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVG-------------------GRSRRGKKRGPPGSKDWGTALKGCDDYLFIE-FLKRCLHWDPSARLT-------PA-QALRHPWI--------------------------------------------------------
-------------------------------F-KKIKVLGSGAFGTVYKGLW---IP---EGEKVKI---PVAIKEL---R-E--A-TS----PKA---NK-E-IL-D-------------------------EAYVMASV--D------NPH-----VCRLLGICL--------------------------------TST------VQLITQLMPFG---CLL-DYVR----------EH-----------------------KDNI----GSQYLLNWCVQIAKGMNYLED--R--------R---LVHRDLAARNVL--VK----T--------PQHV-------------------KITDFGLAKLL-----------G---------A--EEKE--------------YHAEGGKVPIKWMALES--IL-----------HRI----YTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI---------PASEI-SSIL-EKGER----LP-QPPICT-----------------------------------------------------------------------------IDVYM-IMVKCWMIDADSRPK-------FR-ELI----IEF------------------------------------------------------
-------------------------------F-KEIELIGSGGFGQVFKAKH---R-------IDGK---TYVIKRV---KYN--N-EKA---ER--------------------------------------EVKALAKL--D------HVN-----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKC------LFIQMEFCDKG---TLE-QWIEK-------RRGE-------------------------KL----DKVLALELFEQITKGVDYIHS--K--------K---LIHRDLKPSNIF--LV----D--------TKQV-------------------KIGDFGLVTS----------------------LKNDGKR--------------TR---SKGTLRYMSPEQ--IS-----------SQD----YGKEVDLYALGLILAELLH-VC---------DTA---------------FET-----------------SKF-FTDLR----DG-IISDIFDK----------------------------------------------------------------------------KEKT-LLQKLLSKKPEDRPN-------TS-EILR----TLT-----------------------------------------------------
EDENSKSQNQDEDCNEKNGCHESEPSVTTEAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------HY------LYIQMEYCEKS---TLR-DTID---------QGL-------------------------YR----DTVRLWRLFREILDGLAYIHE--K--------G---MIHRDLKPVNIF--LD----S--------DDHV-------------------KIGDFGLATDHLAFSADSKQ---DDQTGDLIKSDPSGHL--------------TG---MVGTALYVSPEV-QGS----------TKSA----YNQKVDLFSLGIIFFEMSY-HP----------MV---------------TASE------------RI-FVLN-QLRDP----TS-PKFPEDFDDGEH-----------------------------------------------------------------------AKQKS-VISWLLNHDPAKRPT-------AT-ELLKSEL-L-------------------------------------------------------
-------------------------------V-KIEEVIGAGEFGEVYKGRL---K----LPGKREI---YVAIKTL---K-A--G-YS----EKQ---RR-D-FL-S-------------------------EASIMGQF--D------HPN-----IIRLEGVVT--K-----------------------------SRP------VMIITEFMENG---ALD-SFLR----------QN-----------------------DGQF----TVIQLVGMLRGIAAGMKYLAE--M--------N---YVHRDLAARNIL--VN----S--------NLVC-------------------KVSDFGLSRYLQ--------DDT---------S--DPTY--------------TSSLGGKIPVRWTAPEA--IA-----------YRK----FTSASDVWSYGIVMWEVMSFGE----------RP---------------YWDM---------SNQDV-INAI-EQDYR----LP-PPMDCP-----------------------------------------------------------------------------AALHQ-LMLDCWQKDRNSRPR-------FA-EIVNTL----------------------------------------------------------
-------------------------------V-KIEQVIGAGEFGEVCSGHL---K----LPGKREI---FVAIKTL---K-S--G-YT----EKQ---RR-D-FL-S-------------------------EASIMGQF--D------HPN-----VIHLEGVVT--K-----------------------------STP------VMIITEFMENG---SLD-SFLR----------QN-----------------------DGQF----TVIQLVGMLRGIAAGMKYLAD--M--------N---YVHRDLAARNIL--VN----S--------NLVC-------------------KVSDFGLSRFLE--------DDT---------S--DPTY--------------TSALGGKIPIRWTAPEA--IQ-----------YRK----FTSASDVWSYGIVMWEVMSYGE----------RP---------------YWDM---------TNQDV-INAI-EQDYR----LP-PPMDCP-----------------------------------------------------------------------------SALHQ-LMLDCWQKDRNHRPK-------FG-QIVNTL----------------------------------------------------------
-------------------------------V-KIEEVIGAGEFGEVCRGRL---K----APGKKES---CVAIKTL---K-G--G-YT----ERQ---RR-E-FL-S-------------------------EASIMGQF--E------HPN-----IIRLEGVVT--N-----------------------------SMP------VMILTEFMENG---ALD-SFLR----------LN-----------------------DGQF----TVIQLVGMLRGIASGMRYLAE--M--------S---YVHRDLAARNIL--VN----S--------NLVC-------------------KVSDFGLSRFLE--------ENS---------S--DPTY--------------TSSLGGKIPIRWTAPEA--IA-----------FRK----FTSASDAWSYGIVMWEVMSFGE----------RP---------------YWDM---------SNQDV-INAI-EQDYR----LP-PPPDCP-----------------------------------------------------------------------------TSLHQ-LMLDCWQKDRNARPR-------FP-QVVSAL----------------------------------------------------------
--------------------------------IKIEEVIGTGSFGEVRQGRL---Q----PRGRREQ---TVAIQAL---W-A--G-GA----ESL---QM-T-FL-G-------------------------RAAVLGQF--Q------HPN-----ILRLEGVVT--K-----------------------------SRP------LMVLTEFMELG---PLD-SFLR----------QR-----------------------EGQF----SSLQLVAMQRGVAAAMQYLSS--F--------A---FVHRSLSAHSVL--VN----S--------HLVC-------------------KVARLGHSPQG-----------------------------------------------PSCLLRWAAPEV--IA-----------HGK----HTTSSDVWSFGILMWEVMSYGE----------RP---------------YWDM---------SEQEV-LNAI-EQEFR----LP-PPPGCP-----------------------------------------------------------------------------PGLHL-LMLDTWQKDRARRPH-------FD-QLVA---AF-------------------------------------------------------
-------------------------------L-KRVKVLGSGAFGTVYKGIW---VP---EGETVKI---PVAIKIL---N-E--T-TG----PKA---NV-E-FM-D-------------------------EALIMASM--D------HPH-----LVRLLGVCL--------------------------------SPT------IQLVTQLMPHG---CLL-EYVH----------EH-----------------------KDNI----GSQLLLNWCVQIAKGMMYLEE--R--------R---LVHRDLAARNVL--VK----S--------PNHV-------------------KITDFGLARLL-----------E---------G--DEKE--------------YNADGGKMPIKWMALEC--IH-----------YRK----FTHQSDVWSYGVTIWELMTFGG----------KP---------------YDGI---------PTREI-PDLL-EKGER----LP-QPPICT-----------------------------------------------------------------------------IDVYM-VMVKCWMIDADSRPK-------FK-ELAAE--F--------------------------------------------------------
------------------------------VI--LGELLGKGNFGEVYKGTL---K--------DKT---SVAVKTC---K-E--D-LP----QEL---KI-K-FL-Q-------------------------EAKILKQY--D------HPN-----IVKLIGVCT--Q-----------------------------RQP------VYIIMELVSGG---DFL-TFLR----------RK-----------------------KDEL----KLKQLVKFSLDAAAGMLYLES--K--------N---CIHRDLAARNCL--VG----E--------NNVL-------------------KISDFGMSRQE---------------------D--GGVY--------------SSSGLKQIPIKWTAPEA--LN-----------YGR----YSSESDVWSFGILLWETFSLGV----------CP---------------YPGM---------TNQQA-REQV-ERGYR----MS-APQHCP-----------------------------------------------------------------------------EDISK-IMMKCWDYKPENRPK-------FS-ELQKEL----------------------------------------------------------
-------------------------------L-VLGEQIGRGNFGEVFSGRL---R-------ADNT---LVAVKSC---R-E--T-LP----PDL---KA-K-FL-Q-------------------------EARILKQY--S------HPN-----IVRLIGVCT--Q-----------------------------KQP------IYIVMELVQGG---DFL-TFLR----------TE-----------------------GARL----RVKTLLQMVGDAAAGMEYLES--K--------C---CIHRDLAARNCL--VT----E--------KNVL-------------------KISDFGMSREE-----------A---------D--GVYA--------------ASGGLRQVPVKWTAPEA--LN-----------YGR----YSSESDVWSFGILLWETFSLGA----------SP---------------YPNL---------SNQQT-REFV-EKGGR----LP-CPELCP-----------------------------------------------------------------------------DAVFR-LMEQCWAYEPGQRPS-------FS-TIYQEL----------------------------------------------------------
-------------------------------L-VLGKPLGEGCFGQVVLAEA---IGLDKDKPNRVT---KVAVKML---K-S--D-AT----EKD---LS-D-LI-S-------------------------EMEMMKMIG-K------HKN-----IINLLGACT--Q-----------------------------DGP------LYVIVEYASKG---NLR-EYLQ----------ARRPPGLEY--------CYNPSHNPEEQL----SSKDLVSCAYQVARGMEYLAS--K--------K---CIHRDLAARNVL--VT----E--------DNVM-------------------KIADFGLARDI-----------H---------H--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----------DRI----YTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGV---------PVEEL-FKLL-KEGHR----MD-KPSNCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-------FK-QLVEDL----------------------------------------------------------
--------------------------------LTLGKPLGEGCFGQVVMAEA---VGIDKDKPKEAV---TVAVKML---K-D--D-AT----EKD---LS-D-LV-S-------------------------EMEMMKMIG-K------HKN-----IINLLGACT--Q-----------------------------DGP------LYVIVEYASKG---NLR-EYLR----------ARRPPGMEY--------SYDINRVPEEQM----TFKDLVSCTYQLARGMEYLAS--Q--------K---CIHRDLAARNVL--VT----E--------NNVM-------------------KIADFGLARDI-----------N---------N--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----------DRV----YTHQSDVWSFGVLMWEIFTLGG----------SP---------------YPGI---------PVEEL-FKLL-KEGHR----MD-KPANCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-------FK-QLVEDL----------------------------------------------------------
--------------------------------LTLGKPLGEGCFGQVVMAEA---IGIDKDRAAKPV---TVAVKML---K-D--D-AT----DKD---LS-D-LV-S-------------------------EMEMMKMIG-K------HKN-----IINLLGACT--Q-----------------------------GGP------LYVLVEYAAKG---NLR-EFLR----------ARRPPGLDY--------SFDTCKPPEEQL----TFKDLVSCAYQVARGMEYLAS--Q--------K---CIHRDLAARNVL--VT----E--------DNVM-------------------KIADFGLARDV-----------H---------N--LDYY--------------KKTTNGRLPVKWMAPEA--LF-----------DRV----YTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGI---------PVEEL-FKLL-KEGHR----MD-KPANCT-----------------------------------------------------------------------------HDLYM-IMRECWHAAPSQRPT-------FK-QLVEDL----------------------------------------------------------
-------------------------------L-VLGKPLGEGCFGQVVRAEA---FGMDPARPDQAS---TVAVKML---K-D--N-AS----DKD---LA-D-LV-S-------------------------EMEVMKLIG-R------HKN-----IINLLGVCT--Q-----------------------------EGP------LYVIVECAAKG---NLR-EFLR----------ARRPPGPDL--------SPDGPRSSEGPL----SFPVLVSCAYQVARGMQYLES--R--------K---CIHRDLAARNVL--VT----E--------DNVM-------------------KIADFGLARGV-----------H---------H--IDYY--------------KKTSNGRLPVKWMAPEA--LF-----------DRV----YTHQSDVWSFGILLWEIFTLGG----------SP---------------YPGI---------PVEEL-FSLL-REGHR----MD-RPPHCP-----------------------------------------------------------------------------PELYG-LMRECWHAAPSQRPT-------FK-QLVEAL----------------------------------------------------------
--------------------------------ITLERRLGTGCFGDVWLGTW---N--------GST---KVAVKTL---K-P--G-TM----SP-----K-A-FL-E-------------------------EAQVMKLL--R------HDK-----LVQLYAVVS--------------------------------EEP------IYIVTEFMCHG---SLL-DFLK----------NP----------------------EGQDL----RLPQLVDMAAQVAEGMAYMER--M--------N---YIHRDLRAANIL--VG----E--------RLAC-------------------KIADFGLARLI---------------------K--DDEY--------------NPCQGSKFPIKWTAPEA--AL-----------FGR----FTIKSDVWSFGILLTELITKGR----------IP---------------YPGM---------NKREV-LEQV-EQGYH----MP-CPPGCP-----------------------------------------------------------------------------ASLYE-AMEQTWRLDPEERPT-------FE-YLQSFL----------------------------------------------------------
--------------------------------LQLIKRLGNGQFGEVWMGTW---N--------GNT---KVAIKTL---K-P--G-TM----SP-----E-S-FL-E-------------------------EAQIMKKL--K------HDK-----LVQLYAVVS--------------------------------EEP------IYIVTEYMNKG---SLL-DFLK----------DG----------------------EGRAL----KLPNLVDMAAQVAAGMAYIER--M--------N---YIHRDLRSANIL--VG----N--------GLIC-------------------KIADFGLARLI---------------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL-----------YGR----FTIKSDVWSFGILLTELVTKGR----------VP---------------YPGM---------NNREV-LEQV-ERGYR----MP-CPQDCP-----------------------------------------------------------------------------ISLHE-LMIHCWKKDPEERPT-------FE-YLQSFL----------------------------------------------------------
