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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK12 203
Other AURKA 133
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
AGC GRK6 186
CMGC GSK3B 56
CMGC MAPK10 64
AGC PDPK1 82
Other PLK1 53
TK SRC 270
STE STK24 24
Other TTK 525
--YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAK-RAYR------ELRLLKHM-R-HENVIGLLDVFTPDET--LDDFTDFY--LVMPFMGT---DLGKLMK-----HE---KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCEL----KILDFGLAR-------QADSEMTG---YVVTRWYRAPEVIL----------NWMRYTQTVDIWSVGCIMAEMIT-GKTLFK-GSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF-----------
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHL-R-HPNILRLYGYFHD--------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL----KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GKPPFE-AN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPS-TAIR------EISLLKEL-N-HPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
--YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPI-TALR------EIKILQLL-K-HENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL----KLADFGLARAFSLAKNSQPNRYTN---RVVTLWYRPPELLL----------GERDYGPPIDLWGAGCIMAEMWT-RSPIMQ-GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF-----------
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKL-N-HPCIIKIKNFF-D--------AEDYY--IVLELMEGG--ELFDKVV----GNK---RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
--YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKR------------EIKILENLRG-GPNIITLADIVKDP------VSRTPA--LVFEHVNNT--DFKQLY-------Q---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF-----YHPGQEYNV---RVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF-----------
--YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRR-TKSSRRG-VSREDI--EREVSILKEI-Q-HPNVITLHEVYEN--------KTDVI--LILELVAGG--ELFDFLA----EKE---SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEFKN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GASPFL-GD---TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
-F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR-IKKRKGE-AMAL-----NEKQILEKV-N-SRFVVSLAYAYET--------KDALC--LVLTLMNGG--DLKFHIYH--MGQA---GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHI----RISDLGLAVH-----VPEGQTIKG---RVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIA-GQSPFQ-QRKKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIMRKL-D-HCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
--YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAK-RAYR------ELVLMKCV-N-HKNIISLLNVFTPQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL----KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVR-HKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
-F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRL-D-HPFFVKLYFTFQD--------DEKLY--FGLSYAKNG--ELLKYIR----KIG---SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQR-EKMS-----MEISIHRSL-A-HQHVVGFHGFFED--------NDFVF--VVLELCRRR--SLLELHK----RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF-----------
-L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PG-TM-SPEA-FL-Q------EAQVMKKL-R-HEKLVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC----KVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELTTKGRVPYP-GMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-----------
--FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE-AEDEIED-IQ-Q------EITVLSQC-D-SPYVTKYYGSYLK--------DTKLW--IIMEYLGGG--SALDLLE-----PG---PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL----TDTQIKRNT---FVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELAR-GEPPHS-ELHPMKVLFLIPKNNPPTLEGNYS-----------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI-----------
--YSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEE-ADNQTLD-SYRN------EIAYLNKLQQHSDKIIRLYDYEIT--------DQYIY--MVMECGNI---DLNSWLK----KKK---SIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV--DGML----KLIDFGIANQMQ--PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPFQ-QI--INQISKLHAIIDPNHEIEFPDIPE-------------------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV-----------
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