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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CLK2 163
CMGC CLK3 156
CMGC CSNK2A1 39
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
TK FGFR1 478
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CAMK HUNK 61
TK LCK 245
TK LYN 247
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK8 26
CMGC MAPK9 26
CAMK MGC42105 74
Other NEK2 8
Other NEK3 4
AGC PDPK1 82
CAMK PHKG2 24
Other PLK1 53
Other PLK2 82
Other PLK3 62
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK6 191
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA6 73
STE SLK 34
TK SRC 270
STE STK10 36
---YQNLSPVGSGAYGSV---CAAFDT-------KTGL---RVAVKKLSRPFQSIIH--AK-RTYR------ELRLLKHM--K-----HEN-----VIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KL---TDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVN-EDCEL--------------------KILDFGLAR-------HTDDEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF-----------
---ITMKHKLGGGQYGEV---YEGVWK-------KYSL---TVAVKTLK-EDTM-EV--EE-FL-K------EAAVMKEI--K-----HPN-----LVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEV---NAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVG-ENHLV--------------------KVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GI-----------DLSQVYELLEKDYRMERPEGCP-----------------------------------------------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F-----------
---YQLFEELGKGAFSVV---RRCMKI-------PTGQ---EYAAKIINTKKLSARD--HQ-KLER------EARICRLL--K-----HPN-----IVRLHDSISE------EGFHY--LVFDLVTGG--ELFEDIV----ARE-----------------YY---SEADASHCIQQILESVNHCHLN-----GIVHRDLKPENLLLA-SKSKGA-----------------AVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDMWACGVILYILLV-GYPPFW-DE--------------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT-----ASEALKHPWI-----------
---YTKIEKIGEGTYGVV---YKGRHK-------TTGQ---VVAMKKIRLESEEEGV--PS-TAIR------EISLLKEL--R-----HPN-----IVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YM---DSSLVKSYLYQILQGIVFCHSR-----RVLHRDLKPQNLLID-DKGTI--------------------KLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF-----------
---FQKVEKIGEGTYGVV---YKARNK-------LTGE---VVALKKIRLDTETEGV--PS-TAIR------EISLLKEL--N-----HPN-----IVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GI---PLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI--------------------KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
---YEKLEKIGEGTYGTV---FKAKNR-------ETHE---IVALKRVRLDDDDEGV--PS-SALR------EICLLKEL--K-----HKN-----IVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DL---DPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLIN-RNGEL--------------------KLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGRPLFP-GN-----------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF-----------
--W-DLVQTLGEGAYGEV---QLAVNR-------VTEE---AVAVKIVDMKRAVDCP--EN-I-KK------EICINKML--N-----HEN-----VVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GM---PEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD-ERDNL--------------------KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
-YI--MSKTLGSGACGEV---KLAFER-------KTCK---KVAIKIISKRKFAIGS--AR-EADPALNVETEIEILKKL--N-----HPC-----IIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV----GNK-----------------RL---KEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-----------------LIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH-------------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