----------------------------FLDF----RVLGKGGFGEVSACQM---K-------ATGK---LYACKKL---NKK--R-LKK---RK-----G-Y-QGAM------------------------VEKKILMKV--H------SRF-----IVSLAYAFE--T-----------------------------KAD------LCLVMTIMNGG---DIR-YHIYNV-----NEENP-------------------------GF----PEPRALFYTAQIICGLEHLHQ--R--------R---IVYRDLKPENVL--LD----N--------DGNV-------------------RISDLGLAVEL---------------------LDGQSKT--------------KG---YAGTPGFMAPEL--LQ-----------GEE----YDFSVDYFALGVTLYEMIA-AR----------GP---------------FRAR--------GEKVEN-KELK-HRIIS----EP-VKYPDKFS---------------------------------------------------------------------------QASKD-FCEALLEKDPEKRLG-------FR-D-------ETCDKLRAHPLF--------------------------------------------
------------------------------FR--HYRVLGKGGFGEVCACQV---R-------ATGK---MYACKKL---QKK--R-IKK---RK-----G-E-AMAL------------------------NEKRILEKV--Q------SRF-----VVSLAYAYE--T-----------------------------KDA------LCLVLTIMNGG---DLK-FHIYN-------LGNP-------------------------GF----DEQRAVFYAAELCCGLEDLQR--E--------R---IVYRDLKPENIL--LD----D--------RGHI-------------------RISDLGLATE----------------------IPEGQRV--------------RG---RVGTVGYMAPEV--VN-----------NEK----YTFSPDWWGLGCLIYEMIQ-GH----------SP---------------FKKY---------KEKVK-WEEV-DQRIK----ND-TEEYSE---KFS-----------------------------------------------------------------------EDAKS-ICRMLLTKNPSKRLGCR--GEGAA-GVKQHPV-F-------------------------------------------------------
-------------------------------F-RQYRVLGKGGFGEVCACQV---R-------ATGK---MYACKRL---EKK--R-IKK---RK-----G-E-SMAL------------------------NEKQILEKV--N------SQF-----VVNLAYAYE--T-----------------------------KDA------LCLVLTIMNGG---DLK-FHIYN-------MGNP-------------------------GF----EEERALFYAAEILCGLEDLHR--E--------N---TVYRDLKPENIL--LD----D--------YGHI-------------------RISDLGLAVK----------------------IPEGDLI--------------RG---RVGTVGYMAPEV--LN-----------NQR----YGLSPDYWGLGCLIYEMIE-GQ----------SP---------------FRGR------------KE-KVKR-EEVDR----RV-LETEEVYSHKFS-----------------------------------------------------------------------EEAKS-ICKMLLTKDAKQRLGCQ--EEGAA-EVKRHPFF--------------------------------------------------------
-------------------------------F-RQYRVLGKGGFGEVCACQV---R-------ATGK---MYACKKL---EKK--R-IKK---RK-----G-E-AMAL------------------------NEKQILEKV--N------SRF-----VVSLAYAYE--T-----------------------------KDA------LCLVLTLMNGG---DLK-FHIYH-------MGQA-------------------------GF----PEARAVFYAAEICCGLEDLHR--E--------R---IVYRDLKPENIL--LD----D--------HGHI-------------------RISDLGLAVH----------------------VPEGQTI--------------KG---RVGTVGYMAPEV--VK-----------NER----YTFSPDWWALGCLLYEMIA-GQ----------SP---------------FQQR---------KKKIK-REEV-ERLVK-----E-VPEEYSER--FS-----------------------------------------------------------------------PQARS-LCSQLLCKDPAERLGCR--GGSAR-EVKEHPLF--------------------------------------------------------
-------------------------------F-TEFRVLGKGGFGEVCAVQV---K-------NTGK---MYACKKL---DKK--R-LKK---KG-----G-E-KMAL------------------------LEKEILEKV--S------SPF-----IVSLAYAFE--S-----------------------------KTH------LCLVMSLMNGG---DLK-FHIYN-------VGTR-------------------------GL----DMSRVIFYSAQIACGMLHLHE--L--------G---IVYRDMKPENVL--LD----D--------LGNC-------------------RLSDLGLAVE----------------------MKGGKPI--------------TQ---RAGTNGYMAPEI--LM----------EKVS----YSYPVDWFAMGCSIYEMVA-GR----------TP---------------FKDY--------KEKVSK-EDLK-QRTLQ----DE-VKFQHDNF---T-----------------------------------------------------------------------EEAKD-ICRLFLAKKPEQRLG-------SR-E-------KSDDPR--------------------------------------------------
--------------------------------LKLEKKLGAGQFGEVWMATY---N--------KHT---KVAVKTM---K-P--G-SM----SV-----E-A-FL-A-------------------------EANVMKTL--Q------HDK-----LVKLHAVVT--------------------------------KEP------IYIITEFMAKG---SLL-DFLK----------SD----------------------EGSKQ----PLPKLIDFSAQIAEGMAFIEQ--R--------N---YIHRDLRAANIL--VS----A--------SLVC-------------------KIADFGLARVI---------------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN-----------FGS----FTIKSDVWSFGILLMEIVTYGR----------IP---------------YPGM---------SNPEV-IRAL-ERGYR----MP-RPENCP-----------------------------------------------------------------------------EELYN-IMMRCWKNRPEERPT-------FE-YIQSV--L--------------------------------------------------------
--------------------------------YDIIEVLGKGTFGEVAKGWR---R-------STGE---MVAIKIL---KND--A-YRN---RI-----I-K-N----------------------------ELKLLHCM--RGL-DPEEAH-----VIRFLEFFH--D-----------------------------ALK------FYLVFELLEQ----NLF-EFQK----------EN-------------------------NFA-PLPARHIRTVTLQVLTALARLKE--L--------A---IIHADLKPENIM--LV----D--------QTRCPF---------------RVKVIDFGSASIF---------------------SEVRYVK--------------EP---YIQSRFYRAPEI--LL-----------GLP----FCEKVDVWSLGCVMAELHL-GW----------PL---------------YPGN---------NEYDQ-VRYI-CETQG----LP-KPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVE-LIKRMLTWESHERIS-------PS-AALRHPFV--------------------------------------------------------
--------------------------------YTTIRQLGDGTYGSVLLGRS---I-------ESGE---LIAIKKM---KRK--F-YSW---EE-----C---MNLR-------------------------EVKSLKKL--N------HAN-----VVKLKEVIR--E-----------------------------NDH------LYFIFEYMKE----NLY-QLIK--------ERNK-------------------------LF----PESAIRNIMYQILQGLAFIHK--H--------G---FFHRDLKPENLL--CM----G--------PELV-------------------KIADFGLARE----------------------IRSKPPY--------------TD---YVSTRWYRAPEV--LL----------RSTN----YSSPIDVWAVGCIMAEVYT-LR----------PL---------------FPGA---------SEIDT-IFKI-CQVLG----TP-KKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-------AS-QALRYPYF--------------------------------------------------------
--------------------------------ITMSRELGQGSFGMVYEGVA---KG--VVKDEPET---RVAIKTV---N-E--A-AS----MRE---RI-E-FL-N-------------------------EASVMKEF--N------CHH-----VVRLLGVVS--Q-----------------------------GQP------TLVIMELMTRG---DLK-SYLR----------SLRPEM--------------ENNPVLAPP----SLSKMIQMAGEIADGMAYLNA--N--------K---FVHRDLAARNCM--VA----E--------DFTV-------------------KIGDFGMTRDI-----------Y---------E--TDYY--------------RKGGKGLLPVRWMSPES--LK-----------DGV----FTTYSDVWSFGVVLWEIATLAE----------QP---------------YQGL---------SNEQV-LRFV-MEGGL----LD-KPDNCP-----------------------------------------------------------------------------DMLFE-LMRMCWQYNPKMRPS-------FL-EIISS--I--------------------------------------------------------
--------------------------------ITLLRELGQGSFGMVYEGNA---RD--IIKGEAET---RVAVKTV---N-E--S-AS----LRE---RI-E-FL-N-------------------------EASVMKGF--T------CHH-----VVRLLGVVS--K-----------------------------GQP------TLVVMELMAHG---DLK-SYLR----------SLRPEA--------------ENNPGRPPP----TLQEMIQMAAEIADGMAYLNA--K--------K---FVHRDLAARNCM--VA----H--------DFTV-------------------KIGDFGMTRDI-----------Y---------E--TDYY--------------RKGGKGLLPVRWMAPES--LK-----------DGV----FTTSSDMWSFGVVLWEITSLAE----------QP---------------YQGL---------SNEQV-LKFV-MDGGY----LD-QPDNCP-----------------------------------------------------------------------------ERVTD-LMRMCWQFNPKMRPT-------FL-EIVNLL----------------------------------------------------------
-------------------------------I-SIIRELGQGSFGMVYEGLA---RG--LEAGEEST---PVALKTV---N-E--L-AS----PRE---CI-E-FL-K-------------------------EASVMKAF--K------CHH-----VVRLLGVVS--Q-----------------------------GQP------TLVIMELMTRG---DLK-SHLR----------SLRPEA--------------ENNPGLPQP----ALGEMIQMAGEIADGMAYLAA--N--------K---FVHRDLAARNCM--VS----Q--------DFTV-------------------KIGDFGMTRDV-----------Y---------E--TDYY--------------RKGGKGLLPVRWMAPES--LK-----------DGI----FTTHSDVWSFGVVLWEIVTLAE----------QP---------------YQGL---------SNEQV-LKFV-MDGGV----LE-ELEGCP-----------------------------------------------------------------------------LQLQE-LMSRCWQPNPRLRPS-------FT-HILD---SI-------------------------------------------------------
-----------------------------VGG----NKMGEGGFGVVYKGYV---N-------NTT-----VAVKKL---AAM--V-DIT---TE-----ELK-QQFD------------------------QEIKVMAKC--Q------HEN-----LVELLGFSS--D-----------------------------GDD------LCLVYVYMPNG---SLL-DRLSC------LDGTP-------------------------PL----SWHMRCKIAQGAANGINFLHE--N--------H---HIHRDIKSANIL--LD----E--------AFTA-------------------KISDFGLARASE-------------------KFAQTVMT--------------SR---IVGTTAYMAPEA--LR------------GE----ITPKSDIYSFGVVLLEIIT-GL----------PA---------------VDEH---------REPQL-LLDI-KEEIE----DE-EKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYS-VASQCLHEKKNKRPD-------IK-KVQQ----LLQ-----------------------------------------------------
--------------------------------LTFVQEIGSGQFGLVHLGYW---L--------NKD---KVAIKTI---R-E--G-AM----SE-----E-D-FI-E-------------------------EAEVMMKL--S------HPK-----LVQLYGVCL--E-----------------------------QAP------ICLVFEFMEHG---CLS-DYLR----------TQ-----------------------RGLF----AAETLLGMCLDVCEGMAYLEE--A--------C---VIHRDLAARNCL--VG----E--------NQVI-------------------KVSDFGMTRFV---------------------L--DDQY--------------TSSTGTKFPVKWASPEV--FS-----------FSR----YSSKSDVWSFGVLMWEVFSEGK----------IP---------------YENR---------SNSEV-VEDI-STGFR----LY-KPRLAS-----------------------------------------------------------------------------THVYQ-IMNHCWKERPEDRPA-------FS-RLLRQL----------------------------------------------------------
-------------------------------L-KRIRDLGEGHFGKVELCRY---DP---EGDNTGE---QVAVKSL---K-P--E-SG----GNH---IA-D-LK-K-------------------------EIEILRNL--Y------HEN-----IVKYKGICT-ED------------------------------GGN----GIKLIMEFLPSG---SLK-EYLP----------KN-----------------------KNKI----NLKQQLKYAVQICKGMDYLGS--R--------Q---YVHRDLAARNVL--VE----S--------EHQV-------------------KIGDFGLTKAI----------ET---------D--KEYY--------------TVKDDRDSPVFWYAPEC--LM-----------QSK----FYIASDVWSFGVTLHELLTYCD----------SDSSPMALF-LKMIGPTHGQM---------TVTRL-VNTL-KEGKR----LP-CPPNCP-----------------------------------------------------------------------------DEVYQ-LMRKCWEFQPSNRTS-------FQ-NLIE---GF-------------------------------------------------------
--------------------------------LKFLQQLGKGNFGSVEMCRY---DP---LQDNTGE---VVAVKKL---Q-H--S-TE-----EH---LR-D-FE-R-------------------------EIEILKSL--Q------HDN-----IVKYKGVCYSAG-----------------------------RRN------LKLIMEYLPYG---SLR-DYLQ----------KH-----------------------KERI----DHIKLLQYTSQICKGMEYLGT--K--------R---YIHRDLATRNIL--VE----N--------ENRV-------------------KIGDFGLTKVL----------PQ---------D--KEYY--------------KVKEPGESPIFWYAPES--LT-----------ESK----FSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM---------IVFHL-IELL-KNNGR----LP-RPDGCP-----------------------------------------------------------------------------DEIYM-IMTECWNNNVNQRPS-------FR-DLA----LRV------------------------------------------------------
-------------------------------L-KYISQLGKGNFGSVELCRY---DP---LGDNTGA---LVAVKQL---Q-H--S-GP----DQ----QR-D-FQ-R-------------------------EIQILKAL--H------SDF-----IVKYRGVSYGPG-----------------------------RQS------LRLVMEYLPSG---CLR-DFLQ----------RH-----------------------RARL----DASRLLLYSSQICKGMEYLGS--R--------R---CVHRDLAARNIL--VE----S--------EAHV-------------------KIADFGLAKLL----------PL---------D--KDYY--------------VVREPGQSPIFWYAPES--LS-----------DNI----FSRQSDVWSFGVVLYELFTYCD----------KSCSPSAE--FLRMMGCERDV-P-------ALCRL-LELL-EEGQR----LP-APPACP-----------------------------------------------------------------------------AEVHE-LMKLCWAPSPQDRPS-------FS-ALGP---QL-------------------------------------------------------
--------------------------------LKLVERLGAGQFGEVWMGYY---N--------GHT---KVAVKSL---K-Q--G-SM----SP-----D-A-FL-A-------------------------EANLMKQL--Q------HQR-----LVRLYAVVT--------------------------------QEP------IYIITEYMENG---SLV-DFLK----------TP----------------------SGIKL----TINKLLDMAAQIAEGMAFIEE--R--------N---YIHRDLRAANIL--VS----D--------TLSC-------------------KIADFGLARLI---------------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN-----------YGT----FTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM---------TNPEV-IQNL-ERGYR----MV-RPDNCP-----------------------------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-------FD-YLRSV--L--------------------------------------------------------
