|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CAMK CHEK2 220
TK FGFR1 478
TK LCK 245
TK LYN 247
CMGC MAPK10 64
CMGC MAPK8 26
CMGC MAPK9 26
AGC PDPK1 82
Other PLK1 53
Other PLK2 82
Other PLK3 62
CAMK PRKD2 551
CAMK PRKD3 576
TK SRC 270
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPFQSIIH--AK-RTYR------ELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR------HTDDEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-----------
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLESEEEGV--PS-TAIR------EISLLKEL-RHPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI---KLADFGLARAF---GIPIRVYTH---EVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-----------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PS-TAIR------EISLLKEL-NHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
--W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKRAVDCP--EN-I-KK------EICINKML-NHENVVKFYGHRRE------GNIQYLFLEYCSGGELFDRIE---PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y----------
-YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKRKFAIGS--AR-EADPALNVETEIEILKKL-NHPCIIKIKNFF-D------AEDYYIVLELMEGGELFDKVV---GNK-----------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-----------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSD-LI-S------EMEMMKMIGKHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM---KIADFGLARDI-H-H--IDYYKKTTNGRLPVKWMAPEALF---DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DA-FL-A------EANLMKQL-QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC---KIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
---IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLK-PGTM-SV--QA-FL-E------EANLMKTL-QHDKLVRLYAVVTR------EEPIYIITEYMAKGSLLDFLK----SD--------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC---KIADFGLARVI---E--DNEYTAREGAKFPIKWTAPEAIN---FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCP-----------------------------------------DELYDIMKMCWKEKAEERPTFDYLQSV--L-----------
---YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRPFQNQTH--AK-RAYR------ELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-----------
---YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKLSRPFQNQTH--AK-RAYR------ELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-----------
---YQQLKPIGSGAQGIVCAAFDT-------VLGINVAVKKLSRPFQNQTH--AK-RAYR------ELVLLKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLART----ACTNFMMTP---YVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI-----------
--F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKRHIIKEN--KVPYVTR------ERDVMSRL-DHPFFVKLYFTFQD------DEKLYFGLSYAKNGELLKYIR---KIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHI---QITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
-YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSLLLKPH--QR-EKMS-----MEISIHRSL-AHQHVVGFHGFFED------NDFVFVVLELCRRRSLLELHK---RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEV---KIGDFGLATKV---EYDGERKKT---LCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-----------
--Y-CRGKVLGKGGFAKCYEMTDL-------TNNKVYAAKIIPHSRVAKPH--QR-EKID-----KEIELHRIL-HHKHVVQFYHYFED------KENIYILLEYCSRRSMAHILK---ARK-----------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMEL---KVGDFGLAARL---EPLEHRRRT---ICGTPNYLSPEVLN---KQGHGCESDIWALGCVMYTMLL-GRPPFETT---NLKETYRCIREARYTMPSSLL---------------------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF-----------
-YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQSRVAKPH--QR-EKIL-----NEIELHRDL-QHRHIVRFSHHFED------ADNIYIFLELCSRKSLAHIWK---ARH-----------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMEL---KVGDFGLAARL---EPPEQRKKT---ICGTPNYVAPEVLL---RQGHGPEADVWSLGCVMYTLLC-GSPPFETA---DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF-----------
-PD----EVLGSGQFGVVYGGKHR-------KTGRDVAVKVIDKLRFPTKQ--ES-QLRN------EVAILQSL-RHPGIVNLECMFET------PEKVFVVMEKLHGDMLEMILS--SEKG-----------------RLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARI----IGEKSFRRS---VVGTPAYLAPEVLL---NQGYNRSLDMWSVGVIMYVSLS-GTFPFNED-----EDINDQIQNAAFMYPASPWSHIS-----------------------------------AGAIDLINNLLQVKMRKRYSVDKSLSHPWL-----------
FAD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKVIDKMRFPTKQ--ES-QLRN------EVAILQNL-HHPGIVNLECMFET------PERVFVVMEKLHGDMLEMILS--SEKS-----------------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARI----IGEKSFRRS---VVGTPAYLAPEVLR---SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL-----------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EA-FL-Q------EAQVMKKL-RHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC---KVADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
|