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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
TK ABL2 288
TK LCK 245
CMGC MAPK11 24
CMGC MAPK9 26
TK SRC 270
TK YES1 277
---YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
---ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK-EDTM-EVEEFL-KEAAVMKEIKHPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
---ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK-EDTM-EVEEFL-KEAAVMKEIKHPNLVQLLGVCTL------EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT--GDTYTAHAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP-----------------------------------------PKVYELMRACWKWSPADRPSFAETHQA--F
---LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFL-AEANLMKQLQHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
LQG---LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
---YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH-M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
--L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM-SPEAFL-QEAQVMKKLRHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
--L-RLEVKLGQGCFGEVWMGTWN-GTTKVAIKTLK-PGTM-MPEAFL-QEAQIMKKLRHDKLVPLYAVVS-------EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIE--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCP-----------------------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL--
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