-----------------------------EFL------LGDGSFGSVYRAAY---E-------GEE-----VAVKIF---NKH--T-SLR---LL-----R-Q------------------------------ELVVLCHL--H------HPS-----LISLLAAGI--R-----------------------------P--------RMLVMELASKG---SLD-RLLQ--------QDKA-------------------------SL----TRTLQHRIALHVADGLRYLHS--A--------M---IIYRDLKPHNVL--LF----T--------LY-PNAA-------------IIAKIADYGIAQ-----------------------YCCRMGI--------------KT---SEGTPGFRAPEV--AR----------GNVI----YNQQADVYSFGLLLYDILTTGG----------RI---------------VEGLK------FPNEFDE-LEIQ-GKLPD----PV-KEYGCAPW---------------------------------------------------------------------------PMVEK-LIKQCLKENPQERPT-------SA-QVF-----DIL-----------------------------------------------------
-------------------------------V-TLLRALGHGAFGEVYEGLV---IG--LPGDSSPL---QVAIKTL---P-E--L-CS----PQD---EL-D-FL-M-------------------------EALIISKF--R------HQN-----IVRCVGLSL--R-----------------------------ATP------RLILLELMSGG---DMK-SFLR----------HSRP-----------------HLGQPSPL----VMRDLLQLAQDIAQGCHYLEE--N--------H---FIHRDIAARNCL--LS----CA-----GPSRVA-------------------KIGDFGMARDI-----------Y---------R--ASYY--------------RRGDRALLPVKWMPPEA--FL-----------EGI----FTSKTDSWSFGVLLWEIFSLGY----------MP---------------YPGR---------TNQEV-LDFV-VGGGR----MD-PPRGCP-----------------------------------------------------------------------------GPVYR-IMTQCWQHEPELRPS-------FA-SILERL----------------------------------------------------------
--------------------------------YTTMRQLGDGTYGSVLMGKS---N-------ESGE---LVAIKRM---KRK--F-YSW---DE-----C-M--NLR-------------------------EVKSLKKL--N------HAN-----VIKLKEVIR--E-----------------------------NDH------LYFIFEYMKE----NLY-QLMK--------DRNK-------------------------LF----PESVIRNIMYQILQGLAFIHK--H--------G---FFHRDMKPENLL--CM----G--------PELV-------------------KIADFGLARE----------------------LRSQPPY--------------TD---YVSTRWYRAPEV--LL----------RSSV----YSSPIDVWAVGSIMAELYM-LR----------PL---------------FPGT---------SEVDE-IFKI-CQVLG----TP-KKSDWPEGYQLASSMNFRFPQCV------------------------------------------------PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT-------AS-QALKHPYF--------------------------------------------------------
--------------------------------FEKISELGAGNGGVVFKVSH---K-------PSGL----VMARKL---IHL--E-IKP---AI-----R-N-QIIR-------------------------ELQVLHEC--N------SPY-----IVGFYGAFY--S-----------------------------DGE------ISICMEHMDGG---SLD-QVLK---------KAG-------------------------RI----PEQILGKVSIAVIKGLTYLRE-KH--------K---IMHRDVKPSNIL--VN----S--------RGEI-------------------KLCDFGVSG-----------------------QLIDSMA--------------NS---FVGTRSYMSPER--LQ-----------GTH----YSVQSDIWSMGLSLVEMAV-GR----------YP---------------IPPP---------DAKEL-ELMF-GCQVE----GD-AAETPPRPRTPGRPLSSYGMDSRPPMAIFE----------------------------------LLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERAD-------LK-QLMVHAFI--------------------------------------------------------
------------------------------LV--TISELGRGAYGVVEKVRH---A-------QSGT---IMAVKRI---RAT--V-NSQ---EQ-----K-R-L-LM-------------------------DLDINMRT-VD------CFY-----TVTFYGALF--R-----------------------------EGD------VWICMELMDTS----LD-KFYRKV-----LDKNM-------------------------TI----PEDILGEIAVSIVRALEHLHS--K-------LS---VIHRDVKPSNVL--IN----K--------EGHV-------------------KMCDFGISGY----------------------LVDSVAK--------------TM---DAGCKPYMAPER--INP-------ELNQKG----YNVKSDVWSLGITMIEMAI-LR----------FP---------------YESW--------GTPFQQ-LKQV-VEEPS----PQ-LPADRF-----S-----------------------------------------------------------------------PEFVD-FTAQCLRKNPAERMS-------YL-ELMEHPFF--------------------------------------------------------
-----------------------------IRY---RDTLGHGNGGTVYKAYH---V-------PSGK---ILAVKVI---LLD--I-TLE---LQ-----K-Q-I-MS-------------------------ELEILYKC--D------SSY-----IIGFYGAFF--V-----------------------------ENR------ISICTEFMDGG---SLD--------------VYR-------------------------KM----PEHVLGRIAVAVVKGLTYLWS--L--------K---ILHRDVKPSNML--VN----T--------RGQV-------------------KLCDFGVST-----------------------QLVNSIA--------------KT---YVGTNAYMAPER--IS-----------GEQ----YGIHSDVWSLGISFMELAL-GR----------FP---------------YPQI---------QKNQG-SLMP-LQLLQ----CI-VDEDSPVLPVGEF---------------------------------------------------------------------SEPFVH-FITQCMRKQPKERPA-------PE-ELMGHPFI--------------------------------------------------------
----------------------------LEPI----MELGRGAYGVVEKMRH---V-------PSGQ---IMAVKRI---RAT--V-NSQ---EQ-----K-R-L-LM-------------------------DLDISMRT-VD------CPF-----TVTFYGALF--R-----------------------------EGD------VWICMELMDTSLDKFYK-QVID---------KGQ-------------------------TI----PEDILGKIAVSIVKALEHLHS--K-------LS---VIHRDVKPSNVL--IN----A--------LGQV-------------------KMCDFGISGY----------------------LVDSVAK--------------TI---DAGCKPYMAPER--INP-------ELNQKG----YSVKSDIWSLGITMIELAI-LR----------FP---------------YDSW--------GTPFQQ-LKQV-VEEPS----PQ-LPADKF-----S-----------------------------------------------------------------------AEFVD-FTSQCLKKNSKERPT-------YP-ELMQHPFF--------------------------------------------------------
--------------------------------LQLEEIIGVGGFGKVYRALW---R---------GE---EVAVKAARLDP-E--K-DP----AVT---AE-Q-VC-Q-------------------------EARLFGAL--Q------HPN-----IIALRGACL--N-----------------------------PPH------LCLVMEYARGG---ALS-RVLA----------GR-------------------------RV----PPHVLVNWAVQVARGMNYLHN--D--------APVPIIHRDLKSINIL--IL----EAIENHNLADTVL-------------------KITDFGLAREW--------------------------HK--------------TTKMSAAGTYAWMAPEV--IR-----------LSL----FSKSSDVWSFGVLLWELLT-GE----------VP---------------YREI---------DALAV-AYGVAMNKLT----LP-IPSTCP-----------------------------------------------------------------------------EPFAR-LLEECWDPDPHGRPD-------FG-SILKRL----------------------------------------------------------
--------------------------------LRLEEVIGIGGFGKVYRGSW---R---------GE---LVAVKAA---R-Q--D-PD----EDISVTAE-S-VR-Q-------------------------EARLFAML--A------HPN-----IIALKAVCL--E-----------------------------EPN------LCLVMEYAAGG---PLS-RALA----------GR-------------------------RV----PPHVLVNWAVQIARGMHYLHC--E--------ALVPVIHRDLKSNNIL--LL----QPIESDDMEHKTL-------------------KITDFGLAREW--------------------------HK--------------TTQMSAAGTYAWMAPEV--IK-----------AST----FSKGSDVWSFGVLLWELLT-GE----------VP---------------YRGI---------DCLAV-AYGVAVNKLT----LP-IPSTCP-----------------------------------------------------------------------------EPFAQ-LMADCWAQDPHRRPD-------FA-SILQQL----------------------------------------------------------
---------------------------LDLQW------VGSGAQGAVFLGRF---H---------GE---EVAVKKV---R-D--L-KE----T---------------------------------------DIKHLRKL--K------HPN-----IITFKGVCT--Q-----------------------------APC------YCILMEFCAQG---QLY-EVLR----------AG------------------------RPV----TPSLLVDWSMGIAGGMNYLHL--H--------K---IIHRDLKSPNML--IT----Y--------DDVV-------------------KISDFGTSKEL-------------------------SDK--------------STKMSFAGTVAWMAPEV--IR-----------NEP----VSEKVDIWSFGVVLWELLT-GE----------IP---------------YKDV---------DSSAI-IWGVGSNSLH----LP-VPSSCP-----------------------------------------------------------------------------DGFKI-LLRQCWNSKPRNRPS-------FR-QILLH--L--------------------------------------------------------
----------------------------ISEL----QWLGSGAQGAVFLGKF---R---------AE---EVAIKKV---R-E--Q-NE----TD---------------------------------------IKHLRKL--K------HPN-----IIAFKGVCT--Q-----------------------------APC------YCIIMEYCAHG---QLY-EVLR----------AG------------------------RKI----TPRLLVDWSTGIASGMNYLHL--H--------K---IIHRDLKSPNVL--VT----H--------TDAV-------------------KISDFGTSKEL-------------------------SDK--------------STKMSFAGTVAWMAPEV--IR-----------NEP----VSEKVDIWSFGVVLWELLT-GE----------IP---------------YKDV---------DSSAI-IWGVGSNSLH----LP-VPSTCP-----------------------------------------------------------------------------DGFKI-LMKQTWQSKPRNRPS-------FR-QTLMH--L--------------------------------------------------------
----------------------------THQL-----RLGRGSFGEVHRMED---K-------QTGF---QCAVKKV---RLE--V-FRA---E---------------------------------------ELMACAGL--T------SPR-----IVPLYGAVR--E-----------------------------GPW------VNIFMELLEGG---SLG-QLVK---------EQG-------------------------CL----PEDRALYYLGQALEGLEYLHS--R--------R---ILHGDVKADNVL--LS----S--------DGSH------------------AALCDFGHAVCLQP----------------DGLGKSLLTG--------------DY---IPGTETHMAPEV--VL-----------GRS----CDAKVDVWSSCCMMLHMLN-GC----------HP---------------WTQF------------FR-GPLC-LKIAS----EPPPVREIPPSCA-------------------------------------------------------------------------PLTAQ-AIQEGLRKEPIHRVS-------AA-EL------GGK-----------------------------------------------------
----------------------------GSDF------IPRGAFGKVYLAQD---I-------KTKK---RMACKLI---PVD--Q-FKP---SD---------------------------------------VEIQACF--R------HEN-----IAELYGAVL--W-----------------------------GET------VHLFMEAGEGG---SVL-EKLE---------SCG-------------------------PM----REFEIIWVTKHVLKGLDFLHS--K--------K---VIHHDIKPSNIV--FM-------------STKA-------------------VLVDFGLSVQM---------------------TEDVYFP--------------KD---LRGTEIYMSPEV--IL-----------CRG----HSTKADIYSLGATLIHMQT-GT----------PP---------------WVKR---------YPRSA-YPSY-LYIIH----KQ-APPLEDIADDCS-----------------------------------------------------------------------PGMRE-LIEASLERNPNHRPR-------AA-DLLKHE--AL------------------------------------------------------
-------------------------------L-TLEEIIGIGGFGKVYRAFW---I-------GDE-----VAVKAA---RHDP-D-EDI---SQ-----T-I-ENVR------------------------QEAKLFAML--K------HPN-----IIALRGVCL--K-----------------------------EPN------LCLVMEFARGG---PLN-RVLS----------GK-------------------------RI----PPDILVNWAVQIARGMNYLHD--EA-----IVP---IIHRDLKSSNIL--IL----Q--------KVENGDLS-----------NKILKITDFGLAR-----------------------EWHRTTK--------------MS---AAGTYAWMAPEV--IR-----------ASM----FSKGSDVWSYGVLLWELLT-GE----------VP---------------FRGI------------DG-LAVA-YGVAM----NK-LALPIPSTCP-------------------------------------------------------------------------EPFAK-LMEDCWNPDPHSRPS-------FT-NILDQ---LT------------------------------------------------------
--------------------------------YDLLQRLGGGTYGEVFKARD---K-------VSGD---LVALKMV---KME--P-DDD---VS-----T----LQK-------------------------EILILKTC--R------HAN-----IVAYHGSYL--W-----------------------------LQK------LWICMEFCGAG---SLQ-DIYQ---------VTG-------------------------SL----SELQISYVCREVLQGLAYLHS--Q--------K---KIHRDIKGANIL--IN----D--------AGEV-------------------RLADFGISAQI---------------------GATLARR--------------LS---FIGTPYWMAPEVAAVA----------LKGG----YNELCDIWSLGITAIELAE-LQ----------PP---------------LFDV---------HPLRV-LFLM-TKSGY----QP-PRLKEKGKWS-------------------------------------------------------------------------AAFHN-FIKVTLTKSPKKRPS-------AT-KMLSHQL-V-------------------------------------------------------
--------------------------------FELLQRVGAGTYGDVYKARD---T-------VTSE---LAAVKIV---KLD--P-GDD---IS-----S-L---QQ-------------------------EITILREC--R------HPN-----VVAYIGSYL--R-----------------------------NDR------LWICMEFCGGG---SLQ-EIYH---------ATG-------------------------PL----EERQIAYVCREALKGLHHLHS--Q--------G---KIHRDIKGANLL--LT----L--------QGDV-------------------KLADFGVSGEL---------------------TASVAKR--------------RS---FIGTPYWMAPEVAAVE----------RKGG----YNELCDVWALGITAIELGE-LQ----------PP---------------LFHL---------HPMRA-LMLM-SKSSF----QP-PKLRDKTR--WT-----------------------------------------------------------------------QNFHH-FLKLALTKNPKKRPT-------AE-KLLQHPF-T-------------------------------------------------------
