|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
CAMK CHEK1 9
CAMK CHEK2 220
TK LCK 245
--YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR------ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK-CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR-----HTDDEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KK------EICINKMLNHENVVKFYGHRRE------GNIQYLFLEYCSGGELFDRIEPDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-D------AEDYYIVLELMEGGELFDKVVGNK---RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI---LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-
--LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFL-A------EANLMKQLQHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK-TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC---KIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
|