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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CMGC GSK3A 119
TK LCK 245
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK12 27
CMGC MAPK13 25
CMGC MAPK8 26
CAMK MKNK2 84
TK PTK6 191
CAMK STK17A 61
----YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH-AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR----------HTDDEMTG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT------------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
----YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV-PSTAIREISLLKEL-RHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF-------GIPIRVYTH---EVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KKPLFHGD------------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-
----FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV-PSTAIREISLLKEL-NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF-------GVPVRTYTH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD------------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
---W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP-ENI-KKEICINKML-NHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE---PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR-----YNNRERLLNK---MCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
----YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNR-------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT--KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ--------LVRGEPNVS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGD------------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-
----LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SP-DAFL-AEANLMKQL-QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI-------E--DNEYTAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM------------TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
----YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYC-QRT-LREIKILLRF-RHENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVAD----PDHDHTGFLTE---YVATRWYRAPEIML----NSKGYTKSIDIWSVGCILAEMLS-NRPIFPGK------------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL-
----YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH-AKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ-----M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART--------AGTSFMMTP---YVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGEMVR-HKILFPGR------------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-
-LQG---LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH-ARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK----CQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCEL---RILDFGLAR----------QADEEMTG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLQ-GKALFPGS------------DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF-
----YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF-AKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFY--LVMPFMGT---DLGKLMK----HE---KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCEL---KILDFGLAR----------QADSEMTG---YVVTRWYRAPEVIL----NWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGS------------DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF-
YVSP----THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF-AKRAYRELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFY--LVMPFMQT---DLQKIM-----GM---EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCEL---KILDFGLAR----------HADAEMTG---YVVTRWYRAPEVIL----SWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGK------------DYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP-----------RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF-
----YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTH-AKRAYRELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ-----M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART--------AGTSFMMTP---YVVTRYYRAPEVIL-----GMGYKENVDLWSVGCIMGEMVC-HKILFPGR------------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-
QLQE----DVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRS-R--VFREVEMLYQCQGHRNVLELIEFFEE------EDRFY--LVFEKMRGG--SILSHIH---KRR---HFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCE-HPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLT---PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLS-GYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHIS-----------------------------------CAAKDLISKLLVRDAKQRLSAAQVLQHPWV-
---F-TLCRKLGSGYFGEVFEGLWK-DRVQVAIKVIS-RDNL-LHQQMLQ-SEIQAMKKL-RHKHILALYAVVSV------GDPVY--IITELMAKG--SLLELLR----DSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLC---KVGDFGLARLI----------KEDVYLSHDHNIPYKWTAPEALS-----RGHYSTKSDVWSFGILLHEMFSRGQVPYPGM------------SNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL---
-LCP---GRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDC-RMEIIHEIAVLELAQDNPWVINLHEVYET------ASEMI--LVLEYAAGG--EIFDQCVA-DREE---AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLT-SESPLGDIKIVDFGLSRI--------LKNSEELRE---IMGTPEYVAPEILS-----YDPISMATDMWSIGVLTYVMLT-GISPFLGN---------------DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------ESAVDFIRTLLVKKPEDRATAEECLKHPWL-
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