--------------------------------FELIQRIGSGTYGDVYKARN---V-------NTGE---LAAIKVI---KLE--P-GED---FA-----V-V-Q--Q-------------------------EIIMMKDC--K------HPN-----IVAYFGSYL--R-----------------------------RDK------LWICMEFCGGG---SLQ-DIYH---------VTG-------------------------PL----SELQIAYVSRETLQGLYYLHS--K--------G---KMHRDIKGANIL--LT----D--------NGHV-------------------KLADFGVSAQI---------------------TATIAKR--------------KS---FIGTPYWMAPEVAAVE----------RKGG----YNQLCDLWAVGITAIELAE-LQ----------PP---------------MFDL---------HPMRA-LFLM-TKSNF----QP-P--KLKDKMKWS-----------------------------------------------------------------------NSFHH-FVKMALTKNPKKRPT-------AE-KLLQHPFV--------------------------------------------------------
--------------------------------YELVQRVGSGTYGDVYKARN---V-------HTGE---LAAVKII---KLE--P-GDD---FS-----L-I-Q--Q-------------------------EIFMVKEC--K------HCN-----IVAYFGSYL--S-----------------------------REK------LWICMEYCGGG---SLQ-DIYH---------VTG-------------------------PL----SELQIAYVCRETLQGLAYLHT--K--------G---KMHRDIKGANIL--LT----D--------HGDV-------------------KLADFGVAAKI---------------------TATIAKR--------------KS---FIGTPYWMAPEVAAVE----------KNGG----YNQLCDIWAVGITAIELGE-LQ----------PP---------------MFDL---------HPMRA-LFLM-SKSNF----QP-PKLKDKTK--WS-----------------------------------------------------------------------STFHN-FVKIALTKNPKKRPT-------AE-RLLTHTFV--------------------------------------------------------
--------------------------------YTNLSYIGEGAYGMVCSAYD---N-------VNKV---RVAIKKI---SPF--E-HQT---YC-----Q-R-T-LR-------------------------EIKILLRF--R------HEN-----IIGINDIIR--APT------------------------IEQMKD------VYIVQDLMET----DLY-KLLK----------TQ-------------------------HL----SNDHICYFLYQILRGLKYIHS--A--------N---VLHRDLKPSNLL--LN----T--------TCDL-------------------KICDFGLARVAD------------------PDHDHTGFL--------------TE---YVATRWYRAPEI--ML----------NSKG----YTKSIDIWSVGCILAEMLS-NR----------PI---------------FPGK---------HYLDQ-LNHI-LGILG----SP-SQEDLNCIINLKARNYLLSLPHKN-----------------------------------------------KVPWNRLFPNADSKALD-LLDKMLTFNPHKRIE-------VE-QALAHPYL--------------------------------------------------------
--------------------------------YRDLQPVGSGAYGAVCSAVD---G-------RTGA---KVAIKKL---YRP--F-QSE---LF-----A-K-RAYR-------------------------ELRLLKHM--R------HEN-----VIGLLDVFT--PDET-----------------------LDDFTD------FYLVMPFMGT----DLG-KLMK----------HE-------------------------KL----GEDRIQFLVYQMLKGLRYIHA--A--------G---IIHRDLKPGNLA--VN----E--------DCEL-------------------KILDFGLAR------------------------QADSEM--------------TG---YVVTRWYRAPEV--IL----------NWMR----YTQTVDIWSVGCIMAEMIT-GK----------TL---------------FKGS---------DHLDQ-LKEI-MKVTG----TP-PAEFVQRLQSDEAKNYMKGLPELE-----------------------------------------------KKDFASILTNASPLAVN-LLEKMLVLDAEQRVT-------AG-EALAHPYF--------------------------------------------------------
----------------------------YVSP----THVGSGAYGSVCSAID---K-------RSGE---KVAIKKL---SRP--F-QSE---IF-----A-K-RAYR-------------------------ELLLLKHM--Q------HEN-----VIGLLDVFT--PASS-----------------------LRNFYD------FYLVMPFMQT----DLQ-KIM-----------GM-------------------------EF----SEEKIQYLVYQMLKGLKYIHS--A--------G---VVHRDLKPGNLA--VN----E--------DCEL-------------------KILDFGLAR------------------------HADAEM--------------TG---YVVTRWYRAPEV--IL----------SWMH----YNQTVDIWSVGCIMAEMLT-GK----------TL---------------FKGK---------DYLDQ-LTQI-LKVTG----VP-GTEFVQKLNDKAAKSYIQSLPQTP-----------------------------------------------RKDFTQLFPRASPQAAD-LLEKMLELDVDKRLT-------AA-QALTHPFF--------------------------------------------------------
--------------------------------YQNLSPVGSGAYGSVCAAFD---T-------KTGL---RVAVKKL---SRP--F-QSI---IH-----A-K-RTYR-------------------------ELRLLKHM--K------HEN-----VIGLLDVFT--PARS-----------------------LEEFND------VYLVTHLMGA----DLN-NIVK----------CQ-------------------------KL----TDDHVQFLIYQILRGLKYIHS--A--------D---IIHRDLKPSNLA--VN----E--------DCEL-------------------KILDFGLAR------------------------HTDDEM--------------TG---YVATRWYRAPEI--ML----------NWMH----YNQTVDIWSVGCIMAELLT-GR----------TL---------------FPGT---------DHIDQ-LKLI-LRLVG----TP-GAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-------AA-QALAHAYF--------------------------------------------------------
------------------------------YM--DLKPLGCGGNGLVFSAVD---N-------DCDK---RVAIKKI---VLT--D-PQS---VK-----H----ALR-------------------------EIKIIRRL--D------HDN-----IVKVFEILG--PSGSQLTD---------------DVGSLTELNS------VYIVQEYMET----DLA-NVLE----------QG-------------------------PL----LEEHARLFMYQLLRGLKYIHS--A--------N---VLHRDLKPANLF--IN---TE--------DLVL-------------------KIGDFGLARIMD------------------PHYSHKGHL--------------SE---GLVTKWYRSPRL--LL----------SPNN----YTKAIDMWAAGCIFAEMLT-GK----------TL---------------FAGA---------HELEQ-MQLI-LESIP----VV-HEEDRQELLSVIPVYIRNDMTEP------------------------------------------------HKPLTQLLPGISREALD-FLEQILTFSPMDRLT-------AE-EALSHPYM--------------------------------------------------------
-----------------------------KVT---SQVLGLGINGKVLQIFN---K-------RTQE---KFALKML---QDC--P-KAR-----------------R-------------------------EVELHWRA-SQ------CPH-----IVRIVDVYE--NLY-------------------------AGRKC------LLIVMECLDGG---ELF-SRIQD-------RGDQ-------------------------AF----TEREASEIMKSIGEAIQYLHS--I--------N---IAHRDVKPENLL--YT----S--------KRPNA----------------ILKLTDFGFAKE----------------------TTSHNSL--------------TT---PCYTPYYVAPEV--LG-----------PEK----YDKSCDMWSLGVIMYILLC-GY----------PP---------------FYSN--------HGLAIS-PGMK-TRIRM----GQ-YEFPNPEWSEVS-----------------------------------------------------------------------EEVKM-LIRNLLKTEPTQRMT-------IT-EFMNHPWI--------------------------------------------------------
--------------------------------LTLGAQIGEGEFGAVLQGEY---L---------GQ---KVAVKNI---K-C--D-VT----AQ-------A-FL-D-------------------------ETAVMTKM--Q------HEN-----LVRLLGVIL--------------------------------HQG------LYIVMEHVSKG---NLV-NFLR----------TR----------------------GRALV----NTAQLLQFSLHVAEGMEYLES--K--------K---LVHRDLAARNIL--VS----E--------DLVA-------------------KVSDFGLAKAE---------------------------R--------------KGLDSSRLPVKWTAPEA--LK-----------HGK----FTSKSDVWSFGVLLWEVFSYGR----------AP---------------YPKM---------SLKEV-SEAV-EKGYR----ME-PPEGCP-----------------------------------------------------------------------------GPVHV-LMSSCWEAEPARRPP-------FR-KLAEKL----------------------------------------------------------
--------------------------------VHFNEVIGRGHFGCVYHGTL---L----DNDGKKI---HCAVKSL---N-R--I-TD----IGE---VS-Q-FL-T-------------------------EGIIMKDF--S------HPN-----VLSLLGICL-RS-----------------------------EGS------PLVVLPYMKHG---DLR-NFIR----------NE-----------------------THNP----TVKDLIGFGLQVAKGMKYLAS--K--------K---FVHRDLAARNCM--LD----E--------KFTV-------------------KVADFGLARDM-----------Y---------D--KEYYS------------VHNKTGAKLPVKWMALES--LQ-----------TQK----FTTKSDVWSFGVLLWELMTRGA----------PP---------------YPDV---------NTFDI-TVYL-LQGRR----LL-QPEYCP-----------------------------------------------------------------------------DPLYE-VMLKCWHPKAEMRPS-------FS-ELVSR--I--------------------------------------------------------
--------------------------------FELVEVVGNGTYGQVYKGRH---V-------KTGQ---LAAIKVM---DVT--E-DEE---EE-----I-K-Q----------------------------EINMLKKY-SH------HRN-----IATYYGAFI--KKSP-----------------------PGNDDQ------LWLVMEFCGAG---SVT-DLVKN-------TKGN-------------------------AL----KEDCIAYICREILRGLAHLHA--H--------K---VIHRDIKGQNVL--LT----E--------NAEV-------------------KLVDFGVSAQL---------------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD------ENPDAT----YDYRSDIWSLGITAIEMAE-GA----------PP---------------LCDM---------HPMRA-LFLI-PRNPP----PR-LKSKKWS----------------------------------------------------------------------------KKFID-FIDTCLIKTYLSRPP-------TE-QLLKFPFI--------------------------------------------------------
--------------------------------FTKLERIGKGSFGEVFKGID---N-------RTQQ---VVAIKII---DLE--E-AED---EI-----E-D-IQ-Q-------------------------EITVLSQC--D------SSY-----VTKYYGSYL--K-----------------------------GSK------LWIIMEYLGGG---SAL-DLLR----------AG-------------------------PF----DEFQIATMLKEILKGLDYLHS--E--------K---KIHRDIKAANVL--LS----E--------QGDV-------------------KLADFGVAGQL---------------------TDTQIKR--------------NT---FVGTPFWMAPEV--IQ-----------QSA----YDSKADIWSLGITAIELAK-GE----------PP---------------NSDM---------HPMRV-LFLI-PKNNP----PT-LVGDFT-----------------------------------------------------------------------------KSFKE-FIDACLNKDPSFRPT-------AK-ELLKHKFI--------------------------------------------------------
-------------------------------I-EYVRDIGEGAFGRVFQARA---PG--LLPYEPFT---MVAVKML---K-E--E-AS----ADM---QA-D-FQ-R-------------------------EAALMAEF--D------NPN-----IVKLLGVCA--V-----------------------------GKP------MCLLFEYMAYG---DLN-EFLR----------SMSPHTVCSLSHSDLSMRAQVSSPGPPPL----SCAEQLCIARQVAAGMAYLSE--R--------K---FVHRDLATRNCL--VG----E--------NMVV-------------------KIADFGLSRNI-----------Y---------S--ADYY--------------KANENDAIPIRWMPPES--IF-----------YNR----YTTESDVWAYGVVLWEIFSYGL----------QP---------------YYGM---------AHEEV-IYYV-RDGNI----LS-CPENCP-----------------------------------------------------------------------------VELYN-LMRLCWSKLPADRPS-------FT-SIHRIL----------------------------------------------------------
--------------------------------WEITETIGKGTYGKVFKVLN---K-------KNGQ---KAAVKIL---DPI--H-DID---EE-----I-E-A----------------------------EYNILKAL-SD------HPN-----VVRFYGIYF--KKD------------------------KVNGDK------LWLVLELCSGG---SVT-DLVKGF-----LKRGE-------------------------RM----SEPLIAYILHEALMGLQHLHN--N--------K---TIHRDVKGNNIL--LT----T--------EGGV-------------------KLVDFGVSAQL---------------------TSTRHRR--------------NT---SVGTPFWMAPEV--IACE------QQLDTT----YDARCDTWSLGITAIELGD-GD----------PP---------------LADL---------HPMRA-LFKI-PRNPP----PK-LRQPELWS---------------------------------------------------------------------------AEFND-FISKCLTKDYEKRPT-------VS-ELLQHKFI--------------------------------------------------------
--------------------------------WEIIETIGKGTYGKVYKVTN---K-------RDGS---LAAVKIL---DPV--S-DMD---EE-----I-E-A----------------------------EYNILQFL-PN------HPN-----VVKFYGMFY--KAD------------------------HCVGGQ------LWLVLELCNGG---SVT-ELVKGL-----LRCGQ-------------------------RL----DEAMISYILYGALLGLQHLHN--N--------R---IIHRDVKGNNIL--LT----T--------EGGV-------------------KLVDFGVSAQL---------------------TSTRLRR--------------NT---SVGTPFWMAPEV--IACE------QQYDSS----YDARCDVWSLGITAIELGD-GD----------PP---------------LFDM---------HPVKT-LFKI-PRNPP----PT-LLHPEKWC---------------------------------------------------------------------------EEFNH-FISQCLIKDFERRPS-------VT-HLLDHPFI--------------------------------------------------------
-----------------------------IEP---DRPIGYGAFGVVWSVTD---P-------RDGK---RVALKKM---PNV--F-QNL---VS-----C-K-RVFR-------------------------ELKMLCFF--K------HDN-----VLSALDILQ--PPH------------------------IDYFEE------IYVVTELMQS----DLH-KIIV---------SPQ-------------------------PL----SSDHVKVFLYQILRGLKYLHS--A--------G---ILHRDIKPGNLL--VN----S--------NCVL-------------------KICDFGLARVE--------------------ELDESRHM--------------TQ---EVVTQYYRAPEI--LM----------GSRH----YSNAIDIWSVGCIFAELLG-RR----------IL---------------FQAQ---------SPIQQ-LDLI-TDLLG----TP-SLEAMRTACEGAKAHILRGPHKQP----------------------------------------------SLPVLYTLSSQATHEAVH-LLCRMLVFDPSKRIS-------AK-DALAHPYL--------------------------------------------------------
------------------------------IV--LKWELGEGAFGKVFLAEC---HN--LLPEQDKM---LVAVKAL---K-E--A-SE----SA----RQ-D-FQ-R-------------------------EAELLTML--Q------HQH-----IVRFFGVCT--E-----------------------------GRP------LLMVFEYMRHG---DLN-RFLR----------SHGPDAKL---------LAGGEDVAPGPL----GLGQLLAVASQVAAGMVYLAG--L--------H---FVHRDLATRNCL--VG----Q--------GLVV-------------------KIGDFGMSRDI-----------Y---------S--TDYY--------------RVGGRTMLPIRWMPPES--IL-----------YRK----FTTESDVWSFGVVLWEIFTYGK----------QP---------------WYQL---------SNTEA-IDCI-TQGRE----LE-RPRACP-----------------------------------------------------------------------------PEVYA-IMRGCWQREPQQRHS-------IK-DVHARL----------------------------------------------------------
