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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
TK ABL2 288
TK BLK 241
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK1 9
CMGC CLK2 163
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
TK EPHB2 621
TK FGFR1 478
TK FGFR2 481
TK FGR 263
TK FYN 271
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
CMGC HIPK2 199
CMGC HIPK3 197
TK LCK 245
TK LYN 247
CMGC MAPK10 64
CMGC MAPK8 26
CMGC MAPK9 26
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK3 56
CAMK MARK4 59
CAMK NUAK1 55
CAMK NUAK2 97
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
CMGC PRPF4B 687
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
TK SRC 270
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
CAMK TSSK1B 12
TK YES1 277
-----YQNLSPVGSGAYGSV---CAAFDT-------K-TGL---RVAVKKLSRPFQSIIH--AK-RTYR-------ELRLLKHM--K------HEN-----VIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK------------------------CQ-----------------KL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL-------------------KILDFGLAR----------HTDDEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------------------------------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AAQALAHAYF-----------
-----ITMKHKLGGGQYGEV---YEGVWK-------K-YSL---TVAVKTLK-EDTM-EV--EE-FL-K-------EAAVMKEI--K------HPN-----LVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR------------------------EC--------------NRQEV--NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV-------------------KVADFGLSRLM-------T--GDTYTAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GI-DLSQVYELLEKDYRMERPEGCP-----------------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F-----------
-----ITMKHKLGGGQYGEV---YVGVWK-------K-YSL---TVAVKTLK-EDTM-EV--EE-FL-K-------EAAVMKEI--K------HPN-----LVQLLGVCTL------EPPFY--IVTEYMPYG--NLLDYLR------------------------EC--------------NREEV--TAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHVV-------------------KVADFGLSRLM-------T--GDTYTAHAGAKFPIKWTAPESLA------YNTFSIKSDVWAFGVLLWEIATYGMSPYP-GI-DLSQVYDLLEKGYRMEQPEGCP-----------------------------------------------------------------------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F-----------
----L-RLVRKLGSGQFGEV---WMGYYK---------NNM---KVAIKTLK-EGTM-SP--EA-FL-G-------EANVMKAL--Q------HER-----LVRLYAVVT-------KEPIY--IVTEYMARG--CLLDFLK------------------------TD--------------EGSRL--SLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVS-EALCC-------------------KIADFGLARII----------DSEYTAQEGAKFPIKWTAPEAIH------FGVFTIKADVWSFGVLLMEVVTYGRVPYP-GM-SNPEVIRNLERGYRMPRPDTCP-----------------------------------------------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L-----------
-----YTKIEKIGEGTYGVV---YKGRHK-------T-TGQ---VVAMKKIRLESEEEGV--PS-TAIR-------EISLLKEL--R------HPN-----IVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS--------------------IPPGQ-----------------YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF-------GIPIRVYTH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GKMALNHPYF-----------
-----FQKVEKIGEGTYGVV---YKARNK-------L-TGE---VVALKKIRLDTETEGV--PS-TAIR-------EISLLKEL--N------HPN-----IVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA---------------------SALT-----------------GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF-------GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AKAALAHPFF-----------
-----YEKLEKIGEGTYGTV---FKAKNR-------E-THE---IVALKRVRLDDDDEGV--PS-SALR-------EICLLKEL--K------HKN-----IVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD----------------------SCNG-----------------DL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL-------------------KLADFGLARAF-------GIPVRCYSA---EVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGRPLFP-GN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AEEALQHPYF-----------
