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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
Other CHUK 15
TK FGFR1 478
CMGC GSK3B 56
TK LCK 245
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK9 26
CMGC NLK 126
CAMK PRKD3 576
TK SRC 270
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPFQSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---------
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-----------DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---------
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKEL-RHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PSTAIREISLLKEL-NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---------
--W-EMRERLGTGGFGNVCLYQHR-------ELDLKIAIKSCRLELSTKNR--ER-WCHEIQIMKKL-NHANVVKACDVPEELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-----------------GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKIIHKIIDLGYAKD---VDQGSLCTS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM---KIADFGLARDIH-H--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-----------PVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----------
---YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDKRFKNR--------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---------
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-----------TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---------
---YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRPFQNQTH--AKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART---AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI---------
LQG---LRPVGSGAYGSVCSAYDA-------RLRQKVAVKKLSRPFQSLIH--ARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ-----------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCEL---RILDFGLAR-----QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGS-----------DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF---------
---YQQLKPIGSGAQGIVCAAFDT-------VLGINVAVKKLSRPFQNQTH--AKRAYRELVLLKCV-NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART---ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGT-----------DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI---------
IEP---DRPIGYGAFGVVWSVTDP-------RDGKRVALKKMPNVFQNLVS--CKRVFRELKMLCFF-KHDNVLSALDILQPPH-IDYFEEIY--VVTELMQS---DLHKIIV----SPQ-----------------PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN-SNCVL---KICDFGLARVE-ELDESRHMTQ---EVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLG-RRILFQAQ-----------SPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL---------
FAD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKVIDKMRFPTKQ--ESQLRNEVAILQNL-HHPGIVNLECMFET------PERVF--VVMEKLHGD--MLEMILS---SEKS-----------------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA-SAEPFPQVKLCDFGFARI---IGEKSFRRS---VVGTPAYLAPEVLR-SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED----------------EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL---------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---KVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-----------VNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---------
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