-------------------------------I-VLKRELGEGAFGKVFLAEC---YN--LCPEQDKI---LVAVKTL---K-D--A-SD----NA----RK-D-FH-R-------------------------EAELLTNL--Q------HEH-----IVKFYGVCV--E-----------------------------GDP------LIMVFEYMKHG---DLN-KFLR----------AHGPDAV-----------LMAEGNPPTEL----TQSQMLHIAQQIAAGMVYLAS--Q--------H---FVHRDLATRNCL--VG----E--------NLLV-------------------KIGDFGMSRDV-----------Y---------S--TDYY--------------RVGGHTMLPIRWMPPES--IM-----------YRK----FTTESDVWSLGVVLWEIFTYGK----------QP---------------WYQL---------SNNEV-IECI-TQGRV----LQ-RPRTCP-----------------------------------------------------------------------------QEVYE-LMLGCWQREPHMRKN-------IK-GIHTL--L--------------------------------------------------------
-------------------------------I-VLKRELGEGAFGKVFLAEC---YN--LSPTKDKM---LVAVKAL---K-D--P-TL----AA----RK-D-FQ-R-------------------------EAELLTNL--Q------HEH-----IVKFYGVCG--D-----------------------------GDP------LIMVFEYMKHG---DLN-KFLR----------AHGPDAMIL--------VDGQPRQAKGEL----GLSQMLHIASQIASGMVYLAS--Q--------H---FVHRDLATRNCL--VG----A--------NLLV-------------------KIGDFGMSRDV-----------Y---------S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM-----------YRK----FTTESDVWSFGVILWEIFTYGK----------QP---------------WFQL---------SNTEV-IECI-TQGRV----LE-RPRVCP-----------------------------------------------------------------------------KEVYD-VMLGCWQREPQQRLN-------IK-EIYKIL----------------------------------------------------------
--------------------------------YTRFEKIGQGASGTVYTAMD---V-------ATGQ---EVAIKQM---NLQ--Q-QPK---KE-----L-I-I--N-------------------------EILVMREN--K------NPN-----IVNYLDSYL--V-----------------------------GDE------LWVVMEYLAGG---SLT-DVVT----------ET-------------------------CM----DEGQIAAVCRECLQALEFLHS--N--------Q---VIHRDIKSDNIL--LG----M--------DGSV-------------------KLTDFGFCAQI---------------------TPEQSKR--------------ST---MVGTPYWMAPEV--VT-----------RKA----YGPKVDIWSLGIMAIEMIE-GE----------PP---------------YLNE---------NPLRA-LYLI-ATNGT----PE-LQNPEKLS---------------------------------------------------------------------------AIFRD-FLNRCLEMDVEKRGS-------AK-ELLQHQFL--------------------------------------------------------
--------------------------------YTRYEKIGQGASGTVFTATD---V-------ALGQ---EVAIKQI---NLQ--K-QPK---KE-----L-I-I--N-------------------------EILVMKEL--K------NPN-----IVNFLDSYL--V-----------------------------GDE------LFVVMEYLAGG---SLT-DVVT----------ET-------------------------CM----DEAQIAAVCRECLQALEFLHA--N--------Q---VIHRDIKSDNVL--LG----M--------EGSV-------------------KLTDFGFCAQI---------------------TPEQSKR--------------ST---MVGTPYWMAPEV--VT-----------RKA----YGPKVDIWSLGIMAIEMVE-GE----------PP---------------YLNE---------NPLRA-LYLI-ATNGT----PE-LQNPEKLS---------------------------------------------------------------------------PIFRD-FLNRCLEMDVEKRGS-------AK-ELLQHPFL--------------------------------------------------------
--------------------------------YTRFEKIGQGASGTVYTALD---I-------ATGQ---EVAIKQM---NLQ--Q-QPK---KE-----L-I-I--N-------------------------EILVMREN--K------NPN-----IVNYLDSYL--V-----------------------------GDE------LWVVMEYLAGG---SLT-DVVT----------ET-------------------------CM----DEGQIAAVCRECLQALDFLHS--N--------Q---VIHRDIKSDNIL--LG----M--------DGSV-------------------KLTDFGFCAQI---------------------TPEQSKR--------------ST---MVGTPYWMAPEV--VT-----------RKA----YGPKVDIWSLGIMAIEMVE-GE----------PP---------------YLNE---------NPLRA-LYLI-ATNGT----PE-LQNPERLS---------------------------------------------------------------------------AVFRD-FLNRCLEMDVDRRGS-------AK-ELLQHPFL--------------------------------------------------------
----------------------------ANFI-----KIGEGSTGIVCIATE---K-------HTGK---QVAVKKM---DLR--K-QQR---RE-----L----LFN-------------------------EVVIMRDY--H------HDN-----VVDMYSSYL--V-----------------------------GDE------LWVVMEFLEGG---ALT-DIVT----------HT-------------------------RM----NEEQIATVCLSVLRALSYLHN--Q--------G---VIHRDIKSDSIL--LT----S--------DGRI-------------------KLSDFGFCAQV---------------------SKEVPKR--------------KS---LVGTPYWMAPEV--IS-----------RLP----YGTEVDIWSLGIMVIEMID-GE----------PP---------------YFNE---------PPLQA-MRRI-RDSLP----PR-VKDLHK----VS-----------------------------------------------------------------------SVLRG-FLDLMLVREPSQRAT-------AQ-ELLGHPFL--------------------------------------------------------
-------------------------------Y-IKLDKLGEGTYATVYKGKS---K-------LTDN---LVALKEI---RLE--H-EEG---AP-----C---TAIR-------------------------EVSLLKDL--K------HAN-----IVTLHDIIH--T-----------------------------EKS------LTLVFEYLDK----DLK-QYLD--------DCGN-------------------------II----NMHNVKLFLFQLLRGLAYCHR--Q--------K---VLHRDLKPQNLL--IN----E--------RGEL-------------------KLADFGLARAK---------------------SIPTKTY--------------SN---EVVTLWYRPPDI--LL----------GSTD----YSTQIDMWGVGCIFYEMAT-GR----------PL---------------FPGS---------TVEEQ-LHFI-FRILG----TP-TEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGAD-LLTKLLQFEGRNRIS-------AE-DAMKHPFF--------------------------------------------------------
-------------------------------Y-IKLEKLGEGTYATVYKGRS---K-------LTEN---LVALKEI---RLE--H-EEG---AP-----C---TAIR-------------------------EVSLLKDL--K------HAN-----IVTLHDIVH--T-----------------------------DKS------LTLVFEYLDK----DLK-QYMD--------DCGN-------------------------IM----SMHNVKLFLYQILRGLAYCHR--R--------K---VLHRDLKPQNLL--IN----E--------KGEL-------------------KLADFGLARAK---------------------SVPTKTY--------------SN---EVVTLWYRPPDV--LL----------GSSE----YSTQIDMWGVGCIFFEMAS-GR----------PL---------------FPGS---------TVEDE-LHLI-FRLLG----TP-SQETWPGISSNEEFKNYNFPKYK------------------------------------------------PQPLINHAPRLDSEGIE-LITKFLQYESKKRVS-------AE-EAMKHVYF--------------------------------------------------------
--------------------------------YVKLDKLGEGTYATVFKGRS---K-------LTEN---LVALKEI---RLE--H-EEG---AP-----C---TAIR-------------------------EVSLLKNL--K------HAN-----IVTLHDLIH--T-----------------------------DRS------LTLVFEYLDS----DLK-QYLD---------HCG-------------------------NL---MSMHNVKIFMFQLLRGLAYCHH--R--------K---ILHRDLKPQNLL--IN----E--------RGEL-------------------KLADFGLARAK---------------------SVPTKTY--------------SN---EVVTLWYRPPDV--LL----------GSTE----YSTPIDMWGVGCIHYEMAT-GR----------PL---------------FPGS---------TVKEE-LHLI-FRLLG----TP-TEETWPGVTAFSEFRTYSFPCYL------------------------------------------------PQPLINHAPRLDTDGIH-LLSSLLLYESKSRMS-------AE-AALSHSYF--------------------------------------------------------
-------------------------------F-KFGKILGEGSFSTVVLARE---L-------ATSR---EYAIKIL---EKR--H-IIK---EN-----K-VPYVTR-------------------------ERDVMSRL--D------HPF-----FVKLYFTFQ--D-----------------------------DEK------LYFGLSYAKNG---ELL-KYIR---------KIG-------------------------SF----DETCTRFYTAEIVSALEYLHG--K--------G---IIHRDLKPENIL--LN----E--------DMHI-------------------QITDFGTAKVLS-------------------PESKQARA--------------NS---FVGTAQYVSPEL--LT-----------EKS----ACKSSDLWALGCIIYQLVA-GL----------PP---------------FRAG------------NE-YLIF-QKIIK----LE-YDFPEKFF---------------------------------------------------------------------------PKARD-LVEKLLVLDATKRLG-------CE-EM------EGYGPLKAHPF---------------------------------------------
--------------------------------YEKLEKLGEGSYATVYKGKS---K-------VNGK---LVALKVI---RLQ--E-EEG---TP-----F---TAIR-------------------------EASLLKGL--K------HAN-----IVLLHDIIH--T-----------------------------KET------LTLVFEYVHT----DLC-QYMD--------KHPG-------------------------GL----HPDNVKLFLFQLLRGLSYIHQ--R--------Y---ILHRDLKPQNLL--IS----D--------TGEL-------------------KLADFGLARAK---------------------SVPSHTY--------------SN---EVVTLWYRPPDV--LL----------GSTE----YSTCLDMWGVGCIFVEMIQ-GV----------AA---------------FPGM--------KDIQDQ-LERI-FLVLG----TP-NEDTWPGVHSLPHFKPERFTLYSS----------------------------------------------KNLRQAWNKLSYVNHAED-LASKLLQCSPKNRLS-------AQ-AALSHEYF--------------------------------------------------------
--------------------------------YEPKEILGRGVSSVVRRCIH---K-------PTSQ---EYAVKVI---DVT--G-GGS---FS-----P-E-EVRELRE------------------ATLKEVDILRKV-SG------HPN-----IIQLKDTYE--T-----------------------------NTF------FFLVFDLMKRG---ELF-DYLT---------EKV-------------------------TL----SEKETRKIMRALLEVICTLHK--L--------N---IVHRDLKPENIL--LD----D--------NMNI-------------------KLTDFGFSCQ----------------------LEPGERL--------------RE---VCGTPSYLAPEI--IECS-----MNEDHPG----YGKEVDMWSTGVIMYTLLA-GS----------PP---------------FWHR------------KQ-MLML-RMIMS----GN-YQFGSPEWDDYS-----------------------------------------------------------------------DTVKD-LVSRFLVVQPQNRYT-------AE-EALAHPFF--------------------------------------------------------
-----------------------------YDP---KDVIGRGVSSVVRRCVH---R-------ATGH---EFAVKIM---EVT--A-ERL---SP-----E-Q-LEEVREA-------------------TRRETHILRQV-AG------HPH-----IITLIDSYE--S-----------------------------SSF------MFLVFDLMRKG---ELF-DYLT---------EKV-------------------------AL----SEKETRSIMRSLLEAVSFLHA--N--------N---IVHRDLKPENIL--LD----D--------NMQI-------------------RLSDFGFSCH----------------------LEPGEKL--------------RE---LCGTPGYLAPEI--LKCS-----MDETHPG----YGKEVDLWACGVILFTLLA-GS----------PP---------------FWHR------------RQ-ILML-RMIME----GQ-YQFSSPEWDDRS-----------------------------------------------------------------------STVKD-LISRLLQVDPEARLT-------AE-QALQHPFF--------------------------------------------------------
--------------------------------YQVGPLLGSGGFGSVYSGIR---V-------SDNL---PVAIKHV---EKD--R-ISD---WG-----E-L-PNGTRV---------------------PMEVVLLKKV--S------SGFS---GVIRLLDWFE--R-----------------------------PDS------FVLILERPEPV--QDLF-DFIT---------ERG-------------------------AL----QEELARSFFWQVLEAVRHCHN--C--------G---VLHRDIKDENIL--ID---LN--------RGEL-------------------KLIDFGSGA-----------------------LLKDTVY--------------TD---FDGTRVYSPPEW--IR----------YHRY----HGRSAAVWSLGILLYDMVC-GD----------IP---------------FEHD--------------------EEIIR----GQ-VFFRQRVS---------------------------------------------------------------------------SECQH-LIRWCLALRPSDRPT-------FE-EIQNHPWM--------------------------------------------------------
-------------------------------F-KFLAVLGRGHFGKVLLSEF---R-------PSGE---LFAIKAL---KKG--D-IVA---RD-----E-V-ESLM------------------------CEKRILAAV--TS---AGHPF-----LVNLFGCFQ--T-----------------------------PEH------VCFVMEYSAGG---DLM-LHIH----------SD-------------------------VF----SEPRAIFYSACVVLGLQFLHE--H--------K---IVYRDLKLDNLL--LD----T--------EGYV-------------------KIADFGLCKEG---------------------MGYGDRT--------------ST---FCGTPEFLAPEV--LT-----------DTS----YTRAVDWWGLGVLLYEMLV-GE----------SP---------------FPGD------------DE-EEVF-DSIVN----DE-VRYPRFLS---------------------------------------------------------------------------AEAIG-IMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF--------------------------------------------------------
------------------------------FR--CCAVLGRGHFGKVLLAEY---K-------NTNE---MFAIKAL---KKG--D-IVA---RD-----E-V-DSLM------------------------CEKRIFETV--NS---VRHPF-----LVNLFACFQ--T-----------------------------KEH------VCFVMEYAAGG---DLM-MHIH----------TD-------------------------VF----SEPRAVFYAACVVLGLQYLHE--H--------K---IVYRDLKLDNLL--LD----T--------EGFV-------------------KIADFGLCKEG---------------------MGYGDRT--------------ST---FCGTPEFLAPEV--LT-----------ETS----YTRAVDWWGLGVLIYEMLV-GE----------SP---------------FPGD------------DE-EEVF-DSIVN----DE-VRYPRFLS---------------------------------------------------------------------------TEAIS-IMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF--------------------------------------------------------