----W-DLVQTLGEGAYGEV---QLAVNR-------V-TEE---AVAVKIVDMKRAVDCP--EN-I-KK-------EICINKML--N------HEN-----VVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE-----------------------PDI-----------------GM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL-------------------KISDFGLATVFR-----YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP---SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------SAPLA-LLHKILVENPSARIT-----IPDIKKDRW-Y----------
-----YEIVSTLGEGTFGRV---VQCVDH-------R-RGG--ARVALKIIKNVEKYKEA--AR----L-------EINVLEKI--NEK-DPDNKN----LCVQMFDWFDY------HGHMC--ISFELLGL---STFDFLK-----------------------DNN-----------------YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV-NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT----------FDHEHHST---IVSTRHYRAPEVIL------ELGWSQPCDVWSIGCIIFEYYV-GFTLFQ-TH-DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY----------------------------VRENCKPLRRYLTSEAEEHHQLFD-LIESMLEYEPAKRLT-----LGEALQHPFF-----------
-----YQLVRKLGRGKYSEV---FEAINI-------T-NNE---RVVVKILKPVKKKKIK--R-------------EVKILENL-RG------GTN-----IIKLIDTVKDP----VSKTPA--LVFEYINNT--DFKQLY--------------------------Q-----------------IL--TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL-------------------RLIDWGLAEF--------YHPAQEYNV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RREPFFHGQ-DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------------------RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQRLT-----AKEAMEHPYF-----------
-----YDTGEELGSGQFAVV---KKCREK-------S-TGL---QYAAKFIKKRRTKSSR--RG-VSREDI---EREVSILKEI--Q------HPN-----VITLHEVYEN------KTDVI--LILELVAGG--ELFDFLA-----------------------EKE-----------------SL--TEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKP---------------RIKIIDFGLAHK--------IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFL-GD----TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------ALAKD-FIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
-----YDIGEELGSGQFAIV---KKCREK-------S-TGL---EYAAKFIKKRQSRASR--RG-VSREEI---EREVSILRQV--L------HHN-----VITLHDVYEN------RTDVV--LILELVSGG--ELFDFLA-----------------------QKE-----------------SL--SEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL-DKNIPIP---------------HIKLIDFGLAHE--------IEDGVEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFL-GD----TKQETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------ELAKD-FIRKLLVKETRKRLT-----IQEALRHPWI-----------
-----YEMGEELGSGQFAIV---RKCRQK-------G-TGK---EYAAKFIKKRRLSSSR--RG-VSREEI---EREVNILREI--R------HPN-----IITLHDIFEN------KTDVV--LILELVSGG--ELFDFLA-----------------------EKE-----------------SL--TEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL-DKNVPNP---------------RIKLIDFGIAHK--------IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFL-GE----TKQETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------ELAKD-FIRRLLVKDPKRRMT-----IAQSLEHSWI-----------
----V-KIEQVIGAGEFGEV---CSGHLK----LPGK-REI---FVAIKTLK-SGYT-EKQRRD-FL-S-------EASIMGQF--D------HPN-----VIHLEGVVTK------STPVM--IITEFMENG--SLDSFLR------------------------QN---------------DGQF--TVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVN-SNLVC-------------------KVSDFGLSRFLE-DDT--S--DPTYTSALGGKIPIRWTAPEAIQ------YRKFTSASDVWSYGIVMWEVMSYGERPYW-DM-TNQDVINAIEQDYRLPPPMDCP-----------------------------------------------------------------------SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL-------------
----L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPN-RVT---KVAVKMLK-SDAT-EKDLSD-LI-S-------EMEMMKMIG-K------HKN-----IINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ------------------------ARRPPGLEYCYNPSHNPEEQL--SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM-------------------KIADFGLARDI----H--H--IDYYKKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGGSPYP-GV-PVEELFKLLKEGHRMDKPSNCT-----------------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
