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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK1 203
CMGC CDK2 4
CMGC CDK4 6
CAMK CHEK1 9
CAMK CHEK2 220
CMGC GSK3A 119
CMGC GSK3B 56
TK LCK 245
--YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQT---YCQRT-LR------EIKILLRFR---HENIIGINDIIRAPTIEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVADPDHDHTGFLTE---YVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL-
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIR------EISLLKELN---HPNIVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
-Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR------EVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV---KLADFGLARI----YSYQMALTP---VVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD---CPENI-KK------EICINKMLN---HENVVKFYGHRRE-----GNIQY--LFLEYCSGG--ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAI---GSAREADPALNVETEIEILKKLN---HPCIIKIKNFF-D-----AEDYY--IVLELMEGG--ELFDKVV----GNK---RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-
--YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFK---NR------------ELQIMRKLD---HCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFT---KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---NR------------ELQIMRKLD---HCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-
--LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM----SPDAFL-A------EANLMKQLQ---HQRLVRLYAVVT------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
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