------------------------------YV--RGRFLGKGGFAKCFEISD---A-------DTKE---VFAGKIV---PKS--L-LLK---PH-----Q-R-EKMS------------------------MEISIHRSL--A------HQH-----VVGFHGFFE--D-----------------------------NDF------VFVVLELCRRR---SLL-ELHK---------RRK-------------------------AL----TEPEARYYLRQIVLGCQYLHR--N--------R---VIHRDLKLGNLF--LN----E--------DLEV-------------------KIGDFGLATKV---------------------EYDGERK--------------KT---LCGTPNYIAPEV--LS-----------KKG----HSFEVDVWSIGCIMYTLLV-GK----------PP---------------FETS------------CL-KETY-LRIKK----NE-YSIPKHIN---------------------------------------------------------------------------PVAAS-LIQKMLQTDPTARPT-------IN-ELLNDEFF--------------------------------------------------------
-------------------------------Y-CRGKVLGKGGFAKCYEMTD---L-------TNNK---VYAAKII---PHS--R-VAK---PH-----Q-R-EKID------------------------KEIELHRIL--H------HKH-----VVQFYHYFE--D-----------------------------KEN------IYILLEYCSRR---SMA-HILK---------ARK-------------------------VL----TEPEVRYYLRQIVSGLKYLHE--Q--------E---ILHRDLKLGNFF--IN----E--------AMEL-------------------KVGDFGLAARL---------------------EPLEHRR--------------RT---ICGTPNYLSPEV--LN-----------KQG----HGCESDIWALGCVMYTMLL-GR----------PP---------------FETT------------NL-KETY-RCIRE----AR-YTMPSSLL---------------------------------------------------------------------------APAKH-LIASMLSKNPEDRPS-------LD-DIIRHDFF--------------------------------------------------------
------------------------------YL--KGRLLGKGGFARCYEATD---T-------ETGS---AYAVKVI---PQS--R-VAK---PH-----Q-R-EKIL------------------------NEIELHRDL--Q------HRH-----IVRFSHHFE--D-----------------------------ADN------IYIFLELCSRK---SLA-HIWK---------ARH-------------------------TL----LEPEVRYYLRQILSGLKYLHQ--R--------G---ILHRDLKLGNFF--IT----E--------NMEL-------------------KVGDFGLAARL---------------------EPPEQRK--------------KT---ICGTPNYVAPEV--LL-----------RQG----HGPEADVWSLGCVMYTLLC-GS----------PP---------------FETA------------DL-KETY-RCIKQ----VH-YTLPASLS---------------------------------------------------------------------------LPARQ-LLAAILRASPRDRPS-------ID-QILRHDFF--------------------------------------------------------
-------------------------------F-NFLMVLGKGSFGKVMLADR---K-------GTEE---LYAIKIL---KKD--V-VIQ---DD-----D-V-ECTM------------------------VEKRVLALL-DK------PPF-----LTQLHSCFQ--T-----------------------------VDR------LYFVMEYVNGG---DLM-YHIQ---------QVG-------------------------KF----KEPQAVFYAAEISIGLFFLHK--R--------G---IIYRDLKLDNVM--LD----S--------EGHI-------------------KIADFGMCKEH---------------------MMDGVTT--------------RT---FCGTPDYIAPEI--IA-----------YQP----YGKSVDWWAYGVLLYEMLA-GQ----------PP---------------FDGE------------DE-DELF-QSIME----HN-VSYPKSLS---------------------------------------------------------------------------KEAVS-VCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF------------------------------------------
------------------------------FI--FHKVLGKGSFGKVLLGEL---K-------GRGE---YFAIKAL---KKD--V-VLI---DD-----D-V-ECTM------------------------VEKRVLTLA-AE------NPF-----LTHLICTFQ--T-----------------------------KDH------LFFVMEFLNGG---DLM-YHIQ---------DKG-------------------------RF----ELYRATFYAAEIMCGLQFLHS--K--------G---IIYRDLKLDNVL--LD----R--------DGHI-------------------KIADFGMCKEN---------------------IFGESRA--------------ST---FCGTPDYIAPEI--LQ-----------GLK----YTFSVDWWSFGVLLYEMLI-GQ----------SP---------------FHGD------------DE-DELF-ESIRV----DT-PHYPRWIT---------------------------------------------------------------------------KESKD-ILEKLFEREPTKRLG------VTG-NIKIHPFF--------------------------------------------------------
-------------------------------F-NFIKVLGKGSFGKVMLAEL---K-------GKDE---VYAVKVL---KKD--V-ILQ---DD-----D-V-DCTM------------------------TEKRILALA-RK------HPY-----LTQLYCCFQ--T-----------------------------KDR------LFFVMEYVNGG---DLM-FQIQ---------RSR-------------------------KF----DEPRSRFYAAEVTSALMFLHQ--H--------G---VIYRDLKLDNIL--LD----A--------EGHC-------------------KLADFGMCKEG---------------------ILNGVTT--------------TT---FCGTPDYIAPEI--LQ-----------ELE----YGPSVDWWALGVLMYEMMA-GQ----------PP---------------FEAD------------NE-DDLF-ESILH----DD-VLYPVWLS---------------------------------------------------------------------------KEAVS-ILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------------------------------------------------
-------------------------------F-DLLRVIGRGSYAKVLLVRL---K-------KTDR---IYAMKVV---KKE--L-VND---DE-----D-I-DWVQ------------------------TEKHVFEQA-SN------HPF-----LVGLHSCFQ--T-----------------------------ESR------LFFVIEYVNGG---DLM-FHMQ---------RQR-------------------------KL----PEEHARFYSAEISLALNYLHE--R--------G---IIYRDLKLDNVL--LD----S--------EGHI-------------------KLTDYGMCKEG---------------------LRPGDTT--------------ST---FCGTPNYIAPEI--LR-----------GED----YGFSVDWWALGVLMFEMMA-GR----------SP---------------FDIVGSS---DNPDQNTE-DYLF-QVILE----KQ-IRIPRSLS---------------------------------------------------------------------------VKAAS-VLKSFLNKDPKERLGCHP-QTGFA-DIQGHPF-F-------------------------------------------------------
------------------------------FI--LHKMLGKGSFGKVFLAEF---K-------KTNQ---FFAIKAL---KKD--V-VLM---DD-----D-V-ECTM------------------------VEKRVLSLA-WE------HPF-----LTHMFCTFQ--T-----------------------------KEN------LFFVMEYLNGG---DLM-YHIQ---------SCH-------------------------KF----DLSRATFYAAEIILGLQFLHS--K--------G---IVYRDLKLDNIL--LD----K--------DGHI-------------------KIADFGMCKEN---------------------MLGDAKT--------------NT---FCGTPDYIAPEI--LL-----------GQK----YNHSVDWWSFGVLLYEMLI-GQ----------SP---------------FHGQ------------DE-EELF-HSIRM----DN-PFYPRWLE---------------------------------------------------------------------------KEAKD-LLVKLFVREPEKRLG-------VRGDIRQHPLF--------------------------------------------------------
-------------------------------F-DLIRVIGRGSYAKVLLVRL---K-------KNDQ---IYAMKVV---KKE--L-VHD---DE-----D-I-DWVQ------------------------TEKHVFEQA-SS------NPF-----LVGLHSCFQ--T-----------------------------TSR------LFLVIEYVNGG---DLM-FHMQ---------RQR-------------------------KL----PEEHARFYAAEICIALNFLHE--R--------G---IIYRDLKLDNVL--LD----A--------DGHI-------------------KLTDYGMCKEG---------------------LGPGDTT--------------ST---FCGTPNYIAPEI--LR-----------GEE----YGFSVDWWALGVLMFEMMA-GR----------SP---------------FDIITD-----NPDMNTE-DYLF-QVILE----KP-IRIPRFLS---------------------------------------------------------------------------VKASH-VLKGFLNKDPKERLGCRP-QTGF----------SDIKSHAFF-----------------------------------------------
------------------------------PD----EVLGSGQFGIVYGGKH---R-------KTGR---DVAIKII---DKL--R-FPT---KQ-----E-S-QLRN-------------------------EVAILQNL--H------HPG-----VVNLECMFE--T-----------------------------PER------VFVVMEKLHGD---MLE-MILS--------SEKG-------------------------RL----PEHITKFLITQILVALRHLHF--K--------N---IVHCDLKPENVL--LA----S--------ADPFP----------------QVKLCDFGFARI----------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LR-----------NKG----YNRSLDMWSVGVIIYVSLS-GT----------FP---------------FNED---------------EDIH-DQIQN----AA-FMYPPNPWKEIS-----------------------------------------------------------------------HEAID-LINNLLQVKMRKRYS-------VD-KTLSHPWL--------------------------------------------------------
------------------------------PD----EVLGSGQFGVVYGGKH---R-------KTGR---DVAVKVI---DKL--R-FPT---KQ-----E-S-QLRN-------------------------EVAILQSL--R------HPG-----IVNLECMFE--T-----------------------------PEK------VFVVMEKLHGD---MLE-MILS--------SEKG-------------------------RL----PERLTKFLITQILVALRHLHF--K--------N---IVHCDLKPENVL--LA----S--------ADPFP----------------QVKLCDFGFARI----------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LL-----------NQG----YNRSLDMWSVGVIMYVSLS-GT----------FP---------------FNED---------------EDIN-DQIQN----AA-FMYPASPWSHIS-----------------------------------------------------------------------AGAID-LINNLLQVKMRKRYS-------VD-KSLSHPWL--------------------------------------------------------
-----------------------------FAD----EVLGSGQFGIVYGGKH---R-------KTGR---DVAIKVI---DKM--R-FPT---KQ-----E-S-QLRN-------------------------EVAILQNL--H------HPG-----IVNLECMFE--T-----------------------------PER------VFVVMEKLHGD---MLE-MILS--------SEKS-------------------------RL----PERITKFMVTQILVALRNLHF--K--------N---IVHCDLKPENVL--LA----S--------AEPFP----------------QVKLCDFGFARI----------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LR-----------SKG----YNRSLDMWSVGVIIYVSLS-GT----------FP---------------FNED---------------EDIN-DQIQN----AA-FMYPPNPWREIS-----------------------------------------------------------------------GEAID-LINNLLQVKMRKRYS-------VD-KSLSHPWL--------------------------------------------------------
--------------------------------IELGRCIGEGQFGDVHQGIY---M----SPENPAL---AVAIKTC---K-N--C-TS----DSV---RE-K-FL-Q-------------------------EALTMRQF--D------HPH-----IVKLIGVIT--------------------------------ENP------VWIIMELCTLG---ELR-SFLQ----------VR-----------------------KYSL----DLASLILYAYQLSTALAYLES--K--------R---FVHRDIAARNVL--VS----S--------NDCV-------------------KLGDFGLSRYM---------------------E--DSTY--------------YKASKGKLPIKWMAPES--IN-----------FRR----FTSASDVWMFGVCMWEILMHGV----------KP---------------FQGV---------KNNDV-IGRI-ENGER----LP-MPPNCP-----------------------------------------------------------------------------PTLYS-LMTKCWAYDPSRRPR-------FT-ELKAQL----------------------------------------------------------
-------------------------------F-TLCRKLGSGYFGEVFEGLW---K--------DRV---QVAIKVI---S-R--D-NL----LH----QQ-M-LQ-S-------------------------EIQAMKKL--R------HKH-----ILALYAVVS--V-----------------------------GDP------VYIITELMAKG---SLL-ELLR----------DS----------------------DEKVL----PVSELLDIAWQVAEGMCYLES--Q--------N---YIHRDLAARNIL--VG----E--------NTLC-------------------KVGDFGLARLI------------------------KEDV--------------YLSHDHNIPYKWTAPEA--LS-----------RGH----YSTKSDVWSFGILLHEMFSRGQ----------VP---------------YPGM---------SNHEA-FLRV-DAGYR----MP-CPLECP-----------------------------------------------------------------------------PSVHK-LMLTCWCRDPEQRPC-------FK-ALRERL----------------------------------------------------------
------------------------------VM--LSTRIGSGSFGTVYKGKW---H----------G---DVAVKIL---K-V-VD-PT----PEQ---FQ-A-FR-N-------------------------EVAVLRKT--R------HVN-----ILLFMGYMT--------------------------------KDN------LAIVTQWCEGS---SLY-KHLH----------VQ-----------------------ETKF----QMFQLIDIARQTAQGMDYLHA--K--------N---IIHRDMKSNNIF--LH----E--------GLTV-------------------KIGDFGLATVK-----------S---------R--WSGS--------------QQVEQPTGSVLWMAPEV--IR-----------MQDN-NPFSFQSDVYSYGIVLYELMT-GE----------LP---------------YSHI-N-------NRDQI-IFMV-GRGYASPDLSK-LYKNCP-----------------------------------------------------------------------------KAMKR-LVADCVKKVKEERPL-------FP-QILSS--I--------------------------------------------------------
-------------------------------L-VLGKTLGEGEFGKVVKATA---FH--LKGRAGYT---TVAVKML---K-E--N-AS----PSE---LR-D-LL-S-------------------------EFNVLKQV--N------HPH-----VIKLYGACS--Q-----------------------------DGP------LLLIVEYAKYG---SLR-GFLR----------ESRKVGPGYLGSGGSRNSSSLDHPDERAL----TMGDLISFAWQISQGMQYLAE--M--------K---LVHRDLAARNIL--VA----E--------GRKM-------------------KISDFGLSRDV-----------Y---------E--EDSY--------------VKRSQGRIPVKWMAIES--LF-----------DHI----YTTQSDVWSFGVLLWEIVTLGG----------NP---------------YPGI---------PPERL-FNLL-KTGHR----ME-RPDNCS-----------------------------------------------------------------------------EEMYR-LMLQCWKQEPDKRPV-------FA-DISKDL----------------------------------------------------------
------------------------------LT--LRLLLGSGAFGEVYEGTA---VDI-LGVGSGEI---KVAVKTL---K-K--G-ST----DQE---KI-E-FL-K-------------------------EAHLMSKF--N------HPN-----ILKQLGVCL--L-----------------------------NEP------QYIILELMEGG---DLL-TYLR----------KARM-----------------ATFYGPLL----TLVDLVDLCVDISKGCVYLER--M--------H---FIHRDLAARNCL--VS----VKD---YTSPRIV-------------------KIGDFGLARDI-----------Y---------K--NDYY--------------RKRGEGLLPVRWMAPES--LM-----------DGI----FTTQSDVWSFGILIWEILTLGH----------QP---------------YPAH---------SNLDV-LNYV-QTGGR----LE-PPRNCP-----------------------------------------------------------------------------DDLWN-LMTQCWAQEPDQRPT-------FH-RIQDQL----------------------------------------------------------