-----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPK-EAV---TVAVKMLK-DDAT-EKDLSD-LV-S-------EMEMMKMIG-K------HKN-----IINLLGACTQ------DGPLY--VIVEYASKG--NLREYLR------------------------ARRPPGMEYSYDINRVPEEQM--TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVM-------------------KIADFGLARDI----N--N--IDYYKKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLMWEIFTLGGSPYP-GI-PVEELFKLLKEGHRMDKPANCT-----------------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
-----ITLERRLGTGCFGDV---WLGTWN---------GST---KVAVKTLK-PGTM-SP--KA-FL-E-------EAQVMKLL--R------HDK-----LVQLYAVVS-------EEPIY--IVTEFMCHG--SLLDFLK------------------------NP--------------EGQDL--RLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVG-ERLAC-------------------KIADFGLARLI-------K--DDEYNPCQGSKFPIKWTAPEAAL------FGRFTIKSDVWSFGILLTELITKGRIPYP-GM-NKREVLEQVEQGYHMPCPPGCP-----------------------------------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL-------------
-----LQLIKRLGNGQFGEV---WMGTWN---------GNT---KVAIKTLK-PGTM-SP--ES-FL-E-------EAQIMKKL--K------HDK-----LVQLYAVVS-------EEPIY--IVTEYMNKG--SLLDFLK------------------------DG--------------EGRAL--KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLIC-------------------KIADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGRVPYP-GM-NNREVLEQVERGYRMPCPQDCP-----------------------------------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL-------------
----F-TEFRVLGKGGFGEV---CAVQVK-------N-TGK---MYACKKLDKKRLKKKG--GE-KMAL------LEKEILEKV--S------SPF-----IVSLAYAFES------KTHLC--LVMSLMNGG--DLKFHIYN---------------------VGTR-----------------GL--DMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLD-DLGNC-------------------RLSDLGLAVE--------MKGGKPITQ---RAGTNGYMAPEILM-----EKVSYSYPVDWFAMGCSIYEMVA-GRTPFK-DYKEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------EEAKD-ICRLFLAKKPEQRLG-----SRE-------KSDDPR-----
-----YTDIKVIGNGSFGVV---YQARLA-------E-TRE---LVAIKKVLQDKRFKNR----------------ELQIMRKL--D------HCN-----IVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT----------------------KAKL-----------------TI--PILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL-------------------KLCDFGSAKQ--------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSSRLS-----PLEACAHSFF-----------
-----YTDTKVIGNGSFGVV---YQAKLC-------D-SGE---LVAIKKVLQDKRFKNR----------------ELQIMRKL--D------HCN-----IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHY-------------------SRAKQ-----------------TL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-------------------KLCDFGSAKQ--------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-----PLEACAHSFF-----------
-----LKLEKKLGAGQFGEV---WMATYN---------KHT---KVAVKTMK-PGSM-SV--EA-FL-A-------EANVMKTL--Q------HDK-----LVKLHAVVT-------KEPIY--IITEFMAKG--SLLDFLK------------------------SD--------------EGSKQ--PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLVC-------------------KIADFGLARVI-------E--DNEYTAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGRIPYP-GM-SNPEVIRALERGYRMPRPENCP-----------------------------------------------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L-----------
-----YEVLEFLGRGTFGQV---VKCWKR-------G-TNE---IVAIKILKNHPSYARQ--GQ-I----------EVSILARL--STE-SADDYN-----FVRAYECFQH------KNHTC--LVFEMLEQ---NLYDFLKQ---------------------NKFS-----------------PL--PLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV-DPSRQPY---------------RVKVIDFGSAS---------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPLYP-GA-SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFID-LLKKMLTIDADKRIT-----PIETLNHPFV-----------
-----YEVLDFLGRGTFGQV---VKCWKR-------G-TNE---IVAIKILKNHPSYARQ--GQ-I----------EVSILARL--S------TENADEYNFVRAYECFQH------RNHTC--LVFEMLEQ---NLYDFLKQ---------------------NKFS-----------------PL--PLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLV-DPVRQPY---------------RVKVIDFGSAS---------HVSKTVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPLYP-GA-LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVS-LLKKMLLIDADLRIT-----PAETLNHPFV-----------