--W-EMRERLGTGGFGNV---CLYQHR-------ELDL---KIAIKSCRLELSTKNR--ER--WCH------EIQIMKKL--N-----HAN-----VVKACDVPEELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-----------------GL---KESQILSLLSDIGSGIRYLHEN-----KIIHRDLKPENIVLQ-DVGGKI-----------------IHKIIDLGYAKD-----VDQGSLCTS---FVGTLQYLAPELFE------NKPYTATVDYWSFGTMVFECIA-GYRPFL-HHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------------------------------------------LVVEPMENWLQLMLNWDPQQRG----------------GPVDLTLKQ--
---YEIVSTLGEGTFGRV---VQCVDH-------RRGG--ARVALKIIKNVEKYKEA--AR----L------EINVLEKI--NEKDPDNKN----LCVQMFDWFDY------HGHMC--ISFELLGL---STFDFLK----DNN-----------------YLP-YPIHQVRHMAFQLCQAVKFLHDN-----KLTHTDLKPENILFV-NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT-------FDHEHHST---IVSTRHYRAPEVIL------ELGWSQPCDVWSIGCIIFEYYV-GFTLFQ-TH-----------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY----------------------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-----LGEALQHPFF-----------
---YEIVGNLGEGTFGKV---VECLDH-------ARGK--SQVALKIIRNVGKYREA--AR----L------EINVLKKI--KE--KDKENK--FLCVLMSDWFNF------HGHMC--IAFELLGK---NTFEFLK-----EN-----------------NFQPYPLPHVRHMAYQLCHALRFLHEN-----QLTHTDLKPENILFV-NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT-------FDHEHHTT---IVATRHYRPPEVIL------ELGWAQPCDVWSIGCILFEYYR-GFTLFQ-TH-----------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY----------------------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRIT-----LAEALLHPFF-----------
---YQLVRKLGRGKYSEV---FEAINI-------TNNE---KVVVKILKPVKKKKIK--R------------EIKILENL-RG-----GPN-----IITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------Q-----------------TL---TDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL--------------------RLIDWGLAEF-----YHPGQEYNV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH-----------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF-----------
---YDTGEELGSGQFAVV---KKCREK-------STGL---QYAAKFIKKRRTKSSR--RG-VSREDI--EREVSILKEI--Q-----HPN-----VITLHEVYEN------KTDVI--LILELVAGG--ELFDFLA----EKE-----------------SL---TEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKP----------------RIKIIDFGLAHK-----IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFL-GD--------------TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
---YDIGEELGSGQFAIV---KKCREK-------STGL---EYAAKFIKKRQSRASR--RG-VSREEI--EREVSILRQV--L-----HHN-----VITLHDVYEN------RTDVV--LILELVSGG--ELFDFLA----QKE-----------------SL---SEEEATSFIKQILDGVNYLHTK-----KIAHFDLKPENIMLL-DKNIPIP----------------HIKLIDFGLAHE-----IEDGVEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFL-GD--------------TKQETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------------ELAKDFIRKLLVKETRKRLT-----IQEALRHPWI-----------
---YEMGEELGSGQFAIV---RKCRQK-------GTGK---EYAAKFIKKRRLSSSR--RG-VSREEI--EREVNILREI--R-----HPN-----IITLHDIFEN------KTDVV--LILELVSGG--ELFDFLA----EKE-----------------SL---TEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLL-DKNVPNP----------------RIKLIDFGIAHK-----IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFL-GE--------------TKQETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI-----------
--L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVT---KVAVKMLK-SDAT-EKDLSD-LI-S------EMEMMKMIG-K-----HKN-----IINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLASK-----KCIHRDLAARNVLVT-EDNVM--------------------KIADFGLARDI-H--H--IDYYKKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGGSPYP-GV-----------PVEELFKLLKEGHRMDKPSNCT-----------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-------------
--F-TEFRVLGKGGFGEV---CAVQVK-------NTGK---MYACKKLDKKRLKKKG--GE-KMAL-----LEKEILEKV--S-----SPF-----IVSLAYAFES------KTHLC--LVMSLMNGG--DLKFHIYN--VGTR-----------------GL---DMSRVIFYSAQIACGMLHLHEL-----GIVYRDMKPENVLLD-DLGNC--------------------RLSDLGLAVE-----MKGGKPITQ---RAGTNGYMAPEILM-----EKVSYSYPVDWFAMGCSIYEMVA-GRTPFK-DY----------KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG-----SRE-------KSDDPR-----