--------------------------------FELLRVLGKGGYGKVFQVRKVTGA-------NTGK---IFAMKVL---KKA--M-IVR---NA-----K-D-TAHTK-----------------------AERNILEEV--K------HPF-----IVDLIYAFQ--T-----------------------------GGK------LYLILEYLSGG---ELF-MQLE---------REG-------------------------IF----MEDTACFYLAEISMALGHLHQ--K--------G---IIYRDLKPENIM--LN----H--------QGHV-------------------KLTDFGLCKES---------------------IHDGTVT--------------HT---FCGTIEYMAPEI--LM-----------RSG----HNRAVDWWSLGALMYDMLT-GA----------PP---------------FTGE------------NR-KKTI-DKILK----CK-LNLPPYLT---------------------------------------------------------------------------QEARD-LLKKLLKRNAASRLGAG--PGDAG-EVQAHPFF--------------------------------------------------------
--------------------------------FELLRVLGKGGYGKVFQVRK---V-------QGTNLGKIYAMKVL---RKA--K-IVR---NA-----K-D-TAHTR-----------------------AERNILESV--K------HPF-----IVELAYAFQ--T-----------------------------GGK------LYLILECLSGG---ELF-THLE---------REG-------------------------IF----LEDTACFYLAEITLALGHLHS--Q--------G---IIYRDLKPENIM--LS----S--------QGHI-------------------KLTDFGLCKES---------------------IHEGAVT--------------HT---FCGTIEYMAPEI--LV-----------RSG----HNRAVDWWSLGALMYDMLT-GS----------PP---------------FTAE------------NR-KKTM-DKIIR----GK-LALPPYLT---------------------------------------------------------------------------PDARD-LVKKFLKRNPSQRIGGG--PGDAA-DVQRHPFF--------------------------------------------------------
--------------------------------YELVRELGKGTYGKVDLVVY---K-------GTGT---KMALKFV---NKS--K-TKL---KN-----F-----LR-------------------------EVSITNSL-SS------SPF-----IIKVFDVVF--E----------------------------TEDC------YVFAQEYAPAG---DLF-DIIP---------PQV-------------------------GL----PEDTVKRCVQQLGLALDFMHG--R--------Q---LVHRDIKPENVL--LFD--RE--------CRRV-------------------KLADFGMTR------------------------RVGCRV--------------KR---VSGTIPYTAPEV--CQAG------RADGLA----VDTGVDVWAFGVLIFCVLT-GN----------FP---------------WEAA---------SGADAFFEEF-VRWQR----GR-LPGLPSQWRRFT-----------------------------------------------------------------------EPALR-MFQRLLALEPERRGP-------AK-EVF-----RFLKH---------------------------------------------------
--------------------------------WEIIGELGDGAFGKVYKAQN---K-------ETSV---LAAAKVI---DTK--S-EEE---LE-----D-Y-M--V-------------------------EIDILASC--D------HPN-----IVKLLDAFY--Y-----------------------------ENN------LWILIEFCAGG---AVD-AVML--------ELER-------------------------PL----TESQIQVVCKQTLDALNYLHD--N--------K---IIHRDLKAGNIL--FT----L--------DGDI-------------------KLADFGVSAKN---------------------TRTIQRR--------------DS---FIGTPYWMAPEV--VMCE------TSKDRP----YDYKADVWSLGITLIEMAE-IE----------PP---------------HHEL---------NPMRV-LLKI-AKSEP----PT-LAQPSRWS---------------------------------------------------------------------------SNFKD-FLKKCLEKNVDARWT-------TS-QLLQHPFV--------------------------------------------------------
-------------------------------L-RLEVKLGQGCFGEVWMGTW---N--------GTT---RVAIKTL---K-P--G-TM----SP-----E-A-FL-Q-------------------------EAQVMKKL--R------HEK-----LVQLYAVVS--------------------------------EEP------IYIVTEYMSKG---SLL-DFLK----------GE----------------------TGKYL----RLPQLVDMAAQIASGMAYVER--M--------N---YVHRDLRAANIL--VG----E--------NLVC-------------------KVADFGLARLI---------------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL-----------YGR----FTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM---------VNREV-LDQV-ERGYR----MP-CPPECP-----------------------------------------------------------------------------ESLHD-LMCQCWRKEPEERPT-------FE-YLQAF--L--------------------------------------------------------
--------------------------------WEIVGELGDGAFGKVYKAKN---K-------ETGA---LAAAKVI---ETK--S-EEE---LE-----D-Y-I--V-------------------------EIEILATC--D------HPY-----IVKLLGAYY--H-----------------------------DGK------LWIMIEFCPGG---AVD-AIML--------ELDR-------------------------GL----TEPQIQVVCRQMLEALNFLHS--K--------R---IIHRDLKAGNVL--MT----L--------EGDI-------------------RLADFGVSAKN---------------------LKTLQKR--------------DS---FIGTPYWMAPEV--VMCE------TMKDTP----YDYKADIWSLGITLIEMAQ-IE----------PP---------------HHEL---------NPMRV-LLKI-AKSDP----PT-LLTPSKWS---------------------------------------------------------------------------VEFRD-FLKIALDKNPETRPS-------AA-QLLEHPFV--------------------------------------------------------
-----------------------------LCP---GRELGRGKFAVVRKCIK---K-------DSGK---EFAAKFM---RKR--R-KGQ---DC-----R-M-EIIH-------------------------EIAVLELA-QD------NPW-----VINLHEVYE--T-----------------------------ASE------MILVLEYAAGG---EIF-DQCVA-------DREE-------------------------AF----KEKDVQRLMRQILEGVHFLHT--R--------D---VVHLDLKPQNIL--LT----S--------ESPLG----------------DIKIVDFGLSRI----------------------LKNSEEL--------------RE---IMGTPEYVAPEI--LS-----------YDP----ISMATDMWSIGVLTYVMLT-GI----------SP---------------FLGN------------DK-QETF-LNISQ----MN-LSYSEEEFDVLS-----------------------------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-------AE-ECLKHPWL--------------------------------------------------------
-----------------------------ILT---SKELGRGKFAVVRQCIS---K-------STGQ---EYAAKFL---KKR--R-RGQ---DC-----R-A-EILH-------------------------EIAVLELA-KS------CPR-----VINLHEVYE--N-----------------------------TSE------IILILEYAAGG---EIF-SLCLP-------ELAE-------------------------MV----SENDVIRLIKQILEGVYYLHQ--N--------N---IVHLDLKPQNIL--LS----S--------IYPLG----------------DIKIVDFGMSRK----------------------IGHACEL--------------RE---IMGTPEYLAPEI--LN-----------YDP----ITTATDMWNIGIIAYMLLT-HT----------SP---------------FVGE------------DN-QETY-LNISQ----VN-VDYSEETFSSVS-----------------------------------------------------------------------QLATD-FIQSLLVKNPEKRPT-------AE-ICLSHSWL--------------------------------------------------------
--------------------------------FTKLEKIGKGSFGEVFKGID---N-------RTQK---VVAIKII---DLE--E-AED---EI-----E-D-IQ-Q-------------------------EITVLSQC--D------SPY-----VTKYYGSYL--K-----------------------------DTK------LWIIMEYLGGG---SAL-DLLE----------PG-------------------------PL----DETQIATILREILKGLDYLHS--E--------K---KIHRDIKAANVL--LS----E--------HGEV-------------------KLADFGVAGQL---------------------TDTQIKR--------------NT---FVGTPFWMAPEV--IK-----------QSA----YDSKADIWSLGITAIELAR-GE----------PP---------------HSEL---------HPMKV-LFLI-PKNNP----PT-LEGNYS-----------------------------------------------------------------------------KPLKE-FVEACLNKEPSFRPT-------AK-ELLKHKFI--------------------------------------------------------
-------------------------------F-TKLDRIGKGSFGEVYKGID---N-------HTKE---VVAIKII---DLE--E-AED---EI-----E-D-IQ-Q-------------------------EITVLSQC--D------SPY-----ITRYFGSYL--K-----------------------------STK------LWIIMEYLGGG---SAL-DLLK----------PG-------------------------PL----EETYIATILREILKGLDYLHS--E--------R---KIHRDIKAANVL--LS----E--------QGDV-------------------KLADFGVAGQL---------------------TDTQIKR--------------NT---FVGTPFWMAPEV--IK-----------QSA----YDFKADIWSLGITAIELAK-GE----------PP---------------NSDL---------HPMRV-LFLI-PKNSP----PT-LEGQHS-----------------------------------------------------------------------------KPFKE-FVEACLNKDPRFRPT-------AK-ELLKHKFI--------------------------------------------------------
-------------------------------F-DVLEKLGEGSYGSVFKAIH---K-------ESGQ---VVAIKQV---PVE--S-DLQ---EI-----------IK-------------------------EISIMQQC--D------SPY-----VVKYYGSYF--K-----------------------------NTD------LWIVMEYCGAG---SVS-DIIR--------LRNK-------------------------TL----IEDEIATILKSTLKGLEYLHF--M--------R---KIHRDIKAGNIL--LN----T--------EGHA-------------------KLADFGVAGQL---------------------TDTMAKR--------------NT---VIGTPFWMAPEV--IQ-----------EIG----YNCVADIWSLGITSIEMAE-GK----------PP---------------YADI---------HPMRA-IFMI-PTNPP----PT-FRKPELWS---------------------------------------------------------------------------DDFTD-FVKKCLVKNPEQRAT-------AT-QLLQHPFI--------------------------------------------------------
--------------------------------YTFGRILGKGSFGIVIEATD---K-------ETET---KWAIKKV---NKE--K-AGS---SA-----V-K-LLER-------------------------EVNILKSV--K------HEH-----IIHLEQVFE--T-----------------------------PKK------MYLVMELCEDG---ELK-EILD---------RKG-------------------------HF----SENETRWIIQSLASAIAYLHN--N--------D---IVHRDLKLENIM--VK----S--------SLIDDNNE----------INLNIKVTDFGLAVKK--------------------QSRSEAML--------------QA---TCGTPIYMAPEV--IS-----------AHD----YSQQCDIWSIGVVMYMLLR-GE----------PP---------------FLAS------------SE-EKLF-ELIRK----GE-LHFENAVWNSIS-----------------------------------------------------------------------DCAKS-VLKQLMKVDPAHRIT-------AK-ELLDNQWL--------------------------------------------------------
--------------------------------YHVLEMIGEGSFGRVYKGRR---K-------YSAQ---VVALKFI---PKL--G-RSE---KE-----L-R-NLQR-------------------------EIEIMRGL--R------HPN-----IVHMLDSFE--T-----------------------------DKE------VVVVTDYAEG----ELF-QILE---------DDG-------------------------KL----PEDQVQAIAAQLVSALYYLHS--H--------R---ILHRDMKPQNIL--LA----K--------GGGI-------------------KLCDFGFARAM---------------------STNTMVL--------------TS---IKGTPLYMSPEL--VE-----------ERP----YDHTADLWSVGCILYELAV-GT----------PP---------------FYAT------------SI-FQLV-SLILK----DP-VRWPSTIS---------------------------------------------------------------------------PCFKN-FLQGLLTKDPRQRLS-------WP-DLLYHPFI--------------------------------------------------------
-------------------------------F-DVLEKLGEGSYGSVYKAIH---K-------ETGQ---IVAIKQV---PVE--S-DLQ---EI-----------IK-------------------------EISIMQQC--D------SPH-----VVKYYGSYF--K-----------------------------NTD------LWIVMEYCGAG---SVS-DIIR--------LRNK-------------------------TL----TEDEIATILQSTLKGLEYLHF--M--------R---KIHRDIKAGNIL--LN----T--------EGHA-------------------KLADFGVAGQL---------------------TDTMAKR--------------NT---VIGTPFWMAPEV--IQ-----------EIG----YNCVADIWSLGITAIEMAE-GK----------PP---------------YADI---------HPMRA-IFMI-PTNPP----PT-FRKPELWS---------------------------------------------------------------------------DNFTD-FVKQCLVKSPEQRAT-------AT-QLLQHPFV--------------------------------------------------------
-----------------------------TLE---DKELGSGNFGTVKKGYY---Q-----MKKVVK---TVAVKIL---K-N--E-AN----DPA--LKD-E-LL-A-------------------------EANVMQQL--D------NPY-----IVRMIGICE--------------------------------AES------WMLVMEMAELG---PLN-KYLQ----------QN------------------------RHV----KDKNIIELVHQVSMGMKYLEE--S--------N---FVHRDLAARNVL--LV----T--------QHYA-------------------KISDFGLSKAL-----------R---------A--DENY-------------YKAQTHGKWPVKWYAPEC--IN-----------YYK----FSSKSDVWSFGVLMWEAFSYGQ----------KP---------------YRGM---------KGSEV-TAML-EKGER----MG-CPAGCP-----------------------------------------------------------------------------REMYD-LMNLCWTYDVENRPG-------FA-AVE----LRL------------------------------------------------------
-------------------------------F-TDLREIGHGSFGAVYFARD---V-------RTNE---VVAIKKM---SYS--G-KQS---TE-----K-W-QDII------------------------KEVKFLQRI--K------HPN-----SIEYKGCYL--R-----------------------------EHT------AWLVMEYCLG----SAS-DLLE--------VHKK-------------------------PL----QEVEIAAITHGALQGLAYLHS--H--------T---MIHRDIKAGNIL--LT----E--------PGQV-------------------KLADFGSASM-------------------------ASPA--------------NS---FVGTPYWMAPEV--ILA--------MDEGQ----YDGKVDVWSLGITCIELAE-RK----------PP---------------LFNM---------NAMSA-LYHI-AQNES----PT-LQSNEWS----------------------------------------------------------------------------DYFRN-FVDSCLQKIPQDRPT-------SE-ELLKHIF-V-------------------------------------------------------