-----LKLVERLGAGQFGEV---WMGYYN---------GHT---KVAVKSLK-QGSM-SP--DA-FL-A-------EANLMKQL--Q------HQR-----LVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK------------------------TP--------------SGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC-------------------KIADFGLARLI-------E--DNEYTAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGRIPYP-GM-TNPEVIQNLERGYRMVRPDNCP-----------------------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L-----------
-----IKLVKRLGAGQFGEV---WMGYYN---------NST---KVAVKTLK-PGTM-SV--QA-FL-E-------EANLMKTL--Q------HDK-----LVRLYAVVTR------EEPIY--IITEYMAKG--SLLDFLK------------------------SD--------------EGGKV--LLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS-ESLMC-------------------KIADFGLARVI-------E--DNEYTAREGAKFPIKWTAPEAIN------FGCFTIKSDVWSFGILLYEIVTYGKIPYP-GR-TNADVMTALSQGYRMPRVENCP-----------------------------------------------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L-----------
-----YQNLKPIGSGAQGIV---CAAYDA-------V-LDR---NVAIKKLSRPFQNQTH--AK-RAYR-------ELVLMKCV--N------HKN-----IISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ-------------------------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART--------AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGEMVR-HKILFP-GR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS-----VDDALQHPYI-----------
-----YQNLKPIGSGAQGIV---CAAYDA-------I-LER---NVAIKKLSRPFQNQTH--AK-RAYR-------ELVLMKCV--N------HKN-----IIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ-------------------------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART--------AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDLWSVGCIMGEMVC-HKILFP-GR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS-----VDEALQHPYI-----------
-----YQQLKPIGSGAQGIV---CAAFDT-------V-LGI---NVAVKKLSRPFQNQTH--AK-RAYR-------ELVLLKCV--N------HKN-----IISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH-------------------------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART--------ACTNFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGELVK-GCVIFQ-GT-DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------LFPDWIFPSESERDKIKTSQARD-LLSKMLVIDPDKRIS-----VDEALRHPYI-----------
-----YRLQKTIGKGNFAKV---KLARHV-------L-TGR---EVAVKIIDKTQLNPTS--LQ-KLFR-------EVRIMKIL--N------HPN-----IVKLFEVIET------EKTLY--LVMEYASGG--EVFDYLV-----------------------AHG-----------------RM--KEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLD-GDMNI-------------------KIADFGFSNE--------FTVGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ----NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------TDCEN-LLKKLLVLNPIKRGS-----LEQIMKDRWM-----------
-----YRLLKTIGKGNFAKV---KLARHI-------L-TGK---EVAVKIIDKTQLNSSS--LQ-KLFR-------EVRIMKVL--N------HPN-----IVKLFEVIET------EKTLY--LVMEYASGG--EVFDYLV-----------------------AHG-----------------RM--KEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNI-------------------KIADFGFSNE--------FTFGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ----NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------TDCEN-LLKKFLILNPSKRGT-----LEQIMKDRWM-----------
-----YRLLKTIGKGNFAKV---KLARHI-------L-TGR---EVAIKIIDKTQLNPTS--LQ-KLFR-------EVRIMKIL--N------HPN-----IVKLFEVIET------EKTLY--LIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV-----------------QV--SFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLD-ADMNI-------------------KIADFGFSNE--------FTVGGKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ----NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------TDCEN-LLKRFLVLNPIKRGT-----LEQIMKDRWI-----------
