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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK LCK 245
CMGC MAPK11 24
TK SRC 270
---YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
---LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFL-AEANLMKQLQHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
LQG---LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
--L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM-SPEAFL-QEAQVMKKLRHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
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