Protein Surface  Ribbon
Inhibitor 891
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 8 kinases in KIF 3FLQA_891 (MAPK14, PDB code: 3FLQ, chain A)

Multiple sequence alignment of family kinases

Conserved residues:   
                            
Group      Kinase           
CMGC       MAPK14       203 
CMGC       MAPK10        64 
CMGC       MAPK11        24 
CMGC       MAPK8         26 
CMGC       MAPK9         26 
CMGC       NLK          126 
AGC        RPS6KA3       68 
Other      STK36          4 



---YQNLSPVGSGAYGSVCAAFDTKTGL---RVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK-CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF
---YQNLKPIGSGAQGIVCAAYDAVLDR---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI
LQG---LRPVGSGAYGSVCSAYDARLRQ---KVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVK-CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR----QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF
---YQNLKPIGSGAQGIVCAAYDAILER---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI
---YQQLKPIGSGAQGIVCAAFDTVLGI---NVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI
IEP---DRPIGYGAFGVVWSVTDPRDGK---RVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-IDYFEEIYVVTELMQS-DLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL
---FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQT------EGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKES-IDHEKKAYSFCGTVEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLTGTLPFQGK---DRKETMTMILKAKLGMPQFLS---------------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
---YHVLEMIGEGSFGRVYKGRRKYSAQ---VVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFET------DKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAM-STNTMVLTSIKGTPLYMSPELVE-ERPYDHTADLWSVGCILYELAVGTPPFYAT---SIFQLVSLILKDPVRWPSTIS---------------------------------------PCFKNFLQGLLTKDPRQRLS-----WPDLLYHPFI