-----YRLLRTIGKGNFAKV---KLARHI-------L-TGR---EVAIKIIDKTQLNPSS--LQ-KLFR-------EVRIMKGL--N------HPN-----IVKLFEVIET------EKTLY--LVMEYASAG--EVFDYLV-----------------------SHG-----------------RM--KEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLD-AEANI-------------------KIADFGFSNE--------FTLGSKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDIWSLGVILYTLVS-GSLPFD-GH----NLKELRERVLRGKYRVPFYMS---------------------------------------------------------------------TDCES-ILRRFLVLNPAKRCT-----LEQIMKDKWI-----------
-----YELQETLGKGTYGKV---KRATER-------F-SGR---VVAIKSIRKDKIKDEQ--DM-VHIR------REIEIMSSL--N------HPH-----IISIYEVFEN------KDKIV--IIMEYASKG--ELYDYIS-----------------------ERR-----------------RL--SERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI-------------------KIADFGLSNL--------YQKDKFLQT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMPFD-GF----DHKNLIRQISSGEYREPTQP----------------------------------------------------------------------SDARG-LIRWMLMVNPDRRAT-----IEDIANHWW-V----------
-----YEFLETLGKGTYGKV---KKARES-------S-GR----LVAIKSIRKDKIKDEQ--DL-MHIR------REIEIMSSL--N------HPH-----IIAIHEVFEN------SSKIV--IVMEYASRG--DLYDYIS-----------------------ERQ-----------------QL--SEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLD-ANGNI-------------------KIADFGLSNL--------YHQGKFLQT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GTMPFD-GH----DHKILVKQISNGAYREPPK-----P-----------------------------------------------------------------SDACG-LIRWLLMVNPTRRAT-----LEDVASHWW-V----------
----F-KFGKILGEGSFSTV---VLAREL-------A-TSR---EYAIKILEKRHIIKEN--KVPYVTR-------ERDVMSRL--D------HPF-----FVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR-----------------------KIG-----------------SF--DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI-------------------QITDFGTAKVLS-----PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG----NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------PKARD-LVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-----YEPKEILGRGVSSVV---RRCIHK-------P-TSQ---EYAVKVIDVTGGGSFS--PE-EVRELREATLKEVDILRKV-SG------HPN-----IIQLKDTYET------NTFFF--LVFDLMKRG--ELFDYLT-----------------------EKV-----------------TL--SEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLD-DNMNI-------------------KLTDFGFSCQ--------LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFW-HR----KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------DTVKD-LVSRFLVVQPQNRYT-----AEEALAHPFF-----------
--YDP---KDVIGRGVSSVV---RRCVHR-------A-TGH---EFAVKIMEVTAERLSP--EQ-LEEVREA-TRRETHILRQV-AG------HPH-----IITLIDSYES------SSFMF--LVFDLMRKG--ELFDYLT-----------------------EKV-----------------AL--SEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLD-DNMQI-------------------RLSDFGFSCH--------LEPGEKLRE---LCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFW-HR----RQILMLRMIMEGQYQFSSPEWDDRS-----------------------------------------------------------------STVKD-LISRLLQVDPEARLT-----AEQALQHPFF-----------
---PD----EVLGSGQFGIV---YGGKHR-------K-TGR---DVAIKIIDKLRFPTKQ--ES-QLRN-------EVAILQNL--H------HPG-----VVNLECMFET------PERVF--VVMEKLHGD--MLEMILS----------------------SEKG-----------------RL--PEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFP----------------QVKLCDFGFARI--------IGEKSFRRS---VVGTPAYLAPEVLR------NKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------------------------------------HEAID-LINNLLQVKMRKRYS-----VDKTLSHPWL-----------
---PD----EVLGSGQFGVV---YGGKHR-------K-TGR---DVAVKVIDKLRFPTKQ--ES-QLRN-------EVAILQSL--R------HPG-----IVNLECMFET------PEKVF--VVMEKLHGD--MLEMILS----------------------SEKG-----------------RL--PERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFP----------------QVKLCDFGFARI--------IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GTFPFN-ED------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------AGAID-LINNLLQVKMRKRYS-----VDKSLSHPWL-----------
