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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK10 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CMGC CLK4 159
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
YQNLKPIGSGAQGIVCAAYDAV-LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN--HKN----IISLLNVFTPQKT--LEEFQDVYLVMELMDANLCQVIQ-----MEL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL-------------------KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
YTKIEKIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELR--HPN----IVSLQDVLMQ--------DSRLYLIFEFLSMDLKKYLDSIPPGQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-------------------KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
FQKVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELN--HPN----IVKLLDVIHT--------ENKLYLVFEFLHQDLKKFMDA-SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-------------------KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
FQKVEKIGEGTYGVVYKAKNRE-TGQLVALKKIRLDLEMEGVPSTAIREISLLKELK--HPN----IVRLLDVVHN--------ERKLYLVFEFLSQDLKKYMDS-TPGSEL--PLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAI-------------------KLADFGLARAF----GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF
YEKLEKIGEGTYGTVFKAKNRE-THEIVALKRVRLDDDDEGVPSSALREICLLKELK--HKN----IVRLHDVLHS--------DKKLTLVFEFCDQDLKKYFD--SCNGDL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL-------------------KLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
YEKLAKIGQGTFGEVFKARHRK-TGQKVALKKVLMENEKEGFPITALREIKILQLLK--HEN----VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS--NVLVKF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL-------------------KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARS---EIQVLEHLNSTDPNSVFRCVQMLEWFDH--------HGHVCIVFELLGLSTYDFIK---ENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA-------TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
YQNLSPVGSGAYGSVCAAFDTK-TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK--HEN----VIGLLDVFTPARS--LEEFNDVYLVTHLMGADLNNIVK----CQKL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL-------------------KILDFGLAR-------HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
YQNLKPIGSGAQGIVCAAYDAI-LERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN--HKN----IIGLLNVFTPQKS--LEEFQDVYIVMELMDANLCQVIQ-----MEL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL-------------------KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK--LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
YQQLKPIGSGAQGIVCAAFDTV-LGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVN--HKN----IISLLNVFTPQKT--LEEFQDVYLVMELMDANLCQVIH-----MEL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL-------------------KILDFGLART-----ACTNFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE--LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
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