---YTDIKVIGNGSFGVV---YQARLA-------ETRE---LVAIKKVLQDKRFKNR---------------ELQIMRKL--D-----HCN-----IVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------------TI---PILYVKVYMYQLFRSLAYIHSQ-----GVCHRDIKPQNLLVDPDTAVL--------------------KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF-----------
---YTDTKVIGNGSFGVV---YQAKLC-------DSGE---LVAIKKVLQDKRFKNR---------------ELQIMRKL--D-----HCN-----IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TL---PVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL--------------------KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
---LKLEKKLGAGQFGEV---WMATYN--------KHT---KVAVKTMK-PGSM-SV--EA-FL-A------EANVMKTL--Q-----HDK-----LVKLHAVVT-------KEPIY--IITEFMAKG--SLLDFLK-----SD--------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVS-ASLVC--------------------KIADFGLARVI----E--DNEYTAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGRIPYP-GM-----------SNPEVIRALERGYRMPRPENCP-----------------------------------------------------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L-----------
---YEVLEFLGRGTFGQV---AKCWKR-------STKE---IVAIKILKNHPSYARQ--GQ-I---------EVSILSRL--S-----SENADEYNFVRSYECFQH------KNHTC--LVFEMLEQ---NLYDFLKQ--NKFS-----------------PL---PLKYIRPILQQVATALMKLKSL-----GLIHADLKPENIMLV-DPVRQPY----------------RVKVIDFGSAS------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPLYP-GA-----------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT-----PLKTLNHQFV-----------
---YEVLEFLGRGTFGQV---VKCWKR-------GTNE---IVAIKILKNHPSYARQ--GQ-I---------EVSILARL--STESADDYN-----FVRAYECFQH------KNHTC--LVFEMLEQ---NLYDFLKQ--NKFS-----------------PL---PLKYIRPVLQQVATALMKLKSL-----GLIHADLKPENIMLV-DPSRQPY----------------RVKVIDFGSAS------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPLYP-GA-----------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT-----PIETLNHPFV-----------
---YEVLDFLGRGTFGQV---VKCWKR-------GTNE---IVAIKILKNHPSYARQ--GQ-I---------EVSILARL--S-----TENADEYNFVRAYECFQH------RNHTC--LVFEMLEQ---NLYDFLKQ--NKFS-----------------PL---PLKVIRPILQQVATALKKLKSL-----GLIHADLKPENIMLV-DPVRQPY----------------RVKVIDFGSAS------HVSKTVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPLYP-GA-----------LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT-----PAETLNHPFV-----------
---YDIIEVLGKGTFGEV---AKGWRR-------STGE---MVAIKILKNDAYRNRI--IK-N---------ELKLLHCM--RGLDPEEAH-----VIRFLEFFHD------ALKFY--LVFELLEQ---NLFEFQK-----EN-----------------NFAPLPARHIRTVTLQVLTALARLKEL-----AIIHADLKPENIMLV-DQTRCPF----------------RVKVIDFGSASIF----SEVRYVKEP---YIQSRFYRAPEILL------GLPFCEKVDVWSLGCVMAELHL-GWPLYP-GN-----------NEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-----PSAALRHPFV-----------
IGS----RKLGEGSFAKV---REGLHV-------LTGE---KVAIKVIDKKRAKKDT--YV-TKNLR----REGQIQQMI--R-----HPN-----ITQLLDILET------ENSYY--LVMELCPGG--NLMHKIY----EKK-----------------RL---EESEARRYIRQLISAVEHLHRA-----GVVHRDLKIENLLLD-EDNNI--------------------KLIDFGLSNCAG--ILGYSDPFST---QCGSPAYAAPELLA------RKKYGPKIDVWSIGVNMYAMLT-GTLPFT-VE------------PFSLRALYQKMVD-KEMNPLPTQ--LS-----------------------------------------------------------------------TGAISFLRSLLEPDPVKRPN-----IQQALANRWL-----------
---LKLVERLGAGQFGEV---WMGYYN--------GHT---KVAVKSLK-QGSM-SP--DA-FL-A------EANLMKQL--Q-----HQR-----LVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKL---TINKLLDMAAQIAEGMAFIEER-----NYIHRDLRAANILVS-DTLSC--------------------KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGRIPYP-GM-----------TNPEVIQNLERGYRMVRPDNCP-----------------------------------------------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L-----------