--FAD----EVLGSGQFGIV---YGGKHR-------K-TGR---DVAIKVIDKMRFPTKQ--ES-QLRN-------EVAILQNL--H------HPG-----IVNLECMFET------PERVF--VVMEKLHGD--MLEMILS----------------------SEKS-----------------RL--PERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA-SAEPFP----------------QVKLCDFGFARI--------IGEKSFRRS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED------EDINDQIQNAAFMYPPNPWREIS-----------------------------------------------------------------GEAID-LINNLLQVKMRKRYS-----VDKSLSHPWL-----------
-YNVY----GYTGQGVFSNV---VRARDN-------ARANQ---EVAVKIIRNNELMQKT--G----LK-------ELEFLKKL--NDADPDDKFH-----CLRLFRHFYH------KQHLC--LVFEPLSM---NLREVLKK--------------------YGKDV-----------------GL--HIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVN-ESKTI------------------LKLCDFGSAS---------HVADNDITP---YLVSRFYRAPEIII------GKSYDYGIDMWSVGCTLYELYT-GKILFP-GK-TNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM------------STINPTKDLLADLIGCQRLPEDQRKKVHQLKD-LLDQILMLDPAKRIS-----INQALQHAFI-----------
-----FELLKVLGQGSFGKVFLVRKVTRP-------D-SGH---LYAMKVLKKATLKVRD--RV-RTKM-------ERDILADV--N------HPF-----VVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS-----------------------KEV-----------------MF--TEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHI-------------------KLTDFGLSKEA-------IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GSLPFQ-GK----DRKETMTLILKAKLGMPQFLS---------------------------------------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
-----FELLKVLGQGSYGKV---FLVRKV-------K-GSDAGQLYAMKVLKKATLKVRD--RV-RSKM-------ERDILAEV--N------HPF-----IVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS-----------------------KEV-----------------MF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI-------------------KITDFGLSKEA-------IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLPFQ-GK----DRKETMALILKAKLGMPQFLS---------------------------------------------------------------------GEAQS-LLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
-----FELLKVLGQGSFGKV---FLVKKI-------S-GSDARQLYAMKVLKKATLKVRD--RV-RTKM-------ERDILVEV--N------HPF-----IVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS-----------------------KEV-----------------MF--TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI-------------------KLTDFGLSKES-------IDHEKKAYS---FCGTVEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GTLPFQ-GK----DRKETMTMILKAKLGMPQFLS---------------------------------------------------------------------PEAQS-LLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----------
-----FELLKVLGQGSFGKV---FLVRKK-------T-GPDAGQLYAMKVLKKASLKVRD--RV-RTKM-------ERDILVEV--N------HPF-----IVKLHYAFQT------EGKLY--LILDFLRGG--DVFTRLS-----------------------KEV-----------------LF--TEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHI-------------------KLTDFGLSKES-------VDQEKKAYS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GTLPFQ-GK----DRNETMNMILKAKLGMPQFLS---------------------------------------------------------------------AEAQS-LLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
-----YDIERTLGKGNFAVV---KLARHR-------V-TKT---QVAIKIIDKTRLDSSN--LE-KIYR-------EVQLMKLL--N------HPH-----IIKLYQVMET------KDMLY--IVTEFAKNG--EMFDYLT-----------------------SNG-----------------HL--SENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLD-GNMDI-------------------KLADFGFGNF--------YKSGEPLST---WCGSPPYAAPEVFE-----GKEYEGPQLDIWSLGVVLYVLVC-GSLPFD-GP----NLPTLRQRVLEGRFRIPFFMS---------------------------------------------------------------------QDCES-LIRRMLVVDPARRIT-----IAQIRQHRWM-----------
-----YDIEGTLGKGNFAVV---KLGRHR-------I-TKT---EVAIKIIDKSQLDAVN--LE-KIYR-------EVQIMKML--D------HPH-----IIKLYQVMET------KSMLY--LVTEYAKNG--EIFDYLA-----------------------NHG-----------------RL--NESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLD-NNMNI-------------------KIADFGFGNF--------FKSGELLAT---WCGSPPYAAPEVFE-----GQQYEGPQLDIWSMGVVLYVLVC-GALPFD-GP----TLPILRQRVLEGRFRIPYFMS---------------------------------------------------------------------EDCEH-LIRRMLVLDPSKRLT-----IAQIKEHKWM-----------
