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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK1 203
CMGC CDK2 4
CAMK CHEK1 9
Other EIF2AK2 267
CMGC GSK3A 119
TK LCK 245
AGC PDPK1 82
AGC RPS6KB1 91
TK SRC 270
-YTNLSYIGEGAYGMVCSAYD---NVNKVRVAIKKISPFEHQTYCQR-T-LR--EIKILLRFRHENIIGINDIIRAPT------------------------IEQMKDVY--IVQDLMET---DLYKLLK---TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVADPDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL-----------
-FQKVEKIGEGTYGVVYKARN---KLTGEVVALKKIRLDTETEGVPS-TAIR--EISLLKELNHPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDASALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
W-DLVQTLGEGAYGEVQLAVN---RVTEEAVAVKIVDMKRAVDCPEN-I-KK--EICINKMLNHENVVKFYGHRRE-----------------------------GNIQY--LFLEYCSGG--ELFDRIE--PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GE-LPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
F-KEIELIGSGGFGQVFKAKH---RIDGKTYVIKRVKYNNEKAER---------EVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEKRRGE---KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV-DTKQVKIGDFGLVTS----LKNDGKRTR---SKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELLH-VCDTAFET-------SKFFTDLRDGIISDIFDK-----------------------------KEKTLLQKLLSKKPEDRPN-----TSEILR----TLT--------
-YTDIKVIGNGSFGVVYQARL---AETRELVAIKKVLQDKRFKNR---------ELQIMRKLDHCNIVRLRYFFYSSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT-KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF-----------
-LKLVERLGAGQFGEVWMGYY---N-GHTKVAVKSLK-QGSM-SPDA-FL-A--EANLMKQLQHQRLVRLYAVVT------------------------------QEPIY--IITEYMENG--SLVDFLK---TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGR-IPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L-----------
F-KFGKILGEGSFSTVVLARE---LATSREYAIKILEKRHIIKENKVPYVTR--ERDVMSRLDHPFFVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELLKYIR--KIG---SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GL-PPFRAG---NEYLIFQKIIKLEYDFPEKFF----------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKD-TAHTKAERNILEEVKHPFIVDLIYAFQT-----------------------------GGKLY--LILEYLSGG--ELFMQLE--REG---IFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLN-HQGHVKLTDFGLCKES---IHDGTVTHT---FCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLT-GA-PPFTGE---NRKKTIDKILKCKLNLPPYLT----------------------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF-----------
L-RLEVKLGQGCFGEVWMGTW---N-GTTRVAIKTLK-PGTM-SPEA-FL-Q--EAQVMKKLRHEKLVQLYAVVS------------------------------EEPIY--IVTEYMSKG--SLLDFLK---GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGR-VPYPGMVNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-----------
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