---IKLVKRLGAGQFGEV---WMGYYN--------NST---KVAVKTLK-PGTM-SV--QA-FL-E------EANLMKTL--Q-----HDK-----LVRLYAVVTR------EEPIY--IITEYMAKG--SLLDFLK-----SD--------------EGGKV---LLPKLIDFSAQIAEGMAYIERK-----NYIHRDLRAANVLVS-ESLMC--------------------KIADFGLARVI----E--DNEYTAREGAKFPIKWTAPEAIN------FGCFTIKSDVWSFGILLYEIVTYGKIPYP-GR-----------TNADVMTALSQGYRMPRVENCP-----------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT-----FDYLQSV--L-----------
---YTNLSYIGEGAYGMV---CSAYDN-------VNKV---RVAIKKISPFEHQTYC--QR-T-LR------EIKILLRF--R-----HEN-----IIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ-----------------HL---SNDHICYFLYQILRGLKYIHSA-----NVLHRDLKPSNLLLN-TTCDL--------------------KICDFGLARVAD-PDHDHTGFLTE---YVATRWYRAPEIML-----NSKGYTKSIDIWSVGCILAEMLS-NRPIFP-GK-----------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------------------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL-----------
---YQNLKPIGSGAQGIV---CAAYDA-------VLDR---NVAIKKLSRPFQNQTH--AK-RAYR------ELVLMKCV--N-----HKN-----IISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------EL---DHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-SDCTL--------------------KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGEMVR-HKILFP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
LQG---LRPVGSGAYGSV---CSAYDA-------RLRQ---KVAVKKLSRPFQSLIH--AR-RTYR------ELRLLKHL--K-----HEN-----VIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ-----------------AL---SDEHVQFLVYQLLRGLKYIHSA-----GIIHRDLKPSNVAVN-EDCEL--------------------RILDFGLAR-------QADEEMTG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLQ-GKALFP-GS-----------DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------------------------------------------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF-----------
---YQNLKPIGSGAQGIV---CAAYDA-------ILER---NVAIKKLSRPFQNQTH--AK-RAYR------ELVLMKCV--N-----HKN-----IIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------EL---DHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-SDCTL--------------------KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDLWSVGCIMGEMVC-HKILFP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI-----------
---YQQLKPIGSGAQGIV---CAAFDT-------VLGI---NVAVKKLSRPFQNQTH--AK-RAYR------ELVLLKCV--N-----HKN-----IISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M-----------------EL---DHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-SDCTL--------------------KILDFGLART-----ACTNFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGELVK-GCVIFQ-GT-----------DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------------LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI-----------
---YRIRGEIGSGNFSQV---KLGIHS-------LTKE---KVAIKILDKTKLDQKT--QR-LLSR------EISSMEKL--H-----HPN-----IIRLYEVVET------LSKLH--LVMEYAGGG--ELFGKIS----TEG-----------------KL---SEPESKLIFSQIVSAVKHMHEN-----QIIHRDLKAENVFYT-SNTCV--------------------KVGDFGFSTV-----SKKGEMLNT---FCGSPPYAAPELFR-----DEHYIGIYVDIWALGVLLYFMVT-GTMPFR-AE--------------TVAKLKKSILEGTYSVPPHV----S-----------------------------------------------------------------------EPCHRLIRGVLQQIPTERYG-----IDCIMNDEWM-----------
---YEVLYTIGTGSYGRC---QKIRRK-------SDGK---ILVWKELDYGSMTEAE--KQ-MLVS------EVNLLREL--K-----HPN-----IVRYYDRIIDR----TNTTLY--IVMEYCEGG--DLASVITKGTKERQ-----------------YL---DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV--------------------KLGDFGLARIL----NHDTSFAKT---FVGTPYYMSPEQMN------RMSYNEKSDIWSLGCLLYELCA-LMPPFT-AF--------------SQKELAGKIREGKFRRIPYRY---S-----------------------------------------------------------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I----------