-----WEIIGELGDGAFGKV---YKAQNK-------E-TSV---LAAAKVIDTKSEEELE--DY-M--V-------EIDILASC--D------HPN-----IVKLLDAFYY------ENNLW--ILIEFCAGG--AVDAVML----------------------ELER-----------------PL--TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDI-------------------KLADFGVSAKN-------TRTIQRRDS---FIGTPYWMAPEVVMCE-TSKDRPYDYKADVWSLGITLIEMAE-IEPPHH-EL-NPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------------------------------------SNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV-----------
----L-RLEVKLGQGCFGEV---WMGTWN---------GTT---RVAIKTLK-PGTM-SP--EA-FL-Q-------EAQVMKKL--R------HEK-----LVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK------------------------GE--------------TGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC-------------------KVADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGRVPYP-GM-VNREVLDQVERGYRMPCPPECP-----------------------------------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L-----------
-----WEIVGELGDGAFGKV---YKAKNK-------E-TGA---LAAAKVIETKSEEELE--DY-I--V-------EIEILATC--D------HPY-----IVKLLGAYYH------DGKLW--IMIEFCPGG--AVDAIML----------------------ELDR-----------------GL--TEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMT-LEGDI-------------------RLADFGVSAKN-------LKTLQKRDS---FIGTPYWMAPEVVMCE-TMKDTPYDYKADIWSLGITLIEMAQ-IEPPHH-EL-NPMRVLLKIAKSDPPTLLTPSKWS---------------------------------------------------------------------VEFRD-FLKIALDKNPETRPS-----AAQLLEHPFV-----------
--LCP---GRELGRGKFAVV---RKCIKK-------D-SGK---EFAAKFMRKRRKGQDC--RM-EIIH-------EIAVLELA-QD------NPW-----VINLHEVYET------ASEMI--LVLEYAAGG--EIFDQCVA---------------------DREE-----------------AF--KEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLT-SESPLG----------------DIKIVDFGLSRI--------LKNSEELRE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GISPFL-GN----DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-----AEECLKHPWL-----------
--ILT---SKELGRGKFAVV---RQCISK-------S-TGQ---EYAAKFLKKRRRGQDC--RA-EILH-------EIAVLELA-KS------CPR-----VINLHEVYEN------TSEII--LILEYAAGG--EIFSLCLP---------------------ELAE-----------------MV--SENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS-SIYPLG----------------DIKIVDFGMSRK--------IGHACELRE---IMGTPEYLAPEILN------YDPITTATDMWNIGIIAYMLLT-HTSPFV-GE----DNQETYLNISQVNVDYSEETFSSVS-----------------------------------------------------------------QLATD-FIQSLLVKNPEKRPT-----AEICLSHSWL-----------
-----FTKLEKIGKGSFGEV---FKGIDN-------R-TQK---VVAIKIIDLEEAEDEI--ED-IQ-Q-------EITVLSQC--D------SPY-----VTKYYGSYLK------DTKLW--IIMEYLGGG--SALDLLE------------------------PG-----------------PL--DETQIATILREILKGLDYLHSEKKIHRDIKAANVLLS-EHGEV-------------------KLADFGVAGQL-------TDTQIKRNT---FVGTPFWMAPEVIK------QSAYDSKADIWSLGITAIELAR-GEPPHS-EL-HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------------------------------------KPLKE-FVEACLNKEPSFRPT-----AKELLKHKFI-----------
YLLGI-----NLGEGSYAKV---KSAYSE-------R-LKF---NVAIKIIDRKKAPADF--LE-KFLP------REIEILAML--N------HCS-----IIKTYEIFET-----SHGKVY--IVMELAVQG--DLLELIK-----------------------TRG-----------------AL--HEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLD-KDFNI-------------------KLSDFSFSKRCLR---DDSGRMALSKT---FCGSPAYAAPEVLQ-----GIPYQPKVYDIWSLGVILYIMVC-GSMPYD-DS----NIKKMLRIQKEHRVNFPRSKHLT-------------------------------------------------------------------GECKD-LIYHMLQPDVNRRLH-----IDEILSHCWM-----------
----L-RLEVKLGQGCFGEV---WMGTWN---------GTT---KVAIKTLK-PGTM-MP--EA-FL-Q-------EAQIMKKL--R------HDK-----LVPLYAVVS-------EEPIY--IVTEFMSKG--SLLDFLK------------------------EG--------------DGKYL--KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG-ENLVC-------------------KIADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGRVPYP-GM-VNREVLEQVERGYRMPCPQGCP-----------------------------------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL-------------
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