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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
CMGC CDC2 4
CMGC CDK2 4
TK FGFR1 478
TK FGFR2 481
AGC RPS6KB1 91
-YQNLSPVGSGAYGSVCAAFD---T-------KTGLRVAVKKLSRPFQSIIH--AKRTYR--ELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF
-YTKIEKIGEGTYGVVYKGRH---K-------TTGQVVAMKKIRLESEEEGV--PSTAIR--EISLLKEL-RHPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF
-FQKVEKIGEGTYGVVYKARN---K-------LTGEVVALKKIRLDTETEGV--PSTAIR--EISLLKEL-NHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
L-VLGKPLGEGCFGQVVLAEA---IGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-S--EMEMMKMIGKHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL--
-LTLGKPLGEGCFGQVVMAEA---VGIDKDKPKEAVTVAVKMLK-DDAT-EKDLSDLV-S--EMEMMKMIGKHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN--IDYYKKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL--
-FELLRVLGKGGYGKVFQVRKVTGA-------NTGKIFAMKVLKKAMIVRNA--KDTAHTKAERNILEEV-KHPFIVDLIYAFQT------GGKLYLILEYLSGGELFMQLE---REG-----------------IFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKES-IHDGTVTHT---FCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLT-GAPPFTGE---NRKKTIDKILKCKLNLPPYLT----------------------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF
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