--Y-MVLRMIGEGSFGRA---LLVQHE-------SSNQ---MFAMKEIRLPKSFSNT--QN--SRK------EAVLLAKM--K-----HPN-----IVAFKESFEA------EGHLY--IVMEYCDGG--DLMQKIKQ--QKGK-----------------LF---PEDMILNWFTQMCLGVNHIHKK-----RVLHRDIKSKNIFLT-QNGKV--------------------KLGDFGSARLL----SNPMAFACT---YVGTPYYVPPEIWE------NLPYNNKSDIWSLGCILYELCT-LKHPFQ-AN-----------SWKNLILKVCQGCISPLPSHYS-----------------------------------------------------------------------------YELQFLVKQMFKRNPSHRPS-----ATTLLS----RGIV-------
--F-KFGKILGEGSFSTV---VLAREL-------ATSR---EYAIKILEKRHIIKEN--KVPYVTR------ERDVMSRL--D-----HPF-----FVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SF---DETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI--------------------QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG--------------NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
YDP---KDVIGRGVSSVV---RRCVHR-------ATGH---EFAVKIMEVTAERLSP--EQ-LEEVREATRRETHILRQV-AG-----HPH-----IITLIDSYES------SSFMF--LVFDLMRKG--ELFDYLT----EKV-----------------AL---SEKETRSIMRSLLEAVSFLHAN-----NIVHRDLKPENILLD-DNMQI--------------------RLSDFGFSCH-----LEPGEKLRE---LCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFW-HR--------------RQILMLRMIMEGQYQFSSPEWDDRS-----------------------------------------------------------------------STVKDLISRLLQVDPEARLT-----AEQALQHPFF-----------
-YV--RGRFLGKGGFAKC---FEISDA-------DTKE---VFAGKIVPKSLLLKPH--QR-EKMS-----MEISIHRSL--A-----HQH-----VVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------AL---TEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV--------------------KIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS------KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS--------------CLKETYLRIKKNEYSIPKHIN---------------------------------------------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF-----------
--Y-CRGKVLGKGGFAKC---YEMTDL-------TNNK---VYAAKIIPHSRVAKPH--QR-EKID-----KEIELHRIL--H-----HKH-----VVQFYHYFED------KENIY--ILLEYCSRR--SMAHILK----ARK-----------------VL---TEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFIN-EAMEL--------------------KVGDFGLAARL----EPLEHRRRT---ICGTPNYLSPEVLN------KQGHGCESDIWALGCVMYTMLL-GRPPFE-TT--------------NLKETYRCIREARYTMPSSLL---------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS-----LDDIIRHDFF-----------
-YL--KGRLLGKGGFARC---YEATDT-------ETGS---AYAVKVIPQSRVAKPH--QR-EKIL-----NEIELHRDL--Q-----HRH-----IVRFSHHFED------ADNIY--IFLELCSRK--SLAHIWK----ARH-----------------TL---LEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFIT-ENMEL--------------------KVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLL------RQGHGPEADVWSLGCVMYTLLC-GSPPFE-TA--------------DLKETYRCIKQVHYTLPASLS---------------------------------------------------------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF-----------
-PD----EVLGSGQFGIV---YGGKHR-------KTGR---DVAIKIIDKLRFPTKQ--ES-QLRN------EVAILQNL--H-----HPG-----VVNLECMFET------PERVF--VVMEKLHGD--MLEMILS---SEKG-----------------RL---PEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFP-----------------QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR------NKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED----------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------------------------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL-----------
-PD----EVLGSGQFGVV---YGGKHR-------KTGR---DVAVKVIDKLRFPTKQ--ES-QLRN------EVAILQSL--R-----HPG-----IVNLECMFET------PEKVF--VVMEKLHGD--MLEMILS---SEKG-----------------RL---PERLTKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFP-----------------QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GTFPFN-ED----------------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS-----VDKSLSHPWL-----------