------------------------------FS--DLREIGHGSFGAVYFARD---V-------RNSE---VVAIKKM---SYS--G-KQS---NE-----K-W-QDII------------------------KEVRFLQKL--R------HPN-----TIQYRGCYL--R-----------------------------EHT------AWLVMEYCLG----SAS-DLLE--------VHKK-------------------------PL----QEVEIAAVTHGALQGLAYLHS--H--------N---MIHRDVKAGNIL--LS----E--------PGLV-------------------KLGDFGSASI-------------------------MAPA--------------NS---FVGTPYWMAPEV--ILA--------MDEGQ----YDGKVDVWSLGITCIELAE-RK----------PP---------------LFNM---------NAMSA-LYHI-AQNES----PV-LQSGHWS----------------------------------------------------------------------------EYFRN-FVDSCLQKIPQDRPT-------SE-VLLKHRFV--------------------------------------------------------
----------------------------FIGL----HEIGHGSFGAVYFATN---A-------HTSE---VVAIKKM---SYS--G-KQT---HE-----K-W-QDIL------------------------KEVKFLRQL--K------HPN-----TIEYKGCYL--K-----------------------------EHT------AWLVMEYCLG----SAS-DLLE--------VHKK-------------------------PL----QEVEIAAITHGALHGLAYLHS--H--------A---LIHRDIKAGNIL--LT----E--------PGQV-------------------KLADFGSASM-------------------------ASPA--------------NS---FVGTPYWMAPEV--ILA--------MDEGQ----YDGKVDIWSLGITCIELAE-RK----------PP---------------LFNM---------NAMSA-LYHI-AQNDS----PT-LQSNEWTD----------------------------------------------------------------------------SFRR-FVDYCLQKIPQERPT-------SA-ELLRHDFV--------------------------------------------------------
-----------------------------WLL---SDILGQGATANVFRGRH---K-------KTGD---LFAIKVF---NNI--S-FLR---PV-----D-V-Q-MR-------------------------EFEVLKKL--N------HKN-----IVKLFAIEE--ET---------------------------TTRH------KVLIMEFCPCG---SLY-TVLEE------PSNAY-------------------------GL----PESEFLIVLRDVVGGMNHLRE--N--------G---IVHRDIKPGNIMRVIG----E--------DGQSV-----------------YKLTDFGAARE----------------------LEDDEQF--------------VS---LYGTEEYLHPDM--YERAV---LRKDHQKK----YGATVDLWSIGVTFYHAAT-GS----------LP---------------FRPF--------EGPRRN-KEVM-YKIIT----GK-PSGAISGVQKAENGPIDWSGDM--------------------------------------------------PVSCSLSRGLQV--------------------------------------LLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSY--
--------------------------------LTFMRELGSGLFGVVRLGKW---R--------AQY---KVAIKAI---R-E--G-AM----CE-----E-D-FI-E-------------------------EAKVMMKL--T------HPK-----LVQLYGVCT--Q-----------------------------QKP------IYIVTEFMERG---CLL-NFLR----------QR-----------------------QGHF----SRDVLLSMCQDVCEGMEYLER--N--------S---FIHRDLAARNCL--VS----E--------AGVV-------------------KVSDFGMARYV---------------------L--DDQY--------------TSSSGAKFPVKWCPPEV--FN-----------YSR----FSSKSDVWSFGVLMWEVFTEGR----------MP---------------FEKY---------TNYEV-VTMV-TRGHR----LY-QPKLAS-----------------------------------------------------------------------------NYVYE-VMLRCWQEKPEGRPS-------FE-DLLRT--I--------------------------------------------------------
--------------------------------IKFQDVIGEGNFGQVLKARI---K-----KDGLRM---DAAIKRM---K-E--Y-AS----KDD---HR-D-FA-G-------------------------ELEVLCKLG-H------HPN-----IINLLGACE--H-----------------------------RGY------LYLAIEYAPHG---NLL-DFLR----------KSRVLETDP--------AFAIANSTASTL----SSQQLLHFAADVARGMDYLSQ--K--------Q---FIHRDLAARNIL--VG----E--------NYVA-------------------KIADFGLSRGQ-------------------------EVY--------------VKKTMGRLPVRWMAIES--LN-----------YSV----YTTNSDVWSYGVLLWEIVSLGG----------TP---------------YCGM---------TCAEL-YEKL-PQGYR----LE-KPLNCD-----------------------------------------------------------------------------DEVYD-LMRQCWREKPYERPS-------FA-QILV---SL-------------------------------------------------------
-------------------------------F-HCAEKIGAGFFSEVYKVRH---R-------QSGQ---VMVLKMN---KLP--S-NRG---NT-----------LR-------------------------EVQLMNRL--R------HPN-----ILRFMGVCV--H-----------------------------QGQ------LHALTEYMNGG---TLE-QLLS---------SPE-------------------------PL----SWPVRLHLALDIARGLRYLHS--K--------G---VFHRDLTSKNCL--VR----R--------EDRGF----------------TAVVGDFGLAEKIPV-----------------YREGARKEP--------------LA---VVGSPYWMAPEV--LR-----------GEL----YDEKADVFAFGIVLCELIA-R-----------VP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHL
--------------------------------ITFEDLIGEGNFGQVIRAMI---K-----KDGLKM---NAAIKML---K-E--Y-AS----END---HR-D-FA-G-------------------------ELEVLCKLG-H------HPN-----IINLLGACK--N-----------------------------RGY------LYIAIEYAPYG---NLL-DFLR----------KSRVLETDP--------AFAREHGTASTL----SSRQLLRFASDAANGMQYLSE--K--------Q---FIHRDLAARNVL--VG----E--------NLAS-------------------KIADFGLSRGE-------------------------EVY--------------VKKTMGRLPVRWMAIES--LN-----------YSV----YTTKSDVWSFGVLLWEIVSLGG----------TP---------------YCGM---------TCAEL-YEKL-PQGYR----ME-QPRNCD-----------------------------------------------------------------------------DEVYE-LMRQCWRDRPYERPP-------FA-QIALQ--L--------------------------------------------------------
--------------------------------FELVELVGNGTYGQVYKGRH---V-------KTGQ---LAAIKVM---DVT--G-DEE---EE-----I-K-Q----------------------------EINMLKKY-SH------HRN-----IATYYGAFI--KKNP-----------------------PGMDDQ------LWLVMEFCGAG---SVT-DLIKN-------TKGN-------------------------TL----KEEWIAYICREILRGLSHLHQ--H--------K---VIHRDIKGQNVL--LT----E--------NAEV-------------------KLVDFGVSAQL---------------------DRTVGRR--------------NT---FIGTPYWMAPEV--IACD------ENPDAT----YDFKSDLWSLGITAIEMAE-GA----------PP---------------LCDM---------HPMRA-LFLI-PRNPA----PR-LKSKKWS----------------------------------------------------------------------------KKFQS-FIESCLVKNHSQRPA-------TE-QLMKHPFI--------------------------------------------------------
-----------------------------VCR---GELLGSGCFGVVHRGLW---T----LPSGKSV---PVAVKSLRVGP-E--G-PM----GTE---LG-D-FL-R-------------------------EVSVMMNL--E------HPH-----VLRLHGLVL--------------------------------GQP------LQMVMELAPLG---SLH-ARLT----------AP---------------------APTPPL----LVALLCLFLRQLAGAMAYLGA--R--------G---LVHRDLATRNLL--LA----S--------PRTI-------------------KVADFGLVRPL----------GG---------A--RGRY--------------VMGGPRPIPYAWCAPES--LR-----------HGA----FSSASDVWMFGVTLWEMFSGGE----------EP---------------WAGV---------PPYLI-LQRL-EDRAR----LP-RPPLCS-----------------------------------------------------------------------------RALYS-LALRCWAPHPADRPS-------FS-HLE----GLL------------------------------------------------------
-------------------------------L-RLLEKLGDGSFGVVRRGEW---D----APSGKTV---SVAVKCL---K-PDVL-SQ----PEA---MD-D-FI-R-------------------------EVNAMHSL--D------HRN-----LIRLYGVVL--------------------------------TPP------MKMVTELAPLG---SLL-DRLR----------KH-----------------------QGHF----LLGTLSRYAVQVAEGMGYLES--K--------R---FIHRDLAARNLL--LA----T--------RDLV-------------------KIGDFGLMRAL----------PQ---------N--DDHY--------------VMQEHRKVPFAWCAPES--LK-----------TRT----FSHASDTWMFGVTLWEMFTYGQ----------EP---------------WIGL---------NGSQI-LHKIDKEGER----LP-RPEDCP-----------------------------------------------------------------------------QDIYN-VMVQCWAHKPEDRPT-------FV-ALRDF--L--------------------------------------------------------
--------------------------------YSILKQIGSGGSSKVFQVLN---E-------KKQ----IYAIKYV---NLE--E-ADN---QT-----L-D-SYRN-------------------------EIAYLNKL-QQ-----HSDK-----IIRLYDYEI--T-----------------------------DQY------IYMVMECGNI----DLN-SWLK---------KKK-------------------------SI----DPWERKSYWKNMLEAVHTIHQ--H--------G---IVHSDLKPANFL--IV-------------DGML-------------------KLIDFGIANQMQ-------------------PDTTSVVK--------------DS---QVGTVNYMPPEA--IKDMSSSRENGKSKSK----ISPKSDVWSLGCILYYMTY-GK----------TP---------------FQQI-----------INQ-ISKL-HAIID----PN-HEIEFPDIPE-------------------------------------------------------------------------KDLQD-VLKCCLKRDPKQRIS-------IP-ELLAHPYV--------------------------------------------------------
-------------------------------L-AFIKEIGSGQFGVVHLGEW---R--------SHI---QVAIKAI---N-E--G-SM----SE-----E-D-FI-E-------------------------EAKVMMKL--S------HSK-----LVQLYGVCI--Q-----------------------------RKP------LYIVTEFMENG---CLL-NYLR----------EN-----------------------KGKL----RKEMLLSVCQDICEGMEYLER--N--------G---YIHRDLAARNCL--VS----S--------TCIV-------------------KISDFGMTRYV---------------------L--DDEY--------------VSSFGAKFPIKWSPPEV--FL-----------FNK----YSSKSDVWSFGVLMWEVFTEGK----------MP---------------FENK---------SNLQV-VEAI-SEGFR----LY-RPHLAP-----------------------------------------------------------------------------MSIYE-VMYSCWHEKPEGRPT-------FA-ELLR---AV-------------------------------------------------------
-------------------------------F-TLGRMLGKGEFGSVREAQL---K----QEDGSFV---KVAVKML---K-A-DI-IA----SSD---IE-E-FL-R-------------------------EAACMKEF--D------HPH-----VAKLVGVSL--R-----------------------------SRAKGRLPIPMVILPFMKHG---DLH-AFLL----------ASRI------------------GENPFNL----PLQTLIRFMVDIACGMEYLSS--R--------N---FIHRDLAARNCM--LA----E--------DMTV-------------------CVADFGLSRKI-----------Y---------S--GDYY--------------RQGCASKLPVKWLALES--LA-----------DNL----YTVQSDVWAFGVTMWEIMTRGQ----------TP---------------YAGI---------ENAEI-YNYL-IGGNR----LK-QPPECM-----------------------------------------------------------------------------EDVYD-LMYQCWSADPKQRPS-------FT-CLRME--L--------------------------------------------------------
------------------------------FI--LTERLGSGTYATVYKAYA---KK------DTRE---VVAIKCV---AKK--S-LNK---AS-----V-E-NLLT-------------------------EIEILKGI--R------HPH-----IVQLKDFQW--D-----------------------------SDN------IYLIMEFCAGG---DLS-RFIH---------TRR-------------------------IL----PEKVARVFMQQLASALQFLHE--R--------N---ISHLDLKPQNIL--LSS--LE--------KPHL-------------------KLADFGFAQH----------------------MSPWDEK--------------HV---LRGSPLYMAPEM--VC-----------QRQ----YDARVDLWSMGVILYEALF-GQ----------PP---------------FASR---------SFSEL-EEKI-RSNRV----IE-LPLRPLLS---------------------------------------------------------------------------RDCRD-LLQRLLERDPSRRIS-------FQ-DFFAHPWV--------------------------------------------------------
--------------------------------FHELEKIGSGEFGSVFKCVK---R-------LDGC---IYAIKRS---KKP--L-AGS---VD-----E-Q-NALR-------------------------EVYAHAVL-GQ------HSH-----VVRYFSAWA--E-----------------------------DDH------MLIQNEYCNGG---SLA-DAIS---------ENY-------------------------RIMSYFKEAELKDLLLQVGRGLRYIHS--M--------S---LVHMDIKPSNIF--IS----R--------TSIPNAASEEGDEDDWASNKVMFKIGDLGHV-------------------------TRISSP--------------QV---EEGDSRFLANEV--LQ----------ENYT----HLPKADIFALALTVVCAAG-AE----------PL---------------PRNG------------DQ-WHEI-RQGRL----PR-IPQVLS-----------------------------------------------------------------------------QEFTE-LLKVMIHPDPERRPS-------AM-ALVKHSV-L-------------------------------------------------------
-------------------------------L-RLEVKLGQGCFGEVWMGTW---N--------GTT---KVAIKTL---K-P--G-TM----MP-----E-A-FL-Q-------------------------EAQIMKKL--R------HDK-----LVPLYAVVS--------------------------------EEP------IYIVTEFMSKG---SLL-DFLK----------EG----------------------DGKYL----KLPQLVDMAAQIADGMAYIER--M--------N---YIHRDLRAANIL--VG----E--------NLVC-------------------KIADFGLARLI---------------------E--DNEY--------------TARQGAKFPIKWTAPEA--AL-----------YGR----FTIKSDVWSFGILQTELVTKGR----------VP---------------YPGM---------VNREV-LEQV-ERGYR----MP-CPQGCP-----------------------------------------------------------------------------ESLHE-LMNLCWKKDPDERPT-------FE-YIQSFL----------------------------------------------------------
----------------------------LIAD----IELGCGNFGSVRQGVY---R-----MRKKQI---DVAIKVL---K-Q--G-TE----KAD---TE-E-MM-R-------------------------EAQIMHQL--D------NPY-----IVRLIGVCQ--------------------------------AEA------LMLVMEMAGGG---PLH-KFLV----------GK-----------------------REEI----PVSNVAELLHQVSMGMKYLEE--K--------N---FVHRDLAARNVL--LV----N--------RHYA-------------------KISDFGLSKAL----------GA---------D--DSYY--------------TARSAGKWPLKWYAPEC--IN-----------FRK----FSSRSDVWSYGVTMWEALSYGQ----------KP---------------YKKM---------KGPEV-MAFI-EQGKR----ME-CPPECP-----------------------------------------------------------------------------PELYA-LMSDCWIYKWEDRPD-------FL-TVEQR--M--------------------------------------------------------