FAD----EVLGSGQFGIV---YGGKHR-------KTGR---DVAIKVIDKMRFPTKQ--ES-QLRN------EVAILQNL--H-----HPG-----IVNLECMFET------PERVF--VVMEKLHGD--MLEMILS---SEKS-----------------RL---PERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVLLA-SAEPFP-----------------QVKLCDFGFARI-----IGEKSFRRS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED----------------EDINDQIQNAAFMYPPNPWREIS-----------------------------------------------------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL-----------
--F-TLCRKLGSGYFGEV---FEGLWK--------DRV---QVAIKVIS-RDNL-LH-QQM-LQ-S------EIQAMKKL--R-----HKH-----ILALYAVVSV------GDPVY--IITELMAKG--SLLELLR-----DS--------------DEKVL---PVSELLDIAWQVAEGMCYLESQ-----NYIHRDLAARNILVG-ENTLC--------------------KVGDFGLARLI-------KEDVYLSHDHNIPYKWTAPEALS------RGHYSTKSDVWSFGILLHEMFSRGQVPYP-GM-----------SNHEAFLRVDAGYRMPCPLECP-----------------------------------------------------------------------------PSVHKLMLTCWCRDPEQRPC-----FKALRERL-------------
---FELLKVLGQGSFGKVFLVRKVTRP-------DSGH---LYAMKVLKKATLKVRD--RV-RTKM------ERDILADV--N-----HPF-----VVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS----KEV-----------------MF---TEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLD-EEGHI--------------------KLTDFGLSKEA----IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GSLPFQ-GK--------------DRKETMTLILKAKLGMPQFLS---------------------------------------------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
---FELLKVLGQGSYGKV---FLVRKV-------KGSDAGQLYAMKVLKKATLKVRD--RV-RSKM------ERDILAEV--N-----HPF-----IVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS----KEV-----------------MF---TEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLD-EEGHI--------------------KITDFGLSKEA----IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLPFQ-GK--------------DRKETMALILKAKLGMPQFLS---------------------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
---FELLKVLGQGSFGKV---FLVRKK-------TGPDAGQLYAMKVLKKASLKVRD--RV-RTKM------ERDILVEV--N-----HPF-----IVKLHYAFQT------EGKLY--LILDFLRGG--DVFTRLS----KEV-----------------LF---TEEDVKFYLAELALALDHLHQL-----GIVYRDLKPENILLD-EIGHI--------------------KLTDFGLSKES----VDQEKKAYS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GTLPFQ-GK--------------DRNETMNMILKAKLGMPQFLS---------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
---WEIIGELGDGAFGKV---YKAQNK-------ETSV---LAAAKVIDTKSEEELE--DY-M--V------EIDILASC--D-----HPN-----IVKLLDAFYY------ENNLW--ILIEFCAGG--AVDAVML---ELER-----------------PL---TESQIQVVCKQTLDALNYLHDN-----KIIHRDLKAGNILFT-LDGDI--------------------KLADFGVSAKN----TRTIQRRDS---FIGTPYWMAPEVVMCE-TSKDRPYDYKADVWSLGITLIEMAE-IEPPHH-EL-----------NPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV-----------
--L-RLEVKLGQGCFGEV---WMGTWN--------GTT---RVAIKTLK-PGTM-SP--EA-FL-Q------EAQVMKKL--R-----HEK-----LVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYL---RLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVG-ENLVC--------------------KVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGRVPYP-GM-----------VNREVLDQVERGYRMPCPPECP-----------------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-----------
---WEIVGELGDGAFGKV---YKAKNK-------ETGA---LAAAKVIETKSEEELE--DY-I--V------EIEILATC--D-----HPY-----IVKLLGAYYH------DGKLW--IMIEFCPGG--AVDAIML---ELDR-----------------GL---TEPQIQVVCRQMLEALNFLHSK-----RIIHRDLKAGNVLMT-LEGDI--------------------RLADFGVSAKN----LKTLQKRDS---FIGTPYWMAPEVVMCE-TMKDTPYDYKADIWSLGITLIEMAQ-IEPPHH-EL-----------NPMRVLLKIAKSDPPTLLTPSKWS---------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS-----AAQLLEHPFV-----------
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